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https://www.readbyqxmd.com/read/28794824/the-clinical-and-economic-burden-of-hyperkalemia-on-medicare-and-commercial-payers
#1
Kathryn Fitch, J Michael Woolley, Tyler Engel, Helen Blumen
BACKGROUND: Hyperkalemia (serum potassium >5.0 mEq/L) may be caused by reduced kidney function and drugs affecting the renin-angiotensin-aldosterone system and is often present in patients with chronic kidney disease (CKD). OBJECTIVE: To quantify the burden of hyperkalemia in US Medicare fee-for-service and commercially insured populations using real-world claims data, focusing on prevalence, comorbidities, mortality, medical utilization, and cost. METHODS: A descriptive, retrospective claims data analysis was performed on patients with hyperkalemia using the 2014 Medicare 5% sample and the 2014 Truven Health Analytics MarketScan Commercial Claims and Encounter databases...
June 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28794653/real-world-utilization-of-once-daily-extended-release-abuse-deterrent-formulation-of-hydrocodone-a-comparison-with-the-pre-approval-randomized-clinical-trials
#2
Louise Taber, T Christopher Bond, Xuezhe Wang, Aditi Kadakia, Tracy J Mayne
BACKGROUND AND OBJECTIVE: Hydrocodone bitartrate extended release (Hysingla(®) ER, HYD) was previously studied in a 12-week randomized, double-blind, placebo-controlled trial and a 52-week open-label safety study. Both of these preapproval studies allowed dose titration to efficacy. The purpose of the present analysis was to compare dosing and utilization patterns in these previous clinical trials with real-world data (RWD) usage in a retrospective claim analysis performed 12-14 months post approval in the US...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28749665/summary-of-the-acs-symposium-public-health-perspectives-of-mycotoxins-in-food
#3
Lauren S Jackson, Dojin Ryu
A symposium entitled "Public Health Perspectives of Mycotoxins in Food" was held at the 251st American Chemical Society Meeting in March 2016 in San Diego, CA and was sponsored by the ACS Division of Agricultural and Food Chemistry. The purpose of the symposium was to convene the leading mycotoxin researchers throughout the world to discuss the current state of knowledge as well as research needs with respect to evaluating the toxicological properties of mycotoxins, and ways to detect, control and reduce human and animal exposure to these natural toxins...
July 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28688188/quality-indicators-of-laryngeal-cancer-care-in-commercially-insured-patients
#4
Christopher J Britt, Hsien-Yen Chang, Harry Quon, Hyunseok Kang, Ana P Kiess, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To examine associations between quality, complications, and costs in commercially insured patients treated for laryngeal cancer. STUDY DESIGN: Retrospective cross-sectional analysis of MarketScan Commercial Claim and Encounters data (Truven Health Analytics, Ann Arbor, Michigan, U.S.A.). METHODS: We evaluated 10,969 patients diagnosed with laryngeal cancer from 2010 to 2012 using cross-tabulations and multivariate regression. Using quality indicators derived from guidelines for recommended care, summary measures of quality were calculated for diagnosis, initial treatment, surveillance, treatment for recurrence, performance, and an overall summary measure of quality...
July 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28650250/a-retrospective-longitudinal-claims-based-comparison-of-concomitant-diagnoses-between-individuals-with-and-without-down-syndrome
#5
Amanda M Kong, Dana Hurley, Kristin A Evans, Diana Brixner, Csilla Csoboth, Jeannie Visootsak
BACKGROUND: Individuals with Down syndrome (DS) experience various comorbidities in excess of the prevalence seen among the non-DS population. However, the extent of the excess burden of comorbidities specifically within commercially and publicly insured DS populations aged < 21 years is not currently known. OBJECTIVES: To (a) describe the most common diagnoses among individuals with DS who have either commercial or Medicaid insurance and (b) compare the prevalence of those diagnoses between DS cases and non-DS controls...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28635342/healthcare-costs-in-psoriasis-and-psoriasis-sub-groups-over-time-following-psoriasis-diagnosis
#6
Sarah Al Sawah, Shonda A Foster, Orin M Goldblum, William N Malatestinic, Baojin Zhu, Nianwen Shi, Xue Song, Steven R Feldman
AIMS: To quantify healthcare costs in patients with psoriasis overall and in psoriasis patient sub-groups, by level of disease severity, presence or absence of psoriatic arthritis, or use of biologics. METHODS: Administrative data from Truven Health Analytics MarketScan Research Database were used to select adult patients with psoriasis from January 2009 to January 2014. The first psoriasis diagnosis was set as the index date. Patients were required to have ≥6 months of continuous enrollment with medical and pharmacy benefits pre-index and ≥12 months post-index...
