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https://www.readbyqxmd.com/read/28441516/epoxynemanione-a-nemanifuranones-a-f-and-nemanilactones-a-c-from-nemania-serpens-an-endophytic-fungus-isolated-from-riesling-grapevines
#1
Ashraf Ibrahim, Dan Sørensen, Hilary A Jenkins, Linda Ejim, Alfredo Capretta, Mark W Sumarah
Ten polyketide specialized metabolites, epoxynemanione A, nemanifuranones A-F, and nemanilactones A-C, were isolated from the culture filtrate of Nemania serpens (Pers.) Grey (1821), an endophytic fungus from a Riesling grapevine (Vitis vinifera) found in Canada's Niagara region. Additionally, four known metabolites 2-(hydroxymethyl)-3-methoxy-benzoic acid, phyllostine, 5-methylmellein and a nordammarane triterpenoid were isolated. A related known metabolite 2,3-dihydro-2-hydroxy-2,4-dimethyl-5-trans-propenylfuran-3-one has also been included for structural and biological comparison to the nemanifuranones...
April 22, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28434855/health-care-use-before-a-first-demyelinating-event-suggestive-of-a-multiple-sclerosis-prodrome-a-matched-cohort-study
#2
José M A Wijnands, Elaine Kingwell, Feng Zhu, Yinshan Zhao, Tanja Högg, Karen Stadnyk, Okechukwu Ekuma, Xinya Lu, Charity Evans, John D Fisk, Ruth Ann Marrie, Helen Tremlett
BACKGROUND: Degenerative processes in neurodegenerative diseases can start years before clinical manifestation. We aimed to establish whether a multiple sclerosis prodromal period exists by examining patterns of health-care use before a first demyelinating event. METHODS: In this matched cohort study, we used data from linked health administrative and clinical databases from four Canadian provinces (British Columbia, Saskatchewan, Manitoba, and Nova Scotia) to compare hospital, physician, and prescription use data from people with multiple sclerosis and matched general population controls in the 5 years before the first demyelinating disease claim (health administrative index date) or clinically reported symptom onset (clinical index date)...
April 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28428843/rad-sequencing-reveals-genomewide-divergence-between-independent-invasions-of-the-european-green-crab-carcinus-maenas-in-the-northwest-atlantic
#3
Nicholas W Jeffery, Claudio DiBacco, Mallory Van Wyngaarden, Lorraine C Hamilton, Ryan R E Stanley, Renée Bernier, Jennifer FitzGerald, K Matheson, C H McKenzie, Praveen Nadukkalam Ravindran, Robert Beiko, Ian R Bradbury
Genomic studies of invasive species can reveal both invasive pathways and functional differences underpinning patterns of colonization success. The European green crab (Carcinus maenas) was initially introduced to eastern North America nearly 200 years ago where it expanded northwards to eastern Nova Scotia. A subsequent invasion to Nova Scotia from a northern European source allowed further range expansion, providing a unique opportunity to study the invasion genomics of a species with multiple invasions...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28422135/genomic-evidence-of-hybridization-between-two-independent-invasions-of-european-green-crab-carcinus-maenas-in-the-northwest-atlantic
#4
N W Jeffery, C DiBacco, B F Wringe, R R E Stanley, L C Hamilton, P N Ravindran, I R Bradbury
Invasive species have been associated with significant negative impacts in their introduced range often outcompeting native species, yet the long-term evolutionary dynamics of biological invasions are not well understood. Hybridization, either among waves of invasion or between native and introduced populations, could alter the ecological and evolutionary impacts of invasions yet has rarely been studied in marine invasive species. The European green crab (Carcinus maenas) invaded eastern North America twice from northern and southern locations in its native range...
