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Spinal low grade astrocytoma

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https://www.readbyqxmd.com/read/28870453/spinal-cord-tumors-in-children-a-review-of-21-cases-treated-at-the-same-institution
#1
I Merlot, J Francois, J-C Marchal, A Joud, R Guerbouz, P Chastagner, O Klein
INTRODUCTION: Spinal cord tumors in children (SCTC) are rare with a frequent diagnostic delay. Its management is multidisciplinary and challenging due to functional implications. The position of surgery is now better established but the role and timing of chemotherapy (CT) and radiotherapy (RT) still remains under debate. Adverse effects of treatments are important to be taken into account, in the follow-up of these children. The aim of this paper was to present a series of 21 cases of SCTC treated at the same institution, to briefly present clinical features, treatments and outcome, with a special focus on spinal deformities in children with this condition...
September 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28828715/treatment-of-childhood-astrocytomas-with-irinotecan-and-cisplatin
#2
J Mora, S Perez-Jaume, O Cruz
BACKGROUND: Previously we described the outcome of children with spinal cord astrocytoma treated with irinotecan and cisplatin (I/C). We here report the review of the initial institutional experience using this combination for children with low-grade glioma (LGG). PROCEDURE: I/C chemotherapy consisted of weekly cisplatin (30 mg/m(2)) and irinotecan (50-65 mg/m(2)) for a total maximum of 16 doses, administered in an outpatient basis. RESULTS: Between November 2002 and December 2009, 46 children (median age 6...
August 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28522280/primary-spinal-glioma-in-children-results-from-a-referral-pediatric-institution-in-shanghai
#3
J Khalil, Z Chuanying, Z Qing, Y Belkacémi, J Mawei
PURPOSE: Primary spinal cord glioma is a rare entity especially in children; accounting for less than 10% of all central nervous system tumors. Low grade is the most reported subtype. Treatment modalities have largely evolved; large improvements have been made in the surgical field but also in both of radiotherapy and chemotherapy. Nevertheless, the optimal treatment is yet to be defined. MATERIAL AND METHODS: A chart review of 11 pediatric patients with a diagnosis of low grade spinal cord glioma at Xhinhua hospital in Shanghai was conducted...
June 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28490167/endoscopic-treatment-of-an-adult-with-tegmental-astrocytoma-accompanied-by-cerebrospinal-fluid-dissemination
#4
Runchun Lu, Chuzhong Li, Xinsheng Wang, Yazhuo Zhang
Midbrain gliomas are relatively rare neoplasms with a generally benign prognosis, with dissemination or metastasis not previously reported. We describe here a woman, in whom magnetic resonance imaging scans showed hydrocephalus and a tegmental lesion in the upper aqueduct. Endoscopic third ventriculostomy and biopsy were performed; during surgery, a second small lesion was observed in the infundibular recess. Histologically, the two lesions had the characteristics of low grade astrocytoma, suggesting that the midbrain astrocytoma may have been disseminated via the cerebral spinal fluid to the infundibular recess...
May 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27997032/k27m-midline-gliomas-display-malignant-progression-by-imaging-and-histology
#5
Franziska J Vettermann, Julia E Neumann, Bogdana Suchorska, Peter Bartenstein, Armin Giese, Mario M Dorostkar, Nathalie L Albert, Ulrich Schüller
K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV)...
December 20, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27842677/spinal-diffusion-tensor-tractography-for-differentiation-of-intramedullary-tumor-suspected-lesions
#6
K Egger, M Hohenhaus, V Van Velthoven, S Heil, H Urbach
BACKGROUND AND PURPOSE: Primary MRI diagnosis of spinal intramedullary tumor-suspected lesions can be challenging and often requires spinal biopsy or resection with a substantial risk of neurological deficits. We evaluated whether Diffusion Tensor Imaging (DTI) tractography can facilitate the differential diagnosis. MATERIALS AND METHODS: Twenty-five consecutive patients with an intramedullary tumor-suspected lesion considered for spinal surgery were studied with a Diffusion-weighted multi-shot read out segmented EPI sequence (RESOLVE)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27559457/clinical-factors-for-prognosis-and-treatment-guidance-of-spinal-cord-astrocytoma
#7
Toshitaka Seki, Kazutoshi Hida, Shunsuke Yano, Takeshi Aoyama, Izumi Koyanagi, Toru Sasamori, Shuji Hamauch, Kiyohiro Houkin
STUDY DESIGN: Retrospective study. PURPOSE: To obtain information useful in establishing treatment guidelines by evaluating baseline clinical features and treatment outcomes of patients with spinal cord astrocytoma (SCA). OVERVIEW OF LITERATURE: The optimal management of SCA remains controversial, and there are no standard guidelines. METHODS: The study included 20 patients with low-grade and 13 with high-grade SCA surgically treated between 1989 and 2014...