September 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28629442/treatment-patterns-healthcare-resource-utilization-and-costs-following-first-line-antidepressant-treatment-in-major-depressive-disorder-a-retrospective-us-claims-database-analysis
#7
Geneviève Gauthier, Annie Guérin, Maryia Zhdanava, William Jacobson, George Nomikos, Elizabeth Merikle, Clément François, Vanessa Perez
BACKGROUND: Although the symptoms of major depressive disorder (MDD) are often manageable with pharmacotherapy, response to first-line antidepressant treatment is often less than optimal. This study describes long-term treatment patterns in MDD patients in the United States and quantifies the economic burden associated with different treatment patterns following first-line antidepressant therapy. METHODS: MDD patients starting first-line antidepressant monotherapy and having continuous enrollment ≥12 months before and ≥24 months following the index date (i...
June 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28623046/real-world-burden-of-comorbidities-in-us-patients-with-psoriasis
#8
Kamal Shah, Lillian Mellars, Arun Changolkar, Steven R Feldman
BACKGROUND: Understanding background comorbidity rates in psoriasis can provide perspective for adverse events associated with new therapies. OBJECTIVE: We sought to assess the extent of comorbidities in psoriasis patients by use of the Truven Health Analytics MarketScan database. METHODS: MarketScan, comprising commercial claims representative of a large US-insured population, had 1.22 million patients with ≥1 claim with a psoriasis diagnosis between January 1, 2008, and December 31, 2014...
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28581025/clinical-characteristics-and-treatment-patterns-among-patients-diagnosed-with-cluster-headache-in-u-s-healthcare-claims-data
#9
Casey K Choong, Janet H Ford, Allen W Nyhuis, Shivang G Joshi, Rebecca L Robinson, Sheena K Aurora, James M Martinez
OBJECTIVE: To characterize demographics, clinical characteristics, and treatment patterns of patients with cluster headache (CH). BACKGROUND: CH is an uncommon trigeminal autonomic cephalalgia with limited evidence-based treatment options. Patients suffer from extremely painful unilateral headache attacks and autonomic symptoms with episodic and chronic cycles. DESIGN/METHODS: This retrospective analysis used insurance claims from Truven Health Analytics MarketScan(®) research databases from 2009 to 2014...
June 5, 2017: Headache
https://www.readbyqxmd.com/read/28559004/the-impact-of-self-and-physician-administered-cancer-treatment-on-work-productivity-and-healthcare-utilization
#10
Seth A Seabury, Melissa A Frasco, Emma van Eijndhoven, Steve Sison, Christopher Zacker
BACKGROUND: Lost productivity in the workplace represents a significant portion of the economic burden of cancer in the United States. Cancer treatments have historically been physician-administered, while recent innovations have led to the development of self-administered, usually oral, agents. Self-administered treatments have the potential to reduce healthcare utilization and time away from work, but the magnitude of these effects is unknown. OBJECTIVE: To compare the effects of self- and physician-administered cancer treatment on work productivity and health care utilization...