April 19, 2017: Heredity
https://www.readbyqxmd.com/read/28417994/trends-in-epidemiology-of-pediatric-inflammatory-bowel-disease-in-canada-distributed-network-analysis-of-multiple-population-based-provincial-health-administrative-databases
#5
Eric I Benchimol, Charles N Bernstein, Alain Bitton, Matthew W Carroll, Harminder Singh, Anthony R Otley, Maria Vutcovici, Wael El-Matary, Geoffrey C Nguyen, Anne M Griffiths, David R Mack, Kevan Jacobson, Nassim Mojaverian, Divine Tanyingoh, Yunsong Cui, Zoann J Nugent, Janie Coulombe, Laura E Targownik, Jennifer L Jones, Desmond Leddin, Sanjay K Murthy, Gilaad G Kaplan
OBJECTIVES: The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time of childhood-onset IBD. METHODS: We identified children <16 years (y) diagnosed with IBD 1999-2010 from health administrative data in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% of the Canadian population...
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28416005/serum-c-reactive-protein-concentrations-in-nova-scotia-duck-tolling-retrievers-with-immune-mediated-rheumatic-disease
#6
Hanna Dorotea Bremer, Anna Hillström, Malin Kånåhols, Ragnvi Hagman, Helene Hansson-Hamlin
Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic stiffness and joint pain. Most, but not all, dogs with IMRD, have antinuclear antibodies (ANA), which are also commonly present in the autoimmune disease systemic lupus erythematosus (SLE). The clinical and diagnostic findings of IMRD indicate that it is an SLE-related disorder. C-reactive protein (CRP), an acute phase protein, is a quantitative marker of inflammation for many diseases and is used for diagnosing and monitoring systemic inflammation in both humans and dogs...
April 17, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28412132/pre-existing-psychiatric-disorder-in-the-burn-patient-is-associated-with-worse-outcomes
#7
Alexandra Hudson, Sarah Al Youha, Osama A Samargandi, Justin Paletz
OBJECTIVE: To compare patient and burn characteristics between patients who had a pre-existing psychiatric diagnosis and patients who did not in a Burn Unit at an academic hospital. BACKGROUND: Psychosocial issues are common in patients recovering from a burn; however, little is known regarding hospital course and discharge outcomes in patients with a pre-existing psychiatric diagnosis presenting with a burn. Baseline medical comorbidities of burn patients have been shown to be a significant risk for in-hospital mortality...
April 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28401137/changes-in-breastfeeding-initiation-at-hospital-discharge-between-first-and-second-births-in-nova-scotia-a-population-based-cohort-study
#8
Kimberley Nix, Linda Dodds
BACKGROUND: Breastfeeding has well-recognized health benefits for infants and mothers. However, little research has been conducted to investigate changes in breastfeeding from one pregnancy to another. This study was conducted to describe rates of breastfeeding initiation at hospital discharge for women's first and second births and to identify factors associated with changes in initiation at the second birth. METHODS: We conducted a longitudinal, population-based cohort study involving women residing in Nova Scotia who delivered a first and second live-born singleton between 2007 and 2013...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28389739/does-socioeconomic-status-affect-lengthy-wait-time-in-canada-evidence-from-canadian-community-health-surveys
#9
Mohammad Hajizadeh
Reasonable access to health services without financial or other barriers is a primary objective of the Canadian health system. Notwithstanding such concern about accessibility of services, long waiting times for health services have been a prominent health policy issue in recent years. Using pooled data from four nationally representative Canadian Community Health Surveys (CCHSs, 2000/01, 2003, 2005 and 2010; n = 266,962) we examine socioeconomic inequality in lengthy wait time (LWT) to health care among adults (aged 18-65) in Canada...
April 7, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28369873/a-comparison-of-molecular-markers-and-morphology-for-neidium-taxa-bacillariophyta-from-eastern-north-america
#10
Keely E Lefebvre, Paul B Hamilton, Frances R Pick
Historically a morphological species concept has applied shape subjectively in the delimitation of diatom species. This has led to confusion between taxa within the benthic diatom genus Neidium. Samples from Ontario, Quebec, Nova Scotia, Newfoundland (Canada) and New York, (USA) were examined for Neidium taxa under LM and SEM. Fourier shape analysis showed that shape as a taxonomic character was not able to discern all species. Isolated individuals from the samples were amplified and sequenced for three chloroplast molecular markers (rbcL, psbC, and psbA) and one nuclear ribosomal molecular marker (18S)...
