Andrea Shin, Yue Xing, Mohammed Rayyan Waseem, Robert Siwiec, Toyia James-Stevenson, Nicholas Rogers, Matthew Bohm, John Wo, Carolyn Lockett, Anita Gupta, Anita Gupta, Jhalka Kadariya, Evelyn Toh, Rachel Anderson, Huiping Xu, Xiang Gao
OBJECTIVE: Identifying microbial targets in irritable bowel syndrome (IBS) is challenged by dynamic microbiota-metabolite-host interactions. We aimed to assess microbial features associated with short chain fatty acids (SCFA) and determine if features were related to IBS symptoms, subtypes, and endophenotypes. DESIGN: We performed an observational study of stool microbial metagenomes, stool SCFA, and IBS traits (stool form, stool bile acids, and colonic transit) in patients with IBS (IBS with constipation [IBS-C] IBS with diarrhea [IBS-D]) and healthy controls...
February 1, 2024: medRxiv