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Vascular Aging

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https://www.readbyqxmd.com/read/28944849/celastrol-alleviates-angiotensin-ii%C3%A2-mediated-vascular-smooth-muscle-cell-senescence-via-induction-of-autophagy
#1
Xian-Jie Xu, Wei-Bo Zhao, Shi-Bin Feng, Cheng Sun, Qiang Chen, Bing Ni, Hou-Yuan Hu
Reactive oxygen species (ROS) production has been implicated in the promotion of cellular senescence. Celastrol, a quinone methide triterpenoid isolated from the Celastraceae family, exerts antioxidant effects and enhances autophagy in various cell types. Since autophagy serves an important role in regulating ROS, it was hypothesized that the antioxidant effect of celastrol is via enhanced autophagy, thus inhibiting cell senescence. Therefore, the present study used a Senescence β‑Galactosidase Staining kit, western blot analysis and cell cycle analysis to investigate whether celastrol alleviates angiotensin (Ang) II‑induced cellular senescence by upregulating autophagy in vascular smooth muscle cells (VSMCs)...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944745/obesity-a-possible-risk-factor-for-restless-legs-syndrome
#2
Demet Yildiz, Nilufer Buyukkoyuncu, Ahmet Kasim Kilic, Soner Cander, Abdülmecit Yıldız, Aygul Gunes, Meral Seferoglu, Sevda Erer Ozbek
AIM/BACKGROUND: Restless legs syndrome (RLS) is a frequent neurological and sleep disorder. Metabolic disorders are known to be related to sleep disorders. We prospectively evaluated whether obesity and its possible cofactors were related to the presence of RLS. MATERIALS AND METHODS: The study included 143 obese and 94 non-obese individuals. Obese patients had a BMI of 30 and over, while non-obese patients had a BMI lower than 30. Patients with arthritis and pregnancy were excluded but not those with diabetes mellitus...
September 25, 2017: Neurological Research
https://www.readbyqxmd.com/read/28944725/intermediate-risk-of-cardiac-events-and-recurrent-stroke-after-stroke-admission-in-young-adults
#3
Peter Jin, Ivan Matos Diaz, Laura Stein, Alison Thaler, Stanley Tuhrim, Mandip S Dhamoon
Background In older adults with stroke, there is an increased risk of cardiovascular events in the intermediate period, up to one year after stroke. The risk of cardiovascular events in this period in young adults after stroke has not been studied. We hypothesized that in the intermediate risk period, young adults with ischemic stroke have an increased risk of recurrent stroke and a smaller increase of cardiac events. Methods Using the National Readmissions Database during the year 2013, we identified ischemic stroke admissions among those aged 18-45 years using International Classification of Disease, Ninth Revision, Clinical Modification codes to identify index vascular events and risk factors...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28943908/expression-of-chicken-ovalbumin-upstream-promoter-transcription-factor-ii-and-liver-x-receptor-as-prognostic-indicators-for-human-colorectal-cancer
#4
Seong-Hoon Yun, Min-Gyoung Park, Yu-Mi Kim, Mee-Sook Roh, Joo-In Park
Cholesterol increases the risk of colorectal cancer. Liver X receptor (LXR), retinoid X receptor (RXR)α and sterol regulatory element binding protein (SREBP)-1c are transcriptional regulators of lipid metabolism. Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) serves an essential role in angiogenesis and development, but its role in cancer is controversial. The expression of COUP-TFII, LXR, RXRα and SREBP-1c in colorectal cancer, as well as their association with clinicopathologic features, was assessed, and their utility as prognostic indicators in colorectal cancer evaluated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943594/effect-of-rosuvastatin-on-cholesterol-efflux-capacity-and-endothelial-function-in-type-2-diabetes-mellitus-and-dyslipidemia
#5
Kyong Yeun Jung, Kyoung Min Kim, Sun Kyoung Han, Han Mi Yun, Tae Jung Oh, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
BACKGROUND: Quality and quantity of high-density lipoprotein cholesterol (HDL-C) may be associated with cardiovascular risk. We investigated the effect of rosuvastatin on cholesterol efflux (CE) for HDL function and vascular health.Methods and Results:We enrolled 30 dyslipidemic patients with type 2 diabetes mellitus and 20 healthy subjects as controls. Vascular health was assessed on flow-medicated dilation (FMD), nitroglycerin-induced dilatation of the brachial artery and carotid artery intima-media thickness (cIMT)...
