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JOURNAL ARTICLE
Kidane Zereabruk, Tensay Kahsay, Hiyab Teklemichael, Woldu Aberhe, Abrha Hailay, Guesh Mebrahtom, Gebrewahd Bezabh
BACKGROUND: Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first-line antituberculosis drugs namely, rifampicin and isoniazid. However, most of these studies were limited only to a single hospital. Therefore, this study aimed to identify the determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in the Tigray region of Ethiopia. METHODS: Hospital-based unmatched case-control study was conducted from 1 April 2019 to 30 June 2019...
May 2, 2024: BMJ Open Respiratory Research
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JOURNAL ARTICLE
Chishala Chabala, Eric Wobudeya, Marieke M van der Zalm, Monica Kapasa, Priyanka Raichur, Robert Mboizi, Megan Palmer, Aarti Kinikar, Syed Hissar, Veronica Mulenga, Vidya Mave, Philippa Musoke, Anneke C Hesseling, Helen McIlleron, Diana Gibb, Angela Crook, Anna Turkova
BACKGROUND: Children living with HIV(CLWH) are at high risk of tuberculosis(TB) and face poor outcomes, despite antiretroviral treatment(ART). We evaluated outcomes in CLWH and HIV-uninfected children treated for non-severe TB in the SHINE trial. METHODS: SHINE was a randomized trial that enrolled children aged <16 years with smear-negative, non-severe TB who were randomized to receive 4 vs 6 months of TB treatment and followed for 72 weeks. We assessed TB relapse/recurrence, mortality, hospitalizations, grade ≥3 adverse events by HIV status, and HIV virological suppression in CLWH...
April 9, 2024: Clinical Infectious Diseases
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JOURNAL ARTICLE
Felicia Dworkin, Alice V Easton, Byron Alex, Diana Nilsen
INTRODUCTION: Acquired rifamycin resistance (ARR) in tuberculosis (TB) has been associated with HIV infection and can necessitate complicated TB treatment regimens, particularly in people living with HIV (PLWH). This work examines clinical characteristics and treatment outcomes of PLWH who developed ARR from 2001 to 2023 in New York City (NYC) to inform best practices for treating these patients. METHODS: PLWH who developed ARR 2001-2023 were identified from the NYC TB registry...
May 2024: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
#4
JOURNAL ARTICLE
Abay Burusie, Fikre Enquesilassie, Nicole Salazar-Austin, Adamu Addissie
BACKGROUND: One of the global key indicators for monitoring the implementation of the World Health Organization's End Tuberculosis (TB) Strategy is the treatment outcome rate. OBJECTIVE: This study aims to assess the magnitude of unfavorable treatment outcomes and estimate their relationship with baseline undernutrition and sustained undernutrition among children receiving TB treatment in central Ethiopia. METHODS: This retrospective cohort study included children treated for drug-susceptible TB between June 2014 and February 2022...
March 30, 2024: Heliyon
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JOURNAL ARTICLE
Victor Vega, Javier Cabrera-Sanchez, Sharon Rodríguez, Kristien Verdonck, Carlos Seas, Larissa Otero, Patrick Van der Stuyft
BACKGROUND: The rate of pulmonary tuberculosis (TB) recurrence is substantial. Identifying risk factors can support the development of prevention strategies. METHODS: We retrieved studies published between 1 January 1980 and 31 December 2022 that assessed factors associated with undifferentiated TB recurrence, relapse or reinfection. For factors reported in at least four studies, we performed random-effects meta-analysis to estimate a pooled relative risk (RR). We assessed heterogeneity, risk of publication bias and certainty of evidence...
