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https://www.readbyqxmd.com/read/28820634/in-vivo-and-in-vitro-effects-of-atm-atr-signaling-pathway-on-proliferation-apoptosis-and-radiosensitivity-of-nasopharyngeal-carcinoma-cells
#1
Ming Wang, Gang Liu, Guo-Ping Shan, Bing-Bing Wang
AIM: The study investigated the ability of ataxia-telangiectasia mutated (ATM)/Rad3-related (ATR) signaling pathway to influence the proliferation, apoptosis, and radiosensitivity of nasopharyngeal carcinoma (NPC) cells. MATERIALS AND METHODS: NPC tissues and corresponding adjacent normal tissues were collected from 143 NPC patients. The NPC CNE2 cells were assigned into a control group, X-ray group, CGK-733 group, and X-ray+CGK-733 group. The mRNA levels of ATM and ATR were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) and the protein levels of ATM and ATR using western blotting...
August 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28820495/human-papillomavirus-and-the-dna-damage-response-exploiting-host-repair-pathways-for-viral-replication
#2
REVIEW
Chelsey C Spriggs, Laimonis A Laimins
High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other genital cancers. In addition, HPV infections are associated with the development of many oropharyngeal cancers. HPVs activate and repress a number of host cellular pathways to promote their viral life cycles, including those of the DNA damage response. High-risk HPVs activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) DNA damage repair pathways, which are essential for viral replication (particularly differentiation-dependent genome amplification)...
August 18, 2017: Viruses
https://www.readbyqxmd.com/read/28819120/dual-delivery-of-fgf-2-ctgf-from-silk-fibroin-plcl-peo-coaxial-fibers-enhances-msc-proliferation-and-fibrogenesis
#3
Ruodan Xu, Huiling Zhao, Hanif Muhammad, Mingdong Dong, Flemming Besenbacher, Menglin Chen
The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolactone)-polyethylene oxide (SF/PLCL-PEO) enhanced fibrogenic lineage differentiation of MSCs. The core-shell structure was confirmed by transmission electron microscopy (TEM), fluorescence microscopy and attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818686/methyleugenol-and-selected-oxidative-metabolites-affect-dna-damage-signalling-pathways-and-induce-apoptosis-in-human-colon-tumour-ht29-cells
#4
Isabel Anna Maria Groh, Melanie Esselen
Previously the food carcinogen methyleugenol was found to be cytotoxic and genotoxic in multiple cell lines and in primary hepatocytes. In this study, the question addressed was whether methyleugenol and the selected oxidative metabolites, 1'-hydroxymethyleugenol, methyleugenol-2',3'-epoxide, and 3'-oxomethylisoeugenol trigger a DNA damage response in the human colon carcinoma HT29 cell line. Most notably investigations by flow cytometry revealed that the metabolites induce an accumulation of HT29 cells in the G2 phase of the cell cycle...
August 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28815191/a-randomized-fellow-eye-comparison-of-keratometry-aberrometry-tear-film-axial-length-and-the-anterior-chamber-depth-after-eye-rubbing-in-non-keratoconic-eyes
#5
Jordan V Chervenkoff, Elizabeth Hawkes, Gabriela Ortiz, Deborah Horney, Mayank A Nanavaty
BACKGROUND: To investigate the effect of eye rubbing on keratometry (K), aberrometry, tear film break-up-time (TFBUT) and anterior chamber depth (ACD). METHODS: Volunteers without any corneal pathology or dry eyes were randomised to rubbing in one eye and the fellow-eye was control. Eye rubbing was performed for 2 min. Primary outcomes studied were anterior and posterior K changes. Secondary outcomes were changes in TFBUT, axial length (AL) & ACD, K changes in various zones, asphericity and aberrometry...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28814785/comparison-between-spectral-analysis-and-symbolic-dynamics-for-heart-rate-variability-analysis-in-the-rat
#6
Luiz Eduardo Virgilio Silva, Victor Rezende Geraldini, Bianca Potratz de Oliveira, Carlos Alberto Aguiar Silva, Alberto Porta, Rubens Fazan
Spectral analysis of heart rate (HR) has been widely used to assess the autonomic cardiovascular control. A nonlinear approach, known as symbolic analysis, has been reported to be very useful to assess the autonomic control of cardiovascular system in humans, but very few studies reported on the differences between these two approaches on experimental models. Two distinct approaches were used to elicit autonomic changes in conscious Wistar rats: (1) pharmacological blockade of cardiac autonomic receptors with atenolol (ATE, N = 9) or methylatropine (ATR, N = 9) and (2) mild changes in arterial pressure (AP) induced by phenylephrine (PHE, N = 9) or sodium nitroprusside (NPS, N = 9)...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811666/the-essential-kinase-atr-ensuring-faithful-duplication-of-a-challenging-genome
#7
REVIEW
Joshua C Saldivar, David Cortez, Karlene A Cimprich
One way to preserve a rare book is to lock it away from all potential sources of damage. Of course, an inaccessible book is also of little use, and the paper and ink will continue to degrade with age in any case. Like a book, the information stored in our DNA needs to be read, but it is also subject to continuous assault and therefore needs to be protected. In this Review, we examine how the replication stress response that is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR) senses and resolves threats to DNA integrity so that the DNA remains available to read in all of our cells...
