keyword
https://read.qxmd.com/read/38536584/complications-of-outpatient-chest-tube-management-for-prolonged-air-leaks-after-pulmonary-surgery
#1
JOURNAL ARTICLE
Ryan J Randle, Prasha Bhandari, Hao He, Mark F Berry, Leah M Backhus, Natalie S Lui, Douglas Z Liou, Joseph B Shrager
PURPOSE: Air leaks are common after pulmonary surgery. Prolonged air leaks (PALs) may persist through discharge and often are managed with one-way valve devices (OWD). We sought to determine the course and complications of patients discharged with OWDs, risk factors for complications, and to evaluate the utility of clamp trials before chest tube (CT) removal. METHODS: Single-institution, retrospective review of patients discharged with a OWD after pulmonary surgery between 2008 and 2022...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38534359/insights-into-disease-progression-of-translational-preclinical-rat-model-of-interstitial-pulmonary-fibrosis-through-endpoint-analysis
#2
JOURNAL ARTICLE
Anil H Kadam, Jan E Schnitzer
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the relentless deposition of extracellular matrix (ECM), causing lung distortions and dysfunction. Animal models of human IPF can provide great insight into the mechanistic pathways underlying disease progression and a means for evaluating novel therapeutic approaches. In this study, we describe the effect of bleomycin concentration on disease progression in the classical rat bleomycin model. In a dose-response study (1...
March 15, 2024: Cells
https://read.qxmd.com/read/38533127/decoding-the-historical-tale-covid-19-impact-on-haematological-malignancy-patients-epicovideha-insights-from-2020-to-2022
#3
JOURNAL ARTICLE
Jon Salmanton-García, Francesco Marchesi, Francesca Farina, Barbora Weinbergerová, Federico Itri, Julio Dávila-Valls, Sonia Martín-Pérez, Andreas Glenthøj, Ditte Stampe Hersby, Maria Gomes da Silva, Raquel Nunes Rodrigues, Alberto López-García, Raúl Córdoba, Yavuz M Bilgin, Iker Falces-Romero, Shaimaa El-Ashwah, Ziad Emarah, Caroline Besson, Milena Kohn, Jaap Van Doesum, Emanuele Ammatuna, Monia Marchetti, Jorge Labrador, Giovanni Paolo Maria Zambrotta, Luisa Verga, Ozren Jaksic, Marcio Nucci, Klára Piukovics, Alba Cabirta-Touzón, Moraima Jiménez, Elena Arellano, Ildefonso Espigado, Ola Blennow, Anna Nordlander, Stef Meers, Jens van Praet, Tommaso Francesco Aiello, Carolina Garcia-Vidal, Nicola Fracchiolla, Mariarita Sciumè, Guldane Cengiz Seval, Pavel Žák, Caterina Buquicchio, Carlo Tascini, Stefanie K Gräfe, Martin Schönlein, Tatjana Adžić-Vukičević, Valentina Bonuomo, Chiara Cattaneo, Summiya Nizamuddin, Martin Čerňan, Gaëtan Plantefeve, Romane Prin, Tomas Szotkovski, Graham P Collins, Michelina Dargenio, Verena Petzer, Dominik Wolf, Natasha Čolović, Lucia Prezioso, Toni Valković, Francesco Passamonti, Gustavo-Adolfo Méndez, Uluhan Sili, Antonio Vena, Martina Bavastro, Alessandro Limongelli, Rafael F Duarte, Marie-Pierre Ledoux, Milche Cvetanoski, Zlate Stojanoski, Marina Machado, Josip Batinić, Gabriele Magliano, Monika M Biernat, Nikola Pantić, Christian Bjørn Poulsen, Annarosa Cuccaro, Maria Ilaria Del Principe, Austin Kulasekararaj, Irati Ormazabal-Vélez, Alessandro Busca, Fatih Demirkan, Marriyam Ijaz, Nikolai Klimko, Igor Stoma, Sofya Khostelidi, Noemí Fernández, Ali S Omrani, Rui Bergantim, Nick De Jonge, Guillemette Fouquet, Milan Navrátil, Ghaith Abu-Zeinah, Michail Samarkos, Johan Maertens, Cristina De Ramón, Anna Guidetti, Ferenc Magyari, Tomás José González-López, Tobias Lahmer, Olimpia Finizio, Natasha Ali, László Imre Pinczés, Esperanza Lavilla-Rubira, Alessandra Romano, Maria Merelli, Mario Delia, Maria Calbacho, Joseph Meletiadis, Darko Antić, José-Ángel Hernández-Rivas, Joyce Marques de Almeida, Murtadha Al-Khabori, Martin Hoenigl, Maria Chiara Tisi, Nina Khanna, Aleksandra Barać, Noha Eisa, Roberta Di Blasi, Raphaël Liévin, Carolina Miranda-Castillo, Nathan C Bahr, Sylvain Lamure, Mario Virgilio Papa, Ayel Yahya, Avinash Aujayeb, Jan Novák, Nurettin Erben, María Fernández-Galán, José-María Ribera-Santa Susana, Ikhwan Rinaldi, Rita Fazzi, Monica Piedimonte, Rémy Duléry, Yung Gonzaga, Andrés Soto-Silva, Giuseppe Sapienza, Alexandra Serris, Ľuboš Drgoňa, Ana Groh, Laura Serrano, Eleni Gavriilaki, Athanasios Tragiannidis, Juergen Prattes, Nicola Coppola, Vladimir Otašević, Miloš Mladenović, Mirjana Mitrović, Bojana Mišković, Pavel Jindra, Sofia Zompi, Maria Vittoria Sacchi, Carolin Krekeler, Maria Stefania Infante, Daniel García-Bordallo, Gökçe Melis Çolak, Jiří Mayer, Marietta Nygaard, Michaela Hanáková, Zdeněk Ráčil, Matteo Bonanni, Philipp Koehler, Laman Rahimli, Oliver A Cornely, Livio Pagano
