keyword
https://read.qxmd.com/read/34453415/the-cat-as-a-small-dog-comparison-of-trabecular-and-cortical-bone-microarchitecture-of-radius-and-ulna-in-cats-and-small-dogs-using-microcomputed-tomography
#21
JOURNAL ARTICLE
Franziska Planner, Franziska Feichtner, Andrea Meyer-Lindenberg
The forearms of dogs and cats do not only differ anatomically from each other, but there are also differences in prevalence of radius and ulna fractures between the two species. The prevalence of antebrachial fractures is 18.0% in dogs and 2.0-8.0% in cats. Many studies focus solely on the trabecular and cortical bone structure of dogs and the characteristics of the cat are often disregarded. The aim of this study was to evaluate the trabecular structure parameters [bone volume fraction per total volume (BV/TV), bone surface per total volume (BS/BV), trabecular number (Tb...
August 27, 2021: Veterinary Medicine and Science
https://read.qxmd.com/read/33957959/vector-role-and-human-biting-activity-of-anophelinae-mosquitoes-in-different-landscapes-in-the-brazilian-amazon
#22
JOURNAL ARTICLE
Tatiane M P Oliveira, Gabriel Z Laporta, Eduardo S Bergo, Leonardo Suveges Moreira Chaves, José Leopoldo F Antunes, Sara A Bickersmith, Jan E Conn, Eduardo Massad, Maria Anice Mureb Sallum
BACKGROUND: Environmental disturbance, deforestation and socioeconomic factors all affect malaria incidence in tropical and subtropical endemic areas. Deforestation is the major driver of habitat loss and fragmentation, which frequently leads to shifts in the composition, abundance and spatial distribution of vector species. The goals of the present study were to: (i) identify anophelines found naturally infected with Plasmodium; (ii) measure the effects of landscape on the number of Nyssorhynchus darlingi, presence of Plasmodium-infected Anophelinae, human biting rate (HBR) and malaria cases; and (iii) determine the frequency and peak biting time of Plasmodium-infected mosquitoes and Ny...
May 6, 2021: Parasites & Vectors
https://read.qxmd.com/read/33761436/comparative-microcomputed-tomographic-structural-analysis-of-the-trabecular-and-cortical-bone-architecture-of-radius-and-ulna-in-toy-dog-breeds
#23
JOURNAL ARTICLE
Franziska Planner, Franziska Feichtner, Andrea Meyer-Lindenberg
Radius and ulna fractures can be detected in dogs with an incidence of 18.0% and occur more frequently in toy breeds with increased complication rates. The reasons for the predisposition and the increased complication rate of antebrachial fractures in toy breeds are not yet fully understood. The aim of this study was to research the associated mechanisms by investigating the trabecular structure parameters (BV/TV (%), Tb.N (mm-1 ), Tb.Th (mm), Tb.Sp (mm), Conn. D (mm-3 ), DA) and the cortical bone density (Mean Density (mg HA/ccm)) for toy breeds and small dogs of other breeds using microcomputed tomography and to identify the differences between both groups...
March 13, 2021: Research in Veterinary Science
https://read.qxmd.com/read/33437632/lingzhi-and-san-miao-san-with-hyaluronic-acid-gel-mitigate-cartilage-degeneration-in-anterior-cruciate-ligament-transection-induced-osteoarthritis
#24
JOURNAL ARTICLE
Man Chu, Ping Wu, Ming Hong, Huasong Zeng, Chun Kwok Wong, Yu Feng, Zhe Cai, William Weijia Lu
Objective: To investigate the mitigate efficacy of Chinese medicine Lingzhi (LZ) and San-Miao-San (SMS) combined with hyaluronic acid (HA)-gel in attenuating cartilage degeneration in traumatic osteoarthritis (OA). Methods: The standardized surgery of anterior cruciate ligament transection (ACLT) was made from the medial compartment of right hind limbs of 8-week-old female SD rats and resulted in a traumatic OA. Rats (n ​= ​5/group) were treated once intra-articular injection of 50 ​μl HA-gel, 50 ​μl HA-gel+50 ​μg LZ-SMS, 50 ​μl of saline+50 ​μg LZ-SMS and null (ACLT group) respectively, except sham group...