August 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27420482/role-of-resection-and-adjuvant-therapy-in-long-term-disease-outcomes-for-low-grade-pediatric-intramedullary-spinal-cord-tumors
#8
Raheel Ahmed, Arnold H Menezes, James C Torner
OBJECTIVE Surgical excision is the mainstay treatment for resectable low-grade intramedullary spinal cord tumors (IMSCTs) in the pediatric age group. Chemotherapy and radiation treatments are generally reserved for progressive or recurrent disease. Given the indolent nature of low-grade tumors and the potential side effects of these approaches, their long-term treatment benefits are unclear. The aim of the study was to determine long-term disease outcomes and the therapeutic roles of surgery and adjuvant therapies in pediatric patients with low-grade IMSCTs over an extended follow-up period...
November 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27313931/spinal-intradural-extramedullary-ependymoma-with-astrocytoma-component-a-case-report-and-review-of-the-literature
#9
Gene M Weinstein, Knarik Arkun, James Kryzanski, Michael Lanfranchi, Gaurav K Gupta, Harprit Bedi
Ependymomas are common spinal lesions, with the vast majority arising in an intramedullary location. Several cases have been described in the literature of ependymomas in an intradural, extramedullary location. The authors present a case of a 56-year-old female who presented with several weeks of lower back pain and weakness. MRI revealed an intradural, extramedullary enhancing mass at L1-L2. The mass was successfully resected surgically. Pathologic evaluation revealed a low grade glioma with components of both ependymoma and pilocytic astrocytoma with MUTYH G382D mutation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27228211/further-understanding-of-the-pathology-of-glioma-implications-for-the-clinic
#10
REVIEW
Sandra Camelo-Piragua, Santosh Kesari
INTRODUCTION: Glioma classification and grading has been historically based in morphologic appearance of tumor cells: astrocytomas, oligodendrogliomas, oligoastrocytomas and ependymomas. Recent molecular advances have transformed the field of neuro-oncology, as some molecular markers harbor diagnostic, prognostic and therapeutic implications. AREAS COVERED: In this paper we will review the major molecular changes associated with gliomas and their implications in diagnosis, prognosis, and opportunities in therapeutics...
September 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27162602/diffuse-spinal-leptomeningeal-spread-of-a-pilocytic-astrocytoma-in-a-3-year-old-child
#11
Ameer Alyeldien, Sarah Teuber-Hanselmann, Azad Cheko, Tanja Höll, Martin Scholz, Athanasios K Petridis
Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic astrocytoma of the optic chiasm with leptomeningeal dissemination of the spinal meninges. Partial resection of the cerebral tumor has been performed. Since the leptomeningeal dissemination was seen all over the spinal meninges, the child did not undergo further surgical treatment...
March 25, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/27081238/multiple-hypertrophic-relapsing-remitting-cranial-neuropathies-as-an-initial-presentation-of-primary-cns-lymphoma-without-any-brain-or-spinal-cord-lesion
#12
Gaurav V Watane, Saumil P Pandya, Isha D Atre, Foram N Kothari
Cranial nerve thickening as an initial isolated presentation of CNS lymphoma is rare. Once an extremely rare neoplasm, primary lymphoma of the central nervous system (CNS) now ranks only next to meningiomas and low-grade astrocytomas in prevalence. Multiple cranial nerve thickening can be a feature of primary CNS lymphoma. Here we report a case of a 45-year-old immunocompetent female who presented with relapsing remitting multiple cranial nerve thickening as an initial feature of primary CNS lymphoma without any other brain or spinal cord lesions...
January 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/26984877/a-retrospective-observational-study-on-the-treatment-outcomes-of-26-patients-with-spinal-cord-astrocytoma-including-two-cases-of-malignant-transformation
#13
Seong Jun Ryu, Jong Yul Kim, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Se Hoon Kim
PURPOSE: To determine the biologic behavior and prognostic factors of spinal cord astrocytoma, we reviewed surgical and clinical outcomes. Due to the rarity of spinal cord astrocytoma, there is a lack of research regarding this type of tumor and malignant transformation. METHODS: We retrospectively reviewed the data from all patients on whom we performed spinal cord tumor removal between 1983 and 2014. Twenty-six patients were pathologically confirmed to have spinal cord astrocytoma or glioblastoma...
