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https://www.readbyqxmd.com/read/29035878/resveratrol-ameliorates-contrast-induced-nephropathy-through-the-activation-of-sirt1-pgc-1%C3%AE-foxo1-signaling-in-mice
#1
Yu Ah Hong, So Yeon Bae, Shin Young Ahn, Jieun Kim, Young Joo Kwon, Woon Yong Jung, Gang Jee Ko
BACKGROUND/AIMS: SIRT1 activation promotes the resistance of renal tubular cells to oxidative stress, and resveratrol is known as a SIRT1 activator. METHODS: Resveratrol was injected intraperitoneally with iohexol for 24 hours. NRK-52E cells were pretreated with resveratrol for 24 hours and then exposed to iohexol for 3 hours. Renal function was measured by serum creatinine and cell survival was assessed by MTT assay. We investigated whether resveratrol attenuates oxidative stress and apoptosis in contrast-induced nephropathy (CIN)...
October 13, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29030491/autophagy-is-activated-in-the-ovarian-tissue-of-polycystic-ovary-syndrome
#2
Da Li, Yue You, Fang-Fang Bi, Tie-Ning Zhang, Jiao Jiao, Tian-Ren Wang, Yi-Ming Zhou, Zi-Qi Shen, Xiu-Xia Wang, Qing Yang
The importance of autophagy in polycystic ovary syndrome (PCOS)-related metabolic disorders is increasingly being recognized, but few studies have investigated the role of autophagy in PCOS. Here, transmission electron microscopy demonstrated that autophagy was enhanced in the ovarian tissue from both humans and rats with PCOS. Consistent with this, ovarian granulosa cells from PCOS rats showed increases in the autophagy marker protein light chain 3B (LC3B), whereas levels of the autophagy substrate SQSTM1/p62 were decreased...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29020797/extracellular-superoxide-dismutase-attenuates-renal-oxidative-stress-through-the-activation-of-ampk-in-diabetic-nephropathy
#3
Yu Ah Hong, Ji Hee Lim, Min Young Kim, Yaeni Kim, Hoon Suk Park, Hyung Wook Kim, Bum Soon Choi, Yoon Sik Chang, Hye Won Kim, Tae-Yoon Kim, Cheol Whee Park
AIMS: Oxidative stress plays a crucial role in the pathogenesis of diabetic nephropathy. We evaluated whether extracellular superoxide dismutase (EC-SOD) has a renoprotective effect through activation of AMPK in diabetic kidneys. RESULTS: Human recombinant EC-SOD (hEC-SOD) was administered to 8-week-old male C57BLKS/J db/db mice via subcutaneous injection once a week for 8 weeks. Renal SOD3 expression was suppressed in db/db mice, which was significantly enhanced by hEC-SOD treatment...
October 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29018172/foxo1-and-foxp1-play-opposing-roles-in-regulating-the-differentiation-and-antitumor-activity-of-th9-cells-programmed-by-il-7
#4
Enguang Bi, Xingzhe Ma, Yong Lu, Maojie Yang, Qiang Wang, Gang Xue, Jianfei Qian, Siqing Wang, Qing Yi
Tumor-specific CD4(+) T helper 9 (TH9) cells, so-called because of their production of the cytokine interleukin-9 (IL-9), are a powerful effector T cell subset for cancer immunotherapy. We found that pretreatment of naïve CD4(+) T cells with IL-7 further enhanced their differentiation into TH9 cells and augmented their antitumor activity. IL-7 markedly increased the abundance of the histone acetyltransferase p300 by activating the STAT5 and PI3K-AKT-mTOR signaling pathways and promoting the acetylation of histones at the Il9 promoter...
October 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28994342/malignant-ectomesenchymoma-series-analysis-of-a-histologically-and-genetically-heterogeneous-tumor
#5
Brannan B Griffin, Pauline M Chou, David George, Lawrence J Jennings, Nicoleta C Arva
AIMS: Malignant ectomesenchymoma is a rare pediatric neoplasm with dual mesenchymal and neuroectodermal elements. Mesenchymal component is usually rhabdomyosarcoma, particularly embryonal subtype, whereas neuroectodermal derivatives are frequently a neuroblastic tumor. Ectomesenchymoma manifests in various sites given the wide migration of neural crest cells during development, though the pelvis/perineum is most often involved. Moreover, no unique unifying molecular abnormality has been determined...