BACKGROUND: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. METHODS: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide...
May 2024: EClinicalMedicine
https://read.qxmd.com/read/38532759/closure-of-tb-pulmonary-cavern-using-endobronchial-valve-placement
#4
Teona Mskhaladze, David Tchkonia, Kakha Vacharadze, Nana Kiria, Mikolay Chkonia
INTRODUCTION: Enhancing the efficacy of treatment for Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Tuberculosis has prompted exploration into adjunctive therapies, such as Endobronchial Valve Placement (EVP) in addition to pharmacological interventions. MATERIALS AND METHODS: EVP was performed utilizing a combination of rigid and flexible bronchoscopes to address airway hemorrhage and facilitate closure of TB cavities. The procedure involved the deployment of large valves (12 mm and 17 mm), necessitating the utilization of a rigid bronchoscope...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38532405/lung-transcriptomics-reveals-the-underlying-mechanism-by-which-aerobic-training-enhances-pulmonary-function-in-chronic-obstructive-pulmonary-disease
#5
JOURNAL ARTICLE
Jian Li, Cai-Tao Chen, Peijun Li, Xiaoyun Zhang, Xiaodan Liu, Weibing Wu, Wei Gu
BACKGROUND: Aerobic training is the primary method of rehabilitation for improving respiratory function in patients with chronic obstructive pulmonary disease (COPD) in remission. However, the mechanism underlying this improvement is not yet fully understood. The use of transcriptomics in rehabilitation medicine offers a promising strategy for uncovering the ways in which exercise training improves respiratory dysfunction in COPD patients. In this study, lung tissue was analyzed using transcriptomics to investigate the relationship between exercise and lung changes...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38532376/efficacy-of-respiratory-rehabilitation-in-patients-with-covid-19-a-retrospective-study
#6
JOURNAL ARTICLE
Zhiyou Zhang, Congcong Wang, Zhendong Li, Yueyang Liu, Yutong Nie, Jianwei Zhang, Dawei Li
OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technology combined with prone ventilation on patients infected with COVID-19. METHODS: 38 patients with COVID-19 (severe) who were treated in the intensive rehabilitation group of Shengli Oilfield Central Hospital. They were randomly divided into a control group and an observation group...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38531709/palliative-care-in-the-cardiovascular-intensive-care-unit-a-systematic-review-of-current-literature
#7
REVIEW
Agastya D Belur, Aryan Mehta, Mridul Bansal, Patrick M Wieruszewski, Rachna Kataria, Marwan Saad, Annaliese Clancy, Daniel J Levine, Neel R Sodha, Douglas M Burtt, Gregory S Rachu, J Dawn Abbott, Saraschandra Vallabhajosyula
BACKGROUND: There has been an evolution in the disease severity and complexity of patients presenting to the cardiac intensive care unit (CICU). There are limited data evaluating the role of palliative care in contemporary CICU practice. METHODS: PubMed Central, CINAHL, EMBASE, Medline, Cochrane Library, Scopus, and Web of Science databases were evaluated for studies on palliative care in adults (≥18 years) admitted with acute cardiovascular conditions - acute myocardial infarction, cardiogenic shock, cardiac arrest, advanced heart failure, post-cardiac surgery, spontaneous coronary artery dissection, Takotsubo cardiomyopathy, and pulmonary embolism - admitted to the CICU, coronary care unit or cardiovascular intensive care unit from 1/1/2000 to 8/8/2022...