January 2021: Journal of Orthopaedic Translation
https://read.qxmd.com/read/33308809/does-endurance-training-improve-red-blood-cell-aging-and-hemorheology-in-moderate-trained-healthy-individuals
#25
JOURNAL ARTICLE
Daniel A Bizjak, Fabian Tomschi, Gunnar Bales, Elie Nader, Marc Romana, Philippe Connes, Wilhelm Bloch, Marijke Grau
OBJECTIVE: To examine the impact of a 6-week endurance training on red blood cell (RBC) aging and deformability of healthy participants to detect possible improved hemorheological and performance-related adaptations. METHODS: A total of 31 participants (17 females and 14 males) performed a 6-week moderate training protocol (three 1-h running sessions per week at 70% of maximal heart rate). Blood was sampled before and after the training. RBCs from each participant were fractioned according to density and age into 4 RBC subfractions...
December 2020: Journal of Sport and Health Science
https://read.qxmd.com/read/33152787/clinical-practice-variation-and-outcomes-for-stanford-type-a-aortic-dissection-repair-surgery-in-maryland-report-from-a-statewide-quality-initiative
#26
JOURNAL ARTICLE
Michael Mazzeffi, Mehrdad Ghoreishi, Diane Alejo, Clifford E Fonner, Kenichi Tanaka, James H Abernathy, Glenn Whitman, Rawn Salenger, Jennifer Lawton, Niv Ad, James Brown, James Gammie, Bradley Taylor
BACKGROUND:  Stanford Type A aortic dissection repair surgery is associated with high mortality and clinical practice remains variable among hospitals. Few studies have examined statewide practice variation. METHODS:  Patients who had Stanford Type A aortic dissection repair surgery in Maryland between July 1, 2014 and June 30, 2018 were identified using the Maryland Cardiac Surgery Quality Initiative (MCSQI) database. Patient demographics, comorbidities, surgery details, and outcomes were compared between hospitals...
June 2020: Aorta (Stamford, Conn.)
https://read.qxmd.com/read/32928246/examining-trabecular-morphology-and-chemical-composition-of-peri-scaffold-osseointegrated-bone
#27
JOURNAL ARTICLE
Linwei Lyu, Shicai Yang, Ye Jing, Chunqiu Zhang, Jikun Wang
BACKGROUND: Porous titanium alloy scaffold fabricated by 3D printing technology could induce osseointegration well to repair bone defect during early postoperative period. However, trabecular histomorphological features and chemical compositions of ingrowth bone in the long term after surgery still lacked in-depth research. METHODS: Fourteen New Zealand rabbits were divided into two groups (7 rabbits in surgery group and 7 rabbits in control group). A 3D-printed porous titanium alloy scaffold was implanted into right femoral condyle of each rabbit in the surgery group...
September 14, 2020: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/32771653/the-risk-of-malaria-infection-for-travelers-visiting-the-brazilian-amazonian-region-a-mathematical-modeling-approach
#28
JOURNAL ARTICLE
Eduardo Massad, Gabriel Zorello Laporta, Jan Evelyn Conn, Leonardo Suveges Chaves, Eduardo Sterlino Bergo, Elder Augusto Guimarães Figueira, Francisco Antonio Bezerra Coutinho, Luis Fernandez Lopez, Claudio Struchiner, Maria Anice Mureb Sallum
BACKGROUND: Human mobility between malaria endemic and malaria-free areas can hinder control and elimination efforts in the Amazon basin, maintaining Plasmodium circulation and introduction to new areas. METHODS: The analysis begins by estimating the incidence of malaria in areas of interest. Then, the risk of infection as a function of the duration of stay after t0 was calculated as the number of infected travelers over the number of arrived travelers. Differential equations were employed to estimate the risk of nonimmune travelers acquiring malaria in Amazonian municipalities...
