keyword
MENU ▼
Read by QxMD icon Read
search

ATR

keyword
https://www.readbyqxmd.com/read/29345572/breaking-the-dna-damage-response-via-serine-threonine-kinase-inhibitors-to-improve-cancer-treatment
#1
Wioletta Rozpedek, Dariusz Pytel, Alicja Nowak-Zdunczyk, Dawid Lewko, Radoslaw Wojtczak, John Alan Diehl, Ireneusz Majsterek
Multiple, both endogenous and exogenous, sources may induce DNA damage and DNA replication stress. Cells have developed DNA damage response (DDR) signaling pathways to maintain genomic stability and effectively detect and repair DNA lesions. Serine/threonine kinases such as Ataxia-telangiectasia mutated (ATM) and Ataxia-telangiectasia and Rad3-Related (ATR) are the major regulators of DDR, since after sensing stalled DNA replication forks, DNA double- or single-strand breaks, may directly phosphorylate and activate their downstream targets, that play a key role in DNA repair, cell cycle arrest and apoptotic cell death...
January 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29345468/photochemistry-of-solid-films-of-the-neonicotinoid-nitenpyram
#2
Kifle Z Aregahegn, Michael J Ezell, Barbara J Finlayson-Pitts
The environmental fates of nitenpyram (NPM), a widely used neonicotinoid insecticide, are not well known. A thin solid film of NPM deposited on a germanium attenuated total reflectance (ATR) crystal was exposed to radiation from a low-pressure mercury lamp at 254 nm, or from broadband low pressure mercury photolysis lamps centered at 350 or 313 nm. The loss during photolysis was followed in time using FTIR. The photolysis quantum yields (), defined as the number of NPM molecules lost per photon absorbed, were determined to be (9...
January 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29345453/poly-glycidol-coating-on-ultrahigh-molecular-weight-polyethylene-for-reduced-biofilm-growth
#3
Jacob N Lockhart, Thomas J Spoonmore, Michael W McCurdy, Bridget R Rogers, Scott A Guelcher, Eva Harth
Semibranched poly(glycidol) (PG-OH) and poly(glycidol allylglycidyl ether) (PG-Allyl) coatings were formed on ultrahigh molecular weight polyethylene (UMWPE) in a unique two-step process which included radiation of UHMWPE followed by grafting of PG-OH or PG-Allyl to the surface via free radical cross-linking. Resulting surfaces were extensively characterized by FTIR-ATR, XPS, fluorescent microscopy, and contact goniometry. The performance was evaluated using the most prominent biofilm-forming bacteria Staphylococcus aureus for 24 and 48 h...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29344638/garcinone-c-exerts-antitumor-activity-by-modulating-the-expression-of-atr-stat3-4e%C3%A2-bp1-in-nasopharyngeal-carcinoma-cells
#4
Yudui Xia, Xia Liu, Chunlin Zou, Shixiu Feng, Hongwei Guo, Yeguo Yang, Yong Lei, Jian Zhang, Yi Lu
Nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies and is typically treated with radiotherapy and chemotherapy. Garcinone C, a natural compound isolated from Garcinia oblongifolia Champ., is a xanthone derivative with potential cytotoxic effects on certain cancers. However, there are limited studies regarding its effects on NPC cells, and its mechanism of action in NPC remains unknown. In the present study, we found that garcinone C significantly inhibited cell viability of the human NPC cell lines CNE1, CNE2, HK1 and HONE1...