October 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28993609/transcription-factor-foxo1-is-essential-for-il-9-induction-in-t-helper-cells
#6
Sakshi Malik, Srikanth Sadhu, Srikanth Elesela, Ramendra Pati Pandey, Amanpreet Singh Chawla, Deepak Sharma, Lipsa Panda, Deepak Rathore, Balram Ghosh, Vineet Ahuja, Amit Awasthi
Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3(+) regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1...
October 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28993481/mtor-bach2-cascade-controls-cell-cycle-and-class-switch-recombination-during-b-cell-differentiation
#7
Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki, Kazuhiko Igarashi
The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular mechanisms of Bach2 regulation in response to signaling of cytokines and antigen. We show here that mammalian target of rapamycin (mTOR) controls Bach2 along B cell differentiation with two distinct mechanisms in pre-B cells. Firstly, mTOR complex 1 (mTORC1) inhibited accumulation of Bach2 protein in nuclei and reduced its stability...
October 9, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28993340/erratum-ddb1-mediated-cry1-degradation-promotes-foxo1-driven-gluconeogenesis-in-liver-diabetes-2017-66-2571-2582
#8
Xin Tong, Deqiang Zhang, Nicholas Charney, Ethan Jin, Kyle VanDommelon, Kenneth Stamper, Neil Gupta, Johnny Saldate, Lei Yin
No abstract text is available yet for this article.
October 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28993270/reduced-silent-information-regulator-1-signaling-exacerbates-sepsis-induced-myocardial-injury-and-mitigates-the-protective-effect-of-a-liver-x-receptor-agonist
#9
Dong Han, Xiang Li, Shuang Li, Tao Su, Wen-Si Fan, Hong-Yu Qiao, Jiang-Wei Chen, Miao-Miao Fan, Xiu-Juan Li, Ya-Bin Wang, Sai Ma, Ya Qiu, Zu-Hong Tian, Feng Cao
Myocardial injury and dysfunction are critical manifestations of sepsis. Previous studies have reported that liver X receptor (LXR) activation is protective during sepsis. However, whether LXR activation protects against septic heart injury and its underlying mechanisms remain elusive. This study was designed to determine the role of LXR activation in the septic heart with a focus on SIRT1 (silent information regulator 1) signaling. Male cardiac-specific SIRT1 knockout mice (SIRT1-/-) and their wild-type littermates were subjected to sepsis by cecal ligation and puncture (CLP) in the presence or absence of LXR agonist T0901317...
October 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28986382/loss-of-foxo1-cooperates-with-tmprss2-erg-overexpression-to-promote-prostate-tumorigenesis-and-cell-invasion
#10
Yinhui Yang, Alexandra M Blee, Dejie Wang, Jian An, Yunqian Pan, Yuqian Yan, Tao Ma, Yundong He, Joseph Dugdale, Xiaonan Hou, Jun Zhang, S John Weroha, Wei-Guo Zhu, Y Alan Wang, Ronald A DePinho, Wanhai Xu, Haojie Huang
E26 transformation-specific (ETS) transcription factor ERG is aberrantly overexpressed in approximately 50% of all human PCa due to TMPRSS2-ERG gene rearrangements. However, mice with prostate-specific transgenic expression of PCa-associated ERG alone fail to develop PCa, highlighting that ERG requires other lesions to drive prostate tumorigenesis. Forkhead box (FOXO) transcription factor FOXO1 is a tumor suppressor that is frequently inactivated in human PCa. Here we demonstrate that FOXO1, but not other FOXO proteins (FOXO3 and FOXO4), binds and inhibits the transcriptional activity of PCa-associated ERG independently of FOXO1 transcriptional activity...
