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https://www.readbyqxmd.com/read/28489674/differentiation-between-crohn-s-disease-and-intestinal-tuberculosis-in-children
#1
Sumit Kumar Singh, Anshu Srivastava, Niraj Kumari, Ujjal Poddar, Surender Kumar Yachha, Chandra Mani Pandey
OBJECTIVES: To study clinical, endoscopic, radiologic and histopathological features helpful in differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) in children. METHODS: Patients diagnosed to have CD or ITB based on standard recommended criteria were enrolled. Children with inflammatory bowel disease unclassified or suspected ITB or CD with incomplete work-up or lost to follow-up were excluded. The clinical and laboratory (radiology, endoscopy and histology) details of children were analyzed...
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28384907/a-study-of-haematological-and-haemostasis-parameters-and-hypercoagulable-state-in-tuberculosis-patients-in-northern-india-and-the-outcome-with-anti-tubercular-therapy
#2
Aditya Singh Kutiyal, Naresh Gupta, Sandeep Garg, Harmanjit Singh Hira
INTRODUCTION: Tuberculosis is one of the leading infectious diseases with high morbidity and mortality in the developing countries. Tuberculosis is also rarely associated with hypercoagulable state and very limited literature is available on this association. AIM: To study the haematological and haemostasis laboratory parameters, to correlate the abnormalities for a hypercoagulable state and to study the outcome with anti-tubercular therapy. MATERIALS AND METHODS: The study population included 128 patients with newly diagnosed tuberculosis...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28284263/immune-thrombocytopenia-secondary-to-tuberculosis-a-case-and-review-of-literature
#3
S F Weber, S Bélard, S Rai, R Reddy, S Belurkar, K Saravu
Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224437/baseline-hbv-load-increases-the-risk-of-anti-tuberculous-drug-induced-hepatitis-flares-in-patients-with-tuberculosis
#4
Chun-Hui Zhu, Man-Zhi Zhao, Guang Chen, Jun-Ying Qi, Jian-Xin Song, Qin Ning, Dong Xu
Hepatitis associated anti-tuberculous treatment (HATT) has been a main obstacle in managing patients co-infected with Mycobacterium tuberculosis and hepatitis B virus (HBV). Therefore, we evaluated the factors related to the severity of adverse effects during HATT, especially those associated with liver failure. A retrospective study was carried out at Tongji Hospital from 2007 to 2012. Increases in serum transaminase levels of >3, 5, and 10 times the upper limit of normal (ULN) were used to define liver damage as mild, moderate, and severe, respectively...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28207542/rifampicin-induced-disseminated-intravascular-coagulation-in-pulmonary-tuberculosis-treatment-a-case-report-and-literature-review
#5
Guo Chen, Jian-Qing He
RATIONALE: Disseminated intravascular coagulation (DIC) induced by daily rifampicin therapy is rare, especially the patient is absent of malignancy, severe infection, and prior exposure to rifampicin. PATIENT CONCERNS: We report a case of DIC induced by daily rifampicin treatment for pulmonary tuberculosis. A 22-year-old, previously healthy man received an anti-tuberculosis therapy consisting of isoniazid, rifampicin, ethambutol, and pyrazinamide on the daily dose recommended by the World Health Organization tuberculosis guidelines after a diagnosis of pulmonary tuberculosis...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28043617/bedaquiline-in-the-multidrug-resistant-tuberculosis-treatment-belarus-experience
#6
Alena Skrahina, Hennadz Hurevich, Dennis Falzon, Liudmila Zhilevich, Valiantsin Rusovich, Masoud Dara, Svetlana Setkina
BACKGROUND/OBJECTIVE: Outcomes of treatment for multidrug-resistant tuberculosis (MDR-TB) remain poor worldwide. Among patients with MDR-TB in Belarus who started treatment in 2012, only 54% completed it successfully, with treatment failure reported in 22% of the patients; additionally, 11% died and 13% were lost to follow-up or remained unevaluated. In Belarus, to improve outcomes, bedaquiline was introduced in MDR-TB treatment in June 2015. The national TB program developed measures to monitor safety and effectiveness of bedaquiline-containing regimens in line with the World Health Organization recommendations...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27891377/immune-thrombocytopenia-as-a-presenting-manifestation-of-tuberculosis-challenge-in-resource-constraint-settings
#7
Deba Prasad Dhibar, Kamal Kant Sahu, Varun Dhir, Surjit Singh
Tuberculosis can infect almost any organ of our body leading to various presentations and its complication. Various haematological manifestations of tuberculosis are well known. But isolated thrombocytopenia and Immune Thrombocytopenia (ITP) in patients with tuberculosis is very rare. Here we report a case of young man who presented with acute onset of bleeding manifestations in the form of epistaxis and macroscopic haematuria with platelets count of 5×10(9)/L. The patient was diagnosed to have ITP along with clinical and radiological evidence of active tuberculosis...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27867196/extracellular-adp-facilitates-monocyte-recruitment-in-bacterial-infection-via-erk-signaling
#8
Xiaoyu Zhang, Juliang Qin, Junyan Zou, Zhangsheng Lv, Binghe Tan, Jueping Shi, Yihan Zhao, Hua Ren, Mingyao Liu, Min Qian, Bing Du
As the most prominent clinical drug targets for the inhibition of platelet aggregation, P2Y12 and P2Y13 have been found to be highly expressed in both platelets and macrophages. However, the roles and function of P2Y12/13 in the regulation of macrophage-mediated innate immune responses remain unclear. Here, we demonstrate that adenosine 5'-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4...