March 24, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38531395/post-pulmonary-embolism-syndrome-an-update-based-on-the-revised-awmf-s2k-guideline
#8
JOURNAL ARTICLE
F Joachim Meyer, Christian Opitz
In survivors of acute pulmonary embolism (PE), the post-PE syndrome (PPES) may occur. In PPES, patients typically present with persisting or progressive dyspnea on exertion despite 3 months of therapeutic anticoagulation. Therefore, a structured follow-up is warranted to identify patients with chronic thromboembolic pulmonary disease (CTEPD) with normal pulmonary pressure or chronic thromboembolic pulmonary hypertension (CTEPH). Both are currently understood as a dual vasculopathy, that is, secondary arterio- and arteriolopathy, affecting the large and medium-sized pulmonary arteries as well as the peripheral vessels (diameter < 50 µm)...
March 26, 2024: Hämostaseologie
https://read.qxmd.com/read/38530702/clinical-trial-inclusion-and-impact-on-early-adoption-of-medical-innovation-in%C3%A2-diverse-populations
#9
JOURNAL ARTICLE
Philip B Adamson, Melvin Echols, Ersilia M DeFilippis, Alanna A Morris, Mosi Bennett, William T Abraham, JoAnn Lindenfeld, John R Teerlink, Christopher M O'Connor, Allison T Connolly, Huanan Li, Mona Fiuzat, Muthiah Vaduganathan, Orly Vardeny, Wayne Batchelor, Kelly C McCants
BACKGROUND: Inadequate inclusion in clinical trial enrollment may contribute to health inequities by evaluating interventions in cohorts that do not fully represent target populations. OBJECTIVES: The aim of this study was to determine if characteristics of patients with heart failure (HF) enrolled in a pivotal trial are associated with who receives an intervention after approval. METHODS: Demographics from 2,017,107 Medicare patients hospitalized for HF were compared with those of the first 10,631 Medicare beneficiaries who received implantable pulmonary artery pressure sensors...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530687/the-natural-history-of-atrial-functional-mitral-regurgitation
#10
JOURNAL ARTICLE
Jwan A Naser, Francisco B Alexandrino, Tomonari Harada, Hector I Michelena, Barry A Borlaug, Mackram F Eleid, Grace Lin, Christopher Scott, Austin M Kennedy, Patricia A Pellikka, Vuyisile T Nkomo, Sorin V Pislaru
BACKGROUND: The natural history of moderate/severe atrial functional mitral regurgitation (AFMR) is unknown. OBJECTIVES: The authors sought to study the incidence of left ventricular (LV) systolic dysfunction (LVSD), progression or regression of ≥mild-moderate AFMR, and impact on mortality. METHODS: Adults with left atrial (LA) volume index ≥40 mL/m2 , ≥mild-moderate AFMR, and follow-up echocardiogram were followed for incident LVSD (ejection fraction <50% and ≥10% lower than baseline), progression of mild-moderate/moderate AFMR to severe, and persistent regression of AFMR to no/trivial...