August 16, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28809543/infrared-spectroscopy-coupled-with-a-dispersion-model-for-quantifying-the-real-time-dynamics-of-kanamycin-resistance-in-artificial-microbiota
#8
Naifu Jin, Maria Paraskevaidi, Kirk T Semple, Francis Luke Martin, Dayi Zhang
Over-usage of antibiotics leads to the widespread induction of antibiotic resistance genes (ARGs). Developing an approach to allow real-time monitoring and fast prediction of ARGs dynamics in clinical or environmental samples has become an urgent matter. Vibrational spectroscopy is potentially an ideal technique towards the characterization of the microbial composition of microbiota as it is non-destructive, high-throughput and label-free. Herein, we employed attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy and developed a spectrochemical tool to quantify the static and dynamic composition of kanamycin resistance in artificial microbiota to evaluate microbial antibiotic resistance...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28809481/spectral-mining-for-discriminating-blood-origins-in-the-presence-of-substrate-interference-via-atr-ft-ir-postmortem-or-antemortem-blood
#9
Ayari Takamura, Ken Watanabe, Tomoko Akutsu, Hiroshi Ikegaya, Takeaki Ozawa
Often in criminal investigations, discrimination of types of body fluid evidence is crucially important to ascertain how a crime was committed. Compared to current methods using biochemical techniques, vibrational spectroscopic approaches can provide versatile applicability to identify various body fluid types without sample invasion. However, their applicability is limited to pure body fluid samples because important signals from body fluids incorporated in a substrate are affected strongly by interference from substrate signals...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28808232/analysis-of-the-atr-chk1-and-atm-chk2-pathways-in-male-breast-cancer-revealed-the-prognostic-significance-of-atr-expression
#10
Anna Di Benedetto, Cristiana Ercolani, Marcella Mottolese, Francesca Sperati, Laura Pizzuti, Patrizia Vici, Irene Terrenato, Abeer M Shaaban, Matthew P Humphries, Luigi Di Lauro, Maddalena Barba, Ilio Vitale, Gennaro Ciliberto, Valerie Speirs, Ruggero De Maria, Marcello Maugeri-Saccà
The ATR-Chk1 and ATM-Chk2 pathways are central in DNA damage repair (DDR) and their over-activation may confer aggressive molecular features, being an adaptive response to endogenous DNA damage and oncogene-induced replication stress. Herein we investigated the ATR-Chk1 and ATM-Chk2 signalings in male breast cancer (MBC). The expression of DDR kinases (pATR, pATM, pChk1, pChk2, and pWee1) and DNA damage markers (pRPA32 and γ-H2AX) was evaluated by immunohistochemistry in 289 MBC samples to assess their association...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808226/atr-inhibition-facilitates-targeting-of-leukemia-dependence-on-convergent-nucleotide-biosynthetic-pathways
#11
Thuc M Le, Soumya Poddar, Joseph R Capri, Evan R Abt, Woosuk Kim, Liu Wei, Nhu T Uong, Chloe M Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I Kornblum, Antoni Ribas, Harvey R Herschman, Julian Whitelegge, Kym F Faull, Timothy R Donahue, Johannes Czernin, Caius G Radu
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein (ATR) reduces the output of both de novo and salvage pathways by regulating the activity of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) and deoxycytidine kinase (dCK), via distinct molecular mechanisms...