September 22, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943515/bleeding-impacting-mortality-after-noncardiac-surgery-a-protocol-to-establish-diagnostic-criteria-estimate-prognostic-importance-and-develop-and-validate-a-prediction-guide-in-an-international-prospective-cohort-study
#6
Pavel S Roshanov, John W Eikelboom, Mark Crowther, Vikas Tandon, Flavia K Borges, Clive Kearon, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Gordon H Guyatt, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Daniel I Sessler, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, P J Devereaux
INTRODUCTION: Various definitions of bleeding have been used in perioperative studies without systematic assessment of the diagnostic criteria for their independent association with outcomes important to patients. Our proposed definition of bleeding impacting mortality after noncardiac surgery (BIMS) is bleeding that is independently associated with death during or within 30 days after noncardiac surgery. We describe our analysis plan to sequentially 1) establish the diagnostic criteria for BIMS, 2) estimate the independent contribution of BIMS to 30-day mortality and 3) develop and internally validate a clinical prediction guide to estimate patient-specific risk of BIMS...
August 4, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28943485/results-of-infrageniculate-bypasses-using-the-profunda-femoris-artery-as-inflow-source
#7
Giulio Illuminati, Francesco G Calio', Giulia Pizzardi, Rocco Pasqua, Federica Masci, Francesca Frezzotti, Piergaspare Palumbo, Francesco Vietri
BACKGROUND: When the common femoral artery is not accessible for infrainguinal bypass grafting, the profunda femoris artery (PFA) can be a valuable alternative inflow source for distal arterial revascularization. The purpose of this retrospective study was to evaluate the results of infrageniculate bypass grafting via the PFA as inflow source for critical limb ischemia. METHODS: Between 1994 and 2016, 68 patients, 51 men of a mean age of 74 years, underwent an infrageniculate arterial bypass grafting for critical limb ischemia, using the PFA as inflow site...
September 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28943482/atrial-fibrillation-and-cognitive-decline-in-the-framingham-heart-study
#8
Arvind Nishtala, Ryan J Piers, Jayandra J Himali, Alexa S Beiser, Kendra L Davis-Plourde, Jane S Saczynski, David D McManus, Emelia J Enjamin, Rhoda Au
BACKGROUND: There is a paucity of longitudinal research investigating the relations between AF and domain-specific cognitive performance. OBJECTIVE: Our study investigated the association between AF and cognitive performance cross-sectionally and longitudinally. METHODS: Eligible participants were dementia- and stroke-free at the time of baseline neuropsychological (NP) assessment, and underwent at least one additional NP assessment with a one year or greater inter-test interval...
