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corticotrophin releasing factor

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https://www.readbyqxmd.com/read/28970041/crassifoside-h-improve-the-depressive-like-behavior-of-rats-under-chronic-unpredictable-mild-stress-possible-involved-mechanisms
#1
Yue Zhang, Jin-Fang Ge, Fei-Fei Wang, Feng Liu, Chao Shi, Ning Li
Crassifoside (CH) is a novel chlorine-containing compound isolated from rhizomes of Curculigo glabrescens. This study aimed to explore the antidepressant-like effect of CH and involved mechanisms. A rat depression model was established using chronic unpredictable mild stress (CUMS) paradigm. Behavioral tests including sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effect of CH. The levels of plasma corticosterone (CORT) and corticotrophin-releasing factor (CRF) in hypothalamus were measured to determine the activity of hypothalamic pituitary-adrenal (HPA) axis...
September 29, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28958685/saikosaponin-a-attenuates-perimenopausal-depression-like-symptoms-by-chronic-unpredictable-mild-stress
#2
Xue-Qin Chen, Shu-Jiao Chen, Wen-Na Liang, Miao Wang, Cheng-Fu Li, Shuang-Shuang Wang, Shu-Qi Dong, Li-Tao Yi, Can-Dong Li
Accumulating studies have shown that a traditional Chinese decoction Chaihu-Shugan-San produced the antidepressant-like effects in rodents including in perimenopausal. Previous studies and our preliminary study indicated that saikosaponin A, one of the main constituents of Chaihu-Shugan-San, enhanced brain-derived neurotrophic factor (BDNF) expression in rats. Herein, this study aimed to evaluate the antidepressant-like effects of saikosaponin A in perimenopausal rats exposed to chronic unpredictable mild stress (CUMS)...
September 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28935440/effects-of-acute-restraint-and-unpredictable-chronic-mild-stress-on-brain-corticotrophin-releasing-factor-mrna-in-the-elevated-t-maze
#3
José S de Andrade, Isabel C Céspedes, Renata O Abrão, Joelcimar M da Silva, Ricardo Ceneviva, Daniel Araki Ribeiro, Jackson C Bittencourt, Milena B Viana
Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation of ETM avoidance and escape reactions, in unstressed rats and in animals exposed to acute restraint or to UCMS, by quantifying CRF mRNA concentrations in stress/anxiety-related brain regions, through semiquantitative in situ hybridization...
September 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28932185/hyperactivity-of-hypothalamic-pituitary-adrenal-axis-due-to-dysfunction-of-the-hypothalamic-glucocorticoid-receptor-in-sigma-1-receptor-knockout-mice
#4
Tingting Di, Suyun Zhang, Juan Hong, Tingting Zhang, Ling Chen
Sigma-1 receptor knockout (σ1R-KO) mice exhibit a depressive-like phenotype. Because σ1R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN), this study investigated the influence of σ1R deficiency on the regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Here, we show that the levels of basal serum corticosterone (CORT), adrenocorticotropic hormone (ACTH) and corticotrophin releasing factor (CRF) as well as the level of CRF mRNA in PVN did not significantly differ between adult male σ1R-KO mice and wild-type (WT) mice...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28845039/preoperative-and-postoperative-pituitary-function-in-patients-with-tuberculum-sellae-meningioma-based-on-pituitary-provocation-tests
#5
Shingo Fujio, Hirofumi Hirano, Mami Yamashita, Satoshi Usui, Yasuyuki Kinoshita, Atsushi Tominaga, Tomoko Hanada, Hitoshi Yamahata, Hiroshi Tokimura, Ryosuke Hanaya, Kaoru Kurisu, Kazunori Arita
Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 patients) or transsphenoidal surgery (two patients); surgeries were performed carefully to avoid injuring the pituitary stalk...
