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https://www.readbyqxmd.com/read/28214223/evaluation-of-a-field-test-for-antibodies-against-chlamydia-trachomatis-during-trachoma-surveillance-in-nepal
#1
Michelle J Sun, Andrea I Zambrano, Laura Dize, Beatriz Munoz, Sarah Gwyn, Sailesh Mishra, Diana L Martin, Shekhar Sharma, Sheila K West
PURPOSE: Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from 1509 children and tested onsite for anti-Pgp3 antibodies by LFA. The LFA was read at 30min as negative, positive, or invalid. Tests results were also rated as difficult to read ("equivocal")...
January 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28208724/assessing-the-knowledge-level-attitudes-risky-behaviors-and-preventive-practices-on-sexually-transmitted-diseases-among-university-students-as-future-healthcare-providers-in-the-central-zone-of-malaysia-a-cross-sectional-study
#2
Adigun Temiloluwa Folasayo, Afolayan John Oluwasegun, Suhailah Samsudin, Siti Nor Sakinah Saudi, Malina Osman, Rukman Awang Hamat
This study was done to assess the knowledge, attitudes, risky behaviors and preventive practices related to sexually-transmitted diseases (STDs) among health and non-health sciences university students as future healthcare providers in Malaysia. A total of 700 health and non-health sciences university students (255 male; 445 female) aged between 17 and 30 years were surveyed by using a self-administered questionnaire. The majority (86.6%) had heard of STDs, and 50.4% knew STDs could present without symptoms...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28205505/establishment-of-a-voluntary-electronic-chlamydia-trachomatis-laboratory-surveillance-system-in-germany-2008-to-2014
#3
Sandra Dudareva-Vizule, Karin Haar, Andrea Sailer, Klaus Jansen, Osamah Hamouda, Hilmar Wisplinghoff, Carsten Tiemann, Eberhard Pape, Viviane Bremer
Chlamydia trachomatis (CT) infections are not reportable in Germany and limited data on prevalence are available. CT screening has been offered free of charge to pregnant women since 1995 and to all women under 25 years since 2008. For symptomatic women and men, diagnostic testing is covered by statutory health insurance. We describe the establishment of a nationwide, laboratory-based, voluntary sentinel that electronically collects information on all performed CT tests with test results, test reason and patient information...
February 9, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28205377/culture-independent-genomics-of-a-novel-chlamydial-pathogen-of-fish-provides-new-insight-into-host-specific-adaptations-utilised-by-these-intracellular-bacteria
#4
Alyce Taylor-Brown, Trestan Pillonel, Andrew Bridle, Weihong Qi, Nathan Bachmann, Terrence L Miller, Gilbert Greub, Barbara Nowak, Helena M B Seth-Smith, Lloyd Vaughan, Adam Polkinghorne
Several Chlamydiales families are associated with epitheliocystis, a common condition of the fish gill epithelium. These families share common ancestors with the Chlamydiaceae and environmental Chlamydiae. Due to the lack of culture systems, little is known about the biology of these chlamydial fish pathogens. We investigated epitheliocystis in cultured Orange-spotted grouper (Epinephelus coioides) from North Queensland, Australia. Basophilic inclusions were present in the gills of 22/31 fish and the presence of the chlamydial pathogen in the cysts was confirmed by in situ hybridisation...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28204474/recombinant-protein-cpsit_0846-induces-protective-immunity-against-chlamydia-psittaci-infection-in-balb-c-mice
#5
O Ran, M X Liang, J Yu, M J Yu, Y Song, Y M Wu
No abstract text is available yet for this article.
February 15, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28201979/wide-variation-in-sexually-transmitted-infection-testing-and-counselling-at-aboriginal-primary-health-care-centres-in-australia-analysis-of-longitudinal-continuous-quality-improvement-data
#6
Barbara Nattabi, Veronica Matthews, Jodie Bailie, Alice Rumbold, David Scrimgeour, Gill Schierhout, James Ward, Rebecca Guy, John Kaldor, Sandra C Thompson, Ross Bailie
BACKGROUND: Chlamydia, gonorrhoea and syphilis are readily treatable sexually transmitted infections (STIs) which continue to occur at high rates in Australia, particularly among Aboriginal Australians. This study aimed to: explore the extent of variation in delivery of recommended STI screening investigations and counselling within Aboriginal primary health care (PHC) centres; identify the factors associated with variation in screening practices; and determine if provision of STI testing and counselling increased with participation in continuous quality improvement (CQI)...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28201947/including-medical-students-in-research-characteristics-of-participants-and-non-participants-in-the-test-n-treat-feasibility-trial-of-rapid-chlamydia-gonorrhoea-tests
#7
Alastair Green, Elizabeth Pillai, Catherine Smith, Elesha Vooght, Sarah Kerry-Barnard, Charlotte Fleming, Pippa Oakeshott
No abstract text is available yet for this article.