March 13, 2024: BMJ Open Respiratory Research
#6
Kaidi Xie, Yang Zhang, Mei Zhang, Hao Wu, Luyao Zheng, Jiahao Ji, Zhen Li, Wen Wang, Tong Zhang
BACKGROUND: Vitamin D deficiency (VDD) is a worldwide disease. VDD is also associated with an increased risk of HIV-related comorbidities and mortality, and patients have a tendency to develop active tuberculosis compared to those with latent tuberculosis infection. Vitamin D supplementation may modulate HIV replication, improve TB inflammation and reduce progression of HIV-TB co-infection. METHODS: We meta-analyzed individual participant data from cohort studies, cross-sectional study, and RCTs of vitamin D in HIV group, TB group, and HIV-TB group...
2024: Frontiers in Public Health
#7
JOURNAL ARTICLE
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Ousmane Abdoulaye, Abdoul Kadir Ibrahim Mamadou, Oumarou Amadou, Hassane Boureima, Biraima Ahamadou, Nouhou Hama Aghali, Nana Hadiza Abdourahamane Maifada, Abdoulaziz Kabirou Amoussa, Chaibou Maidakouale
AIM OF STUDY: To describe the clinical, therapeutic and evolutionary profile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. METHODS: We conducted a retrospective and descriptive study based on the records of patients followed for Multidrug-resistant tuberculosis (MDR-TB) between January 1, 2014 and June 30, 2018 at the resistant tuberculosis management unit in Maradi (Niger)...
December 31, 2023: Med Trop Sante Int
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JOURNAL ARTICLE
Richard Long, Matthew Croxen, Robyn Lee, Alexander Doroshenko, Angela Lau, Leyla Asadi, Courtney Heffernan, Catherine Paulsen, Mary Lou Egedahl, Colin Lloyd, Vincent Li, Gregory Tyrrell
BACKGROUND: Subclinical pulmonary tuberculosis (PTB) is an asymptomatic disease state between established TB infection and symptomatic (clinical) TB disease. It is present in 20-25% of PTB patients in high-income countries. Mycobacterium tuberculosis complex (MTBC) genetic heterogeneity, and differential host immunological responses, have been implicated in its pathogenesis. METHODS: To determine the association between MTBC lineage and PTB disease phenotype, we used two retrospective cohorts of PTB patients in Canada and two independent lineage attribution methods (DNA fingerprinting and genome sequencing)...
December 15, 2023: Journal of Infection
#9
JOURNAL ARTICLE
Yohane Gadama, Marié Du Preez, Jonathan Carr, Sarel Theron, Christine Albertyn, Kenneth Ssebambulidde, Deanna Saylor, Naeem Brey, Franclo Henning
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described autoimmune inflammatory disorder of the central nervous system (CNS). There is limited data on the association between Human Immunodeficiency virus (HIV) infection and MOGAD. We report three patients with HIV infection and myelin oligodendrocyte glycoprotein (MOG) antibodies in the setting of other central nervous system infections. CASE DESCRIPTIONS: The first patient, a 44-year-old black African man, presented with acute disseminated encephalomyelitis (ADEM) with positive serum MOG antibodies...
October 17, 2023: Journal of Medical Case Reports
#10
Rao Du, Yinhe Feng, Hui Mao
BACKGROUND: Sepsis is a life-threatening condition caused by a dysfunctional response to infection from the host. Septic shock, a subset of sepsis, caused by Talaromyces marneffei infection (talaromycosis) has rarely been reported. Owing to its slow culture and low yield, talaromycosis is typically misdiagnosed in HIV-negative patients as other infections, such as tuberculosis, bacterial pneumonia, and lung cancer, especially in non-endemic regions. Early and accurate diagnosis as well as efficient treatment options are required to improve prognosis...
2023: Frontiers in Cellular and Infection Microbiology
#11
JOURNAL ARTICLE
Abay Burusie, Fikre Enquesilassie, Nicole Salazar-Austin, Adamu Addissie
BACKGROUND: Childhood tuberculosis (TB) was poorly studied in Ethiopia. This study aimed to describe the epidemiology of childhood TB and identify predictors of death among children on TB treatment. METHODS: This is a retrospective cohort study of children aged 16 and younger who were treated for TB between 2014 and 2022. Data were extracted from TB registers of 32 healthcare facilities in central Ethiopia. Phone interview was also conducted to measure variables without a space and not recorded in the registers...