August 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28807818/novel-concentrated-water-in-oil-emulsions-based-on-a-non-ionic-silicone-surfactant-appealing-application-properties-and-tuneable-viscoelasticity
#12
Lisa Binder, Johannes Jatschka, Dieter Baurecht, Michael Wirth, Claudia Valenta
Silicone excipients are non-irritating ingredients that are extensively used in topical formulations. In the present study, innovative water-in-oil emulsions with a high water content stabilised by a non-ionic silicone surfactant were developed. Effects of formulation composition on its properties and stability were investigated. It was possible to prepare highly stable emulsions with a water volume fraction of up to 80%. The emulsions exhibited desirable application properties such as non-sticky and cooling qualities...
August 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28802845/fluorescence-quenching-structural-and-unfolding-studies-of-a-purified-cysteine-protease-zcpg-from-zingiber-montanum-rhizome
#13
Kizukala Jamir, Kottapalli Seshagirirao
A first attempt was made to study the fluorescence quenching, structure and unfolding nature of the purified Zingiber montanum (J.Koenig) Link ex A.Dietr. cysteine protease glycoprotein (ZCPG). ATR-IR spectra showed the presences of amide groups along with carbohydrate stretch indicating the glycoprotein nature. UV-vis spectra determined the presences of peptide groups and aromatic sidechains of tyrosine, tryptophan and phenylalanine. Far UV-Circular Dichroism spectrum revealed that the secondary structure consists of 47...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28797943/adsorption-study-of-selenium-ions-from-aqueous-solutions-using-mgo-nanosheets-synthesized-by-ultrasonic-method
#14
Wenwen Cui, Ping Li, Zheming Wang, Shili Zheng, Yi Zhang
MgO nanosheets with thickness ranges of 3-10 molecule layers and high specific area (166.44m(2)g(-1)) were successfully fabricated by an ultrasound-assisted exfoliation method and used as adsorbent for the removal of both selenite (Se(IV)) and selenate (Se(VI)) from aqueous solutions. The resulting MgO nanosheets displayed high maximum adsorption capacities of 103.52 and 10.28mgg(-1) for Se(IV) and Se(VI), respectively. ATR-FTIR and XPS spectroscopic results suggested that both Se(IV) and Se(VI) formed inner-sphere surface complexes on MgO nanosheets under the present experimental conditions...
August 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28796478/spectroscopic-evidence-of-size-dependent-buffering-of-interfacial-ph-by-cation-hydrolysis-during-co2-electroreduction
#15
Onagie Ayemoba, Angel Cuesta
The nature of the electrolyte cation is known to affect the Faradaic efficiency and selectivity of CO2 electroreduction. Singh et al. (J. Am. Chem. Soc. 2016, 138, 13006-13012) recently attributed this effect to the buffering ability of cation hydrolysis at the electrical double layer. According to them, the pKa of hydrolysis decreases close to the cathode due to the polarization of the solvation water molecules sandwiched between the cation's positive charge and the negative charge on the electrode surface...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28796244/bet-bromodomain-inhibitors-synergize-with-atr-inhibitors-in-melanoma-in-melanoma
#16
Somsundar Veppil Muralidharan, Berglind Osk Einarsdottir, Joydeep Bhadury, Mattias F Lindberg, Jin Wu, Eric Campeau, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
Metastatic malignant melanoma continues to be a challenging disease despite clinical translation of the comprehensive understanding of driver mutations and how melanoma cells evade immune attack. In Myc-driven lymphoma, efficacy of epigenetic inhibitors of the bromodomain and extra-terminal domain (BET) family of bromodomain proteins can be enhanced by combination therapy with inhibitors of the DNA damage response kinase ATR. Whether this combination is active in solid malignancies like melanoma, and how it relates to immune therapy, has not previously investigated...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28795814/anion-exchange-membrane-fuel-cells-with-improved-co2-tolerance-impact-of-chemically-induced-bicarbonate-ion-consumption
