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Mirjam Kretzschmar, Janneke C M Heijne
For modelling sexually transmitted infections, duration of partnerships can strongly influence the transmission dynamics of the infection. If partnerships are monogamous, pairs of susceptible individuals are protected from becoming infected, while pairs of infected individuals delay onward transmission of the infection as long as they persist. In addition, for curable infections re-infection from an infected partner may occur. Furthermore, interventions based on contact tracing rely on the possibility of identifying and treating partners of infected individuals...
August 2017: Infectious Disease Modelling
Claudio Foschi, Valeria Gaspari, Paola Sgubbi, Melissa Salvo, Antonietta D'Antuono, Antonella Marangoni
PURPOSE: We assessed the prevalence and predictors of Chlamydia trachomatis, Neisseriagonorrhoeae and Mycoplasmagenitalium rectal infections in a population of 'men having sex with men' (MSM). METHODOLOGY: From January to November 2017, 165 MSM attending a STI outpatients clinic in Bologna (Italy) and reporting unsafe anal intercourses were enrolled. An ano-rectal swab was collected from each patient: chlamydial and gonococcal infections were diagnosed by a commercial NAAT, whereas an in-house quantitative PCR was used for M...
June 21, 2018: Journal of Medical Microbiology
Janneke C M Heijne, Ingrid V F van den Broek, Sylvia M Bruisten, Jan E A van Bergen, Hanneke de Graaf, Birgit H B van Benthem
OBJECTIVES: National prevalence estimates of Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhoea) are important for providing insights in the occurrence and control of these STIs. The aim was to obtain national prevalence estimates for chlamydia and gonorrhoea and to investigate risk factors associated with infection. METHODS: Between November 2016 and January 2017, we performed a national population-based cross-sectional probability sample survey among men and women aged 18-34 years in the Netherlands...
June 20, 2018: Sexually Transmitted Infections
P Horner, G Donders, M Cusini, M Gomberg, J S Jensen, M Unemo
At present, we have no evidence that we are doing more good than harm detecting and subsequently treating Mycoplasma hominis, Ureaplasma parvum and Ureaplasma urealyticum colonisations/infections. Consequently, routine testing and treatment of asymptomatic or symptomatic men and women for M. hominis, U. urealyticum, and U. parvum is not recommended. Asymptomatic carriage of these bacteria is common and the majority of individuals do not develop disease. Although U. urealyticum has been associated with urethritis in men, it is probably not causal unless a high load is present (likely carriage in 40-80% of detected cases)...
June 20, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
A Perutelli, C Tascini, L Domenici, S Garibaldi, C Baroni, E Cecchi, M G Salerno
OBJECTIVE: Tigecycline is a glycylcycline antimicrobial structurally related to minocycline, with a wide spectrum of activity that includes anaerobes and typical and atypical microorganisms causing pelvic inflammatory disease (PID). This study aimed to evaluate efficacy and safety of tigecycline in complicated PID and un-complicated PID after the failure of first-line antibiotic therapy. PATIENTS AND METHODS: Between May 2014 and April 2016 at the 2nd Unit of Obstetrics and Gynecology, Santa Chiara Hospital of Pisa a pilot study on 20 women with mild/moderate PID after the failure of first-line antibiotic therapy and on 8 women with complicated PID was conducted...
June 2018: European Review for Medical and Pharmacological Sciences
David Mesher, Kavita Panwar, Sara L Thomas, Claire Edmundson, Yoon Hong Choi, Simon Beddows, Kate Soldan
Background: The national human papillomavirus (HPV) immunization program was introduced in England in September 2008 using the bivalent vaccine. Methods: We collected residual vulva-vaginal swab specimens from 16 to 24-year-old women attending for chlamydia screening between 2010 and 2016 and tested for HPV DNA. We compared changes in type-specific (vaccine and nonvaccine) HPV prevalence over time and association with vaccination coverage. For women with known vaccination status, vaccine effectiveness was estimated...
June 18, 2018: Journal of Infectious Diseases
Stephen J Jordan, Rakesh K Bakshi, LaDraka' T Brown, Xiaofei Chi, William M Geisler
Chlamydia trachomatis infection (chlamydia) is the most prevalent sexually transmitted bacterial infection and causes significant reproductive morbidity in women. Little is known about how immunity to chlamydia develops in women, though animal models of chlamydia indicate that T-helper type 1 (Th1) responses are important for chlamydia clearance and protective immunity, whereas T-helper type 2 (Th2) responses are associated with persisting infection. In chlamydia-infected women, whether the predominant immune response is Th1- or Th2-polarizing remains controversial...