July 4, 2023: BMC Public Health
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JOURNAL ARTICLE
Alpaslan Tanoglu, Hakan Erdem, Jon S Friedland, Handan Ankaralı, Jose Fernando Garcia-Goez, Ayse Albayrak, Amani El-Kholy, Sevil Alkan Ceviker, Fatma Amer, Serpil Erol, Ilad Alavi Darazam, Mohammad Mahdi Rabiei, Muhammad Zeeshan Sarwar, Misbah Zeb, Hassan Nawaz, Mehmet Resat Ceylan, Roxana Cernat, Meltem Tasbakan, Folusakin Ayoade, Yvon Ruch, Elif Tükenmez Tigen, Goffredo Angioni, Dhanji P Rajani, Nasim Akhtar, Serkan Surme, Gonul Sengoz, Gulden Eser Karlıdag, Andrea Marino, Rezaul Karim Ripon, Yasemin Çağ, Özlem Aydın, Yasemin Akkoyunlu, Derya Seyman, Kumar Angamuthu, Antonio Cascio, Corneliu Petru Popescu, Fatma Sirmatel, Esma Eren, Razi Even Dar, Foday Usman Munu, Esra Guzel Tanoglu, Esteban Echeverry, Juan Diego Velez, Cumhur Artuk, Safak Ozer Balin, Nirav Pandya, Aysegul Erdem, Emine Kübra Dindar Demiray, Adalet Aypak
Existing literature about peritoneal tuberculosis (TBP) is relatively insufficient. The majority of reports are from a single center and do not assess predictive factors for mortality. In this international study, we investigated the clinicopathological characteristics of a large series of patients with TBP and determined the key features associated with mortality. TBP patients detected between 2010 and 2022 in 38 medical centers in 13 countries were included in this retrospective cohort. Participating physicians filled out an online questionnaire to report study data...
August 2023: European Journal of Clinical Microbiology & Infectious Diseases
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JOURNAL ARTICLE
Tomas Getahun, Hailemikael Debebe, Helen Getahun, Yonas Abebe, Kidist Assefa, Mizan Habtemichael
INTRODUCTION: Tuberculosis is a bacterial disease caused by the Mycobacterium tuberculosis . Regardless of many efforts made to control tuberculosis, the disease remains to be a major public health problem. Nonadherence to antituberculosis treatment poses a challenge to the disease treatment as it potentially increases the risk of drug resistance, mortality, relapse, and extended infectiousness. The North Shewa Zone had a poor performed on TB control status, so this study assessed the prevalence of antituberculosis drug nonadherence and its associated factors at governmental health institutions in Debre Berhan town, North Shewa Zone, Ethiopia, 2020...
2023: Tuberculosis Research and Treatment
#14
JOURNAL ARTICLE
Mariana Araújo-Pereira, Betânia M F Nogueira, Renata Spener-Gomes, Anna C C Carvalho, Flávia Marinho Sant'Anna, Marina C Figueiredo, Megan M Turner, Afrânio L Kritski, Marcelo Cordeiro-Santos, Valeria C Rolla, Timothy R Sterling, Bruno B Andrade
BACKGROUND: Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. METHODS: Patients ≥ 18 years old with culture-confirmed drug-susceptible pulmonary TB enrolled between 2015 and 2019 in a multi-center Brazilian cohort were followed for up to 24 months and classified according to anemia severity (mild, moderate, and severe), based on hemoglobin levels...
April 18, 2023: Journal of Infection and Public Health
#15
JOURNAL ARTICLE
Sanjeev Sinha, Himanshu Thukral, Imtiyaz Shareef, Devashish Desai, Binit Kumar Singh, Bimal Kumar Das, Sahajal Dhooria, Rohit Sarin, Rupak Singla, Saroj Kumari Meena, Ravindra Mohan Pandey, Shivam Pandey, Sunil Sethi, Ashumeet Kajal, Rakesh Yadav, Ashutosh Nath Aggarwal, Sanjay Bhadada, Digambar Behera
BACKGROUND: The immunomodulatory effects of vitamin D are widely recognized and a few studies have been conducted to determine its utility in the treatment of tuberculosis, with mixed results. This study was conducted to see if vitamin D supplementation in patients with active pulmonary tuberculosis (PTB) in the Indian population contributed to sputum smear and culture conversion as well as the prevention of relapse. METHODS: This randomized double-blind placebo-controlled trial was conducted in three sites in India...
