keyword
MENU ▼
Read by QxMD icon Read
search

Irritable colon syndrome

keyword
https://www.readbyqxmd.com/read/29218037/wuji-wan-formula-ameliorates-diarrhea-and-disordered-colonic-motility-in-post-inflammation-irritable-bowel-syndrome-rats-by-modulating-the-gut-microbiota
#1
Ying Chen, Shuiming Xiao, Zipeng Gong, Xiaoxin Zhu, Qing Yang, Yujie Li, Shuangrong Gao, Yu Dong, Zhe Shi, Yajie Wang, Xiaogang Weng, Qi Li, Weiyan Cai, Weijie Qiang
Emerging evidence suggests that gut microbiota contribute to the treatment of post-inflammatory irritable bowel syndrome (PI-IBS). Our previous studies have demonstrated that a Chinese formula, Wuji Wan, has the ability to mitigate abdominal pain and diarrhea in PI-IBS rats. However, little is known about the underlying mechanism and whether the gut microbiota mediate the effect of Wuji Wan on PI-IBS. Thus, the aim of this study was to determine whether Wuji Wan mitigated PI-IBS by modifying the gut microbiota...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29210899/distinct-microbial-populations-exist-in-the-mucosa-associated-microbiota-of-diarrhea-predominant-irritable-bowel-syndrome-and-ulcerative-colitis
#2
Wenting Zhong, Xiaolan Lu, Haitao Shi, Gang Zhao, Yahua Song, Yonghua Wang, Jing Zhang, Yaofeng Jin, Shenhao Wang
GOALS: The goal of this study was to observe the bacterial colonization in the intestinal mucosa in the patients with diarrhea predominant irritable bowel syndrome (IBS-D) and ulcerative colitis (UC), and compare the mucosa-associated microbiota among the IBS-D patients, UC patients and the healthy control, and explore the correlation of the mucosa-associated microbiota with clinical manifestations. STUDY: A total of 20 IBS-D patients, 28 patients with UC (16 active, 12 inactive) and 16 healthy subjects were enrolled in the study...
November 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29194775/involvement-of-shared-mucosal-associated-microbiota-in-the-duodenum-and-rectum-in-diarrhea-predominant-irritable-bowel-syndrome
#3
Gangping Li, Min Yang, Yu Jin, Ying Li, Wei Qian, Hanhua Xiong, Jun Song, Xiaohua Hou
BACKGROUND AND AIM: Most studies of diarrhea-predominant irritable bowel syndrome (IBS-D) focused on microbiota dysbiosis in a single segment of the intestine such as the colon. However, the intestine as a whole is involved in IBS-D and knowledge about the role of microbiota shared by the duodenum and rectum in IBS-D is limited. Here we investigated the characteristics of mucosal microbiota shared by the duodenum and rectum in IBS-D patients. METHODS: We collected duodenal and rectal mucosal samples from 33 adult IBS-D patients and 15 healthy subjects (HC)...
November 30, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29194563/cyclic-analogues-of-%C3%AE-conotoxin-vc1-1-inhibit-colonic-nociceptors-and-provide-analgesia-in-a-mouse-model-of-chronic-abdominal-pain
#4
Joel Castro, Luke Grundy, Annemie Deiteren, Andrea M Harrington, Tracey O'Donnell, Jessica Maddern, Jessi Moore, Sonia Garcia-Caraballo, Grigori Y Rychkov, Rilei Yu, Quentin Kaas, David J Craik, David J Adams, Stuart M Brierley
BACKGROUND AND PURPOSE: Patients with Irritable Bowel Syndrome suffer from chronic visceral pain (CVP); however, limited analgesic therapeutic options are currently available. We have shown that α-conotoxin Vc1.1-induced activation of GABAB receptors on the peripheral endings of colonic afferents reduces nociceptive signalling from the viscera. However, the analgesic efficacy of more stable, cyclized versions of Vc1.1 on CVP remains to be determined. EXPERIMENTAL APPROACH: Using ex vivo colonic afferent preparations, we determined the inhibitory actions of cyclized Vc1...
