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https://www.readbyqxmd.com/read/29226741/side-effects-associated-with-current-and-prospective-antimigraine-pharmacotherapies
#1
Abimael González-Hernández, Bruno A Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M Villalón
Migraine is a neurovascular disorder. Current acute specific antimigraine pharmacotherapies target trigeminovascular 5-HT1B/1D, 5-HT1F and CGRP receptors but, unfortunately, they induce some cardiovascular and central side effects that lead to poor treatment adherence/compliance. Therefore, new antimigraine drugs are being explored. Areas covered. This review considers the adverse (or potential) side effects produced by current and prospective antimigraine drugs, including medication overuse headache (MOH) produced by ergots and triptans, the side effects observed in clinical trials for the new gepants and CGRP antibodies, and a section discussing the potential effects resulting from disruption of the cardiovascular CGRPergic neurotransmission...
December 9, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29226616/clinical-characteristics-of-maternal-mental-health-service-users-treated-with-mood-stabilizing-or-antipsychotic-medication
#2
Charmian Møller-Olsen, Susan Hatters Friedman, Chandni Prakash, Abigail North
INTRODUCTION: We aimed to investigate the characteristics of pregnant women who required either mood stabilizer or antipsychotic treatment. These women requiring such treatment are likely to be more mentally unwell and thus carry a higher burden of comorbidities associated with poor pregnancy outcomes. METHODS: This retrospective review investigated the common characteristics of pregnant women who were prescribed with antipsychotics or mood stabilizers under a major city's public maternal mental health service...
December 11, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/29226493/a-prospective-study-comparing-perioperative-anxiety-and-posthospital-behavior-in-children-with-autism-spectrum-disorder-vs-typically-developing-children-undergoing-outpatient-surgery
#3
Anila B Elliott, Amy Lewandowski Holley, Alexandra C Ross, Amy O Soleta, Jeffrey L Koh
BACKGROUND: Research describing the experience of youth with autism spectrum disorders in the perioperative setting is limited. This study compared youth with autism spectrum disorder to typically developing children in the perioperative setting and examined group differences in: child anxiety, parent anxiety, premedication patterns, induction compliance, and changes in behavior postprocedure. METHODS: Participants were 60 youth (32 with autism spectrum disorder, 28 typically developing) of ages 2-19 years undergoing outpatient surgery and their parents...
December 10, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29225455/treatment-of-major-depressive-disorder-with-iyengar-yoga-and-coherent-breathing-a-randomized-controlled-dosing-study
#4
Chris C Streeter, Patricia L Gerbarg, Theodore H Whitfield, Liz Owen, Jennifer Johnston, Marisa M Silveri, Marysia Gensler, Carol L Faulkner, Cathy Mann, Mary Wixted, Anne Marie Hernon, Maren B Nyer, E Richard P Brown, John E Jensen
Objectives: The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD). Methods: Subjects were randomized to the high-dose group (HDG) or low-dose group (LDG) for a 12-week intervention of three or two intervention classes per week, respectively. Eligible subjects were 18-64 years old with MDD, had baseline Beck Depression Inventory-II (BDI-II) scores ≥14, and were either on no antidepressant medications or on a stable dose of antidepressants for ≥3 months...
December 1, 2017: Alternative & Complementary Therapies: a New Bimonthly Publication for Health Care Practitioners
https://www.readbyqxmd.com/read/29225151/injectable-in-situ-forming-gel-based-on-lyotropic-liquid-crystal-for-persistent-postoperative-analgesia
#5
Liling Mei, Yecheng Xie, Ying Huang, Bei Wang, Jintian Chen, Guilan Quan, Xin Pan, Hu Liu, Lili Wang, Xianguo Liu, Chuanbin Wu
Local anesthetics have been widely used for postoperative analgesia. However, multiple injections or local infiltration is required due to the short half-lives of local anesthetics after single injection, which results in poor compliance and increasing medical expense. In this study, an in situ forming gel (ISFG) based on lyotropic liquid crystal was developed to deliver bupivacaine hydrochloride (BUP) for long-acting postoperative analgesia. BUP-ISFG was designed to be administrated as a precursor solution which would spontaneously transform into gel with well-defined internal nanostructures for sustained drug release at the site of administration when exposed to physiological fluid...
December 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29223536/polymeric-gels-for-intravaginal-drug-delivery
#6
REVIEW
Michael T Cook, Marc B Brown
Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions. Gel formulations are desirable due to the ease of application, spreading and that they cause little to no discomfort to the patient...
December 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29222923/co-administration-of-low-dose-naltrexone-and-bupropion-reduces-alcohol-drinking-in-alcohol-preferring-p-rats
#7
Emily R Nicholson, Julian E Dilley, Janice C Froehlich
BACKGROUND: This study examined whether combining naltrexone (NTX) with bupropion (BUP) is more effective in reducing alcohol drinking in alcohol-preferring (P) rats with a genetic predisposition toward high voluntary alcohol intake than is either drug alone. METHODS: Alcohol-experienced, adult, male, alcohol-preferring (P) rats were fed NTX alone in a dose of 10.0 mg/kg BW, BUP alone in a dose of 10.0 mg/kg BW, BUP alone in a dose of 20.0 mg/kg BW, NTX (10.0 mg/kg BW) + BUP (10...
December 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29222741/exploratory-study-of-barriers-to-successful-office-contacts-for-attention-deficit-hyperactivity-disorder
#8
Jayde T Hooven, Benjamin N Fogel, James G Waxmonsky, Deepa L Sekhar
The American Academy of Pediatrics published attention deficit hyperactivity disorder (ADHD) guidelines, but significant variability exists in care. This exploratory study aimed to understand barriers to compliance with primary care office contacts for ADHD medication management. The study was conducted at a single academic medical center via retrospective chart review between 6/1/15 and 5/31/16 in combination with telephone interviews. Participants included 306 children 6-12 years old with an ADHD-related ICD-9/ICD-10 diagnosis...
