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https://www.readbyqxmd.com/read/29456727/risk-factors-and-coping-strategies-of-severe-community-acquired-pneumonia-in-chemotherapy-induction-period-of-acute-leukemia
#1
Ning Li, Qingcheng Duan, Weidan Zhang
The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients in both groups, and the samples were detected for pathogens, followed by the analysis of relevant factors...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29455239/genotyping-of-candidatus-syngnamydia-salmonis-chlamydiales-simkaniaceae-co-cultured-in-paramoeba-perurans-amoebozoa-paramoebidae
#2
Are Nylund, Dario Pistone, Christiane Trösse, Steffen Blindheim, Linda Andersen, Heidrun Plarre
Candidatus Syngnamydia salmonis (Chlamydiales, Simkaniaceae) was described as an epitheliocystis-causing bacterium from the gills of Atlantic salmon (Salmo salar) in Norway. A bacterium showing 99.2% 16S rRNA identity to Cand. S. salmonis is able to multiply in Paramoeba perurans and based on the classification criteria this bacterium could represent the same species as Cand. S. salmonis. Sequencing the genome of the cultured bacterium has made it possible to fulfill the minimal standards for genetic characterization of species within the order Chlamydiales...
February 17, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29454196/sexually-transmitted-infections-and-immune-activation-among-hiv-infected-but-virally-suppressed-youth-on-antiretroviral-therapy
#3
Tanya L Kowalczyk Mullins, Su X Li, James Bethel, Maureen M Goodenow, Stephanie Hudey, John W Sleasman
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation. OBJECTIVES: Because HIV-infected youth are at high risk of STIs and little is known about the impact of STIs on immune activation in HIV-infected youth, we conducted an exploratory study examining the association between STIs and systemic inflammation and immune activation among HIV-infected adolescents...
February 7, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29452143/unusual-self-assembly-of-the-recombinant-chlamydia-trachomatis-major-outer-membrane-protein-momp-based-fusion-antigen-cth522-into-protein-nanoparticles
#4
Fabrice Rose, Kasper Karlsen, Pernille Rønde Jensen, Rasmus Uffe Jakobsen, Grith Krøyer Wood, Kasper Dyrberg Rand, Helene Godiksen, Peter Andersen, Frank Follmann, Camilla Foged
Sexually transmitted Chlamydia trachomatis (Ct) infects more than 100 million people annually, and untreated chlamydia infections can cause severe complications. Therefore, there is an urgent need for a chlamydia vaccine. The Ct major outer membrane protein (MOMP) is highly immunogenic but is a challenging vaccine candidate by being an integral membrane protein, and the immunogenicity depends on a correctly folded structure. We investigated the biophysical properties of the recombinant MOMP-based fusion antigen CTH522, which is tested in early human clinical trials...
February 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29451375/-prevalence-and-phylogenetic-analysis-of-chlamydia-trachomatis-in-a-population-of-women-in-posadas-misiones
#5
G B Jordá, S E Hanke, J M Ramos-Rincón, J Mosmann, M L Lopéz, A C Entrocassi, C Cuffini
OBJECTIVE: Chlamydia trachomatis is the most prevalent bacteria causing sexually transmitted infections. In women, this infection can cause cervicitis and urethritis, although it's usually asymptomatic. The aim of this study was to investigate the prevalence of C. trachomatis in women attending the lab Instituto de Previsión Social and detect the genotypes. METHODS: Endocervical samples from 505 symptomatic and asymptomatic women were assayed. It was determined the presence of C...
February 16, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29450767/epididymo-orchitis-caused-by-enteric-organisms-in-men-35-years-old-beyond-fluoroquinolones
#6
REVIEW
Laura Ryan, Padraig Daly, Ivor Cullen, Maeve Doyle
Epididymo-orchitis is a common urological condition in men of all ages, causing a unilateral or bilateral swelling of the epididymis and/or testis. It is frequently caused by sexually transmitted infections, Chlamydia trachomatis and Neisseria gonorrheae, as well as common enteric organisms implicated in urinary tract infections. Men over 35 years old may develop epididymo-orchitis associated with enteric organisms, often associated with functional bladder outlet problems such as benign prostatic hyperplasia or urethral stricture disease...