March 17, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38529683/value-of-rapid-on-site-evaluation-combined-with-interventional-pulmonology-techniques-in-the-diagnosis-of-pulmonary-cryptococcosis
#11
JOURNAL ARTICLE
Jiaqi Cao, Rong Zhou, Qian He, Ming Zhang, Chunlai Feng
OBJECTIVES: The aim of this study is to evaluate the diagnostic value of rapid on-site evaluation (ROSE) combined with computed tomography-guided percutaneous needle biopsy (CT-PNB) or radial endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) for pulmonary cryptococcosis (PC). METHODS: Clinical data of 33 patients diagnosed with PC at the Third Affiliated Hospital of Soochow University between February 2018 and June 2023 were retrospectively analysed...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529639/cardiovascular-disease-and-risk-in-copd-a-state-of-the-art-review
#12
REVIEW
Ricardo Polman, John R Hurst, Omer Faruk Uysal, Swapna Mandal, Dominik Linz, Sami Simons
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular diseases (CVD) commonly co-exist. Outcomes of people living with both conditions are poor in terms of symptom burden, receiving evidence-based treatment and mortality. Increased understanding of the underlying mechanisms may help to identify treatments to relieve this disease burden. This narrative review covers the overlap of COPD and CVD with a focus on clinical presentation, mechanisms, and interventions...
March 26, 2024: Expert Review of Cardiovascular Therapy
https://read.qxmd.com/read/38529638/-circpvt1-promotes-silica-induced-epithelial-mesenchymal-transition-by-modulating-the-mir-497-5p-tcf3-axis
#13
JOURNAL ARTICLE
Siyun Zhou, Yan Li, Wenqing Sun, Dongyu Ma, Yi Liu, Demin Cheng, Guanru Li, Chunhui Ni
Epithelial-mesenchymal transition (EMT) is a vital pathological feature of silica-induced pulmonary fibrosis. However, whether circRNA is involved in the process remains unclear. The present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying mechanisms. We found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial cells. The isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the cytoplasm...
July 3, 2023: Journal of Biomedical Research
https://read.qxmd.com/read/38528530/early-smoking-lead-to-worse-prognosis-of-copd-patients-a-real-world-study
#14
JOURNAL ARTICLE
Jiankang Wu, Weiwei Meng, Yiming Ma, Zhiqi Zhao, Ruoyan Xiong, Jiayu Wang, Rui Zhao, Huihui Zeng, Yan Chen
BACKGROUND: Smoking remains a major risk factor for the development and progression of chronic obstructive pulmonary disease (COPD). Due to the adolescent smoking associated with worse health state, the age, at which an individual started smoking, might play a key role in shaping the trajectory of COPD development and the severity. METHODS: We conducted an observational study from September 2016 through January 2023 of eligible patients hospitalized with COPD. Patients who started smoking during the alveolar development stage (ADS, smoking initiation ≤ 24 years old) were defined as early smoking patients, and patients who started smoking after ADS (smoking initiation > 24 years old) were defined as late smoking patients...
March 25, 2024: Respiratory Research
https://read.qxmd.com/read/38528512/effect-of-home-based-pulmonary-rehabilitation-on-exercise-capacity-in-post-covid-19-patients-a-randomized-controlled-trail
#15
RANDOMIZED CONTROLLED TRIAL
Tamer I Abo Elyazed, Laila A Alsharawy, Shaimaa E Salem, Nesma A Helmy, Ahmed Abd El-Moneim Abd El-Hakim
BACKGROUND: Coronavirus 2019 (COVID-19) is an epidemic condition that compromises various consequences. The goal of this study was to investigate the effect of home-based pulmonary rehabilitation on exercise capacity in patients with post COVID-19 syndrome. METHODS: The study was designed as a randomized control trial. A total of sixty-eight patients with post COVID-19 syndrome complaining of fatigue, dyspnea, and exercise intolerance participated in this study...