November 21, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27843310/platelet-lymphocyte-ratios-a-potential-marker-for-pulmonary-tuberculosis-diagnosis-in-copd-patients
#9
Guozhong Chen, Chunling Wu, Zhiying Luo, Yiming Teng, Suping Mao
BACKGROUND: In recent decades, morbidity and mortality have been found to be significantly increased in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary tuberculosis (PTB). Platelet-lymphocyte ratio (PLR) is an indicator for inflammatory diseases. This study aims to investigate whether PLR could act as a potential marker for patients with COPD complicated with PTB. METHODS: In this retrospective study, laboratory characteristics of 87 COPD patients complicated with PTB (determined by Mycobacterium tuberculosis positive culture from sputum or bronchial lavage fluid) and 83 COPD patients (as the control group, determined by M...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27790357/hematological-and-liver-toxicity-of-anti-tuberculosis-drugs
#10
Maryam-Sadat Mirlohi, Alireza Ekrami, Saeed Shirali, Mehdi Ghobeishavi, Fatemeh Pourmotahari
INTRODUCTION: Tuberculosis (TB) is a major global health problem, and anti-tuberculosis drugs can cause severe adverse reactions. The aim of this study was to determine hematological and biochemical changes and associated risk factors in smear positive pulmonary tuberculosis patients undergoing treatment with standard protocols. METHODS: In a descriptive study, a total of 40 tuberculosis patients aged between 15-60 years were collected from hospitals in Khuzestan Province (Iran) from March 2013 to March 2014...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27554054/plasma-contributes-to-the-antimicrobial-activity-of-whole-blood-against-mycobacterium-tuberculosis
#11
Ramiro López-Medrano, José Manuel Guerra-Laso, Eduardo López-Fidalgo, Cristina Diez-Tascón, Silvia García-García, Sara Blanco-Conde, Octavio Miguel Rivero-Lezcano
The whole blood model for infection has proven useful to analyze the immunological response to Mycobacterium tuberculosis, because it exerts a significant antimicrobial activity. Although this activity has been generally assumed to be cellular, we have found that the leukocyte fraction of blood from healthy volunteers did not kill the bacilli. We have discovered that plasma was responsible for a large proportion, but not all, of the antimicrobial activity. Furthermore, infected monocytes controlled the mycobacterial multiplication when cultivated in the presence of plasma...
October 2016: Innate Immunity
https://www.readbyqxmd.com/read/27525403/-a-pediatric-case-of-hiv-who-diagnosed-by-virtue-of-disseminated-cryptococcus-infection
#12
Manolya Acar, Murat Sütçü, Hacer Aktürk, Selda Hançerli Törün, Nurinisa Karagöz, Hayati Beka, Ensar Yekeler, Ali Ağaçfidan, Nuran Salman, Ayper Somer
Cryptococcus neoformans is an important opportunistic pathogen that causes serious mortality and morbidity in AIDS patients. Although its incidence has decreased with proper antiretroviral treatment (ART), it is still a major concern in areas with low socioeconomic HIV endemic countries with poor sources of therapy. In our country, pediatric HIV infection and so, HIV-related opportunistic infections are very rare. In order to pay attention to this unusual collaboration; herein, we presented a pediatric case who was diagnosed with HIV and disseminated cryptococcus infection concomitantly...
July 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27419136/mean-platelet-volume-in-mycobacterium-tuberculosis-infection
#13
Min Young Lee, Young Jin Kim, Hee Joo Lee, Sun Young Cho, Tae Sung Park
Introduction. Mean platelet volume (MPV) has been thought as a useful index of platelet activation. It is supposed that MPV is also associated with several inflammatory and infectious diseases. Korea still has a high incidence of tuberculosis (TB). The aim of this study was to investigate MPV as an inflammatory marker in TB patients. Materials and Methods. MPV were determined in 221 patients with TB and 143 individuals for control group. MPV was estimated by an Advia 2120 (Siemens Healthcare Diagnostics, Tarrytown, NY, USA)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27382206/assessment-of-hematological-parameters-in-pulmonary-tuberculosis-patients
#14
K Rohini, M Surekha Bhat, P S Srikumar, A Mahesh Kumar
The aim of the study was the assessment of hematological parameters in pulmonary tuberculosis patients. Forty patients diagnosed with tuberculosis were recruited from the Institute of Thoracic Medicine on the basis of history, clinical examination, chest radiography, sputum examination and related laboratory parameters and were compared with age and sex matched healthy volunteers (n = 40). Hematological parameters and CRP in tuberculosis patients were determined. The mean values for serum hemoglobin level, RBC count and platelet count in PTB was found to be less (p < 0...