March 31, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28351651/a-population-based-study-of-prevalence-trends-and-geospatial-analysis-of-hypospadias-and-cryptorchidism-compared-with-non-endocrine-mediated-congenital-anomalies
#11
Ciaran Lane, James Boxall, Dawn MacLellan, Peter A Anderson, Linda Dodds, Rodrigo L P Romao
INTRODUCTION: Several reports have suggested an increase in the prevalence of hypospadias and cryptorchidism over the last few decades. Endocrine disruption caused by exposure to environmental chemicals has been postulated as a possible cause. OBJECTIVES: The objectives of our study were: 1) to determine whether the prevalence of hypospadias and cryptorchidism is increasing compared with other congenital anomalies not known to be mediated by endocrine factors; and 2) to perform a geospatial analysis of these congenital malformations looking for clustering that could offer insight into environmental risk factors...
March 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28347501/knowledge-attitudes-beliefs-and-behaviors-of-university-students-faculty-and-staff-during-a-meningococcal-serogroup-b-outbreak-vaccination-program
#12
D M MacDougall, J M Langley, L Li, L Ye, D MacKinnon-Cameron, K A Top, S A McNeil, B A Halperin, A Swain, J A Bettinger, E Dubé, G De Serres, S A Halperin
OBJECTIVES: During an outbreak of invasive meningococcal B disease on a university campus, we explored the knowledge, attitudes, beliefs, and behaviors of members of the university community in relation to the disease, the vaccine, and the vaccination program. DESIGN: All students, faculty and staff were invited by email to participate in a 71-item online survey, which was administered after completion of the mass clinics for the first and second doses of a meningococcal B vaccination program...
March 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28343457/development-of-a-model-to-quantify-the-accessibility-of-a-canadian-trauma-system
#13
Gavin Tansley, Nadine Schuurman, Mete Erdogan, Matthew Bowes, Robert Green, Mark Asbridge, Natalie Yanchar
OBJECTIVES: Trauma systems have been widely implemented across Canada, but access to trauma care remains a challenge for much of the population. This study aims to develop and validate a model to quantify the accessibility of definitive care within one provincial trauma system and identify populations with poor access to trauma care. METHODS: A geographic information system (GIS) was used to generate models of pre-scene and post-scene intervals, respectively. Models were validated using a population-based trauma registry containing data on prehospital time intervals and injury locations for Nova Scotia (NS)...
March 27, 2017: CJEM
https://www.readbyqxmd.com/read/28334411/first-report-of-mating-disruption-with-an-aggregation-pheromone-a-case-study-with-tetropium-fuscum-coleoptera-cerambycidae
#14
Jon Sweeney, Peter J Silk, Marc Rhainds, Wayne MacKay, Cory Hughes, Kate Van Rooyen, Wayne MacKinnon, Gaetan Leclair, Steve Holmes, Edward G Kettela
Tetropium fuscum (F.), native to Europe and established in Nova Scotia, Canada, since at least 1990, is considered a low-to-moderate threat to spruce (Picea spp.) forests in North America and regulated as a quarantine pest by the Canadian Food Inspection Agency. We tested broadcast applications of the aggregation pheromone racemic (5E)-6,10-dimethyl-5,9-undecadien-2-ol (fuscumol), formulated at 10% concentration in Hercon Bio-Flakes (Hercon International, Emigsville, PA), for efficacy in disrupting T. fuscum mating and suppressing populations...
March 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28302637/protocol-for-determining-primary-healthcare-practice-characteristics-models-of-practice-and-patient-accessibility-using-an-exploratory-census-survey-with-linkage-to-administrative-data-in-nova-scotia-canada
#15
Emily Gard Marshall, Richard J Gibson, Beverley Lawson, Frederick Burge
INTRODUCTION: There is little evidence on how primary care providers (PCPs) model their practices in Nova Scotia (NS), Canada, what services they offer or what accessibility is like for the average patient. This study will create a database of all family physicians and primary healthcare nurse practitioners in NS, including information about accessibility and the model of care in which they practice, and will link the survey data to administrative health databases. METHODS AND ANALYSIS: 3 census surveys of all family physicians, primary care nurse practitioners (ie, PCPs) and their practices in NS will be conducted...