June 15, 2018: Cytokine
Amjad Ahmadi, Rashid Ramazanzadeh, Koroush Sayehmiri, Fatemeh Sayehmiri, Nour Amirmozafari
BACKGROUND: Premature birth is a primary cause of infant mortality and its etiology varies in different countries. Chlamydia trachomatis (CT) is a common infectious agent transmitted through sexual contact. The purpose of this study is to investigate the connection between CT infections and preterm birth by meta-analysis. METHODS: All articles published in literature databases including Google Scholar, PubMed, ISI (Web of Science), Biological Abs, IranMedex, SID, and Scopus were investigated...
June 18, 2018: BMC Pregnancy and Childbirth
Wayne Paes, Adam Dowle, Jamie Coldwell, Andrew Leech, Tim Ganderton, Andrzej Brzozowski
Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterial pathogen, and the leading cause of infectious blindness worldwide. We have recently shown that immunization with the highly conserved antigenic passenger domain of recombinant Ct polymorphic membrane protein D (rPmpD) is protective in the mouse model of Ct genital tract infection, and previously, that ocular anti-rPmpD antibodies are elicited following vaccination. However, the mechanisms governing the assembly and structure-function relationship of PmpD are unknown...
2018: PloS One
Adiba Hassan, Jill S Blumenthal, Michael P Dube, Eric Ellorin, Katya Corado, David J Moore, Sheldon R Morris
OBJECTIVES: Rectal douching/enema (RD) is a common practice among men who have sex with men (MSM) in preparation for sex. RD can break down the rectal mucosal barrier and potentially affect the rectal microbiome. The objective of this study was to understand if RD is associated with acquiring rectal infections (RI) with rectal gonorrhoea (NG) and/or chlamydia (CT). METHODS: From 2013 to 2015, 395 adult HIV-uninfected MSM were enrolled in a randomised controlled study for pre-exposure prophylaxis (PrEP) adherence with routine sexual risk survey and testing...
June 15, 2018: Sexually Transmitted Infections
Emma M Harding-Esch, Sebastian S Fuller, S-L Christine Chow, Achyuta V Nori, Mark A Harrison, Mathew Parker, Olaf Piepenburg, Matthew S Forrest, David G Brooks, Rajul Patel, Phillip Hay, Nicola Fearnley, Marcus J Pond, J Kevin Dunbar, Philip D Butcher, Timothy Planche, Catherine M Lowndes, S Tariq Sadiq
OBJECTIVES: Rapid and accurate sexually transmitted infection diagnosis can reduce onward transmission and improve treatment efficacy. We evaluated the accuracy of a 15-minute run-time recombinase polymerase amplification (RPA)-based prototype point-of-care test (TwistDx) for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). METHODS: Prospective, multi-centre study of symptomatic and asymptomatic patients attending three English sexual health clinics. Research samples provided were: additional self-collected vulvo-vaginal swab (SCVS) (females); first-catch urine (FCU) aliquot (females and males)...
June 12, 2018: Clinical Microbiology and Infection
Jizhang Zhou, Zhaocai Li, Zhongzi Lou, Yuanyuan Fei
Since the first case of Chlamydia infection in duck had been reported in 1956 and the first case from domestic animal had been reported in 1979 in China, the chlamydia prevalence in China was heavily according to the published data. The Chlamydi a in avian prevalence has been reported at least 11 provinces, Chlamydia in sheep and goats at least 11 provinces, in swine at least 15 provinces, in cows at least 13 provinces and in yaks at least 5 provinces with result of IHA detection. Different diagnostic method such as CFT, ELISA and ABC-ELISA (avidin-biotin-complex ELISA) had been established besides IHA...
2018: Frontiers in Veterinary Science
Christos Parthenis, Periklis Panagopoulos, Niki Margari, Christine Kottaridi, Aris Spathis, Abraham Pouliakis, Stefanos Konstantoudakis, George Chrelias, Charalambos Chrelias, Nikolaos Papantoniou, Ioannis G Panayiotides, Sotirios Tsiodras
OBJECTIVES: To investigate STIs diagnosis with HPV infection and the presence of cytological changes of the cervix in a cohort of sexually active women in Greece. METHODS: Cervical cytology testing, molecular typing of HPV and other STIs was performed in 345 sexually active women aged between 18 and 45 years (33.2±7.2) visiting a gynaecology clinic for routine cervical screening. We investigated the association of HPV and STI detection with cytological findings...
