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Vestibular therapy

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https://www.readbyqxmd.com/read/28427224/ponatinib-promotes-a-g1-cell-cycle-arrest-of-merlin-nf2-deficient-human-schwann-cells
#1
Alejandra M Petrilli, Jeanine Garcia, Marga Bott, Stephani Klingeman Plati, Christine T Dinh, Olena R Bracho, Denise Yan, Bing Zou, Rahul Mittal, Fred F Telischi, Xue-Zhong Liu, Long-Sheng Chang, D Bradley Welling, Alicja J Copik, Cristina Fernández-Valle
Neurofibromatosis type 2 (NF2) is a genetic syndrome that predisposes individuals to multiple benign tumors of the central and peripheral nervous systems, including vestibular schwannomas. Currently, there are no FDA approved drug therapies for NF2. Loss of function of merlin encoded by the NF2 tumor suppressor gene leads to activation of multiple mitogenic signaling cascades, including platelet-derived growth factor receptor (PDGFR) and SRC in Schwann cells. The goal of this study was to determine whether ponatinib, an FDA-approved ABL/SRC inhibitor, reduced proliferation and/or survival of merlin-deficient human Schwann cells (HSC)...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422031/the-importance-of-labyrinthine-examination-in-the-prognosis-and-therapy-for-balance-in-spinocerebellar-ataxia
#2
João Henrique Faryniuk, Bianca Simone Zeigelboim, Hélio Afonso Ghizoni Teive, Vinicius Ribas Fo, Paulo Breno Noronha Liberalesso, Jair Mendes Marques
INTRODUCTION: Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that are characterized by the presence of progressive cerebellar ataxia. OBJECTIVE: Identify vestibular disorders and demonstrate the importance of labyrinthine examination in the prognosis and therapy for balance in patients with SCAs. MATERIALS AND METHODS: The study had a retrospective cross-sectional design and evaluated 57 patients, mean age of 41...
April 19, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28420227/efficacy-and-tolerability-of-a-plant-based-multi-component-cream-ginetrox%C3%A2-in-vulvovaginal-disorders-of-the-genitourinary-syndrome-during-menopause
#3
Roberto Marrai, Giovanni Lissi, Stefano Togni, Giada Maramaldi, Marco Barbara, Luca Giacomelli
BACKGROUND: Genitourinary syndrome of menopause (GSM) is a symptomatic condition including vaginal dryness, irritation, dyspareunia and recurrent urinary tract infections which affects 40-54% of post-menopausal women. Although several estrogen-based therapies are available, it is generally preferable to avoid hormonal therapy, particularly in women with mild symptoms or at risk for estrogen-responsive neoplasia. Therefore, the most common treatment options are over-the-counter vaginal creams for symptomatic relief...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28409393/stereotactic-radiosurgery-vs-fractionated-radiotherapy-for-tumor-control-in-vestibular-schwannoma-patients-a-systematic-review
#4
REVIEW
Oscar Persson, Jiri Bartek, Netanel Ben Shalom, Theresa Wangerid, Asgeir Store Jakola, Petter Förander
OBJECTIVE: Repeated controlled studies have revealed that stereotactic radiosurgery is better than microsurgery for patients with vestibular schwannoma (VS) <3 cm in need of intervention. In this systematic review we aimed to compare results from single-fraction stereotactic radiosurgery (SRS) to fractionated stereotactic radiotherapy (FSRT) for patients with VS. DATA SOURCES AND ELIGIBILITY CRITERIA: We systematically searched MEDLINE, Web of Science, Embase and Cochrane and screened relevant articles for references...
April 13, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28408629/pretreatment-adc-values-predict-response-to-radiosurgery-in-vestibular-schwannomas
#5
A Camargo, T Schneider, L Liu, J Pakpoor, L Kleinberg, D M Yousem
BACKGROUND AND PURPOSE: The response rate of vestibular schwannomas to radiation therapy is variable, and there are surgical options available in the event of treatment failure. The aim of this study was to determine whether pre- and posttreatment ADC values can predict the tumor response to radiation therapy. MATERIALS AND METHODS: From a data base of 162 patients with vestibular schwannomas who underwent radiation therapy with gamma knife, CyberKnife, or fractionated stereotactic radiation therapy as the first-line therapy between January 2003 and December 2013, we found 20 patients who had pretreatment ADC values...
April 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28391531/efficacy-of-steroid-therapy-based-on-symptomatic-and-functional-improvement-in-patients-with-vestibular-neuritis-a-prospective-randomized-controlled-trial
#6
Myung Hoon Yoo, Chan Joo Yang, Shin Ae Kim, Marn Joon Park, Joong Ho Ahn, Jong Woo Chung, Hong Ju Park
The aim of this study was to examine the efficacy of methylprednisolone in vestibular neuritis (VN) by objective and subjective measures. This prospective controlled randomized study was conducted at one tertiary hospital. Twenty-nine VN patients were randomized to either the steroid (n = 15) or the control (n = 14) group. The steroid group received methylprednisolone for 2 weeks, whereas control patients did not; both groups underwent regular vestibular exercises and were prescribed a Ginkgo biloba...