February 15, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29447855/rpa-using-a-multiplexed-cartridge-for-low-cost-point-of-care-diagnostics-in-the-field
#7
Luck Tosan Ereku, Ruth E Mackay, Pascal Craw, Angel Naveenathayalan, Thomas Stead, Manorharanehru Branavan, Wamadeva Balachandran
A point of care device utilising Lab-on-a-Chip technologies that is applicable for biological pathogens was designed, fabricated and tested showing sample in to answer out capabilities. The purpose of the design was to develop a cartridge with the capability to perform nucleic acid extraction and purification from a sample using a chitosan membrane at an acidic pH. Waste was stored within the cartridge with the use of sodium polyacrylate to solidify or gelate the sample in a single chamber. Nucleic acid elution was conducted using the RPA amplification reagents (alkaline pH)...
February 12, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29447155/prevalence-of-trachoma-in-school-children-in-the-maraj%C3%A3-archipelago-brazilian-amazon-and-the-impact-of-the-introduction-of-educational-and-preventive-measures-on-the-disease-over-eight-years
#8
Joana Favacho, Antonio José Ledo Alves da Cunha, Samara Tatielle Monteiro Gomes, Felipe Bonfim Freitas, Maria Alice Freitas Queiroz, Antonio Carlos Rosário Vallinoto, Ricardo Ishak, Marluísa de Oliveira Guimarães Ishak
Trachoma is the leading infectious cause of blindness in the world and is associated with precarious living conditions in developing countries. The aim of the present study was to evaluate the prevalence of trachoma in three municipalities of the Marajó Archipelago, located in the state of Pará, Brazil. In 2008, 2,054 schoolchildren from the public primary school system of the urban area of the region and their communicants were clinically examined; in 2016, 1,502 schoolchildren were examined. The positive cases seen during the clinical evaluation were confirmed by direct immunofluorescence (DIF) laboratory tests...
February 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29447087/a-preliminary-survey-of-chlamydia-psittaci-genotypes-from-native-and-introduced-birds-in-new-zealand
#9
K R Gedye, M Fremaux, J C Garcia-Ramirez, B D Gartrell
AIM: To describe the Chlamydia psittaci genotypes in samples from native and introduced birds from New Zealand by analysis of the sequence variation of the ompA gene. METHODS: DNA was extracted from samples collected from a non-random sample of birds; either swabs from live asymptomatic birds or birds with clinical signs, or formalin fixed paraffin embedded (FFPE) samples from historical post-mortem cases. The presence of C. psittaci in all samples had been confirmed using a quantitative PCR assay...
February 15, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29444997/efficacy-of-multicomponent-culturally-tailored-hiv-sti-prevention-interventions-targeting-foreign-female-entertainment-workers-a-quasi-experimental-trial
#10
Raymond B T Lim, Olive N Y Cheung, Bee Choo Tai, Mark I-C Chen, Roy K W Chan, Mee Lian Wong
OBJECTIVES: We assessed the efficacy of a multicomponent culturally tailored HIV/STI prevention intervention programme on consistent condom use and STI incidence among foreign Thai and Vietnamese female entertainment workers (FEWs) in Singapore. METHODS: We conducted a quasi-experimental pretest and post-test intervention trial with a comparison group. We recruited 220 participants (115 Vietnamese and 105 Thai) for the comparison group, followed by the intervention group (same number) from the same sites which were purposively selected after a 3-month interval period...
February 14, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29444088/correction-the-compartmentalized-bacteria-of-the-planctomycetes-verrucomicrobia-chlamydiae-superphylum-have-membrane-coat-like-proteins
#11
Rachel Santarella-Mellwig, Josef Franke, Andreas Jaedicke, Mátyás Gorjánácz, Ulrike Bauer, Aidan Budd, Iain W Mattaj, Damien P Devos
[This corrects the article DOI: 10.1371/journal.pbio.1000281.].