May 22, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28535104/measuring-the-value-of-new-drugs-validity-and-reliability-of-4-value-assessment-frameworks-in-the-oncology-setting
#11
Tanya G K Bentley, Joshua T Cohen, Elena B Elkin, Julie Huynh, Arnab Mukherjea, Thanh H Neville, Matthew Mei, Ronda Copher, Russell Knoth, Ioana Popescu, Jackie Lee, Jenelle M Zambrano, Michael S Broder
BACKGROUND: Several organizations have developed frameworks to systematically assess the value of new drugs. OBJECTIVE: To evaluate the convergent validity and interrater reliability of 4 value frameworks to understand the extent to which these tools can facilitate value-based treatment decisions in oncology. METHODS: Eight panelists used the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), Institute for Clinical and Economic Review (ICER), and National Comprehensive Cancer Network (NCCN) frameworks to conduct value assessments of 15 drugs for advanced lung and breast cancers and castration-refractory prostate cancer...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28499288/impact-of-number-of-human-papillomavirus-vaccine-doses-on-genital-warts-diagnoses-among-a-national-cohort-of-u-s-adolescents
#12
Rebecca B Perkins, Mengyun Lin, Sherrie F Wallington, Amresh Hanchate
BACKGROUND: The impact of fewer than 3 doses of human papillomavirus (HPV) vaccine on genital warts is uncertain. METHODS: Using the Truven Health Analytics Marketscan administrative database, we compared rates of genital warts among women receiving 0, 1, 2, or 3 doses of HPV vaccine. Females aged 9 to 18 years on January 1, 2007, who were continuously enrolled in the database through December 31, 2013, were included. Patients were assigned an HPV dose state (0, 1, 2, or 3) based on the last recorded dose...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28486368/cumulative-incidence-of-a-subsequent-surgery-after-stress-urinary-incontinence-and-pelvic-organ-prolapse-procedure
#13
Jennifer M Wu, Alexis A Dieter, Virginia Pate, Michele Jonsson Funk
OBJECTIVE: To assess the 5-year risk and timing of repeat stress urinary incontinence (SUI) and pelvic organ prolapse (POP) procedures. METHODS: We conducted a retrospective cohort study using a nationwide database, the 2007-2014 MarketScan Commercial Claims and Encounters and Medicare Supplemental Databases (Truven Health Analytics), which contain deidentified health care claims data from approximately 150 employer-based insurance plans across the United States...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28449892/medical-comorbidity-in-narcolepsy-findings-from-the-burden-of-narcolepsy-disease-bond-study
#14
J Black, N L Reaven, S E Funk, K McGaughey, M M Ohayon, C Guilleminault, C Ruoff
OBJECTIVE/BACKGROUND: The objective of this study was to evaluate medical comorbidity patterns in patients with a narcolepsy diagnosis in the United States. PATIENTS/METHODS: This was a retrospective medical claims data analysis. Truven Health Analytics MarketScan® Research Databases were accessed to identify individuals ≥18 years of age with ≥1 diagnosis code for narcolepsy (International Classification of Diseases (ICD)-9, 347.0, 347.00, 347.01, 347.1, 347...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28408265/spine-surgery-outcomes-in-elderly-patients-versus-general-adult-patients-in-the-united-states-a-marketscan-analysis
#15
Carlito Lagman, Beatrice Ugiliweneza, Maxwell Boakye, Doniel Drazin
OBJECTIVE: To compare spine surgery outcomes in elderly patients (80-103 years old) versus general adult patients (18-79 years-old) in the United States. METHODS: Truven Health Analytics MarketScan Research Databases (2000-2012) were queried. Patients with a diagnosis of degenerative disease of the spine without concurrent spinal stenosis, spinal stenosis without concurrent degenerative disease, or degenerative disease with concurrent spinal stenosis and who had undergone decompression without fusion, fusion without decompression, or decompression with fusion procedures were included...