2023: PloS One
#16
JOURNAL ARTICLE
Christina Maier, Dumitru Chesov, Dagmar Schaub, Barbara Kalsdorf, Sönke Andres, Inna Friesen, Maja Reimann, Christoph Lange
OBJECTIVES: To describe long-term treatment outcomes in patients with multi-drug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) and validate established outcome definitions for MDR/RR-TB treatment. METHODS: Among patients with MDR/RR-TB admitted to a German MDR/RR-TB referral centre from 1 September 2002 to 29 February 2020, we compared long-term treatment outcomes derived from individual patient follow-up with treatment outcomes defined by WHO-2013, WHO-2021 and the Tuberculosis Network European Trials Group-2016...
June 2023: Clinical Microbiology and Infection
#17
JOURNAL ARTICLE
Elize Pietersen, Kim Anderson, Helen Cox, Keertan Dheda, Aihua Bian, Bryan E Shepherd, Timothy R Sterling, Robin M Warren, Yuri F van der Heijden
BACKGROUND: Updated World Health Organization (WHO) treatment guidelines prioritize all-oral drug-resistant tuberculosis (DR-TB) regimens. Several poorly tolerated drugs, such as amikacin and para-aminosalicylic acid (PAS), remain treatment options for DR-TB in WHO-recommended longer regimens as Group C drugs. Incomplete treatment with anti-TB drugs increases the risk of treatment failure, relapse, and death. We determined whether missed doses of individual anti-TB drugs, and reasons for their discontinuation, varied in closely monitored hospital settings prior to the 2020 WHO DR-TB treatment guideline updates...
2023: PloS One
#18
JOURNAL ARTICLE
Yi Xie, Jing Han, Weili Yu, Zhili Hou, Zhen Wan
We analyzed the risk factors of mortality for patients with pulmonary tuberculosis under the Directly Observed Treatment Shortcourse (DOTS) and established a predictive nomogram for the risk of mortality. The retrospective cohort analysis was conducted on the treatment outcomes of 11207 tuberculosis patients in the tuberculosis management information system in Tianjin from 2014 to 2019. Based on the multivariable unconditional logistic regression, we analyzed the risk factors of mortality in patients with pulmonary TB and established the death risk prediction nomogram...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
#19
JOURNAL ARTICLE
Hulya Abali, Mediha Gönenc Ortakoylu
Most patients with early recurrent tuberculous lymphadenitis (RTL) can be overlooked due to the paucibacillary character of Mycobacterium tuberculosis complex (MTBC) causing difficulty in the differential diagnosis. Here, we present three cases with early RTL that occurred after completing pulmonary tuberculosis (TB) therapy with a cure, and that improved by early diagnosis and therapy. A 30-year-old migrant male, HIV-negative patient, who had used immunosuppressive drugs for Crohn's disease presented to the TB outpatient clinic with a new anterior cervical lymph node enlargement...
2022: International Journal of Mycobacteriology
#20
JOURNAL ARTICLE
Kristan Alexander Schneider, Carola Janette Salas
Many standard-textbook population-genetic results apply to a wide range of species. Sometimes, however, population-genetic models and principles need to be tailored to a particular species. This is particularly true for malaria, which next to tuberculosis and HIV/AIDS ranks among the economically most relevant infectious diseases. Importantly, malaria is not one disease-five human-pathogenic species of Plasmodium exist. P. falciparum is not only the most severe form of human malaria, but it also causes the majority of infections...
2022: Frontiers in Genetics
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