February 2018: PLoS Biology
https://www.readbyqxmd.com/read/29437985/comparing-the-characteristics-of-users-of-an-online-service-for-sti-self-sampling-with-clinic-service-users-a-cross-sectional-analysis
#12
Sharmani Barnard, Caroline Free, Ioannis Bakolis, Katy M E Turner, Katharine J Looker, Paula Baraitser
OBJECTIVES: Online services for self-sampling at home could improve access to STI testing; however, little is known about those using this new modality of care. This study describes the characteristics of users of online services and compares them with users of clinic services. METHODS: We conducted a cross-sectional analysis of routinely collected data on STI testing activity from online and clinic sexual health services in Lambeth and Southwark between 1January 2016 and 31March 2016...
February 7, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29435591/effect-of-including-alcohol-and-cannabis-content-in-a-sexual-risk-reduction-intervention-on-the-incidence-of-sexually-transmitted-infections-in-adolescents-a-cluster-randomized-clinical-trial
#13
Angela D Bryan, Renee E Magnan, Arielle S Gillman, Elizabeth A Yeater, Sarah W Feldstein Ewing, Alberta S Kong, Sarah J Schmiege
Importance: Adolescents in the juvenile justice system are at high risk for sexually transmitted infections (STIs). Concurrent use of alcohol and cannabis increase this risk. Objective: To determine whether a theory-based sexual risk-reduction intervention that included alcohol- and cannabis-focused content resulted in greater reductions in STIs than an intervention that included alcohol-related content only and an intervention that did not include substance use content...
February 12, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29431149/antiretroviral-therapy-suppresses-rectal-hiv-rna-shedding-despite-inflammation-in-msm-with-rectal-c-trachomatis-and-n-gonorrhoeae-infections-a-cross-sectional-single-center-study
#14
Julian Storim, Jens Verheyen, Eva Wolff, Jeremias Wohlschlaeger, Evelyn Heintschel von Heinegg, Dirk Schadendorf, Stefan Esser
OBJECTIVES: Rectal infections with Chlamydia trachomatis and/or Neisseria gonorrhoeae (CT/NG) are common in men who have sex with men (MSM) and are linked to HIV transmission. However, rectal CT/NG infections are often asymptomatic and it is not known how they contribute to HIV transmission. We assessed clinical and cytological signs of inflammation as well as rectal HIV-RNA in HIV-infected MSM with and without CT/NG infection. METHODS: 112 HIV-positive MSM with or without rectal symptoms and with or without antiretroviral therapy who underwent high-resolution anoscopy (HRA) at the proctological outpatient centre of the University Hospital Essen, Germany, between November 2013 and February 2014 were included in this cross-sectional study...
February 3, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29431148/detection-of-chlamydia-trachomatis-in-rectal-specimens-in-women-and-its-association-with-anal-intercourse-a-systematic-review-and-meta-analysis
#15
REVIEW
Nastassya L Chandra, Claire Broad, Kate Folkard, Katy Town, Emma M Harding-Esch, Sarah C Woodhall, John M Saunders, S Tariq Sadiq, J Kevin Dunbar
OBJECTIVES: Chlamydia trachomatis is the most commonly diagnosed bacterial STI. Lack of prevalence and risk factor data for rectal chlamydia in women has testing and treatment implications, as azithromycin (a first-line urogenital chlamydia treatment) may be less effective for rectal chlamydia. We conducted a systematic review of studies on women in high-income countries to estimate rectal chlamydia prevalence, concurrency with urogenital chlamydia and associations with reported anal intercourse (AI)...