October 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/28982149/the-interplay-of-cd150-and-cd180-receptor-pathways-contribute-to-the-pathobiology-of-chronic-lymphocytic-leukemia-b-cells-by-selective-inhibition-of-akt-and-mapk-signaling
#11
Inna Gordiienko, Larysa Shlapatska, Valeriia Kholodniuk, Lilia Sklyarenko, Daniel F Gluzman, Edward A Clark, Svetlana P Sidorenko
Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL) associates with mutational IGHV status and favourable prognosis. Here we show a direct correlation between cell surface expression and colocalization of these receptors on CLL B cells. In the absence of CD150 and CD180 on the cell surface both receptors were expressed in the cytoplasm. The CD150 receptor was colocalized with markers of the endoplasmic reticulum, the Golgi apparatus and early endosomes. In contrast, CD180 was detected preferentially in early endosomes...
2017: PloS One
https://www.readbyqxmd.com/read/28981396/cancer-specific-energy-metabolism-in-rhabdomyosarcoma-cells-is-regulated-by-microrna
#12
Nobuhiko Sugito, Kohei Taniguchi, Yuki Kuranaga, Maki Ohishi, Tomoyoshi Soga, Yuko Ito, Mitsuru Miyachi, Ken Kikuchi, Hajime Hosoi, Yukihiro Akao
Rhabdomyosarcoma (RMS) is a soft tissue sarcoma and is most frequently found in children. In RMS, there are two major subtypes, that is, embryonal RMS and alveolar RMS (ARMS). ARMS has exclusively the worse prognosis and is caused by formation of the chimeric PAX3-FOXO1 gene. Regarding cancer, the Warburg effect is known as a feature of cancer-specific metabolism. Polypyrimidine tract-binding protein 1 (PTBP1), a splicer of pyruvate kinase muscle (PKM) mRNA, is a positive regulator of cancer-specific energy metabolism...
October 5, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28981116/mir-181a-increases-foxo1-acetylation-and-promotes-granulosa-cell-apoptosis-via-sirt1-downregulation
#13
Mei Zhang, Qun Zhang, Yali Hu, Lu Xu, Yue Jiang, Chunxue Zhang, Lijun Ding, Ruiwei Jiang, Jianxin Sun, Haixiang Sun, Guijun Yan
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here, we found that miR-181a was upregulated in hydrogen peroxide (H2O2)-treated GCs and a 3-nitropropionic acid (NP)-induced in vivo model of ovarian oxidative stress. miR-181a overexpression promoted GC apoptosis, whereas knockdown of endogenous miR-181a blocked H2O2-induced cell apoptosis...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28979813/tumor-microenvironment-interruption-a-novel-anti-cancer-mechanism-of-proton-pump-inhibitor-in-gastric-cancer-by-suppressing-the-release-of-microrna-carrying-exosomes
#14
Xu-Wen Guan, Fang Zhao, Jing-Ya Wang, Hai-Yan Wang, Shao-Hua Ge, Xia Wang, Le Zhang, Rui Liu, Yi Ba, Hong-Li Li, Ting Deng, Li-Kun Zhou, Ming Bai, Tao Ning, Hai-Yang Zhang, Ding-Zhi Huang
Poor prognosis of gastric cancer is related to not only malignancy of gastric cancer cells, but also the tumor microenvironment. Thus drugs, which can inhibit both of them, are urgently needed to be explored. Studies on effect of Proton-pump inhibitors (PPIs) in anti-neoplasms are increasing, but is rare in gastric in gastric cancer. Here we investigated how the gastric cancer microenvironment is regulated by PPIs. The objective response rate of gastric cancer patients in our hospital treated by PPIs is investigated...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28973925/foxo1-opposition-of-cd8-t-cell-effector-programming-confers-early-memory-properties-and-phenotypic-diversity
#15
Arnaud Delpoux, Chen-Yen Lai, Stephen M Hedrick, Andrew L Doedens
The factors and steps controlling postinfection CD8(+) T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias "Tcf-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8(+) T cells. We determined the early postinfection TCF7(high) population is marked by low TIM3 expression and bears memory signature hallmarks before the appearance of established memory precursor marker CD127 (IL-7R)...
October 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973411/foxos-modulate-proteasome-activity-in-human-induced-pluripotent-stem-cells-of-huntington-s-disease-and-their-derived-neural-cells
#16
Yanying Liu, Fangfang Qiao, Patricia C Leiferman, Alan Ross, Evelyn H Schlenker, Hongmin Wang
Although it has been speculated that proteasome dysfunction may contribute to the pathogenesis of Huntington's disease (HD), a devastating neurodegenerative disorder, how proteasome activity is regulated in HD affected stem cells and somatic cells remains largely unclear. To better understand the pathogenesis of HD, we analyzed proteasome activity and the expression of FOXO transcription factors in three wild-type (WT) and three HD induced-pluripotent stem cell (iPSC) lines. HD iPSCs exhibited elevated proteasome activity and higher levels of FOXO1 and FOXO4 proteins...