June 11, 2018: International Journal of Infectious Diseases: IJID
Ivan M Petyaev, Naylia A Zigangirova, Valeriy V Tsibezov, Elena Y Morgunova, Natalia E Bondareva, Nigel H Kyle, Yuriy K Bashmakov
Incubation of B10.MLM cells, a cell line of alveolar macrophages, with lycopene, a carotenoid, leads to an increase of lycopene content in their microsomal fraction. That increase was higher and developed faster when the cells were incubated with immune complexes formed by lycopene and mAb 6B9 (L-6B9 mAb), a monoclonal hapten-specific antibody raised against lycopene, as compared with dimethyl sulfoxide (DMSO)-dissolved lycopene (DMSO-L). Moreover, incubation of B10.MLM cells with L-6B9 mAb complexes was accompanied by more efficient accumulation of lipid droplets in the cultured cells and more significant inhibition of mRNA for 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase, a rate-limiting enzyme of cholesterol biosynthesis known to be targeted by lycopene...
June 14, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Bhupesh K Prusty, Suvagata R Chowdhury, Nitish Gulve, Thomas Rudel
Obligate intracellular pathogenic Chlamydia trachomatis express several serine proteases whose roles in chlamydial development and pathogenicity are not completely understood. The chlamydial protease CPAF is expressed during the replicative phase of the chlamydial developmental cycle and is secreted into the lumen of the Chlamydia -containing vacuole called inclusion. How the secreted protease is activated in the inclusion lumen is currently not fully understood. We have identified human serine peptidase inhibitor PI15 as a potential host factor involved in the regulation of CPAF activation...
2018: Frontiers in Cellular and Infection Microbiology
Kanupriya Gupta, LaDraka' Brown, Rakesh K Bakshi, Christen G Press, Xiaofei Chi, Rachel J Gorwitz, John R Papp, William M Geisler
Chlamydia trachomatis (CT) serological assays with improved sensitivity over commercially available assays are needed to evaluate the burden of CT infection and effectiveness of prevention efforts. We evaluated the performance of a CT outer membrane complex protein B (OmcB) ELISA in the detection of anti-CT antibody responses in CT-infected women. OmcB ELISA was less sensitive than our CT elementary body (EB ELISA), but was highly specific. The magnitude of the antibody response was higher in African Americans and those with prior CT infection...
June 13, 2018: Journal of Clinical Microbiology
Christina Korownyk, Roni Y Kraut, Michael R Kolber
No abstract text is available yet for this article.
June 2018: Canadian Family Physician Médecin de Famille Canadien
Hongyan Xin, Wenlian Liu, Ping Li
The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while 55 subjects of normal intrauterine pregnancy were enrolled as the intrauterine pregnancy group. Transvaginal ultrasonography and quantitative detection of serum β-HCG and CT-IgG were performed for all patients, and the clinical examination results were analyzed and compared...
July 2018: Experimental and Therapeutic Medicine
Sai Qiao, Ningbo Zheng, Lida Sun, Gaoju Pang, Shuhe Wang, Ping Jia, Jude Ezeh Uzonna, Hong Bai, Xi Yang
PI3Ks display integrant significance in T cell development and differentiation, which is related to host defense against infections. Here, we investigated the role of p110δ isoform of PI3Ks in host defense against chlamydial lung infection in a mouse model. Our data showed that lung infection with Chlamydia muridarum (Cm) activated PI3K/AKT signaling pathway. Compared to WT mice, p110δD910A mice, mice with an inactivating knock-in mutation in the p110δ Isoform of PI3Ks, showed more sever disease phenotype and slower recovery, which was associated with reduced chlamydia specific Th1 and Th17 immune responses following infection...
June 11, 2018: Pathogens and Disease
Michael Daugherty, Kendall Glynn, Timothy Byler
Background: Trichomoniasis results from infection of the protozoan to the mucous membrane of the urethra or vagina. It has been estimated to have a higher incidence rate than both Gonorrhea and Chlamydia combined. Although females can experience both clinical symptoms and obstetrical complications, male infections are largely asymptomatic and often unreported. We aim to estimate the prevalence of trichomoniasis in US males utilizing the NHANES database. Methods: The NHANES database was queried for all men 18-59 years old during the years 2013-2016...
June 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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