September 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#9
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
September 21, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28943419/severe-cerebral-complications-secondary-to-perforation-injury-of-the-anterior-skull-base-during-sinonasal-surgery-an-underappreciated-problem
#10
Shadi Al-Afif, Elvis J Hermann, Gökce Hatipoglu Majernik, Makoto Nakamura, Peter Raab, Thomas Lenarz, Joachim K Krauss
OBJECTIVE: Functional endonasal sinus surgery (FESS) is widely practiced and is considered a generally safe procedure. Skull base injuries occur in less than 1% of procedures and are typically associated with cerebrospinal fluid leaks. Rarely, skull base injuries might result in cerebral lesions. Here we present a series of four patients with iatrogenic perforating injuries of the anterior skull base and cerebral lesions after routine FESS. METHODS: Four patients with iatrogenic perforating cerebral lesions after routine FESS performed at other institutions were referred to a tertiary neurosurgery department within a 10-year period...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28943198/incidence-of-dementia-in-elderly-latin-americans-results-of-the-maracaibo-aging-study
#11
Gladys E Maestre, Luis J Mena, Jesus D Melgarejo, Daniel C Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J Chacon, Carlos A Chávez, Luis Falque-Madrid, Ciro A Gaona, Joseph D Terwilliger, Joseph H Lee, Nikolaos Scarmeas
INTRODUCTION: There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. METHODS: The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) was used to diagnose dementia, which was classified as Alzheimer's disease, vascular dementia, or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years (p-y) of follow-up...
September 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28943053/our-experience-with-500-patients-with-benign-paroxysmal-positional-vertigo-reexploring-aetiology-and-reevaluating-mri-investigation
#12
Fei Tan, Constantin Bartels, Rory McConn Walsh
OBJECTIVE: To explore the aetiology of and to evaluate the importance of MRI investigation on the posterior semicircular canal benign paroxysmal positional vertigo in an Irish population. METHODS: A retrospective observational study of 500 patients with posterior semicircular canal benign paroxysmal positional vertigo, diagnosed and treated by the senior author over a 10-year period. Most patients underwent an MRI brain and inner ear, following the same scan protocol...
September 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28943003/comparative-effectiveness-of-one-stage-versus-two-stage-basilic-vein-transposition-arteriovenous-fistulas
#13
Amir A Ghaffarian, Claire L Griffin, Larry W Kraiss, Mark R Sarfati, Benjamin S Brooke
OBJECTIVE: Basilic vein transposition (BVT) fistulas may be performed as either a one-stage or two-stage operation, although there is debate as to which technique is superior. This study was designed to evaluate the comparative clinical efficacy and cost-effectiveness of one-stage vs two-stage BVT. METHODS: We identified all patients at a single large academic hospital who had undergone creation of either a one-stage or two-stage BVT between January 2007 and January 2015...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942979/differences-and-similarities-in-risk-factors-for-postoperative-acute-kidney-injury-between-younger-and-older-adults-undergoing-cardiac-surgery
#14
Nadim Saydy, Amine Mazine, Louis-Mathieu Stevens, Hughes Jeamart, Philippe Demers, Pierre Pagé, Yoan Lamarche, Ismail El-Hamamsy
OBJECTIVES: Acute kidney injury is a frequent complication after cardiac surgery. The purpose of this study was to assess the risk factors for acute kidney injury in patients ≤60 years of age undergoing cardiac surgery and to compare these risk factors with those identified in patients ≥65 years of age. METHODS: From 2010 to 2012, 1253 patients ≤60 years (mean age 52 ± 9 years) and 2488 patients ≥65 years (mean age 74 ± 6 years) underwent cardiac surgery...