April 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28391373/noisy-galvanic-vestibular-stimulation-an-emerging-treatment-option-for-bilateral-vestibulopathy
#7
Max Wuehr, Julian Decker, Roman Schniepp
Patients with bilateral vestibulopathy (BVP) suffer from persistent imbalance during standing and walking as well as an impaired gaze stabilization during head movements. Disabilities associated with BVP severely compromise patients' daily activities and are often linked to an increased risk of falls. Currently, the only established treatment option in BVP is physical therapy. However, treatment effects of physical therapy in BVP are most often limited and many patients do not adequately recover performance...
April 8, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28387548/review-of-vestibular-and-oculomotor-screening-and-concussion-rehabilitation
#8
Anthony P Kontos, Jamie McAllister Deitrick, Michael W Collins, Anne Mucha
Vestibular and oculomotor impairment and symptoms may be associated with worse outcomes after sport-related concussion (SRC), including prolonged recovery. In this review, we evaluate current findings on vestibular and oculomotor impairments as well as treatment approaches after SRC, and we highlight areas in which investigation is needed. Clinical researchers have intimated that recovery from SRC may follow certain clinical profiles that affect the vestibular and oculomotor pathways. Identifying clinical profiles may help to inform better treatment and earlier intervention to reduce recovery time after SRC...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28380634/the-radiosurgery-fractionation-quandary-single-fraction-or-hypofractionation
#9
John P Kirkpatrick, Scott G Soltys, Simon S Lo, Kathryn Beal, Dennis C Shrieve, Paul D Brown
Stereotactic radiosurgery (SRS), typically administered in a single session, is widely employed to safely, efficiently, and effectively treat small intracranial lesions. However, for large lesions or those in close proximity to critical structures, it can be difficult to obtain an acceptable balance of tumor control while avoiding damage to normal tissue when single-fraction SRS is utilized. Treating a lesion in 2 to 5 fractions of SRS (termed "hypofractionated SRS" [HF-SRS]) potentially provides the ability to treat a lesion with a total dose of radiation that provides both adequate tumor control and acceptable toxicity...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28376930/predictors-of-hearing-recovery-in-patients-with-severe-sudden-sensorineural-hearing-loss
#10
Daniel Weiss, Armin Julius Böcker, Mario Koopmann, Eleftherios Savvas, Matthias Borowski, Claudia Rudack
BACKGROUND: Sudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient's social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not predictable. METHODS: We conducted a retrospective study in order to identify parameters that influence hearing recovery. The data base contains results of basic otoneurological tests and clinical parameters of 198 patients with idiopathic SSHL of at least 60 dB in at least four frequencies, diagnosed and treated at the University Hospital of Münster, Germany, between 1999 and 2015...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28367981/cochlear-gene-therapy-with-ancestral-aav-in-adult-mice-complete-transduction-of-inner-hair-cells-without-cochlear-dysfunction
#11
Jun Suzuki, Ken Hashimoto, Ru Xiao, Luk H Vandenberghe, M Charles Liberman
The use of viral vectors for inner ear gene therapy is receiving increased attention for treatment of genetic hearing disorders. Most animal studies to date have injected viral suspensions into neonatal ears, via the round window membrane. Achieving transduction of hair cells, or sensory neurons, throughout the cochlea has proven difficult, and no studies have been able to efficiently transduce sensory cells in adult ears while maintaining normal cochlear function. Here, we show, for the first time, successful transduction of all inner hair cells and the majority of outer hair cells in an adult cochlea via virus injection into the posterior semicircular canal...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28365895/does-proton-therapy-have-a-future-in-cns-tumors
#12
REVIEW
Stephanie E Combs
Proton therapy is characterized by certain physical properties leading to a reduction in integral dose. As proton therapy becomes more widely available, the ongoing discussion on the real indications for proton therapy becomes more important. In the present article, data on proton therapy for tumors of the central nervous system (CNS) is summarized and discussed in view of modern photon treatments. Still today, no randomized controlled trials are available confirming any clinical benefit of protons in CNS tumors...