October 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28782547/early-life-stress-increases-testosterone-and-corticosterone-and-alters-stress-physiology-in-zebra-finches
#6
J Bayley Zito, Angy Hanna, Nora Kadoo, Michelle L Tomaszycki
Early life stress has enduring effects on behavior and physiology. However, the effects on hormones and stress physiology remain poorly understood. In the present study, parents of zebra finches of both sexes were exposed to an increased foraging paradigm from 3 to 33days post hatching. Plasma and brains were collected from chicks at 3 developmental time points: post hatching days 25, 60 and adulthood. Plasma was assayed for testosterone (T), estradiol (E2), and corticosterone (CORT). The paraventricular nucleus of the hypothalamus was assessed for corticotrophin releasing factor (CRH) and glucocorticoid receptor (GR) expression...
August 15, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28728455/asparagine-preserves-intestinal-barrier-function-from-lps-induced-injury-and-regulates-crf-crfr-signaling-pathway
#7
Huiling Zhu, Dingan Pi, Weibo Leng, Xiuying Wang, Chien-An Andy Hu, Yongqing Hou, Jianglin Xiong, Chunwei Wang, Qin Qin, Yulan Liu
Stress causes intestinal inflammation and barrier dysfunction. Corticotrophin-releasing factor (CRF)/CRF receptor (CRFR) signaling pathway has been shown to be important for stress-induced intestinal mucosal alteration. L-Asparagine (ASN) is a powerful stimulator of ornithine decarboxylase and cell proliferation in a variety of cell types, including colonic cells. In the present study, we investigated whether dietary ASN supplementation could alleviate the damage of intestinal barrier function caused by LPS through modulation of CRF/CRFR signaling pathway...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28726252/central-amygdala-relaxin-3-relaxin-family-peptide-receptor-3-signalling-modulates-alcohol-seeking-in-rats
#8
Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
BACKGROUND AND PURPOSE: Alcohol use disorders are a leading cause of preventable deaths worldwide, and stress is a major trigger of relapse. The neuropeptide relaxin-3 and its cognate receptor, relaxin family peptide receptor 3 (RXFP3), modulate stress-induced relapse to alcohol seeking in rats, and while the bed nucleus of the stria terminalis has been implicated in this regard, the central nucleus of the amygdala (CeA) also receives a relaxin-3 innervation and CeA neurons densely express RXFP3 mRNA...
October 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28698920/prevention-and-reversal-of-social-stress-escalated-cocaine-self-administration-in-mice-by-intra-vta-crfr1-antagonism
#9
Xiao Han, Joseph F DeBold, Klaus A Miczek
BACKGROUND: A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How repeated stress modulates CRF release in the ventral tegmental area (VTA) and the roles of CRF receptors during different phases of stress-induced cocaine self-administration remain to be defined...
July 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28665499/restoration-of-pharyngeal-dilator-muscle-force-in-dystrophin-deficient-mdx-mice-following-co-treatment-with-neutralizing-interleukin-6-receptor-antibodies-and-urocortin-2
#10
David P Burns, Jane Rowland, Leonie Canavan, Kevin H Murphy, Molly Brannock, Dervla O'Malley, Ken D O'Halloran, Deirdre Edge
What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our aim was to assess the effect of blocking interleukin-6 receptor signalling and stimulating corticotrophin-releasing factor receptor 2 signalling on mdx sternohyoid muscle structure and function. What is the main finding and its importance? The interventional treatment had a positive inotropic effect on sternohyoid muscle force, restoring mechanical work and power to wild-type values, reduced myofibre central nucleation and preserved the myosin heavy chain type IIb fibre complement of mdx sternohyoid muscle...
June 30, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28663121/the-effects-of-enhancing-endocannabinoid-signaling-and-blocking-corticotrophin-releasing-factor-receptor-in-the-amygdala-and-hippocampus-on-the-consolidation-of-a-stressful-event
#11
Nurit Aisenberg, Lidia Serova, Esther L Sabban, Irit Akirav
Current clinical and pre-clinical data suggest that both cannabinoid agents and blockage of CRF through corticotrophin releasing factor receptor type 1 (CRFr1) may offer therapeutic benefits for post-traumatic stress disorder (PTSD). Here we aim to determine whether they are more effective when combined when microinjected into the basolateral amygdala (BLA) or CA1 area of the hippocampus after exposure to a stressful event in the shock/reminders rat model for PTSD. Injection of the fatty acid amide hydrolase (FAAH) inhibitor URB597 after the shock into either the BLA or CA1 facilitated extinction, and attenuated startle response and anxiety-like behavior...