January 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29342268/reduced-expression-of-mismatch-repair-genes-msh6-msh2-directly-promotes-pituitary-tumor-growth-via-the-atr-chk1-pathway
#5
Shinsuke Uraki, Hiroyuki Ariyasu, Asako Doi, Shintaro Kawai, Ken Takeshima, Shuhei Morita, Junya Fukai, Koji Fujita, Hiroto Furuta, Masahiro Nishi, Kokichi Sugano, Naoko Inoshita, Naoyuki Nakao, Shozo Yamada, Takashi Akamizu
Context: The mechanisms of pituitary adenoma (PA) pathogenesis and proliferation remain largely unknown. Objectives: To evaluate the direct association between PA proliferation and expression of mismatch repair (MMR) genes and proteins, and to clarify the role of MMR genes in the molecular mechanism of PA proliferation. Experimental Design: We performed quantitative analyses by real-time PCR and immunohistochemistry to detect MMR gene and protein expression in human PAs (n = 47)...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29339233/ftir-as-an-easy-and-fast-analytical-approach-to-follow-up-microbial-growth-during-fungal-pretreatment-of-poplar-wood-with-phanerochaete-chrysosporium
#6
I Cornet, N Wittner, G Tofani, S Tavernier
Since the determination of the fermentation kinetics is one of the main challenges in solid state fermentation, the quantitative measurement of biomass growth during microbial pretreatment by FTIR spectroscopy in Attenuated Total Reflectance mode was evaluated. Peaks at wave numbers of 1651 cm-1 and 1593 cm-1 showed to be affected during pretreatment of poplar wood particles by Phanerochaete chrysosporium MUCL 19343. Samples with different microbial biomass fractions were obtained from two different experiments, i...
January 12, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29338752/structural-alteration-of-dna-induced-by-viral-protein-r-of-hiv-1-triggers-the-dna-damage-response
#7
Kenta Iijima, Junya Kobayashi, Yukihito Ishizaka
BACKGROUND: Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR). It was recently proposed that the SLX4 complex of structure-specific endonuclease is involved in Vpr-induced DDR, which implies that aberrant DNA structures are responsible for this phenomenon. However, the mechanism by which Vpr alters the DNA structures remains unclear...
January 16, 2018: Retrovirology
https://www.readbyqxmd.com/read/29334019/chemical-stabilization-of-polymers-implications-for-dermal-exposure-to-additives
#8
N Bartsch, M Girard, L Schneider, V Van De Weijgert, A Wilde, O Kappenstein, B Vieth, C Hutzler, A Luch
Technical benefits of additives in polymers stand in marked contrast to their associated health risks. Here, a multi-analyte method based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) was developed to quantify polymer additives in complex matrices such as low-density polyethylene (LDPE) and isolated human skin layers after dermal exposure ex vivo. That way both technical aspects and dermal exposure were investigated. The effects of polymer additivation on the material were studied using the example of LDPE...
January 15, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29332697/acid-alteration-of-several-ignitable-liquids-of-potential-use-in-arsons
#9
Carlos Martín-Alberca, Héctor Carrascosa, Itxaso San Román, Luis Bartolomé, Carmen García-Ruiz
Ignitable liquids such as fuels, alcohols and thinners can be used in criminal activities, for instance arsons. Forensic experts require to know their chemical compositions, as well as to understand how different modification effects could impact them, in order to detect, classify and identify them properly in fire debris. The acid alteration/acidification of ignitable liquids is a modification effect that sharply alters the chemical composition, for example, of gasoline and diesel fuel, interfering in the forensic analysis and result interpretation...
January 2018: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29331898/coadsorption-and-subsequent-redox-conversion-behaviors-of-as-iii-and-cr-vi-on-al-containing-ferrihydrite
#10
Zecong Ding, Fenglian Fu, Dionysios D Dionysiou, Bing Tang
Naturally occurring ferrihydrite often contains various impurities, and Al is one of the most prominent impurities. However, little is known about how these impurities impact the physical and chemical properties of ferrihydrite with respect to metal(loid) adsorption. In this study, a series of Al-containing ferrihydrites were synthesized and exposed to a mixed solution containing As(III) and Cr(VI). The results showed that the two contaminants can be quickly adsorbed onto the surface of Al-containing ferrihydrite under acidic and neutral conditions...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331820/using-vibrational-molecular-spectroscopy-to-reveal-association-of-steam-flaking-induced-carbohydrates-molecular-structural-changes-with-grain-fractionation-biodigestion-and-biodegradation
#11
Ningning Xu, Jianxin Liu, Peiqiang Yu
Advanced vibrational molecular spectroscopy has been developed as a rapid and non-destructive tool to reveal intrinsic molecular structure conformation of biological tissues. However, this technique has not been used to systematically study flaking induced structure changes at a molecular level. The objective of this study was to use vibrational molecular spectroscopy to reveal association between steam flaking induced CHO molecular structural changes in relation to grain CHO fractionation, predicted CHO biodegradation and biodigestion in ruminant system...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331424/ultra-narrow-surface-lattice-resonances-in-plasmonic-metamaterial-arrays-for-biosensing-applications
#12
Artem Danilov, Gleb Tselikov, Fan Wu, Vasyl G Kravets, Igor Ozerov, Frederic Bedu, Alexander N Grigorenko, Andrei V Kabashin
When excited over a periodic metamaterial lattice of gold nanoparticles (~ 100nm), localized plasmon resonances (LPR) can be coupled by a diffraction wave propagating along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down to a few nm full-width-at-half-maximum) and the generation of singularities of phase of reflected light. These phenomena look very promising for the improvement of performance of plasmonic biosensors, but conditions of implementation of such diffractively coupled plasmonic resonances, also referred to as plasmonic surface lattice resonances (PSLR), are not always compatible with biosensing arrangement implying the placement of the nanoparticles between a glass substrate and a sample medium (air, water)...