#17
Yu Katayama, Kosuke Yamauchi, Kohei Hayashi, Takeou Okanishi, Hiroki Muroyama, Toshiaki Matsui, Yuuki Kikkawa, Takayuki Negishi, Shin Watanabe, Takenori Isomura, Koichi Eguchi
Over the last few decades, owing to the significant development of anion exchange membranes, increasing efforts have been devoted the realization of anion exchange membrane fuel cells (AEMFCs) that operate with the supply of hydrogen generated on-site. In this paper, ammonia was selected as a hydrogen source, following which the effect of conceivable impurities, unreacted NH3 and atmospheric CO2, on the performance of AEMFCs was established. As expected, we show that these impurities worsen the performance of AEMFCs significantly...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28795562/axially-bound-ruthenium-phthalocyanine-monolayers-on-indium-tin-oxide-structure-energetics-and-charge-transfer-properties
#18
Ramanan Ehamparam, Luis E Oquendo, Michael W Liao, Ambjorn Karl Brynnel, Kai-Lin Ou, Neal R Armstrong, Dominic V McGrath, S Scott Saavedra
The efficiency of charge collection at the organic/transparent conducting oxide (TCO) interface in organic photovoltaic (OPV) devices affects overall device efficiency. Modifying the TCO with an electrochemically active molecule may enhance OPV efficiency by providing a charge-transfer pathway between the electrode and the organic active layer, and may also mitigate surface recombination. The synthesis and characterization of phosphonic acid-ruthenium phthalocyanine (RuPcPA) monolayer films on indium tin oxide (ITO), designed to facilitate charge harvesting at ITO electrodes, is presented in this work...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28790064/atm-deficiency-generating-genomic-instability-sensitizes-pancreatic-ductal-adenocarcinoma-cells-to-therapy-induced-dna-damage
#19
Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, Michaela Ihle, Stephanie Hampp, Dietrich Alexander Ruess, Elisabeth Hessmann, Ronan Russell, André Lechel, Ninel Azoitei, Qiong Lin, Stefan Liebau, Meike Hohwieler, Hanibal Bohnenberger, Marina Lesina, Hana Algül, Laura Gieldon, Evelin Schröck, Jochen Gaedcke, Martin Wagner, Lisa Wiesmüller, Bence Sipos, Thomas Seufferlein, Hans Christian Reinhardt, Pierre-Olivier Frappart, Alexander Kleger
Pancreatic adenocarcinomas (PDAC) harbour recurrent functional mutations of the master DNA damage response kinase ATM which has been shown to accelerate tumorigenesis and epithelial-mesenchymal transition. To study how ATM deficiency affects genome integrity in this setting, we evaluated the molecular and functional effects of conditional Atm deletion in a mouse model of PDAC. ATM deficiency was associated with increased mitotic defects, recurrent genomic rearrangements and deregulated DNA integrity checkpoints, reminiscent of human PDAC...
August 8, 2017: Cancer Research
https://www.readbyqxmd.com/read/28783473/heel-rise-height-deficit-1-year-after-achilles-tendon-rupture-relates-to-changes-in-ankle-biomechanics-6-years-after-injury
#20
Annelie Brorsson, Richard W Willy, Roy Tranberg, Karin Grävare Silbernagel
BACKGROUND: It is unknown whether the height of a heel-rise performed in the single-leg standing heel-rise test 1 year after an Achilles tendon rupture (ATR) correlates with ankle biomechanics during walking, jogging, and jumping in the long-term. PURPOSE: To explore the differences in ankle biomechanics, tendon length, calf muscle recovery, and patient-reported outcomes at a mean of 6 years after ATR between 2 groups that, at 1-year follow-up, had less than 15% versus greater than 30% differences in heel-rise height...
August 1, 2017: American Journal of Sports Medicine
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