March 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28274683/gestational-weight-gain-and-interpregnancy-weight-change-in-adolescent-mothers
#16
Emily Whelan, B Anthony Armson, Jillian Ashley-Martin, Kayla MacSween, Christy Woolcott
STUDY OBJECTIVE: To examine the association between gestational weight gain (GWG) and interpregnancy weight change (IPWC) in adolescent mothers (<20 years), and to determine if this association differed from adult women (20-35 years). DESIGN: Retrospective cohort study. SETTING: and Participants: 3,055 adolescents and 17,090 adult women with singleton pregnancies recorded in the Nova Scotia Atlee Perinatal Database with a subsequent pregnancy occurring between 2003-2014...
March 5, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28274260/the-combined-impact-of-diet-physical-activity-sleep-and-screen-time-on-academic-achievement-a-prospective-study-of-elementary-school-students-in-nova-scotia-canada
#17
Erin L Faught, John P Ekwaru, Douglas Gleddie, Kate E Storey, Mark Asbridge, Paul J Veugelers
BACKGROUND: Few studies have investigated the independent associations of lifestyle behaviors (diet, physical activity, sleep, and screen time) and body weight status with academic achievement. Even fewer have investigated the combined effect of these behaviors on academic achievement. We hypothesize that the combined effect of these behaviors will have a higher impact on academic achievement than any behavior alone, or that of body weight status. METHODS: In 2011, 4253 grade 5 (10-11 years old) students and their parents were surveyed about the child's diet, physical activity, screen time and sleep...
March 9, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28249174/reduced-severity-of-histopathological-lesions-in-mink-selected-for-tolerance-to-aleutian-mink-disease-virus-infection
#18
A Hossain Farid, Linda E Ferns
The objective of this study was to measure the effect of selection for tolerance on the severity of the Aleutian disease (AD) lesions in mink. Sensitivity and specificity of antibody detection in the blood by counter-immunoelectrophoresis (CIEP) relative to the presence of Aleutian mink disease virus (AMDV) in the spleen by PCR in naturally infected farmed mink were also estimated. Carcasses of 680 sero-positive (CIEP-P) black mink from 28 farms in Nova Scotia, Canada, and from 132 sero-negative (CIEP-N) mink from 14 of these farms were collected at pelting time...
April 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28242280/the-atlantic-blue-crab-callinectes-sapidus-in-southern-european-coastal-waters-distribution-impact-and-prospective-invasion-management-strategies
#19
REVIEW
Giorgio Mancinelli, Paula Chainho, Lucrezia Cilenti, Silvia Falco, Kostas Kapiris, George Katselis, Filipe Ribeiro
The native distribution of the blue crab Callinectes sapidus in the western Atlantic extends from Nova Scotia to Argentina. Introduced to Europe at the beginning of the 20th century, it is currently recorded almost ubiquitously in the Mediterranean and in the Black Sea. An overview of the occurrence, abundance, and ecological impact of the species in southern European waters is provided; additionally, we present a pragmatic assessment of its management scenarios, explicitly considering the dual nature of C...
February 24, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28224097/understanding-academic-clinicians-intent-to-treat-pediatric-obesity
#20
Claudia Frankfurter, Charles Cunningham, Katherine M Morrison, Heather Rimas, Karen Bailey
AIM: To examine the extent to which the theory of planned behavior (TPB) predicts academic clinicians' intent to treat pediatric obesity. METHODS: A multi-disciplinary panel iteratively devised a Likert scale survey based on the constructs of the TPB applied to a set of pediatric obesity themes. A cross-sectional electronic survey was then administered to academic clinicians at tertiary care centers across Canada from January to April 2012. Descriptive statistics were used to summarize demographic and item agreement data...
February 8, 2017: World Journal of Clinical Pediatrics
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