December 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29329745/poly-methyl-methacrylate-salt-as-film-forming-material-to-design-orodispersible-films
#13
Umberto M Musazzi, Francesca Selmin, Silvia Franzé, Chiara G M Gennari, Paolo Rocco, Paola Minghetti, Francesco Cilurzo
This work aims to evaluate the possible use of a poly(sodium methacrylate, methyl methacrylate) (NaPMM2) plasticized by PEG400 in design orodispersible films (ODF). Placebo ODF prepared by solvent casting were intended to study the impact of the polymer/plasticizer ratio and residual moisture on disintegration time, stickiness and mechanical properties. The drug loading capacity was assessed using ketoprofen and paracetamol. Placebo ODF containing PEG400 in the 10-30% w/w range and 10-15% of residual moisture content were easy-to-handle, packed without failures and completely dissolved within 30 s...
January 9, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29325509/terbinafine-hydrochloride-nail-lacquer-for-the-management-of-onychomycosis-formulation-characterization-and-in-vitro-evaluation
#14
Purva Thatai, Bharti Sapra
AIM: The present investigation's intention was to develop an optimized nail lacquer (NL) for the management of onychomycosis. MATERIALS & METHODS: The NL was optimized statistically adopting 32 full factorial design having different polymer ratios and solvent ratios. The formulations were assessed for drug permeation drying time and peak adhesive strength of the film. Characterization was done using techniques including attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD), etc...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29324324/investigation-of-the-factors-that-influence-lead-accumulation-onto-polyethylene-implication-for-potable-water-plumbing-pipes
#15
Maryam Salehi, Chad T Jafvert, John A Howarter, Andrew J Whelton
The influence of polymer aging, water pH, and aqueous Pb concentration on Pb deposition onto low density polyethylene (LDPE) was investigated. LDPE pellets were aged by ozonation at 85 °C. ATR-FTIR and X-ray photoelectron spectroscopy (XPS) analysis of aged LDPE surfaces showed that a variety of polar functional groups (>CO<, >CO, >COO) were formed during aging. These functional groups likely provided better nucleation sites for Pb(OH)2 deposition compared to new LDPE, which did not have these oxygen-containing functional groups...
December 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29321979/improvement-of-aspergillus-flavus-saponin-hydrolase-thermal-stability-and-productivity-via-immobilization-on-a-novel-carrier-based-on-sugarcane-bagasse
#16
Hala A Amin, Francesco Secundo, Hassan Amer, Faten A Mostafa, Wafaa A Helmy
Soyasapogenol B (SB) is known to have many biological activities such as hepatoprotective, anti-inflammatory, anti-mutagenic, antiviral and anticancer activities. Enzymatic conversion of soyasaponins to SB was carried out using saponin hydrolase (SH) extracted from Aspergillus flavus. The partially purified enzyme was immobilized on different carriers by physical adsorption, covalent binding or entrapment. Among the investigated carriers, Eupergit C and sugarcane bagasse (SCB) activated by DIC and NHS were the most suitable two carriers for immobilization (the immobilized forms recovered 46...