July 2016: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/27319952/clinical-and-laboratory-characteristics-of-patients-with-erythema-nodosum
#15
Sibel Dogan, Aysen Karaduman, Sibel Ersoy Evans
Erythema nodosum (EN) represents an acute, erythematous nodular eruption that is generally found on the lower aspects of the legs. Despite the variety of triggering factors, the clinical findings of EN are classic. It is often hard to determine which patients have an underlying systemic disorder. The aim of this study was to investigate clinical and laboratory parameters in patients with EN, especially those with an underlying systemic disorder. A total of 43 patients diagnosed with EN at an adult and children's hospital were retrospectively reviewed for triggering factors, any underlying systemic diseases, clinical features, laboratory parameters, treatment modalities, and disease outcome...
2016: Skinmed
https://www.readbyqxmd.com/read/27097668/automatic-disease-screening-method-using-image-processing-for-dried-blood-microfluidic-drop-stain-pattern-recognition
#16
Basant S Sikarwar, Mukesh Roy, Priya Ranjan, Ayush Goyal
This paper examines programmed automatic recognition of infection from samples of dried stains of micro-scale drops of patient blood. This technique has the upside of being low-cost and less-intrusive and not requiring puncturing the patient with a needle for drawing blood, which is especially critical for infants and the matured. It also does not require expensive pathological blood test laboratory equipment. The method is shown in this work to be successful for ailment identification in patients suffering from tuberculosis and anaemia...
July 2016: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27086793/cytokinin-nucleosides-natural-compounds-with-a-unique-spectrum-of-biological-activities
#17
REVIEW
Mikhail S Drenichev, Vladimir E Oslovsky, Sergey N Mikhailov
Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing, anti-inflammatory, and antipsychotic activity. These compounds also influence platelet aggregation and exhibit some other biological activities. Cytokinins are N6-substituted adenines and represent an important group of phytohormones with diverse biochemical functions in plants, stimulating cell division and plant growth. The main structural feature of cytokinin nucleosides is the presence of a hydrophobic hydrocarbon moiety at the N6-position of adenosine...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26893604/tuberculosis-associated-hemophagocytic-lymphohistiocytosis-in-adolescent-diagnosed-by-polymerase-chain-reaction
#18
Ju-Hee Seo, Jun Ah Lee, Dong Ho Kim, Joongbum Cho, Jung Sub Lim
We present a case of tuberculosis-associated hemophagocytic lymphohistiocytosis in a 14-year-old girl. The patient presented with weight loss, malaise, fatigue, prolonged fever, and generalized lymphadenopathy. Laboratory investigation revealed pancytopenia (white blood cells, 2,020 cells/µL; hemoglobin, 10.2 g/dL; platelets, 52,000 cells/µL), hypertriglyceridemia (229 mg/dL), and hyperferritinemia (1,420 ng/mL). Bone marrow biopsy showed a hypocellular bone marrow with a large numbers of histiocytes and marked hemophagocytosis; based on these findings, she was diagnosed with hemophagocytic lymphohistiocytosis...
January 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26639719/mild-anemia-as-a-protective-factor-against-pregnancy-loss
#19
L O Buzyan
BACKGROUND: Iron deficiency anemia is traditionally considered to be a pathological condition during pregnancy. According to the standards, prescription of iron supplements to pregnant women is required at hemoglobin levels of 110 g/l and lower. Numerous studies at different periods showed the relationship of anemia and premature birth [5], preeclampsia [1], low birth-weight [2]. Meanwhile, physiological hemodilution carries in pregnancy an important adaptive function. It is well known, that in the second half of pregnancy physiological hypercoagulability develops (increased activity of the plasma clotting factors, platelet aggregation, decreased activity and blood concentrations of physiological anticoagulants) aimed at implementing adequate hemostasis in labor...
2015: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/26409444/an-uncommon-presentation-of-kikuchi-fujimoto-disease-a-case-report-with-literature-review
#20
REVIEW
Sabin Ranabhat, Mamta Tiwari, Jiwan Kshetri, Sushna Maharjan, Bidur Prasad Osti
BACKGROUND: Kikuchi-Fujimoto disease is so named because Kikuchi and Fujimoto were the first scientists to describe it in Japan in 1972. Although the disease has been reported from all over the world and more so from Asia, it is rare. To date only eight cases have been reported from Nepal. Cervical lymphadenopathy, fever and raised Erythrocyte Sedimentation Rate are usual presenting features of this disease. We describe a case which presented with thrombocytopenia and axillary lymphadenopathy in addition to the usual features...
2015: BMC Research Notes
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