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Spinal astrocytoma

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https://www.readbyqxmd.com/read/28089418/distant-spread-of-a-supratentorial-glioblastoma-to-the-spinal-cord
#1
Krishnan Ravindran, Frank Gaillard, Arian Lasocki
Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28074710/canine-spinal-cord-glioma
#2
Daniel R Rissi, Renee Barber, Annabelle Burnum, Andrew D Miller
Spinal cord glioma is uncommonly reported in dogs. We describe the clinicopathologic and diagnostic features of 7 cases of canine spinal cord glioma and briefly review the veterinary literature on this topic. The median age at presentation was 7.2 y. Six females and 1 male were affected and 4 dogs were brachycephalic. The clinical course lasted from 3 d to 12 wk, and clinical signs were progressive and associated with multiple suspected neuroanatomic locations in the spinal cord. Magnetic resonance imaging of 6 cases revealed T2-weighted hyperintense lesions with variable contrast enhancement in the spinal cord...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27997032/k27m-midline-gliomas-display-malignant-progression-by-imaging-and-histology
#3
Franziska J Vettermann, Julia E Neumann, Bogdana Suchorska, Peter Bartenstein, Armin Giese, Mario M Dorostkar, Nathalie L Albert, Ulrich Schüller
K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV)...
December 20, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27958595/childhood-neurofibromatosis-type-2-nf2-and-related-disorders-from-bench-to-bedside-and-biologically-targeted-therapies
#4
M Ruggieri, A D Praticò, A Serra, L Maiolino, S Cocuzza, P Di Mauro, L Licciardello, P Milone, G Privitera, G Belfiore, M Di Pietro, F Di Raimondo, A Romano, A Chiarenza, M Muglia, A Polizzi, D G Evans
Neurofibromatosis type 2 [NF2; MIM # 101000] is an autosomal dominant disorder characterised by the occurrence of vestibular schwannomas (VSs), schwannomas of other cranial, spinal and cutaneous nerves, cranial and spinal meningiomas and/or other central nervous system (CNS) tumours (e.g., ependymomas, astrocytomas). Additional features include early onset cataracts, optic nerve sheath meningiomas, retinal hamartomas, dermal schwannomas (i.e., NF2-plaques), and (few) café-au-lait spots. Clinically, NF2 children fall into two main groups: (1) congenital NF2 - with bilateral VSs detected as early as the first days to months of life, which can be stable/asymptomatic for one-two decades and suddenly progress; and (2) severe pre-pubertal (Wishart type) NF2- with multiple (and rapidly progressive) CNS tumours other-than-VS, which usually present first, years before VSs [vs...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27920686/single-agent-carboplatin-for-a-rare-case-of-pilomyxoid-astrocytoma-of-the-spinal-cord-in-an-adult-with-neurofibromatosis-type-1
#5
Anastasie M Dunn-Pirio, Elizabeth Howell, Roger E McLendon, Katherine B Peters
INTRODUCTION: Pilomyxoid astrocytoma (PMA) is a rare and more aggressive variant of pilocytic astrocytoma, which usually affects young children and is most often located in the hypothalamic/chiasmatic region. The association of PMA with underlying genetic disorders is not well known. METHODS: We identified a 23-year-old woman with a PMA of the spinal cord who was simultaneously diagnosed with neurofibromatosis type 1. Diagnosis of neurofibromatosis type 1 was made clinically and confirmed with genetic testing that revealed a heterozygous one-amino-acid deletion (c...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27915062/rosette-forming-glioneuronal-tumor-originating-from-the-spinal-cord-report-of-2-cases-and-literature-review
#6
Lian Duan, Yunkun Zhang, Weilun Fu, Sumin Geng
Rosette-forming glioneuronal tumor (RGNT) is a recently recognized and rarely encountered tumor occurring in the fourth ventricle. RGNT was first described as a new entity for the distinct clinicopathologic features by Komori et.al. in 2002. Histologically, it is composed of 2 distinct features: a glial component, resembling pilocytic astrocytoma, and a neurocytic component forming neurocytic rosettes and/or perivascular rosettes. We report 2 extremely rare cases of RGNT arising from the spinal cord, which were misdiagnosed as ependymoma and astrocytoma preoperatively...
November 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27900936/malignant-progression-of-a-histone-h3-3-k27m-mutated-spinal-pilocytic-astrocytoma-in-an-adult
#7
Stefan Reers, David Krug, Walter Stummer, Martin Hasselblatt
No abstract text is available yet for this article.
