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https://www.readbyqxmd.com/read/29625537/evaluation-of-dystonia-in-children-and-adolescents-treated-with-atomoxetine-within-the-truven-marketscan-database-a-retrospective-cohort-study
#1
Kristin J Meyers, Himanshu P Upadhyaya, Robert Goodloe, Ludmila A Kryzhanovskaya, Marie A Liles-Burden, Nicole A Kellier-Steele, Michele Mancini
OBJECTIVE: Atomoxetine is a non-stimulant drug indicated for the treatment of attention-deficit/hyperactivity disorder in children aged ≥6 years, adolescents, and adults. In this retrospective cohort study, the incidence and risk of dystonia in children and adolescents treated with atomoxetine was compared to a propensity score-matched cohort of stimulant users. METHODS: Data between 01 January 2006 and 31 December 2014 from patients aged 6-17 years in the Truven Health Analytics MarketScan database were used to generate two cohorts of patients: (1) atomoxetine users and (2) stimulant (methylphenidates or amphetamines) users...
April 6, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29621248/adherence-to-rivaroxaban-versus-apixaban-among-patients-with-non-valvular-atrial-fibrillation-analysis-of-overall-population-and-subgroups-of-prior-oral-anticoagulant-users
#2
Colleen A McHorney, Concetta Crivera, François Laliberté, Guillaume Germain, Willy Wynant, Patrick Lefebvre
BACKGROUND: Medication non-adherence can result in poor health outcomes. Understanding differences in adherence rates to non-vitamin K oral anticoagulants (NOACs) could guide treatment decisions and improve clinical outcomes among patients with non-valvular atrial fibrillation (NVAF). OBJECTIVE: To compare adherence to rivaroxaban and apixaban among the overall NVAF population and subgroups of prior oral anticoagulant (OAC) users (e.g., multiple comorbidities, non-adherence risk factors)...
2018: PloS One
https://www.readbyqxmd.com/read/29597052/risk-of-ischemic-stroke-in-patients-newly-diagnosed-with-heart-failure-focus-on-patients-without-atrial-fibrillation
#3
Jeffrey S Berger, Eric Peterson, François Laliberté, Guillaume Germain, Dominique Lejeune, Jeff Schein, Patrick Lefebvre, Qi Zhao, Matthew R Weir
BACKGROUND: Heart failure (HF) is associated with an incremental risk of ischemic stroke, but limited real-world data exist in Patients with HF without atrial fibrillation (AF). OBJECTIVES: This study quantified the incremental risk of ischemic stroke among newly diagnosed patients with HF and without AF. METHODS: Adult patients with an HF-related claim and ≥18 months of enrollment before their index HF (i.e., baseline period) were identified in Truven Health Analytics MarketScan Databases (01/2010-04/2015)...
March 26, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29566841/sensitivity-of-claims-based-algorithms-to-ascertain-smoking-status-more-than-doubled-with-meaningful-use
#4
Jinhai Huo, Ming Yang, Ya-Chen Tina Shih
BACKGROUND: The "meaningful use of certified electronic health record" policy requires eligible professionals to record smoking status for more than 50% of all individuals aged 13 years or older in 2011 to 2012. OBJECTIVES: To explore whether the coding to document smoking behavior has increased over time and to assess the accuracy of smoking-related diagnosis and procedure codes in identifying previous and current smokers. METHODS: We conducted an observational study with 5,423,880 enrollees from the year 2009 to 2014 in the Truven Health Analytics database...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29556908/economic-burden-of-hr-her2-metastatic-breast-cancer-among-adult-premenopausal-women
#5
Geneviève Gauthier, Patrick Gagnon-Sanschagrin, Annie Guérin, Rebecca Burne, Tania Small, Polly Niravath, Anand A Dalal
INTRODUCTION: Premenopausal women with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) have complex treatment needs and may receive sequential combinations of endocrine therapy (ET) or chemotherapy. This study describes healthcare utilization (HRU) and costs among premenopausal women with HR+/HER2- mBC in real-world settings from a payer's perspective. METHODS: In this retrospective cohort study, premenopausal women with HR+/HER2- mBC who received ET or chemotherapy were identified from the Truven Health Analytics MarketScan database (1 January 2006-31 December 2015)...
March 20, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29554356/comparison-of-fusion-rates-based-on-graft-material-following-occipitocervical-and-atlantoaxial-arthrodesis-in-adults-and-children
#6
Leslie C Robinson, Richard C E Anderson, Douglas L Brockmeyer, Michelle R Torok, Todd C Hankinson
BACKGROUND: Fusion rates following rigid internal instrumentation for occipitocervical and atlantoaxial instability approach 100% in many reports. Based on this success and the morbidity that can be associated with obtaining autograft for fusion, surgeons increasingly select alternative graft materials. OBJECTIVE: To examine fusion failure using various graft materials in a retrospective observational study. METHODS: Insurance claims databases (Truven Health MarketScan® [Truven Health Analytics, Ann Arbor, Michigan] and IMS Health Lifelink/PHARMetrics [IMS Health, Danbury, Connecticut]) were used to identify patients with CPT codes 22590 and 22595...