August 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28973305/metabolic-reproductive-and-neurologic-abnormalities-in-agpat1-null-mice
#17
Anil K Agarwal, Katie Tunison, Jasbir S Dalal, Sneha S Nagamma, F Kent Hamra, Shireesha Sankella, Xinli Shao, Richard J Auchus, Abhimanyu Garg
Defects in the biosynthesis of phospholipids and neutral lipids are associated with cell membrane dysfunction, disrupted energy metabolism, and diseases including lipodystrophy. In these pathways, the 1-acylglycerol-3-phosphate acyltransferase (AGPAT) enzymes transfer a fatty acid to the sn-2 carbon of sn-1-acylglycerol-3-phosphate (lysophosphatidic acid/LPA) to form sn-1, 2-acylglycerol-3-phosphate (phosphatidic acid/PA). PA is a precursor for key phospholipids and diacylglycerol. AGPAT1 and AGPAT2 are highly homologous isoenzymes and are both expressed in adipocytes...
July 26, 2017: Endocrinology
https://www.readbyqxmd.com/read/28972178/nk3-homeobox-1-nkx3-1-upregulates-forkhead-box-o1-expression-in-hepatocellular-carcinoma-and-thereby-suppresses-tumor-proliferation-and-invasion
#18
Jingyi Jiang, Zheng Liu, Chao Ge, Cong Chen, Fangyu Zhao, Hong Li, Taoyang Chen, Ming Yao, Jinjun Li
Hepatocellular carcinoma (HCC) is the leading cause of cancer related mortality in China, and the molecular mechanism of uncontrolled HCC progression remains to be explored. NK3 homeobox 1 (NKX3.1), an androgen regulated prostate-specific transcription factor, suppresses tumors in prostate cancer, but its role in HCC is unknown, especially in hepatocellular carcinoma. In the present study, the differently expression analysis in HCC tissues and matched adjacent noncancerous liver tissues revealed that NKX3.1 is frequently downregulated in human primary HCC tissues compared with matched adjacent noncancerous liver tissues...
September 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28970346/changes-in-the-levels-and-phosphorylation-status-of-akt-ampk-creb-and-foxo1-in-hypothalamus-of-rainbow-trout-under-conditions-of-enhanced-glucosensing-activity
#19
Cristina Otero-Rodiño, Cristina Velasco, Rosa Álvarez-Otero, Marcos A López-Patiño, Jesús M Míguez, José L Soengas
There is no available information in fish about mechanisms linking glucosensing activation and changes in the expression of brain neuropeptides controlling food intake. Therefore, we assessed in rainbow trout hypothalamus the effects of raised levels of glucose on the levels and phosphorylation status of two transcription factors, FoxO1 and CREB, possibly involved in linking those processes. Moreover, we also aimed to assess the changes in the levels and phosphorylation status of two proteins possibly involved in the modulation of these transcription factors such as Akt and AMPK...
October 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28970066/foxo1-reduces-tumorsphere-formation-capacity-and-has-crosstalk-with-lgr5-signaling-in-gastric-cancer-cells
#20
Yiseul Choi, Jinju Park, Young San Ko, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Min A Kim, Jae-Seon Lee, Mee Soo Chang, Byung Lan Lee
Gastric cancer (GC) is a major of cause of cancer-related death and is characterized by its heterogeneity and molecular complexity. FOXO1 is a transcription factor that plays a key role in GC growth and metastasis. However, the implication of FOXO1 in GC cell stemness has been elusive. This study, for the first time, demonstrates that FOXO1 regulates GC cell stemness in association with LGR5. FOXO1 expression was significantly lower in GC tumorsphere cells than in adherent GC cells. FOXO1 silencing and overexpression promoted and inhibited the tumorsphere formation capacity of GC cells, respectively...
September 29, 2017: Biochemical and Biophysical Research Communications
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