August 6, 2020: Travel Medicine and Infectious Disease
https://read.qxmd.com/read/32768686/irisin-inhibits-osteocyte-apoptosis-by-activating-the-erk-signaling-pathway-in-vitro-and-attenuates-alct-induced-osteoarthritis-in-mice
#29
JOURNAL ARTICLE
Zihao He, Hanjun Li, Xuequan Han, Feng Zhou, Jingke Du, Yiqi Yang, Qi Xu, Shuhong Zhang, Shuangyan Zhang, Ning Zhao, Mengning Yan, Zhifeng Yu
Moderate exercise can alleviate symptoms of osteoarthritis (OA) such as pain, stiffness, and joint deformities that are associated with progressive cartilaginous degeneration, osteophyte formation, subchondral bone changes, and synovial inflammation. Irisin is an exercise-related myokine that reportedly plays a crucial role in bone remodeling. However, its role in OA remains unknown. This study aimed to determine whether irisin can attenuate OA progression and the mechanism of its therapeutic effect. Three-month-old male C57BL/6J mice were randomized to groups that underwent sham operation, and anterior cruciate ligament transection (ACLT) intraperitoneally injected with vehicle or irisin in vivo...
August 5, 2020: Bone
https://read.qxmd.com/read/32674689/protective-effect-of-resveratrol-on-estrogen-deficiency-induced-osteoporosis-though-attenuating-nadph-oxidase-4-nuclear-factor-kappa-b-pathway-by-increasing-mir-92b-3p-expression
#30
JOURNAL ARTICLE
Ye Zhang, Ming-Wei Liu, Yun He, Ning Deng, Yan Chen, Jiecong Huang, Wei Xie
INTRODUCTION: Resveratrol (RES) exhibits estrogen-like effects and has potential applications to treatment of osteoporosis caused by estrogen deficiency; however, the specific mechanism of action of RES remains unclear. Here, we examined the therapeutic effects of RES on ovariectomized (OVX) rats with osteoporosis and determined the underlying mechanism. METHODS: We established an OVX rat model to study osteoporosis caused by estrogen deficiency. The treatment groups were given orally with RES (50, 100, and 200 mg/day), the estrogen group received 0...
January 2020: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/31762237/-effects-of-guben-zenggu-decoction-on-bone-metabolism-and-bone-microstructure-in-ovariectomized-rats
#31
JOURNAL ARTICLE
Wan-Tao Dong, Yan-Long Gong, Min Song, Kai Huang, Ping Dong, Zhi-Jing Song, Kai Wang, Yun-Xiang Hai
OBJECTIVE: To test the effects of Guben Zenggu Decoction on bone metabolism and bone microstructure in ovariectomized rats for the purpose of preventing and treating postmenopausal osteoporosis. METHODS: Osteoporosis rat models were established by ovariectomy. The model rats were randomly divided into control, estradiol valerate treatment, and Guben Zenggu Decoction treatment groups with high, medium and low dosages. After 12 weeks of treatments, 10 rats from each group were randomly selected for cardiac blood sampling after abdominal anesthesia...
September 2019: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/31465989/trabecular-bone-structure-scales-allometrically-in-the-foot-of-four-human-groups
#32
JOURNAL ARTICLE
Jaap P P Saers, Timothy M Ryan, Jay T Stock
The human foot is highly derived relative to that of other hominoids and therefore a topic of intense research in paleoanthropology. While trabecular bone is thought to be highly plastic in response to habitual behavior, knowledge of how trabecular structure scale with body size is essential for making functional inferences from trabecular bone morphology. Trabecular bone properties scale with negative allometry in interspecific studies that includes a wide range of body size; however, intraspecific scaling patterns often differ from interspecific trends...