November 30, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29186372/irritable-bowel-like-symptoms-in-ulcerative-colitis-are-as-common-in-patients-in-deep-remission-as-with-inflammation-results-from-a-population-based-study-the-ibsen-study
#5
Magne Henriksen, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Bjørn Moum
Background and aims: An increased prevalence of irritable bowel syndrome (IBS)-like symptoms has been reported in patients with ulcerative colitis (UC). Whether ongoing inflammation increases the prevalence of such symptoms is unknown. The aims of this study were to determine the prevalence of IBS-like symptoms in a population-based cohort of UC patients 20 years after diagnosis and to assess the possible association between such symptoms and ongoing inflammation. Methods: Patients diagnosed with UC between 1990 and 1994 in a geographically well-defined area were included in a prospective follow-up study and IBS symptoms according to Rome III criteria were recorded 20 years after diagnosis...
November 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29156934/-short-chain-fatty-acids-butyric-acid-and-intestinal-diseases
#6
David Manrique Vergara, María Eugenia González Sánchez
INTRODUCTION: Short chain fatty acids contain up to 6 carbon atoms. Among them, butyric acid stands out for its key role in pathologies with intestinal affectation. Butyric acid is the main energetic substrate of the colonocyte, it stimulates the absorption of sodium and water in the colon, and presents trophic action on the intestinal cells. OBJECTIVES: To review the clinical use of formulations for the oral use of butyric acid. METHODS: Review of published articles on oral supplementation with butyric acid in intestinal pathologies...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29156760/microrna-29a-increased-the-intestinal-membrane-permeability-of-colonic-epithelial-cells-in-irritable-bowel-syndrome-rats
#7
Guanqun Chao, Yingying Wang, Shuo Zhang, Weilin Yang, Zheying Ni, Xuliang Zheng
Background: The whole pathogenesis of diarrhea-predominant irritable bowel syndrome(IBS-D) is poorly understood. Our goal was to evaluate the expression change of microRNA-29a(miR-29a) in colonic epithelial cells in IBS rats and clarify the mechanism of miR-29a increasing the intestinal membrane permeability through aquaporins(AQPs). Methods: The IBS-D rats models were induced by rectal distention pressure combining with extremities constraint. The colonic epithelial cells were divided into four groups...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155324/angiotensin-receptor-blocker-irbesartan-reduces-stress-induced-intestinal-inflammation-via-at1a-signaling-and-ace2-dependent-mechanism-in-mice
#8
Maimaiti Yisireyili, Yasuhiro Uchida, Koji Yamamoto, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toyoaki Murohara, Kyosuke Takeshita
Stress is associated with pathophysiology of both irritable bowel syndrome (IBS) and hypertension. Angiotensin receptor blockers (ARB) have anti-inflammatory properties via inhibition of angiotensin II (Ang II)/Ang II type I receptor axis (AT1). Inhibition of the classical RAS pathway is also involved in upregulation of angiotensin converting enzyme-2 (ACE2), which activates the Ang-(1-7) /Mas pathway to counteract inflammatory signaling and acts as a partner of the amino acid transporter, B(0)AT-1, to absorb tryptophan for regulation of microbiota-gut-brain axis...
November 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29153264/relationship-of-peripheral-blood-neutrophil-to-lymphocyte-ratio-and-irritable-bowel-syndrome
#9
Mustafa Güçlü, A. Faruk Ağan
Background/aim: This study aimed to determine the relationship between the peripheral blood neutrophil to lymphocyte ratio (NLR) and irritable bowel syndrome (IBS). Materials and methods: A total of 107 patients suffering from constipation-predominant IBS, diagnosed in accordance with the ROMA III criteria and having complete blood count tests, were enrolled in this study. All patients underwent total colonoscopy in order to rule out any probable underlying organic colonic pathology. Results: The control group consisted of 106 healthy people with no medical complaints...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29147138/an-update-on-prucalopride-in-the-treatment-of-chronic-constipation
#10
REVIEW
Anam Omer, Eamonn M M Quigley
Chronic constipation (CC) is a highly prevalent and often under-appreciated gastrointestinal disorder associated with significant impairment in quality of life. Symptoms of constipation are typically present for a number of years prior to a patient seeking help. Lifestyle modifications followed by, or coupled with, over-the-counter laxatives represent the initial treatment option; however, relief for many is limited and dissatisfaction rates for these approaches remain high. Over recent years, therefore, considerable effort has been exerted on the development of novel pharmacological approaches...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29146678/cross-organ-sensitisation-between-the-colon-and-bladder-to-pee-or-not-to-pee
#11
Luke Grundy, Stuart M Brierley
Chronic abdominal and pelvic pain are common, debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles; the collection, storage and expulsion of waste. These visceral organs are located in close proximity to one another, and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation or diarrhoea are primary symptoms for patients with Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD)...
