Chinatsu Nakane, Koji Nishimoto, Ei Kishimoto, Kosuke Suzuki, Emiko Nakagawa, Moeko Morikawa, Yurina Murakami, Yoichiro Aoshima, Sayomi Matsushima, Masanori Harada, Tomohiro Uto, Shiro Imokawa
Severe immune thrombocytopenia is a rare side-effect of rifampicin (RFP) and can be life-threatening. Here, we report the case of a 74-year-old male with tuberculous pleurisy who developed severe thrombocytopenia after first exposure to RFP. Platelet count decreased to 1 × 103 /μL after 7 days of treatment with RFP, isoniazid, ethambutol, and pyrazinamide. After all the drugs were discontinued, the platelet count recovered. As thrombocytopenia did not occur after re-administration of drugs other than RFP, the patient was diagnosed with RFP-induced thrombocytopenia...
2023: Respiratory Medicine Case Reports