March 15, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29462227/prevalence-of-psoriasis-in-children-and-adolescents-in-the-united-states-a-claims-based-analysis
#7
Amy S Paller, Rakesh Singh, Martin Cloutier, Marjolaine Gauthier-Loiselle, Bruno Emond, Annie Guérin, Arijit Ganguli
IMPORTANCE: While psoriasis (Ps) is mainly characterized as an adult disease, it can also develop during childhood. However, prevalence estimates of pediatric psoriasis in the United States (US) are lacking. OBJECTIVE: To assess the 2015 annual prevalence of Ps and moderate-to-severe Ps in pediatric individuals in the US. DESIGN: This is a retrospective study based on a large administrative insurance claims database in the US. SETTING: Data were extracted from the Truven Health Analytics MarketScan® Commercial Claims and Encounters database, which covers over 60 million individuals with employer-provided health insurance across the US...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29462221/vismodegib-use-in-clinical-practice-analysis-of-a-united-states-medical-claims-database
#8
C William Hanke, Shivani K Mhatre, David Oliveri, Marko Zivkovic, Ivor Caro, Daniel Bergström, Keith Dawson, Camelia S Sima
BACKGROUND: Information is limited on the use of vismodegib for treatment of advanced basal cell carcinoma beyond the setting of clinical trials. OBJECTIVE: To investigate the treatment patterns and characteristics of patients treated with vismodegib in clinical practice. METHODS: A longitudinal, retrospective cohort study was undertaken using data from a US commercial insurance claims (Truven Health Analytics MarketScan) database. Eligible patients were ≥18 years of age, with ≥1 claim for vismodegib from January 2012 to December 2015...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29458287/the-economic-impact-of-switching-from-synthroid-%C3%A2-for-the-treatment-of-hypothyroidism
#9
Nikhil Khandelwal, Beverly Johns, Zsolt Hepp, Jane Castelli-Haley
AIMS: To compare hypothyroidism-related costs for patients who continuously used Synthroid® and patients who switched from Synthroid® to alternative therapies. MATERIALS AND METHODS: Truven's Health Analytics MarketScan® Commercial Claims and Encounters database from January 1, 2007 to June 30, 2014 was queried for US adults diagnosed with hypothyroidism who initiated Synthroid® and adhered to such therapy for at least 6 months. Propensity score matching matched continuous users of Synthroid® to patients who switched from Synthroid® to alternative levothyroxine agents...
February 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29436260/treatment-patterns-and-associated-health-care-costs-before-and-after-treatment-initiation-among-pulmonary-arterial-hypertension-patients-in-the-united-states
#10
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29362899/costs-of-dose-escalation-among-ulcerative-colitis-patients-treated-with-adalimumab-in-germany
#11
Bernadette Pöllinger, Wolfgang Schmidt, Anna Seiffert, Heidi Imhoff, Martin Emmert
AIMS: We determined adalimumab utilisation and associated drug costs in patients with ulcerative colitis (UC), focusing on patients requiring dose escalation. METHODS: The retrospective cohort study analysed the de-identified prescription data of the Arvato Health Analytics (Munich, Germany) database (2010-2015) in adult UC patients undergoing adalimumab therapy. RESULTS: A total of 154 patients were newly treated with adalimumab (average 39...
January 23, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29358254/screening-with-papanicolaou-tests-in-alberta-are-we-choosing-wisely
#12
Christopher J Symonds, Wenxin Chen, Marianne Sarah Rose, Lara J Cooke
OBJECTIVE: To describe the prevalence and geographic distribution of cervical cancer screening, as well as the age groups of those undergoing screening, in Alberta, and to determine if screening practices conform to current guidelines and follow Choosing Wisely Canada recommendations. DESIGN: Descriptive study using data from the Alberta Ministry of Health Analytics and Performance Reporting Branch. SETTING: Alberta. PARTICIPANTS: Women who had 1 or more Papanicolaou tests between 2011 and 2013...
January 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29353160/prediction-of-venous-thromboembolism-using-semantic-and-sentiment-analyses-of-clinical-narratives
#13
Susan Sabra, Khalid Mahmood Malik, Mazen Alobaidi
Venous thromboembolism (VTE) is the third most common cardiovascular disorder. It affects people of both genders at ages as young as 20 years. The increased number of VTE cases with a high fatality rate of 25% at first occurrence makes preventive measures essential. Clinical narratives are a rich source of knowledge and should be included in the diagnosis and treatment processes, as they may contain critical information on risk factors. It is very important to make such narrative blocks of information usable for searching, health analytics, and decision-making...