November 30, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27842677/spinal-diffusion-tensor-tractography-for-differentiation-of-intramedullary-tumor-suspected-lesions
#8
K Egger, M Hohenhaus, V Van Velthoven, S Heil, H Urbach
BACKGROUND AND PURPOSE: Primary MRI diagnosis of spinal intramedullary tumor-suspected lesions can be challenging and often requires spinal biopsy or resection with a substantial risk of neurological deficits. We evaluated whether Diffusion Tensor Imaging (DTI) tractography can facilitate the differential diagnosis. MATERIALS AND METHODS: Twenty-five consecutive patients with an intramedullary tumor-suspected lesion considered for spinal surgery were studied with a Diffusion-weighted multi-shot read out segmented EPI sequence (RESOLVE)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27834627/promotion-of-astrocytoma-cell-invasion-by-micro-rna-22-targeting-of-tissue-inhibitor-of-matrix-metalloproteinase-2
#9
Yu-Ichiro Ohnishi, Koichi Iwatsuki, Masahiro Ishihara, Toshika Ohkawa, Manabu Kinoshita, Koei Shinzawa, Yasunori Fujimoto, Toshiki Yoshimine
OBJECTIVE Diffuse astrocytomas (DAs) have a high recurrence rate due to diffuse infiltration into the brain and spinal cord. Micro RNAs (miRNAs) are small noncoding RNAs that regulate gene expression by binding to complementary sequences of target messenger RNA (mRNA). It has been reported that miRNA-22 (miR-22) is involved in the invasion of some cancer cell lines. The aim of this study was to identify the biological effects of miR-22 in regard to the invasion of human DAs. METHODS The authors evaluated whether the level of miR-22 is elevated in human spinal DAs by using miRNA chips...
November 11, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27659826/supratentorial-tumors-typical-of-the-infantile-age-desmoplastic-infantile-ganglioglioma-dig-and-astrocytoma-dia-a-review
#10
F Bianchi, G Tamburrini, L Massimi, M Caldarelli
OBJECT: Desmoplastic infantile gangliogliomas (DIGs) and desmoplastic infantile astrocytomas (DIAs) are tumors typical of the infantile age. A large size, with a mixed solid and cystic component, clinical presentation with progressing signs of increased intracranial pressure, a prominent benign desmoplastic structure at histological examination, and a favorable clinical course in the majority of cases are the prominent features of these tumors. The objective of the present paper was to review the pertinent literature on the topic together with our personal experience, with the aim of an updated review of the subject...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27616318/neoplastic-and-paraneoplastic-involvement-of-the-spinal-cord
#11
John Michael Hazenfield, Mary F Gaskill-Shipley
Neoplasia of the spinal cord, including both primary and metastatic tumors, is relatively rare, representing 4%-10% of all central nervous system tumors, and can present a diagnostic challenge to the radiologist. More than 90% of primary spinal cord neoplasms are derived from the glial cell lineage, including the 2 most common tumors ependymoma and astrocytoma. However, less common spinal cord tumors, including metastatic disease, as well as nonneoplastic and paraneoplastic processes should be considered in the diagnosis of intramedullary spinal cord lesions...
October 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27615152/development-of-a-lateralization-index-for-intramedullary-astrocytomas-and-ependymomas
#12
A Herbrecht, M Messerer, F Parker
INTRODUCTION: Intramedullary ependymomas are classically described as tumors developing in the center of the spinal cord, whereas intramedullary astrocytomas are more dispersed. This description only remains approximate. The aim of this study was to establish a lateralization index (LI), which is based on radiological measurements and may help in differentiating the two tumors. MATERIAL AND METHODS: Retrospective analysis based on the analysis of MRI of patients operated on for intramedullary astrocytoma or ependymoma in the Neurosurgical Department of Bicêtre Hospital...
September 9, 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27612900/surgical-outcome-of-intradural-spinal-tumors
#13
M K Ahsan, N Sakeb, M Y Ali, M A Awwal, S I Khan, M M Goni, M B Mia, M B Alam, N Zaman, S N Jannat
Results of 63 surgically treated intradural spinal tumors between the period of October 2003 and December 2014 at Bangabandhu Sheikh Mujib Medical University (BSMMU) and in our private settings, Dhaka, were analyzed retrospectively. There were 33 males, 30 females with an average age of 52.4 years (13-70 years) and followed up for at least a year. The preoperative symptom with duration, tumors location and intradural space occupancy and the histopathological diagnosis were analyzed. Pain was evaluated by the visual analogue scale (VAS) and the neurologic function was assessed by Nurick's grade...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27559457/clinical-factors-for-prognosis-and-treatment-guidance-of-spinal-cord-astrocytoma
#14
Toshitaka Seki, Kazutoshi Hida, Shunsuke Yano, Takeshi Aoyama, Izumi Koyanagi, Toru Sasamori, Shuji Hamauch, Kiyohiro Houkin
STUDY DESIGN: Retrospective study. PURPOSE: To obtain information useful in establishing treatment guidelines by evaluating baseline clinical features and treatment outcomes of patients with spinal cord astrocytoma (SCA). OVERVIEW OF LITERATURE: The optimal management of SCA remains controversial, and there are no standard guidelines. METHODS: The study included 20 patients with low-grade and 13 with high-grade SCA surgically treated between 1989 and 2014...