February 3, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29431025/highlighting-the-clinical-need-for-diagnosing-mycoplasma-genitalium-infection
#16
Catherine A Ison, Helen Fifer, Simon Gwynn, Paddy Horner, Peter Muir, Jane Nicholls, Keith Radcliffe, Jonathan Ross, David Taylor-Robinson, John White
Despite Mycoplasma genitalium (MG) being increasingly recognised as a genital pathogen in men and women, awareness and utility of commercially available MG-testing has been low. The opinion of UK sexual health clinicians and allied professionals was sought on how MG-testing should be used. Thirty-two consensus statements were developed by an expert group and circulated to clinicians and laboratory staff, who were asked to evaluate their level of agreement with each statement; 75% agreement was set as the threshold for defining consensus for each statement...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29428823/use-of-long-acting-reversible-contraception-among-adolescent-and-young-adult-women-and-receipt-of-sexually-transmitted-infection-human-immunodeficiency-virus-related-services
#17
Riley J Steiner, Karen Pazol, Andrea Swartzendruber, Nicole Liddon, Michael R Kramer, Laura M Gaydos, Jessica M Sales
PURPOSE: Long-acting reversible contraceptive (LARC) methods do not require annual clinic visits for continuation, potentially impacting receipt of recommended sexually transmitted infection (STI)/human immunodeficiency virus (HIV) services for young women. We assess service receipt among new and continuing LARC users versus moderately and less effective method users and non-contraceptors. METHODS: Using 2011-2015 National Survey of Family Growth data from sexually active women aged 15-24 years (n = 2,018), we conducted logistic comparisons of chlamydia, any STI and HIV testing, and sexual risk assessment in the past year by current contraceptive type...
February 8, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29427803/chlamydia-trachomatis-genotypes-a-and-b-from-urogenital-specimens-of-patients-in-spain-an-organotropism-related-gene-and-multilocus-sequence-typing-study
#18
Luis Piñeiro, Jenny Isaksson, Marisol Zapico, Gustavo Cilla, Björn Herrmann
OBJECTIVES: Chlamydia trachomatis ompA genotypes A and B, primarily associated with trachoma, were unexpectedly detected in urogenital samples of patients in Spain, a trachoma-free country. In this study, we aimed to explain this finding using analysis of organotropism-related genes and a multilocus sequence typing (MLST) technique. METHODS: C. trachomatis genotypes A or B were detected in 8/930 (0.9%) infection episodes between 2006 and 2012. In these strains, organotropism related genes (polymorphic membrane protein gene H, tryptophan synthase gene A, CTA0934, and cytotoxin) were studied...
February 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29427233/an-online-risk-index-for-the-cross-sectional-prediction-of-new-hiv-chlamydia-and-gonorrhea-diagnoses-across-u-s-counties-and-across-years
#19
Man-Pui Sally Chan, Sophie Lohmann, Alex Morales, Chengxiang Zhai, Lyle Ungar, David R Holtgrave, Dolores Albarracín
The present study evaluated the potential use of Twitter data for providing risk indices of STIs. We developed online risk indices (ORIs) based on tweets to predict new HIV, gonorrhea, and chlamydia diagnoses, across U.S. counties and across 5 years. We analyzed over one hundred million tweets from 2009 to 2013 using open-vocabulary techniques and estimated the ORIs for a particular year by entering tweets from the same year into multiple semantic models (one for each year). The ORIs were moderately to strongly associated with the actual rates (...
February 9, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29426279/genomic-analyses-of-the-chlamydia-trachomatis-core-genome-show-an-association-between-chromosomal-genome-plasmid-type-and-disease
#20
Bart Versteeg, Sylvia M Bruisten, Yvonne Pannekoek, Keith A Jolley, Martin C J Maiden, Arie van der Ende, Odile B Harrison
BACKGROUND: Chlamydia trachomatis (Ct) plasmid has been shown to encode genes essential for infection. We evaluated the population structure of Ct using whole-genome sequence data (WGS). In particular, the relationship between the Ct genome, plasmid and disease was investigated. RESULTS: WGS data from 157 Ct isolates deposited in the Chlamydiales pubMLST database ( http://pubMLST.org/chlamydiales/ ) were annotated with 902 genes including the core and accessory genome...
February 9, 2018: BMC Genomics
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