June 26, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28652134/effects-of-thermal-stress-on-the-expression-of-glucocorticoid-receptor-complex-linked-genes-in-senegalese-sole-solea-senegalensis-acute-and-adaptive-stress-responses
#12
Vanessa Benítez-Dorta, María J Caballero, Mónica B Betancor, Manuel Manchado, Lluis Tort, Silvia Torrecillas, María J Zamorano, Marisol Izquierdo, Daniel Montero
The present study examined the short and mid-term effects of a rise in temperature from 18°C to 24°C on the expression of genes related to the stress response regulation in juveniles of Senegalese sole, Solea senegalensis. The animals were exposed to a temperature increase of 6°C, after 1month of acclimation at 18°C. After this process, samples of different tissues were collected from a total of 96 fish at four sampling points: 1h, 24h, 3days and 1week. The transcript levels of a set of genes involved in the stress response such as glucocorticoid receptors 1 and 2, corticotrophin-releasing factor, corticotrophin-releasing factor binding proteins, proopiomelanocortin A and B, and cellular stress defense (heat shock protein 70, 90AA and 90AB) were quantified at these sampling points...
October 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28618089/crh-promotes-human-colon-cancer-cell-proliferation-via-il-6-jak2-stat3-signaling-pathway-and-vegf-induced-tumor-angiogenesis
#13
Xianjun Fang, Yali Hong, Li Dai, Yuanyuan Qian, Chao Zhu, Biao Wu, Shengnan Li
Corticotrophin-releasing hormone (CRH) has been demonstrated to participate in various diseases. Our previous study showed that its receptor CRHR1 mediated the development of colitis-associated cancer in mouse model. However, the detailed mechanisms remain unclear. In this study, we explored the oncogenetic role of CRH/CRHR1 signaling in colon cancer cells. Cell proliferation and colony formation assays revealed that CRH contributed to cell proliferation. Moreover, tube formation assay showed that CRH-treated colon cancer cell supernatant significantly promoted tube formation of human umbilical vein endothelial cells (HUVECs)...
June 15, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28591825/corticotrophin-releasing-hormone-and-corticosterone-impair-development-of-preimplantation-embryos-by-inducing-oviductal-cell-apoptosis-via-activating-the-fas-system-an-in-vitro-study
#14
Xiu-Wen Tan, Chang-Li Ji, Liang-Liang Zheng, Jie Zhang, Hong-Jie Yuan, Shuai Gong, Jiang Zhu, Jing-He Tan
STUDY QUESTION: What are the mechanisms by which corticotrophin-releasing hormone (CRH) and corticosterone impair the development of preimplantation embryos in the oviduct. SUMMARY ANSWER: CRH and corticosterone do not affect preimplantation embryos directly, but impair their development indirectly by triggering apoptosis of oviductal epithelial cells (OECs) through activation of the Fas system. WHAT IS KNOWN ALREADY: Studies report that stress impairs embryo development with facilitated secretion of CRH and glucocorticoids...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28508690/gene-polymorphisms-associated-with-temperament
#15
Xiaoyan Qiu, Graeme B Martin, Dominique Blache
When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of temperament, as well as personality, psychological disorders and behavioral traits, are influenced by genetic factors, and much of the variation appears to involve variation in genes or gene polymorphisms in the hypothalamic-pituitary-adrenocortical (HPA) axis and the behavior-controlling neurotransmitter networks...
May 16, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28435125/the-blockage-of-ventromedial-hypothalamus-crf-type-2-receptors-impairs-escape-responses-in-the-elevated-t-maze
#16
Mariana S C F Silva, Thaissa M O Souza, Bruno A Pereira, Daniel A Ribeiro, Isabel C Céspedes, Jackson C Bittencourt, Milena B Viana
In a previous study, the administration of corticotrophin-releasing factor (CRF) into the dorsomedial hypothalamus (DMH), a region that modulates defensive reactions, was shown to facilitate elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. Intra-DMH administration of the CRF type 1 receptor (CRFR1) antagonist antalarmin induced anxiolytic-like effects and counteracted the anxiogenic effects of CRF. The present study further investigates the role played by CRF receptors of the medial hypothalamus in anxiety...