November 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29138838/effects-of-scn9a-gene-modification-on-na-channel-and-the-expression-of-nerve-growth-factor-in-a-rat-model-of-diarrhea%C3%A2-predominant-irritable-bowel-syndrome
#12
Yong-Yan Cai, Chen Li, Zhi-Xin Yan, Na Ma, Fang-Fang Li
The aim of the present study was to identify whether the sodium voltage-gated channel alpha subunit 9 (SCN9A) gene modification is a potential treatment for diarrhea‑predominant irritable bowel syndrome (D‑IBS), via regulating the Na+ channel and the expression of nerve growth factor (NGF). The recombinant adenovirus vector of the SCN9A gene was established, and rat colon cells were isolated for SCN9A gene modification. All subjects were divided into four groups: i) The SCN9A‑modified (D‑IBS rat model implanted with SCN9A‑modified colon cells), ii) negative control (NC; D‑IBS rat model implanted with colon cells without SCN9A gene modification), iii) blank (D‑IBS rat model without any treatment) and iv) normal (normal rats without any treatment)...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29107672/lovastatin-inhibits-visceral-allodynia-and-increased-colonic-permeability-induced-by-lipopolysaccharide-or-repeated-water-avoidance-stress-in-rats
#13
Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
Statins have been reported to block inflammatory somatic pain and have an anti-cytokine property. Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral hypersensitivity and increases gut permeability in rats, which are mediated through proinflammatory cytokine-dependent pathways. Since visceral hypersensitivity with increased gut permeability plays a crucial role in the pathophysiology of irritable bowel syndrome (IBS), these above animal models are considered to simulate IBS. We hypothesized that lovastatin improves symptoms in the patients with IBS by attenuating these visceral changes...
October 28, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29105467/-effect-of-electroacupuncture-at-zusanli-st-36-on-vimentin-a-kind-of-cytoskeleton-protein-related-to-smooth-muscle-contraction-in-rats-with-diarrhea-predominant-irritable-bowel-syndrome
#14
Da-Ye Yang, Hua Wang, Jia Li, Song Wu, Jian-Min Liu, Dan Wang, Li-Hua Wang
OBJECTIVE: To investigate the effect of electroacupuncture (EA) at "Zusanli" (ST 36) on cytoskeleton protein-Vimentin (related to smooth muscle contraction) in rats with diarrhea-predominant irritable bowel syndrome (IBS-D). METHODS: Sixty female Sprague-Dawley (SD) rats were randomly divided into normal, model, EA and pinaverium bromide (PB) groups (n=15/group). The IBS-D model was established by the method of high lactose feeding and chronic unpredictable mild stress...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29089436/protease-mediated-suppression-of-drg-neuron-excitability-by-commensal-bacteria
#15
Jessica L Sessenwein, Corey C Baker, Sabindra Pradhananga, Megan E Maitland, Elaine O Petrof, Emma Allen-Vercoe, Curtis Noordhof, David E Reed, Stephen J Vanner, Alan E Lomax
Peripheral pain signaling reflects a balance of pro and anti-nociceptive influences; the contribution by the gastrointestinal (GI) microbiota to this balance has received little attention. Disorders such as inflammatory bowel disease and irritable bowel syndrome are associated with exaggerated visceral nociceptive actions that may involve altered microbial signaling, particularly given the evidence for bacterial dysbiosis. Thus, we tested whether a community of commensal GI bacteria derived from a healthy human donor (microbial ecosystem therapeutics; MET-1) can affect the excitability of male mouse dorsal root ganglion (DRG) neurons...