August 26, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28942665/-infantile-haemangioma-clinical-and-demographic-characteristics-experiences-in-the-treatment
#15
Zsanett Renáta Csoma, Szandra Dalmády, Rita Ábrahám, Tamás Rózsa, Katalin Rácz, Lajos Kemény
INTRODUCTION: Infantile haemangiomas are the most common vascular tumours of infancy. The vast majority of the lesions do not require dermatological treatment due to their unique clinical course and the high rate of spontaneous regression. Approximately 10-15% of the tumours result in severe complications and sequale, requiring special management and close follow-up. AIM: The aim of the present study was to assess the data of the patients treated with infantile haemangiomas, and to summarize the results of the therapy during 4...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28942616/differences-in-right-ventricular-morphology-not-function-indicate-the-nature-of-increased-afterload-in-pulmonary-hypertensive-subjects-with-normal-left-ventricular-function
#16
Farhan Raza, Catherine Dillane, Arslan Mirza, Yevgeniy Brailovsky, Sheila Weaver, Martin G Keane, Paul Forfia
BACKGROUND: The aim of study was to assess whether a specific morphology of the right ventricle (RV) by 2D echo predicts the hemodynamic nature of pulmonary hypertension (PH). METHODS: We reviewed clinical, 2D echo, and hemodynamic data of 100 patients with PH: divided into three groups: PH from pulmonary vascular disease (PHPVD ; n = 34) with pulmonary vascular resistance (PVR) > 3 mm Hg/L/min (Wood unit [WU]) and pulmonary artery wedge pressure (PAWP) ≤ 15 mm Hg, pulmonary venous hypertension (PVH; n = 33) with PVR < 3 WU and PAWP > 15 mm Hg and PHMIXED (n = 33) with PVR > 3 WU and PAWP > 15 mm Hg...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28942562/abnormal-levels-of-vascular-endothelial-biomarkers-in-schizophrenia
#17
Tanya T Nguyen, Sheena I Dev, Guanqing Chen, Sharon C Liou, Averria Sirkin Martin, Michael R Irwin, Judith E Carroll, Xin Tu, Dilip V Jeste, Lisa T Eyler
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs)...
September 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28942095/changes-in-truncal-obesity-and-fat-distribution-predict-arterial-health
#18
Frank E Corrigan, Heval Mohamed Kelli, Devinder S Dhindsa, Robert E Heinl, Ibhar Al Mheid, Muhammad Hammadah, Salim S Hayek, Salman Sher, Danny J Eapen, Greg S Martin, Arshed A Quyyumi
BACKGROUND: Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function. OBJECTIVE: We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function. METHODS: We recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year...
September 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28942076/assessment-of-commonly-used-frailty-markers-for-high-and-extreme-risk-patients-undergoing-transcatheter-aortic-valve-replacement
#19
Jessica Forcillo, Jose F Condado, Yi-An Ko, Michael Yuan, Jose N Binongo, Nnaemeka M Ndubisi, John J Kelly, Vasilis Babaliaros, Robert A Guyton, Chandan Devireddy, Bradley G Leshnower, James P Stewart, Louis P Perrault, Paul Khairy, Vinod H Thourani
BACKGROUND: The effect of frailty on outcomes after transcatheter aortic valve replacement (TAVR) remains incompletely understood. The objective of this study was to evaluate the performance of four commonly used frailty markers as predictors of early and late outcomes among patients undergoing TAVR. METHODS: A review was performed of 361 high- and extreme-risk patients undergoing TAVR from 2011 to 2015. Four frailty variables were assessed: serum albumin (g/dL), 5-m walk (seconds), grip strength (kg), and Katz index of independence in activities of daily living...
September 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28941979/proteolytic-degradation-and-inflammation-play-critical-roles-in-polypoidal-choroidal-vasculopathy
#20
Sandeep Kumar, Hiroyuki Nakashizuka, Alex Jones, Alyssia Lambert, Xuchen Zhao, Megan Shen, Mackenzie Parker, Shixian Wang, Zachary Berriochoa, Amrita Fnu, Stephanie VanBeuge, Patricia Chévez-Barrios, Mark Tso, Jon Rainier, Yingbin Fu
Polypoidal choroidal vasculopathy (PCV) is a common subtype of wet age-related macular degeneration (AMD) in Asian populations while choroidal neovascularization (CNV) is the typical subtype in Western populations. The etiology of PCV is unknown. By comparing the phenotype of a PCV mouse model expressing protease HTRA1 in retinal pigment epithelium with transgenic mice expressing the inactive HTRA1(S328A), we showed that HTRA1 mediated degradation of elastin in choroidal vessels is critical for the development of PCV, which exhibited destructive extracellular matrix remodeling and vascular smooth muscle cell loss...
September 20, 2017: American Journal of Pathology
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