February 15, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28201690/sensing-the-enemy-containing-the-threat-cell-autonomous-immunity-to-chlamydia-trachomatis
#8
Ryan Finethy, Jörn Coers
No abstract text is available yet for this article.
November 1, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28199392/comparison-of-the-population-excess-fraction-of-chlamydia-trachomatis-infection-on-pelvic-inflammatory-disease-at-12-months-in-the-presence-and-absence-of-chlamydia-testing-and-treatment-systematic-review-and-retrospective-cohort-analysis
#9
Bethan Davies, Katy M E Turner, Stella Leung, B Nancy Yu, Maria Frølund, Thomas Benfield, James Blanchard, Henrik Westh, Helen Ward
BACKGROUND: The impact of Chlamydia trachomatis (chlamydia) control on the incidence of pelvic inflammatory disease (PID) is theoretically limited by the proportion of PID caused by chlamydia. We estimate the population excess fraction (PEF) of treated chlamydia infection on PID at 12-months in settings with widespread chlamydia control (testing and treatment) and compare this to the estimated PEF of untreated chlamydia. METHODS: We used two large retrospective population-based cohorts of women of reproductive age from settings with widespread chlamydia control to calculate the PEF of treated chlamydia on PID at 12-months...
2017: PloS One
https://www.readbyqxmd.com/read/28198339/sexual-health-of-women-aged-40-and-over-attending-an-inner-city-integrated-sexual-health-clinic
#10
Patrice Grech, Rebecca Marchant, Mannampallil Samuel
Sexual health policy remains focussed on younger adults. However, rates of sexually transmitted infections (STIs) in older people continue to increase. We explored the sexual healthcare needs of women aged 40 and over attending an integrated sexual health clinic in South London. We conducted a retrospective case note review and found that almost 20% of these women had STIs. These included genital herpes, trichomoniasis, genital warts, chlamydia and gonorrhoea. Less than a quarter of women reported use of condoms during most recent sexual contact, indicating sexual risk-taking behaviour...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28196971/multilocus-sequence-typing-identifies-an-avian-like-chlamydia-psittaci-strain-involved-in-equine-placentitis-and-associated-with-subsequent-human-psittacosis
#11
Martina Jelocnik, James Branley, Jane Heller, Shane Raidal, Susan Alderson, Francesca Galea, Melinda Gabor, Adam Polkinghorne
No abstract text is available yet for this article.
February 15, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28194020/cd103-lung-dendritic-cells-ldcs-induce-stronger-th1-th17-immunity-to-a-bacterial-lung-infection-than-cd11b-hi-ldcs
#12
Sudhanshu Shekhar, Ying Peng, Shuhe Wang, Xi Yang
Recent studies suggest differential roles for CD103+ and CD11b(hi) lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We found that CD103+ LDCs showed higher expression of costimulatory molecules (CD40, CD80 and CD86) and increased production of cytokines (IL-12p70, IL-10, IL-23 and IL-6) compared with CD11b(hi) LDCs, but the expression of programmed death-ligand 1 (PD-L1) was similar between the two subsets...
February 13, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28188030/unveiling-of-hiv-dynamics-among-transgender-women-a-respondent-driven-sampling-study-in-rio-de-janeiro-brazil
#13
Beatriz Grinsztejn, Emilia M Jalil, Laylla Monteiro, Luciane Velasque, Ronaldo I Moreira, Ana Cristina F Garcia, Cristiane V Castro, Alícia Krüger, Paula M Luz, Albert Y Liu, Willi McFarland, Susan Buchbinder, Valdilea G Veloso, Erin C Wilson
BACKGROUND: The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections. METHODS: We recruited transwomen from Rio de Janeiro, Brazil, by respondent-driven sampling. Eligibility criteria were self-identification as transwomen, being 18 years of age or older, living in Rio de Janeiro or its metropolitan area, and having a valid peer recruitment coupon...