March 16, 2016: European Spine Journal
https://www.readbyqxmd.com/read/26944214/infiltrating-spinal-cord-astrocytomas-epidemiology-diagnosis-treatments-and-future-directions
#14
REVIEW
Muhammad M Abd-El-Barr, Kevin T Huang, John H Chi
Spinal cord gliomas, consisting mostly of ependymomas and astrocytomas, are rare entities. Of the gliomas, infiltrating astrocytomas are particularly challenging entities to treat due to their invasive nature. Surgical resection is oftentimes not possible without subjecting patients to permanent neurological deficits because of the difficulty in establishing clear tissue planes. As more is learned about the molecular genetics, genomics, and biology of these tumors, it is becoming more apparent that there are important differences between these tumors and their more common intracranial counterparts...
July 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26468485/the-use-of-dual-growing-rods-to-correct-spinal-deformity-secondary-to-a-low-grade-spinal-cord-astrocytoma
#15
Elizabeth N Kuhn, Akhil Muthigi, John Frino, Alexander K Powers
Pediatric intramedullary spinal cord astrocytomas are rare, and the majority are low grade, typically carrying a low risk of mortality, but a high risk of morbidity. Quality of life is, therefore, an important consideration in treating concomitant progressive kyphoscoliosis. Compared with fusion-based spinal stabilization, fusionless techniques may limit some complications related to early instrumentation of the developing spine. Another consideration is the timing of radiation therapy relative to both spinal maturity and spinal instrumentation...
2015: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/26455542/congenital-glioneuronal-tumor-with-neuropil-like-islands
#16
Jason D Chesser, Neil R Friedman, Richard A Prayson
The glioneuronal tumor with neuropil-islands is considered a rare variant of an astrocytoma. Congenital cases of glioneuronal tumor with neuropil-islands, which typically arise in adults, have not been reported to our knowledge. We report an autopsy case of an in-utero demise of a 38-week-gestation female fetus in a 29-year-old female. At autopsy, a previously detected supratentorial tectal mass (by fetal MRI) was identified. Histology showed a biphasic neoplasm marked by island of gray matter-like parenchyma rimmed by mature-appearing neuronal cells intermixed with variably cellular areas resembling a low grade astrocytoma...
February 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26235020/the-genetic-basis-of-intradural-spinal-tumors-and-its-impact-on-clinical-treatment
#17
REVIEW
Michael Karsy, Jian Guan, Walavan Sivakumar, Jayson A Neil, Meic H Schmidt, Mark A Mahan
Genetic alterations in the cells of intradural spinal tumors can have a significant impact on the treatment options, counseling, and prognosis for patients. Although surgery is the primary therapy for most intradural tumors, radiochemothera-peutic modalities and targeted interventions play an ever-evolving role in treating aggressive cancers and in addressing cancer recurrence in long-term survivors. Recent studies have helped delineate specific genetic and molecular differences between intradural spinal tumors and their intracranial counterparts and have also identified significant variation in therapeutic effects on these tumors...
August 2015: Neurosurgical Focus
https://www.readbyqxmd.com/read/26230418/qualitative-analysis-of-spinal-intramedullary-lesions-using-pet-ct
#18
Kentaro Naito, Toru Yamagata, Hironori Arima, Junya Abe, Naohiro Tsuyuguchi, Kenji Ohata, Toshihiro Takami
OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-(11)C]-methionine (MET)- or [(18)F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight...
July 31, 2015: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/25708303/holocord-low-grade-astrocytoma-role-of-radical-irradiation-and-chemotherapy
#19
Shikha Goyal, Tarun Puri, P K Julka
Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as 'holocord' tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer. Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges. We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy...
June 2015: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/25705862/grade-ii-pilocytic-astrocytoma-in-a-3-month-old-patient-with-encephalocraniocutaneous-lipomatosis-eccl-case-report-and-literature-review-of-low-grade-gliomas-in-eccl
#20
REVIEW
Sarah Bieser, Martin Reis, Miguel Guzman, Karen Gauvain, Samer Elbabaa, Stephen R Braddock, Mohamed S Abdel-Baki
Encephalocraniocutaneous lipomatosis (ECCL) is a rare congenital syndrome with an unknown etiology. Since 1970, around 60 cases have been reported in English literature. ECCL is usually classified by cutaneous lesions and non-progressive intracranial or spinal lipomas; however three cases of ECCL associated with low grade glioma (LGG) have been described. We report on the fourth case of LGG in a patient with ECCL; a grade II pilocytic astrocytoma with pilomyxoid features in a 3-month-old male, the youngest in literature...
April 2015: American Journal of Medical Genetics. Part A
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