Rajan Iyyappan, Daria Aleshkina, Hao Ming, Michal Dvoran, Kianoush Kakavand, Denisa Jansova, Edgar Del Llano, Lenka Gahurova, Alexander W Bruce, Tomas Masek, Martin Pospisek, Filip Horvat, Michal Kubelka, Zongliang Jiang, Andrej Susor
Translation is critical for development as transcription in the oocyte and early embryo is silenced. To illustrate the translational changes during meiosis and consecutive two mitoses of the oocyte and early embryo, we performed a genome-wide translatome analysis. Acquired data showed significant and uniform activation of key translational initiation and elongation axes specific to M-phases. Although global protein synthesis decreases in M-phases, translation initiation and elongation activity increases in a uniformly fluctuating manner, leading to qualitative changes in translation regulation via the mTOR1/4F/eEF2 axis...
November 10, 2023: Nucleic Acids Research