October 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29078077/is-epstein-barr-virus-infection-associated-with-the-pathogenesis-of-microscopic-colitis
#16
Aroldo Gabriele Rizzo, Ambrogio Orlando, Elena Gallo, Andrea Bisanti, Stefania Sferrazza, Luigi Maria Montalbano, Fabio Salvatore Macaluso, Mario Cottone
BACKGROUND: Epstein-Barr virus (EBV) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (IBD). Even if a relevant plasmocytosis, similar to IBD, is present in microscopic colitis (MC), the frequency of EBV infection in this setting is unknown. OBJECTIVES: We aimed to compare the frequency of colonic EBV infection in patients with MC, ulcerative colitis (UC), and irritable bowel syndrome (IBS). STUDY DESIGN: The frequency of colonic EBV infection in biopsies of 30 patients with MC, 30 patients with UC, and 30 controls with IBS was retrospectively assessed...
October 20, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29077050/pharmacotherapy-for-irritable-bowel-syndrome
#17
REVIEW
Michael Camilleri, Alexander C Ford
Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, efficacy, and safety of current pharmacotherapy, and medications that are in phase III trials for the treatment of IBS. There remains a significant unmet need for effective treatments-particularly for the pain component of IBS-although the introduction of drugs directed at secretion, motility and a non-absorbable antibiotic provide options for the bowel dysfunction in IBS...
October 27, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29071961/-effect-of-electroacupuncture-at-yintang-gv-29-and-tianshu-st-25-on-the-ethology-and-the-expression-of-trpv-1-receptor-in-colon-of-irritable-bowel-syndrome-rats
#18
Li-Hua Tan, Kai-Ge Li, Yan-Ying Wu, Ying Lan, Meng-Wei Guo, Wen-Lian Zhu, Lu-Fen Zhang, Ya-Fang Zhao, Xiao-Hong Li, Xiao-Xuan Ren
OBJECTIVE: To observe the ethology and expression of transient receptor potential vanilloid-1(TRPV 1) in colon of irritable bowel syndrome (IBS) rats treated by electroacupuncture (EA) at "Yintang" (GV 29) and "Tianshu" (ST 25), so as to explore the different effectiveness of different acupoints and its related mechanism underlying improvement of the symptoms of somatopsychic illness. METHODS: Thirty-two neonatal Wistar rats were randomly divided into blank control group, model group, Yintang (GV 29) group, and Tianshu (ST 25) group (n=8 in each group)...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29067122/analgesic-activity-of-cynaropicrinon-on-post-inflammatory-irritable-bowel-syndrome-visceral-hypersensitivity-in-a-rat-model
#19
Hailong Shi, Xianwei Zhu, Yaya Cui, Yifei Qin, Lin Yang, Xu Deng
Visceral hypersensitivity is one of the most common symptoms in patients with post-inflammatory-irritable bowel syndrome (PI-IBS). Enterochromaffin (EC) cells and 5-hydroxytryptamine (5-HT) are important in the development of visceral hyperalgesia, and EC cells are influenced by helper T-cell subtype 1 or 2 cytokine predominant environments. In the present study, the analgesic effect of cynaropicrin and its underlying mechanism on the treatment of trinitrobenzene sulfonic (TNBS)-induced PI-IBS visceral hyperalgesia rats was investigated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29052293/butyrate-promotes-visceral-hypersensitivity-in-an-ibs-like-model-via-enteric-glial-cell-derived-nerve-growth-factor
#20
X Long, M Li, L-X Li, Y-Y Sun, W-X Zhang, D-Y Zhao, Y-Q Li
BACKGROUND: Altered visceral sensation is common in irritable bowel syndrome (IBS) and nerve growth factor (NGF) participates in visceral pain development. Sodium butyrate (NaB) could induce colonic hypersensitivity via peripheral up-regulation of NGF in animals. Enteric glial cells (EGCs) appear to be an important source of NGF. Whether butyrate could induce visceral hypersensitivity via increased EGC-derived NGF is still unknown. METHODS: CRL-2690 cells were used for transcriptome analyses after butyrate treatment...
October 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
keyword
keyword
71738
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"