keyword
MENU ▼
Read by QxMD icon Read
search

a historical perspective on the discovery

keyword
https://www.readbyqxmd.com/read/29741140/modern-approaches-for-the-discovery-of-anti-infectious-drugs-for-the-treatment-of-neglected-diseases
#1
Carolina L Bellera, Maria L Sbaraglini, Alan Talevi
Neglected diseases comprise a number of infectious diseases historically endemic to low- and middle-income countries, though recently they have spread to high-income countries due to human migrations. In the past, pharmaceutical companies have shown hesitant to invest in these health conditions, due to the limited return on investment. As a result, the role of the academic sector and non-for-profit organizations in the discovery of new drugs for neglected diseases has been particularly relevant. <p> Here, we review recent applications of modern drug discovery technologies in the field of neglected diseases, including high-throughput screening, in silico screening and computer-aided drug design...
May 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29730201/androgen-receptor-targeted-treatments-for-prostate-cancer-35-years-progress-with-antiandrogens
#2
REVIEW
E David Crawford, Paul F Schellhammer, David G McLeod, Judd W Moul, Celestia S Higano, Neal Shore, Louis Denis, Peter Iversen, Mario A Eisenberger, Fernand Labrie
PURPOSE: Antiandrogens inhibit the androgen receptor (AR) and play an important role in the treatment of prostate cancer (PC). This review provides a historical perspective on the development and clinical benefit of antiandrogens in the treatment of PC. MATERIALS AND METHODS: We searched PubMed® for clinical trials with the search terms "antiandrogens" and "prostate cancer" combined with drug names for antiandrogens. This article represents a collaboration of clinical investigators who have made critical scientific contributions leading to the approval of antiandrogens for treating patients with PC...
May 3, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29718101/a-historical-perspective-on-some-new-discoveries-on-spermatogenesis-from-the-laboratory-of-enrico-sertoli-in-1878
#3
Christopher B Geyer
No abstract text is available yet for this article.
May 1, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29668873/sex-and-gender-differences-research-design-for-basic-clinical-and-population-studies-essentials-for-investigators
#4
Janet W Rich-Edwards, Ursula B Kaiser, Grace L Chen, JoAnn E Manson, Jill Goldstein
A sex and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology can improve study design and inference in sex and gender differences research. We address issues of motivation, subject selection, sample size, data collection, analysis, and interpretation, considering implications for basic, clinical, and population research. In particular, we focus on methods to test sex/gender differences as effect modification or interaction, and discuss why some inferences from sex-stratified data should be viewed with caution...
April 12, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29616309/a-historical-perspective-on-the-role-of-sensory-nerves-in-neurogenic-inflammation
#5
REVIEW
João Sousa-Valente, Susan D Brain
The term 'neurogenic inflammation' is commonly used, especially with respect to the role of sensory nerves within inflammatory disease. However, despite over a century of research, we remain unclear about the role of these nerves in the vascular biology of inflammation, as compared with their interacting role in pain processing and of their potential for therapeutic manipulation. This chapter attempts to discuss the progress in understanding, from the initial discovery of sensory nerves until the present day...
April 3, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29544621/la-ferrassie-1-new-perspectives-on-a-classic-neandertal
#6
Asier Gómez-Olivencia, Rolf Quam, Nohemi Sala, Morgane Bardey, James C Ohman, Antoine Balzeau
The La Ferrassie 1 (LF1) skeleton, discovered over a century ago, is one of the most important Neandertal individuals both for its completeness and due to the role it has played historically in the interpretation of Neandertal anatomy and lifeways. Here we present new skeletal remains from this individual, which include a complete right middle ear ossicular chain (malleus, incus, and stapes), three vertebral fragments, and two costal remains. Additionally, the study of the skeleton has allowed us to identify new pathological lesions, including a congenital variant in the atlas, a greenstick fracture of the left clavicle, and a lesion in a mid-thoracic rib of unknown etiology...
April 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29530606/achieving-a-predictive-understanding-of-antimicrobial-stress-physiology-through-systems-biology
#7
REVIEW
Sean G Mack, Randi L Turner, Daniel J Dwyer
The dramatic spread and diversity of antibiotic-resistant pathogens has significantly reduced the efficacy of essentially all antibiotic classes, bringing us ever closer to a postantibiotic era. Exacerbating this issue, our understanding of the multiscale physiological impact of antimicrobial challenge on bacterial pathogens remains incomplete. Concerns over resistance and the need for new antibiotics have motivated the collection of omics measurements to provide systems-level insights into antimicrobial stress responses for nearly 20 years...
March 9, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29477337/fuzziness-in-protein-interactions-a-historical-perspective
#8
REVIEW
Monika Fuxreiter
The proposal that coupled folding to binding is not an obligatory mechanism for intrinsically disordered (ID) proteins was put forward 10 years ago. The notion of fuzziness implies that conformational heterogeneity can be maintained upon interactions of ID proteins, which has a functional impact either on regulated assembly or activity of the corresponding complexes. Here I review how the concept has evolved in the past decade, via increasing experimental data providing insights into the mechanisms, pathways and regulatory modes...
February 23, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29438493/history-of-estrogen-in-the-male-an-historical-perspective
#9
Rex A Hess, Paul S Cooke
Estrogens have traditionally been considered female hormones. Nevertheless, the presence of estrogenic substances in males has been known for over 90 years. Initial work with estrogen suggested that it was deleterious to male reproduction because exogenous estrogen treatments induced developmental abnormalities. However, demonstrations of estrogen synthesis in the testis and high concentrations of 17β-estradiol (E2) in rete testis fluid suggested that the female hormone might have a function in normal male reproduction...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29423487/the-emergence-of-aqueous-chemiluminescence-new-promising-class-of-phenoxy-1-2-dioxetane-luminophores
#10
Samer Gnaim, Ori Green, Doron Shabat
The majority of known chemiluminescent compounds produce light through oxidation-dependent mechanisms. The unique notion of triggering chemiluminescence by a chemical reaction other than oxidation was first introduced by Schaap in 1987 with the development of chemically and enzymatically activated phenoxy-dioxetanes. Such dioxetanes are distinctive among chemiluminescent molecules since the oxidized high-energy species, the dioxetane, is stable for years at room temperature. Light emission is selectively activated by deprotection of the phenol-protecting group...