August 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27535634/cranial-pilocytic-astrocytoma-with-spinal-drop-metastasis-in-an-adult-case-report-and-literature-review
#15
Aasheen Munshey, Justin Moore, Catriona Maclean, Anthony Longano, Tony Goldschlager
BACKGROUND: Pilocytic astrocytoma (PA) is a benign neoplasm that typically occurs in the brain within the pediatric and adolescent age groups and is uncommon in adults. It rarely occurs within the ventricles and the overall prognosis is favourable. A pilocytic astrocytoma of the brain with spinal metastasis at presentation has never been reported in an adult. CASE DESCRIPTION: We report a case of a 47-year-old male presenting with sudden onset frontal headache associated with nausea and lethargy...
August 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27476850/clinical-and-pathological-outcomes-after-resection-of-intramedullary-spinal-cord-tumors-a-single-institution-case-series
#16
Nardin Samuel, Lindsay Tetreault, Carlo Santaguida, Anick Nater, Nizar Moayeri, Eric M Massicotte, Michael G Fehlings
OBJECTIVE The objective of this study was to identify clinically relevant predictors of progression-free survival and functional outcomes in patients who underwent surgery for intramedullary spinal cord tumors (ISCTs). METHODS An institutional spinal tumor registry and billing records were reviewed to identify adult patients who underwent resection of ISCTs between 1993 and 2014. Extensive data were collected from patient charts and operative notes, including demographic information, extent of resection, tumor pathology, and functional and oncological outcomes...
August 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27475420/factors-affecting-functional-outcome-in-patients-with-intramedullary-spinal-cord-tumors-results-from-a-literature-analysis
#17
Nicola Montano, Fabio Papacci, Gianluca Trevisi, Eduardo Fernandez
Recently, great advances have been made in the surgical treatment of intramedullary spinal cord tumors (IMSCTs). Many articles have been published; but looking at the literature of the last 5 years, there are only descriptive reviews and no works in which a literature statistical analysis was performed. Here, we analyzed the literature to identify potential prognosticators of good functional outcome in IMSCT patients. To level out the selected studies, we stratified patients' neurological status as independent (ambulation possible without caregiver assistance) or disabled (cannot ambulate or can only ambulate with caregiver assistance)...
July 30, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27420482/role-of-resection-and-adjuvant-therapy-in-long-term-disease-outcomes-for-low-grade-pediatric-intramedullary-spinal-cord-tumors
#18
Raheel Ahmed, Arnold H Menezes, James C Torner
OBJECTIVE Surgical excision is the mainstay treatment for resectable low-grade intramedullary spinal cord tumors (IMSCTs) in the pediatric age group. Chemotherapy and radiation treatments are generally reserved for progressive or recurrent disease. Given the indolent nature of low-grade tumors and the potential side effects of these approaches, their long-term treatment benefits are unclear. The aim of the study was to determine long-term disease outcomes and the therapeutic roles of surgery and adjuvant therapies in pediatric patients with low-grade IMSCTs over an extended follow-up period...
July 15, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27417401/neuroimaging-of-spinal-tumors
#19
REVIEW
Zulejha Merhemic, Tatjana Stosic-Opincal, Majda M Thurnher
Intradural tumors are relatively rare neoplasms; however, when unrecognized in a timely manner, they can result in serious deficits and disability. These tumors lack obvious clinical symptoms until compression of the cord or neurologic deficits occur. The most common intramedullary lesions are ependymomas, astrocytomas, and hemangioblastomas. Meningiomas and nerve sheath tumors (schwannomas and neurofibromas) comprise most intradural-extramedullary tumors. Less common tumors are hemangiopericytoma, paraganglioma, melanocytoma, melanoma, metastases, and lymphoma...
August 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27313931/spinal-intradural-extramedullary-ependymoma-with-astrocytoma-component-a-case-report-and-review-of-the-literature
#20
Gene M Weinstein, Knarik Arkun, James Kryzanski, Michael Lanfranchi, Gaurav K Gupta, Harprit Bedi
Ependymomas are common spinal lesions, with the vast majority arising in an intramedullary location. Several cases have been described in the literature of ependymomas in an intradural, extramedullary location. The authors present a case of a 56-year-old female who presented with several weeks of lower back pain and weakness. MRI revealed an intradural, extramedullary enhancing mass at L1-L2. The mass was successfully resected surgically. Pathologic evaluation revealed a low grade glioma with components of both ependymoma and pilocytic astrocytoma with MUTYH G382D mutation...
2016: Case Reports in Pathology
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