March 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28360882/vestibular-activation-habituates-the-vasovagal-response-in-the-rat
#13
Bernard Cohen, Giorgio P Martinelli, Yongqing Xiang, Theodore Raphan, Sergei B Yakushin
Vasovagal syncope is a significant medical problem without effective therapy, postulated to be related to a collapse of baroreflex function. While some studies have shown that repeated static tilts can block vasovagal syncope, this was not found in other studies. Using anesthetized, male Long-Evans rats that were highly susceptible to generation of vasovagal responses, we found that repeated activation of the vestibulosympathetic reflex (VSR) with ±2 and ±3 mA, 0.025 Hz sinusoidal galvanic vestibular stimulation (sGVS) caused incremental changes in blood pressure (BP) and heart rate (HR) that blocked further generation of vasovagal responses...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28358888/effectiveness-of-betahistine-48-mg-day-in-patients-with-vestibular-vertigo-during-routine-practice-the-virtuoso-study
#14
Vladimir A Parfenov, Volodymyr A Golyk, Eduard I Matsnev, Svetlana V Morozova, Oleg A Melnikov, Ludmila M Antonenko, Elena E Sigaleva, Maksym I Situkho, Olena I Asaulenko, Vasyl I Popovych, Maxim V Zamergrad
BACKGROUND: Vestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether these effects persist after treatment cessation. METHODS: VIRTUOSO was a prospective, multinational, non-comparative, post-marketing observational programme investigating the effectiveness of betahistine (48 mg/day) and the course of vertigo after the discontinuation of treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28350775/postsurgical-physical-therapy-management-of-congenital-muscular-torticollis
#15
Magdalena Oledzka, Maureen Suhr
PURPOSE: To present 2 cases with severe congenital muscular torticollis and describe postsurgical physical therapy management. DESCRIPTION: Two children diagnosed with severe congenital muscular torticollis underwent surgical release of the involved sternocleidomastoid muscle with subsequent physical therapy. Presurgical examination findings, surgical technique, and postsurgical rehabilitation guidelines are described. RESULTS: Both cases achieved full range of motion and symmetrical muscle strength...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28339331/differential-diagnosis-of-a-patient-referred-to-physical-therapy-for-dizziness-a-case-report
#16
Zachary Rethorn, Susan J Barlow, Emily Gavlick
STUDY DESIGN: Case report. BACKGROUND: Dizziness is a common and debilitating condition across the lifespan. Patients with this complaint must be carefully examined to determine the cause of dizziness, rule out the presence of central nervous system dysfunction, and determine the appropriateness of physical therapy intervention. CASE DESCRIPTION: A 90-year-old male was referred to physical therapy six months after the onset of dizziness. A thorough history was taken and examination was performed...
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28333013/the-risk-of-radiation-induced-tumors-or-malignant-transformation-after-single-fraction-intracranial-radiosurgery-results-based-on-a-25-year-experience
#17
Bruce E Pollock, Michael J Link, Scott L Stafford, Ian F Parney, Yolanda I Garces, Robert L Foote
PURPOSE: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). METHODS AND MATERIALS: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28330815/antimicrobial-photodynamic-therapy-combined-to-periodontal-treatment-experimental-model
#18
Estéfani L Belinello-Souza, Letícia H Alvarenga, Cintia Lima-Leal, Patrícia Almeida, Carolina Guimarães Leite, Tairine R Lima, Jhosepher Previati-Oliveira, Lucas de Pretto, Anderson Zanardi de Freitas, Adjaci U Fernandes, Rodrigo L Marcos, Renato A Prates
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been used as an adjuvant treatment for periodontitis. It combines a photosensitizer with a light source to induce reactive oxygen species and kill microbial cells. PpNetNI is a protoporphyrin derivative, and it has a chemical binding site at biofilm and great affinity to microbial cells. The aim of this study was to investigate the effects of aPDT as an adjuvant treatment for periodontitis. METHODS: Thirty healthy male rats Wistar (Rattus norvegicus) were used in this study (Approved by UNINOVE Ethical committee AN0029/2015)...
March 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28321373/a-review-of-skull-base-tumor-clinical-trials-past-trends-and-future-opportunities
#19
Anand Devaiah, Charles Murchison
Objective Tumors of the anterior and lateral skull base (TALSB) are relatively rare but can be devastating to patients. By examining trials focused on TALSB, we can characterize the studies that predominate and better understand current directions of study. This gives us a better understanding of future studies to pursue. Study Design This is a retrospective analysis. Settings We set skull base tumor clinical trials in the United States which are listed in ClinicalTrials.gov. Subjects and Methods We used the information available on ClinicalTrials...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28319458/quality-of-life-in-807-patients-with-vestibular-schwannoma-comparing-treatment-modalities
#20
Géke Soulier, Bibian M van Leeuwen, Hein Putter, Jeroen C Jansen, Martijn J A Malessy, Peter Paul G van Benthem, Andel G L van der Mey, Anne M Stiggelbout
Objective In vestibular schwannoma treatment, the choice among treatment modalities is controversial. The first aim of this study was to examine the quality of life of patients with vestibular schwannoma having undergone observation, radiation therapy, or microsurgical resection. The second aim was to examine the relationship between perceived symptoms and quality of life. Last, the association between quality of life and time since treatment was studied. Study Design Cross-sectional study. Setting Tertiary referral center...
March 1, 2017: Otolaryngology—Head and Neck Surgery
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