August 26, 2019: Journal of Human Evolution
https://read.qxmd.com/read/31078711/dietary-calcium-intake-and-genetics-have-site-specific-effects-on-peak-trabecular-bone-mass-and-microarchitecture-in-male-mice
#33
JOURNAL ARTICLE
Krittikan Chanpaisaeng, Perla C Reyes Fernandez, James C Fleet
Trabecular bone (Tb) is used for rapid exchange of calcium (Ca) in times of physiologic need and the site-specific characteristics of Tb may explain why certain sites are more vulnerable to osteoporosis. We hypothesized that peak trabecular bone mass (PTBM) and Tb microarchitecture are differentially regulated by dietary Ca intake, genetics, or Gene-by-Diet (GxD) interactions at the distal femur and the fifth lumbar (L5) vertebra. Male mice from 62 genetically distinct lines were fed basal (0.5%) or low (0...
May 9, 2019: Bone
https://read.qxmd.com/read/30759738/developmental-transformation-and-reduction-of-connective-cavities-within-the-subchondral-bone
#34
JOURNAL ARTICLE
Shahed Taheri, Thomas Winkler, Lia Sabrina Schenk, Carl Neuerburg, Sebastian Felix Baumbach, Jozef Zustin, Wolfgang Lehmann, Arndt F Schilling
It is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evaluations of healthy vs. early OA or early OA vs. advanced OA cases, while neglecting how pure maturation could change the SCB's microstructure. To assess the transformations of the healthy SCB from young age to early adulthood, we examined the microstructure and material composition of the medial condyle of the femur in calves (three months) and cattle (18 months) for the calcified cartilage (CC) and the subchondral bone plate (SCBP)...
February 12, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30747440/automatic-depletion-with-spectra-optia-allows-a-safe-16-reduction-of-red-blood-cell-pack-consumption-in-exchanged-sickle-cell-anemia-patients
#35
JOURNAL ARTICLE
O Hequet, S Poutrel, P Connes, D Revesz, Y Chelghoum, K Kebaili, G Cannas, A Gauthier, A Guironnet-Paquet, M Vocanson, J F Nicolas, C Renoux, M Raba, F Cognasse, Y Bertrand, A Hot, P Joly
BACKGROUND: Chronic red blood cell exchanges (RBCXs) are frequently used to prevent complications in patients with sickle cell anemia, but the scarcity of matched red blood cell packs (RBCPs) is a serious concern. The main goal of this study was to compare the number of RBCPs used during RBCXs between the Spectra Optia (SO) device (with the automatic depletion step) and the former Cobe Spectra (CSP) device. STUDY DESIGN AND METHODS: The performances and safety of 300 SO sessions using the automatic depletion step (SO/DE) in 50 patients with sickle cell anemia under a chronic transfusion program over a 1-year period were prospectively analyzed...
May 2019: Transfusion
https://read.qxmd.com/read/30712990/ribosomal-proteins-regulate-mhc-class-i-peptide-generation-for-immunosurveillance
#36
JOURNAL ARTICLE
Jiajie Wei, Rigel J Kishton, Matthew Angel, Crystal S Conn, Nicole Dalla-Venezia, Virginie Marcel, Anne Vincent, Frédéric Catez, Sabrina Ferré, Lilia Ayadi, Virginie Marchand, Devin Dersh, James S Gibbs, Ivaylo P Ivanov, Nathan Fridlyand, Yohann Couté, Jean-Jacques Diaz, Shu-Bing Qian, Louis M Staudt, Nicholas P Restifo, Jonathan W Yewdell
The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal proteins, we identified proteins that modulate peptide generation without altering source protein expression. We show that 60S ribosomal proteins L6 (RPL6) and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide...