March 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29321609/complex-formation-via-hydrogen-bonding-between-rhodamine-b-and-montmorillonite-in-aqueous-solution
#17
Yanfen Fang, Ao Zhou, Wei Yang, Tirusew Araya, Yingping Huang, Ping Zhao, David Johnson, Jianzhu Wang, Zhiyong Jason Ren
This study investigates the adsorption mechanism differences among four nitrogenous dyes, sulforhodamine G (SRG), uncharged/deprotonated rhodamine B (RhB), orange II (Or II) and methyl blue (MB) by montmorillonite (MMT). MMT adsorption capacity for cationic MB was three times that of uncharged RhB and anionic SRG, while anionic Or II was not absorbed. Colloidal MMT particles have two types of surfaces, basal and edge, that interact with nitrogenous dyes very differently. The surface acidity of MMT was characterized with the pyridine adsorption method using in-situ diffuse reflectance infrared Fourier transform spectroscopy (in-situ DRIFTS)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319709/displacement-of-%C3%AE-5-cyclopentadienyl-ligands-from-half-sandwich-c-c-nhc-cyanoalkyl-nickel-ii-metallacycles-further-insight-into-the-structure-of-the-resulting-cp-free-nickelacycles-and-a-catalytic-activity-study
#18
Bernardo de P Cardoso, Jean-Marie Bernard-Schaaf, Saurabh Shahane, Luis F Veiros, Michael J Chetcuti, Vincent Ritleng
Four cationic C,C-(NHC-cyanoalkyl)-nickel(ii) metallacyclic complexes, [Ni{Me-NHC-CH2CH(CN)}(NCMe)](PF6) (2a), [Ni{Mes-NHC-CH2CH(CN)}(NCMe)](PF6) (2b), [Ni{Mes-NHC-(CH2)2CH(CN)}(NCMe)](PF6) (2c) and [Ni{DiPP-NHC-(CH2)2CH(CN)}(NCMe)](PF6) (2d), were prepared by the removal of the Cp ligand under acidic conditions at 0 °C from the corresponding half-sandwich nickelacycles [NiCp{R-NHC-(CH2)nCH(CN)}] (1a-1d; Cp = η5-C5H5; n = 1 or 2; R-NHC-(CH2)nCH(CN) = 1-R-3-[(CH2)nCH(CN)]-imidazol-2-ylidene). Full characterization of 2a-d by 1H and 13C{1H} NMR spectroscopy in CD3CN and pyridine-d5, ATR-FTIR spectroscopy, mass spectrometry, and CHN microanalyses established the presence of only one acetonitrile ligand per nickel atom in the solid state...
January 10, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29318393/infrared-spectroscopy-and-multivariate-methods-as-a-tool-for-identification-and-quantification-of-fuels-and-lubricant-oils-in-soil
#19
Maurílio Gustavo Nespeca, Gabriel Baroffaldi Piassalonga, José Eduardo de Oliveira
Environmental contamination caused by leakage of fuels and lubricant oils at gas stations is of great concern due to the presence of carcinogenic compounds in the composition of gasoline, diesel, and mineral lubricant oils. Chromatographic methods or non-selective infrared methods are usually used to assess soil contamination, which makes environmental monitoring costly or not appropriate. In this perspective, the present work proposes a methodology to identify the type of contaminant (gasoline, diesel, or lubricant oil) and, subsequently, to quantify the contaminant concentration using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and multivariate methods...
January 9, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29316381/rapid-intra-operative-diagnosis-of-kidney-cancer-by-atr-ir-spectroscopy-of-tissue-smears
#20
Milda Pucetaite, Martynas Velicka, Vidita Urboniene, Justinas Ceponkus, Rimante Bandzeviciute, Feliksas Jankevicius, Arunas Zelvys, Valdas Sablinskas, Gerald Steiner
Herein, a technique to analyze air-dried kidney tissue impression smears by means of Attenuated Total Reflection Infrared (ATR-IR) spectroscopy is presented. Spectral tumor markers - absorption bands of glycogen - are identified in the ATR-IR spectra of the kidney tissue smear samples. Thin kidney tissue cryo-sections currently used for IR spectroscopic analysis lack such spectral markers as the sample preparation causes irreversible molecular changes in the tissue. In particular, freeze-thaw cycle results in degradation of the glycogen and reduction or complete dissolution of its content...
January 9, 2018: Journal of Biophotonics
keyword
keyword
71704
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"