March 25, 2024: Journal of Neuroengineering and Rehabilitation
https://read.qxmd.com/read/38527990/pulmonary-epstein-barr-virus-associated-smooth-muscle-tumor-after-kidney-transplantation-two-case-reports-with-review-of-differential-diagnosis
#16
JOURNAL ARTICLE
Xiao-Yu Fu, Xia Gao, Chun-Lei Zhao, Xing-Feng Qi, Xiao-Juan Ouyang, Ling-Hua Zhu, Dong Wang, Li-Juan Qu, Xian-Zong Ye
Pulmonary nodules are a common complication in solid organ transplant recipients, and may have various underlying causes, with Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) being one of them. Given the rarity of this entity, we describe the diagnosis and therapeutic interventions for post-transplant EBV-SMT in two individuals. Both cases involved female patients who were diagnosed with multiple pulmonary nodules 60 months and 116 months, respectively, after receiving living-related kidney transplantation...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527849/adjunctive-pascolizumab-in-rifampicin-susceptible-pulmonary-tuberculosis-proof-of-concept-partially-randomised-double-blind-placebo-controlled-dose-escalation-trial
#17
JOURNAL ARTICLE
Nicholas I Paton, Meera Gurumurthy, Qingshu Lu, Francesca Leek, Philip Kwan, Hiromi W L Koh, James Molton, Lalaine Mortera, Sullian Naval, Zamzurina Abu Bakar, Yong-Kek Pang, Lionel Lum, Tow Keang Lim, Gail B Cross, Ganesh Lekurwale, Hyungwon Choi, Veonice Au, John Connolly, Martin Hibberd, Justin A Green
BACKGROUND: Interleukin-4 (IL-4), increased in tuberculosis infection, may impair bacterial killing. Blocking IL-4 confers benefit in animal models. We evaluated safety and efficacy of pascolizumab (humanised anti-IL-4 monoclonal antibody) as adjunctive tuberculosis treatment. METHODS: Participants with rifampicin-susceptible pulmonary tuberculosis received a single intravenous infusion of pascolizumab or placebo; and standard 6-month tuberculosis treatment. Pascolizumab dose increased in successive cohorts: [1] non-randomised 0...
March 25, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38527173/effect-of-pulmonary-rehabilitation-on-functional-status-dyspnea-and-quality-of-life-among-post-covid-19-patients
#18
JOURNAL ARTICLE
Yatesh Sharma, Tanveer Alam, Ambreen Fatima, Sachin Gupta
OBJECTIVES: To determine the Effect of pulmonary rehabilitation on functional status dyspnea and quality of life among post-COVID-19 patients. METHODS: The study utilized an experimental study designwith a total of 120 participantsto examine the effects of pulmonary rehabilitation. The participants were divided into two groups: Group A (experimental group) and Group B (control group). Demographic variables such as age, weight, and height were collected. Health-related quality of life (HRQL), post-COVID-19 functional status, and perceived exertion were assessed before and after the intervention...
March 25, 2024: Journal of Asthma
https://read.qxmd.com/read/38526522/pharmacologic-prevention-and-therapy-of-postoperative-paralytic-ileus-after-gastrointestinal-cancer-surgery-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Martin Reichert, Franziska Willis, Stefan Post, Martin Schneider, Tim Vilz, Maria Willis, Andreas Hecker
BACKGROUND: Postoperative paralytic ileus (POI) is a significant concern following gastrointestinal tumor surgery. Effective preventive and therapeutic strategies are crucial but remain elusive. Current evidence from randomized-controlled trials on pharmacological interventions for prevention or treatment of POI are systematically reviewed to guide clinical practice and future research. MATERIALS AND METHODS: Literature was systematically searched for prospective randomized-controlled trials testing pharmacological interventions for prevention or treatment of POI after gastrointestinal tumor surgery...
March 25, 2024: International Journal of Surgery
https://read.qxmd.com/read/38526466/postoperative-pulmonary-complications-in-patients-undergoing-upper-abdominal-surgery-risk-factors-and-predictive-models
#20
JOURNAL ARTICLE
Shivam Garg, Vishnukanth Govindaraj, Dharm Prakash Dwivedi, Kalayarasan Raja, Elamurugan Palanivel Theerthar
Postoperative pulmonary complications (PPCs) are unexpected disorders that occur up to 30 days after surgery, affecting the patient's clinical status and requiring therapeutic intervention. Therefore, it becomes important to assess the patient preoperatively, as many of these complications can be minimized with proper perioperative strategies following a thorough preoperative checkup. Herein, we describe the PPCs and risk factors associated with developing PPCs in patients undergoing upper abdominal surgery...
March 25, 2024: Monaldi Archives for Chest Disease
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