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28184217/chlamydial-lipoproteins-stimulate-toll-like-receptors-1-2-mediated-inflammatory-responses-through-myd88-dependent-pathway
#14
Yong Wang, Qiong Liu, Ding Chen, Jie Guan, Linghui Ma, Guangming Zhong, Hengping Shu, Xiang Wu
Chlamydiae are very important pathogens which could cause several types of diseases in human, but little is known about its pathogenic mechanism. In order to elucidate host inflammatory response and the signal pathway induced by Chlamydial lipoproteins, the predicted lipoproteins of Chlamydia trachomatis were tested for their ability to induce the release of proinflammatory cytokines by mouse macrophages or human TLR (Toll-Like Receptor) expressing cell lines. The results showed that recombinant proteins of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28183393/filling-in-the-gaps-estimating-numbers-of-chlamydia-tests-and-diagnoses-by-age-group-and-sex-before-and-during-the-implementation-of-the-english-national-screening-programme-2000-to-2012
#15
Nastassya L Chandra, Kate Soldan, Ciara Dangerfield, Bersabeh Sile, Stephen Duffell, Alireza Talebi, Yoon H Choi, Gwenda Hughes, Sarah C Woodhall
To inform mathematical modelling of the impact of chlamydia screening in England since 2000, a complete picture of chlamydia testing is needed. Monitoring and surveillance systems evolved between 2000 and 2012. Since 2012, data on publicly funded chlamydia tests and diagnoses have been collected nationally. However, gaps exist for earlier years. We collated available data on chlamydia testing and diagnosis rates among 15-44-year-olds by sex and age group for 2000-2012. Where data were unavailable, we applied data- and evidence-based assumptions to construct plausible minimum and maximum estimates and set bounds on uncertainty...
February 2, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28182670/killing-of-diverse-eye-pathogens-acanthamoeba-spp-fusarium-solani-and-chlamydia-trachomatis-with-alcohols
#16
Yousuf Aqeel, Raquel Rodriguez, Aparajita Chatterjee, Robin R Ingalls, John Samuelson
BACKGROUND: Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing with soap and water or alcohol-based hand sanitizers (when water is not available) might reduce their transmission. Recently we showed that ethanol and isopropanol in concentrations present in hand sanitizers kill walled cysts of Giardia and Entamoeba, causes of diarrhea and dysentery, respectively...
February 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28182619/contribution-of-common-infections-to-cardiovascular-risk-in-hiv-positive-individuals
#17
Victoria Berquist, Jennifer F Hoy, Janine M Trevillyan
HIV-positive individuals are at increased risk for cardiovascular disease due to complex interactions between the increased incidence of traditional cardiovascular risk factors and HIV and antiretroviral-associated inflammation and dyslipidemia. Increasing evidence suggests that a number of important co-pathogens, including cytomegalovirus, hepatitis C virus, and periodontal disease, are likely to also be contributing. Mechanisms such as molecular mimicry and modification of lipids play a role; however, induction of systemic inflammation is the likely key pathogenic link by which this occurs...
February 9, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28182592/transmission-behaviors-and-prevalence-of-chlamydia-and-gonorrhea-among-adult-film-performers
#18
Marjan Javanbakht, M Claire Dillavou, Robert W Rigg, Peter R Kerndt, Pamina M Gorbach
BACKGROUND: Adult film work involves multiple sex partners, unprotected intercourse and frequent oral/rectal contact. Data on sexual networks and sexual behaviors of adult film performers (AFP) are limited. METHODS: From August 2012 to May 2013, AFPs in Los Angeles, CA, seeking care at 2 clinics that provide sexually transmitted infections (STIs) testing to performers were offered urogenital, pharyngeal, and rectal chlamydia/gonorrhea testing. Participants were 18 years or older and performed in at least 1 adult film scene within the past year...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28182591/comparison-of-cobas-4800-m2000-viper-xtr-and-infinity-80-automated-instruments-when-processing-urine-specimens-for-the-diagnosis-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae
#19
Max A Chernesky, Dan Jang, Jodi Gilchrist, Marek Smieja, Manuel Arias, Todd Hatchette, Andre Poirier, Donna Mayne, Sam Ratnam
OBJECTIVES: North American and European advisory groups recommend testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) with nucleic acid amplification tests. Testing is often performed on automated instruments. The objectives of this study were to process urines for the diagnosis of CT and NG and to examine workflow procedures and outcomes. METHODS: While processing 1, 24, 48, 96, and 192 urine specimens on 3 batch-mode systems which use 96-well plates: cobas 4800, m2000, and Viper XTR and the random access cartridge testing GeneXpert Infinity 80, we measured assay performance, hands-on time for processing and maintenance, reagents and plastics consumption, time required to obtain results, and testing accuracy...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#20
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
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