June 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28432022/a-crosstalk-between-muscarinic-and-crf2-receptors-regulates-cellular-adhesion-properties-of-human-colon-cancer-cells
#17
M Pelissier-Rota, N T Chartier, B Bonaz, M R Jacquier-Sarlin
Patients with inflammatory bowel disease often suffer from chronic and relapsing intestinal inflammation that favor the development of colitis associated cancer. An alteration of the epithelial intestinal barrier function observed in IBD is supposed to be a consequence of stress. It has been proposed that corticotrophin-releasing factor receptor (CRF2), one of the two receptors of CRF, the principal neuromediator of stress, acts on cholinergic nerves to induce stress-mediated epithelial barrier dysfunction...
July 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28334933/disrupted-in-schizophrenia-1-is-essential-for-normal-hypothalamic-pituitary-interrenal-hpi-axis-function
#18
Helen Eachus, Charlotte Bright, Vincent T Cunliffe, Marysia Placzek, Jonathan D Wood, Penelope J Watt
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental illness, display abnormal behaviours in response to stress, but the mechanisms through which DISC1 affects stress responses remain poorly understood. Using two lines of zebrafish homozygous mutant for disc1, we investigated behaviour and functioning of the hypothalamic-pituitary-interrenal (HPI) axis, the fish equivalent of the hypothalamic-pituitary-adrenal (HPA) axis...
June 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28327597/molecular-signaling-underlying-bulleyaconitine-a-baa-induced-microglial-expression-of-prodynorphin
#19
Teng-Fei Li, Hai-Yun Wu, Yi-Rui Wang, Xin-Yan Li, Yong-Xiang Wang
Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms. The data showed that (1) BAA treatment induced phosphorylation of CREB (rather than NF-κB) and prodynorphin expression in cultured primary microglia, and antiallodynia in neuropathy, which were totally inhibited by the CREB inhibitor KG-501; (2) BAA upregulated phosphorylation of p38 (but not ERK or JNK), and the p38 inhibitor SB203580 (but not ERK or JNK inhibitor) and p38β gene silencer siRNA/p38β (but not siRNA/p38α) completely blocked BAA-induced p38 phosphorylation and/or prodynorphin expression, and antiallodynia; (3) BAA stimulated cAMP production and PKA phosphorylation, and the adenylate cyclase inhibitor DDA and PKA inhibitor H-89 entirely antagonized BAA-induced prodynorphin expression and antiallodynia; (4) The Gs-protein inhibitor NF449 completely inhibited BAA-increased cAMP level, prodynorphin expression and antiallodynia, whereas the antagonists of noradrenergic, corticotrophin-releasing factor, A1 adenosine, formyl peptide, D1/D2 dopamine, and glucagon like-peptide-1 receptors failed to block BAA-induced antiallodynia...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295336/neurochemistry-of-neurons-in-the-ventrolateral-medulla-activated-by-hypotension-are-the-same-neurons-activated-by-glucoprivation
#20
Lindsay M Parker, Sheng Le, Travis A Wearne, Kate Hardwick, Natasha N Kumar, Katherine J Robinson, Simon McMullan, Ann K Goodchild
Previous studies have demonstrated that a range of stimuli activate neurons, including catecholaminergic neurons, in the ventrolateral medulla. Not all catecholaminergic neurons are activated and other neurochemical content is largely unknown hence whether stimulus specific populations exist is unclear. Here we determine the neurochemistry (using in situ hybridization) of catecholaminergic and noncatecholaminergic neurons which express c-Fos immunoreactivity throughout the rostrocaudal extent of the ventrolateral medulla, in Sprague Dawley rats treated with hydralazine or saline...
June 15, 2017: Journal of Comparative Neurology
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