July 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28399914/healthcare-burden-of-pulmonary-hypertension-owing-to-lung-disease-and-or-hypoxia
#16
Gustavo A Heresi, David M Platt, Wenyi Wang, Christine H Divers, Vijay N Joish, Simon A Teal, Justin S Yu
BACKGROUND: Group 3 pulmonary hypertension (PH) encompasses PH owing to lung diseases and/or hypoxia. Treatment patterns, healthcare resource use, and economic burden to US payers of Group 3 PH patients were assessed. METHODS: This retrospective observational study extracted data from July 1, 2010 to June 30, 2013 from two Truven Health Analytics MarketScan databases. Adult Group 3 PH patients were identified based on claims for PH (ICD-9-CM 416.0/416.8), a related lung disease, and an echocardiogram or right heart catheterization (RHC)...
April 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28364155/impact-of-minimally-invasive-surgery-on-healthcare-utilization-cost-and-workplace-absenteeism-in-patients-with-incisional-ventral-hernia-ivh
#17
Dean J Mikami, W Scott Melvin, Michael J Murayama, Kenric M Murayama
BACKGROUND: Incisional hernia repair is one of the most common general surgery operations being performed today. With the advancement of laparoscopy since the 1990s, we have seen vast improvements in faster return to normal activity, shorter hospital stays and less post-operative narcotic use, to name a few. OBJECTIVE: The key aims of this review were to measure the impact of minimally invasive surgery versus open surgery on health care utilization, cost, and work place absenteeism in the patients undergoing inpatient incisional/ventral hernia (IVH) repair...
March 31, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28326894/cost-comparison-of-laparoscopic-colectomy-versus-open-colectomy-in-colon-cancer
#18
Kathryn Fitch, Andrew Bochner, Deborah S Keller
BACKGROUND: Laparoscopic colectomy has been shown to be safe, oncologically comparable, and clinically beneficial over open colectomy for colon cancer, but utilization remains low. Objectives To evaluate the cost of laparoscopic colectomy vs open colectomy for colon cancer. METHODS: The authors conducted a retrospective claims data analysis using the 2012 and 2013 Truven Health Analytics MarketScan Commercial Claims and Encounter Database. The denominator population consisted of individuals who had commercial insurance coverage in all months of 2012 and >1 month in 2013 and pharmacy coverage throughout eligibility...
April 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28322112/national-database-analysis-of-single-level-versus-multilevel-sleep-surgery
#19
COMPARATIVE STUDY
Scott E Brietzke, Stacey L Ishman, Seth Cohen, Derek D Cyr, Jennifer J Shin, Eric J Kezirian
Objective Recent evidence suggests that multilevel sleep surgery improves outcomes when compared with palate surgery alone for most patients. The study objective was to compare demographic and outcomes data for palate surgery (uvulopalatopharyngoplasty [UPPP]) alone versus multilevel surgery through a national insurance claims database. Study Design Retrospective cohort study. Setting National insurance claims database. Subjects and Methods An adult cohort undergoing single-level UPPP versus UPPP with nasal and/or tongue/hypopharyngeal surgery was identified in the Truven Health Analytics MarketScan Research Databases for the years 2010 through 2012...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28263920/healthcare-costs-and-utilization-for-patients-age-50-to-64-years-with-acute-myeloid-leukemia-treated-with-chemotherapy-or-with-chemotherapy-and-allogeneic-hematopoietic-cell-transplantation
#20
Jaime M Preussler, Christa L Meyer, Lih-Wen Mau, Navneet S Majhail, Ellen M Denzen, Kristen C Edsall, Stephanie H Farnia, Wael Saber, Linda J Burns, David J Vanness
The primary aim of this study was to describe healthcare costs and utilization during the first year after a diagnosis of acute myeloid leukemia (AML) for privately insured non-Medicare patients in the United States aged 50 to 64 years who were treated with either chemotherapy or chemotherapy and allogeneic hematopoietic cell transplantation (alloHCT). MarketScan (Truven Health Analytics) adjudicated total payments for inpatient, outpatient, and prescription drug claims from 2007 to 2011 were used to estimate costs from the health system perspective...
June 2017: Biology of Blood and Marrow Transplantation
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