January 24, 2019: Molecular Cell
https://read.qxmd.com/read/30149068/magnoflorine-with-hyaluronic-acid-gel-promotes-subchondral-bone-regeneration-and-attenuates-cartilage-degeneration-in-early-osteoarthritis
#37
JOURNAL ARTICLE
Zhe Cai, Yu Feng, Chentian Li, Kedi Yang, Tianhao Sun, Lei Xu, Yan Chen, Chun-Hoi Yan, William Weijia Lu, Kwong-Yuen Chiu
OBJECTIVE: To investigate efficacy of Chinese medicine magnoflorine combined with hyaluronic acid (HA)-gel in promoting subchondral bone (SCB) regeneration and attenuating cartilage degeneration in early osteoarthritis (OA). METHODS: MC3T3-E1 under magnoflorine treatment was assayed by XTT to determine cell viability. Cell proliferation was reflected through cell cycle. Osteoblast mineralization was stained by Alizarin Red. Standardized bone canal of 1 mm in diameter and 4 mm in depth was made on tibial medial plateau of 4-month-old Dunkin-Hartley spontaneous knee OA guinea pigs...
November 2018: Bone
https://read.qxmd.com/read/29705142/discovery-of-6-pyrimidin-5-ylmethyl-quinoline-8-carboxamide-negative-allosteric-modulators-of-metabotropic-glutamate-receptor-subtype-5
#38
JOURNAL ARTICLE
Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, Anna L Blobaum, Frank W Byers, J Scott Daniels, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Kyle A Emmitte
Based on previous work that established fused heterocycles as viable alternatives for the picolinamide core of our lead series of mGlu5 negative allosteric modulators (NAMs), we designed a novel series of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide mGlu5 NAMs. These new quinoline derivatives also contained carbon linkers as replacements for the diaryl ether oxygen atom common to our previously published chemotypes. Compounds were evaluated in a cell-based functional mGlu5 assay, and an exemplar analog 27 was >60-fold selective versus the other seven mGlu receptors...
June 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://read.qxmd.com/read/29089584/acvr2b-fc-counteracts-chemotherapy-induced-loss-of-muscle-and-bone-mass
#39
JOURNAL ARTICLE
Rafael Barreto, Yukiko Kitase, Tsutomu Matsumoto, Fabrizio Pin, Kyra C Colston, Katherine E Couch, Thomas M O'Connell, Marion E Couch, Lynda F Bonewald, Andrea Bonetto
Chemotherapy promotes the development of cachexia, a debilitating condition characterized by muscle and fat loss. ACVR2B/Fc, an inhibitor of the Activin Receptor 2B signaling, has been shown to preserve muscle mass and prolong survival in tumor hosts, and to increase bone mass in models of osteogenesis imperfecta and muscular dystrophy. We compared the effects of ACVR2B/Fc on muscle and bone mass in mice exposed to Folfiri. In addition to impairing muscle mass and function, Folfiri had severe negative effects on bone, as shown by reduced trabecular bone volume fraction (BV/TV), thickness (Tb...
October 31, 2017: Scientific Reports
https://read.qxmd.com/read/28808745/parathyroid-hormone-1-34-promotes-fracture-healing-in-ovariectomized-rats-with-type-2-diabetes-mellitus
#40
JOURNAL ARTICLE
G Y Liu, G L Cao, F M Tian, H P Song, L L Yuan, L D Geng, Z Y Zheng, L Zhang
Ovariectomized (OVX) rats with type 2 diabetes mellitus (T2DM) with femur fracture received vehicle, insulin, or insulin plus parathyroid hormone (PTH) treatment for 2 and 3 weeks. Radiography, histomorphometry, histology, and immunohistochemistry in callus were evaluated. INTRODUCTION: Reports about effects of PTH plus insulin on callus formation of osteoporotic fracture with T2DM were limited. This study was designed to investigate the effects of the combination of PTH and insulin on fracture healing in OVX rats with T2DM...
October 2017: Osteoporosis International
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