February 22, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29332246/an-historical-perspective-of-the-discovery-of-titin-filaments-part-2
#11
REVIEW
Cristobal G Dos Remedios
In 2017, a Special Issue of Biophysical Reviews was devoted to "Titin and Its Binding Partners. The issue contained a review: "An historical perspective of the discovery of titin filaments" by dos Remedios and Gilmour that was intended to be a history of the discovery of the giant protein titin, previously named connectin. The review took readers back to the earliest discovery of the so-called third filament component of skeletal and cardiac muscle sarcomeres and ended in 1969. Recently, my colleague Shin'ichi Ishiwata gently reminded me of two papers published in 1990 and 1993 that were unwittingly omitted from the original historical perspective...
January 13, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29300977/schemata-consort-and-the-salk-polio-vaccine-trial
#12
Charles J Kowalski, Adam J Mrdjenovich
In this essay, we defend the design of the Salk polio vaccine trial and try to put some limits on the role schemata should play in designing clinical research studies. Our presentation is structured as a response to de Freitas and Pietrobon (de Freitas, R. S. and R. Pietrobon. 2007. Whoever could get rid of the context of discovery/context of justification dichotomy? A proposal based on recent developments in clinical research. Journal of Medicine and Philosophy 32:25-42.) who identified the CONSORT statement as a schema that would have, had it existed at the time, ruled out the design of the Salk polio vaccine trial of 1954 in favor of a completely randomized controlled clinical trial (RCT)...
January 12, 2018: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29243483/relative-binding-free-energy-calculations-in-drug-discovery-recent-advances-and-practical-considerations
#13
Zoe Cournia, Bryce Allen, Woody Sherman
Accurate in silico prediction of protein-ligand binding affinities has been a primary objective of structure-based drug design for decades due to the putative value it would bring to the drug discovery process. However, computational methods have historically failed to deliver value in real-world drug discovery applications due to a variety of scientific, technical, and practical challenges. Recently, a family of approaches commonly referred to as relative binding free energy (RBFE) calculations, which rely on physics-based molecular simulations and statistical mechanics, have shown promise in reliably generating accurate predictions in the context of drug discovery projects...
December 26, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29209322/camelid-single-domain-antibodies-historical-perspective-and-future-outlook
#14
Mehdi Arbabi-Ghahroudi
Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and medicine. In this article, I present a historical perspective on the development of camelid single-domain antibodies (sdAbs or VH Hs, also widely known as nanobodies) since their discovery and discuss the advantages and disadvantages of these unique molecules in various areas of research, industry, and medicine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29143888/-the-art-of-insulin-treatment-diabetes-insulin-and-the-1920s
#15
Kirsten E Gardner
Soon after the discovery of insulin in the early 1920s, the popular press celebrated the miraculous discovery. Although insulin had no curative effect on the chronic state of diabetes, it was frequently heralded as a "cure." This paper examines how the discovery of insulin intersected with the rise of diabetic technology and the transfer of medical technology to the home setting. By analyzing diabetic manuals written for patients and physicians, letters exchanged between patient and physician, medical journals, magazines and newspapers, I trace how patients learned about insulin and more significantly how patients adopted measurement technologies designed to allow better home administration of insulin...
November 16, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29058138/the-paradigms-they-are-a-changin-past-present-and-future-of-pvc-bacteria-research
#16
REVIEW
Elena Rivas-Marín, Damien P Devos
These are exciting times for PVC researchers! The PVC superphylum is composed of the bacterial phyla Planctomycetes, Verrucomicrobia, Chlamydiae (those three founders giving it its name), Lentisphaerae and Kirimatiellaeota as well as some uncultured candidate phyla, such as the Candidatus Omnitrophica (previously known as OP3). Despite early debates, most of the disagreements that surround this group of bacteria have been recently resolved. In this article, we review the history of the study of PVC bacteria, with a particular focus on the misinterpretations that emerged early in the field and their resolution...
October 20, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29053253/surface-plasmon-resonance-material-and-interface-design-for-universal-accessibility
#17
Samuel S Hinman, Kristy S McKeating, Quan Cheng
No abstract text is available yet for this article.
January 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29040380/a-historical-perspective-on-some-new-discoveries-on-spermatogenesis-from-the-laboratory-of-enrico-sertoli-in-1878
#18
Christopher B Geyer
No abstract text is available yet for this article.
October 12, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28979788/zebrafish-heart-regeneration-15-years-of-discoveries
#19
REVIEW
Juan Manuel González-Rosa, Caroline E Burns, C Geoffrey Burns
Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic scale after injury. As a result, myocardial infarctions are responsible for approximately half of all cardiovascular related deaths. In contrast, the zebrafish heart regenerates efficiently upon injury through robust myocardial proliferation. Therefore, deciphering the mechanisms that underlie the zebrafish heart's endogenous regenerative capacity represents an exciting avenue to identify novel therapeutic strategies for inducing regeneration of the human heart...
June 2017: Regeneration
https://www.readbyqxmd.com/read/28926993/satellite-dna-an-evolving-topic
#20
REVIEW
Manuel A Garrido-Ramos
Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes...
September 18, 2017: Genes
keyword
keyword
71775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"