March 1, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29304724/treatment-patterns-healthcare-resource-utilization-and-costs-in-patients-with-acute-myeloid-leukemia-in-commercially-insured-and-medicare-populations
#14
Eytan M Stein, Gaetano Bonifacio, Dominick Latremouille-Viau, Annie Guerin, Sherry Shi, Patrick Gagnon-Sanschagrin, Owanate Briggs, George J Joseph
OBJECTIVE: To describe the setting, duration, and costs of induction and consolidation chemotherapy for adults with newly-diagnosed acute myeloid leukemia (AML), who are candidates for standard induction chemotherapy, in the US. METHODS: Adults newly-diagnosed with AML who received standard induction chemotherapy in an inpatient setting were identified from the Truven Health Analytics MarketScan (2006-2015) and SEER-Medicare (2007-2011) databases. Patients were observed from induction therapy start to the first of hematopoietic stem cell transplant, 180 days after induction discharge, health plan enrollment/data availability end, or death...
January 22, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29290171/health-care-costs-and-thromboembolic-events-in-hydroxyurea-treated-patients-with-polycythemia-vera
#15
Shreekant V Parasuraman, Nianwen Shi, Dilan C Paranagama, Machaon Bonafede
BACKGROUND: Patients with polycythemia vera (PV) are at increased risk of thromboembolic events (TEs), which are key contributors to reduced overall survival compared with the age- and sex-matched general population. In addition to aspirin and phlebotomy to maintain hematocrit level < 45%, many patients receive cytoreduction with hydroxyurea (HU), which is associated with improved survival and may reduce the risk of cardiovascular events and TEs. However, 1 in 4 patients become resistant to or intolerant of HU...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29287033/impact-of-new-medications-and-4-generic-programs-on-overactive-bladder-treatment-among-older-adults-in-the-united-states-2000-2015
#16
Alan C Kinlaw, Michele Jonsson Funk, Mitchell M Conover, Virginia Pate, Alayne D Markland, Jennifer M Wu
BACKGROUND: Despite several new medications being Food and Drug Administration-approved for overactive bladder (OAB) and new prescription drug payment programs, there are limited population-based data regarding OAB medication use among older adults. OBJECTIVES: To examine: (1) impacts of new medications and $4 generic programs on time trends for OAB-related medication dispensing for older adults in the United States; (2) differences by age and sex; and (3) temporal changes in OAB-related medication payments...
February 2018: Medical Care
https://www.readbyqxmd.com/read/29244019/prevalence-healthcare-resource-utilization-and-overall-burden-of-fungal-meningitis-in-the-united-states
#17
Lefko T Charalambous, Alykhan Premji, Caroline Tybout, Anastasia Hunt, Drew Cutshaw, Aladine A Elsamadicy, Siyun Yang, Jichun Xie, Charles Giamberardino, Promila Pagadala, John R Perfect, Shivanand P Lad
PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012...
February 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29234938/impact-of-incisional-hernia-development-following-abdominal-operations-on-total-healthcare-cost
#18
Vamsi V Alli, Jianying Zhang, Dana A Telem
BACKGROUND: Introduction of the category III CPT code (0437T) for prophylactic mesh augmentation (PMA) highlights efforts to reduce incisional hernia (IH). PMA's value in the context of value-based care requires understanding both the cost of IH development and the savings from prevention. We hypothesized large healthcare costs with IH development. Appreciating which subsets of patients are at highest risk for IH, and the subsets who have the costliest care is essential in targeting interventions for hernia prevention...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29191138/differential-reimbursement-of-psychiatric-services-by-psychiatrists-and-other-medical-providers
#19
Tami L Mark, William Olesiuk, Mir M Ali, Laura J Sherman, Ryan Mutter, Judith L Teich
OBJECTIVE: Given low psychiatrist participation in insurance networks, this study examines how psychiatrists are reimbursed in network and out of network under commercial insurance relative to other providers for the same diagnoses and services. METHODS: Paid private insurance claims from the 2014 Truven Health Analytics MarketScan Commercial Claims and Encounters Database were analyzed. The sample included all services billed for 3.8 million individuals with a mental disorder as the primary diagnosis by psychiatrists, nonpsychiatrist medical doctors, psychologists, social workers, or psychiatric nurses...
March 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29170864/risk-of-malignancy-in-a-nationwide-cohort-of-elderly-inflammatory-bowel-disease-patients
#20
Nabeel Khan, Carlos Vallarino, Trevor Lissoos, Umar Darr, Michelle Luo
BACKGROUND: Management of elderly inflammatory bowel disease (IBD) patients (≥ 65 years of age) is complicated due to many factors, including a higher risk of cancer, which may impact therapeutic decisions. OBJECTIVE: The aim of this study was to determine the risk of cancer among elderly IBD patients compared with younger IBD patients. Additionally, the absolute risk of malignancy and factors contributing to it were evaluated, and therapeutic patterns among the elderly were assessed...
November 2017: Drugs & Aging
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