December 8, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29222733/frail-older-people-with-multi-morbidities-in-primary-care-a-new-integrated-care-clinical-pharmacy-service
#9
Lelly Oboh, Catherine Leon, Sulman Qadir, Felicity Smith, Sally-Anne Francis
Background Older people confined to their own homes due to frailty, multiple longterm conditions and/or complex needs, are known to be at risk of medicines-related problems. Whilst a health and social care team approach to supporting these patients is advocated, there is limited evidence regarding how pharmacists can best contribute. Objective To describe a new specialist pharmacy service (called the integrated care clinical pharmacist) in terms of how it works, what it achieves and its policy implications...
December 8, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29222580/-use-of-antibiotics-in-bones-prophylaxis-and-current-treatment-standards
#10
REVIEW
L Frommelt
BACKGROUND: Treatment of bone infection is difficult due the systemic administration of antibiotics, which means that only low concentrations reach the inflamed bone tissue. Loss of bone stock is common in osteomyelitis and device associated infection. Local antibiotics are administered in several ways for prophylactic purposes and also for treatment of bone infection. We intend to show the options and limitations of clinical use of antibiotic-loaded bone grafts. SUITABILITY: Bone grafts are a suitable carrier system for antibiotics...
December 8, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29222541/estimating-cost-effectiveness-of-a-multimodal-ovarian-cancer-screening-program-in-the-united-states-secondary-analysis-of-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#11
Haley A Moss, Andrew Berchuck, Megan L Neely, Evan R Myers, Laura J Havrilesky
Importance: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening's impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer antigen 125 (CA-125) interpreted using a risk algorithm. If the MMS screening method is eventually shown to reduce mortality and be cost-effective, then it may be accepted by the medical community as a feasible screening tool. Objective: To estimate the cost-effectiveness of an MMS screening program in the United States...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222022/do-resident-case-logs-meet-acgme-requirements-a-comparison-between-acute-care-and-elective-cases
#12
Kathryn R Wolf, Zachary A Taylor, Sarah B Placek, Michael W Tsai, Brenton R Franklin, E Matthew Ritter
PURPOSE: Operative experience is at the core of general surgery residency, and recently operative volume requirements for graduating residents were increased. The ACGME has outlined 4 areas of required resident participation and documentation in order for a surgical case to be logged: determination or confirmation of the diagnosis, provision of preoperative care, selection and accomplishment of the operative procedure, and direction of the postoperative care. The purpose of this study was to examine whether general surgery residents are currently meeting the required care participation documentation standard and to examine the effect of acute care vs...
December 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29221484/the-impacts-of-baseline-ventilator-parameters-on-hospital-mortality-in-acute-respiratory-distress-syndrome-treated-with-venovenous-extracorporeal-membrane-oxygenation-a-retrospective-cohort-study
#13
Meng-Yu Wu, Yu-Sheng Chang, Chung-Chi Huang, Tzu-I Wu, Pyng-Jing Lin
BACKGROUND: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by the baseline settings of mechanical ventilation (MV) before its institution. This study was aimed at identifying the baseline ventilator parameters which were independently associated with hospital mortality in non-trauma patients receiving VV-ECMO for severe ARDS. METHODS: This retrospective study included 106 non-trauma patients (mean age: 53 years) who received VV-ECMO for ARDS in a single medical center from 2007 to 2016...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29220615/medication-assisted-treatment-mat-for-opioid-addiction-introduction-to-the-special-issue
#14
Karen McElrath, Herman Joseph
Several countries are experiencing public health crises as a result of opioid addiction. Fatal overdoses have reached record highs in many regions and Hepatitis C virus is the norm among people who inject drugs in several countries. Thus, providing for the global availability of medication-assisted treatment (MAT) for opioid addiction is more important than ever. In this article, we introduce readers to the collection of papers that appear in this special issue on MAT for opioid addiction. We describe the articles and commentaries thematically to include topics that address 1) the contemporary history of methadone maintenance, 2) the provision of and access and barriers to MAT, 3) compliance and outcomes of MAT, 4) health issues among MAT patients, 5) race, ethnicity, and social class backgrounds of MAT patients, 6) criminalization and stigma, and 7) challenges associated with the expansion of MAT...
December 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29218814/knowledge-compliance-with-good-clinical-practices-and-barriers-to-effective-control-of-postoperative-pain-among-nurses-from-hospitals-with-and-without-a-hospital-without-pain-certificate
#15
Lucyna Tomaszek, Grażyna Dębska
AIMS AND OBJECTIVES: (1) To compare knowledge and compliance with good clinical practices regarding control of postoperative pain among nurses employed at hospitals with and without a "Hospital without Pain" certificate. (2) To identify the determinants of nurses' knowledge. (3) To define barriers to effective control of postoperative pain. BACKGROUND: Only a slight improvement in postoperative pain control has been observed recently, if any. Implementation of good clinical practices in the control of postoperative pain requires involvement of nurses...
December 8, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#16
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29217437/carotid-endarterectomy-performed-before-the-weekend-is-associated-with-increased-length-of-stay
#17
Thomas W Cheng, Alik Farber, Jeffrey A Kalish, Douglas W Jones, Myriam Castagne, Denis Rybin, Stephen J Raulli, Jeffrey J Siracuse
OBJECTIVE: Length of stay (LOS) is commonly used to gauge hospital resource utilization and can affect hospital profit margin. Other fields of surgery have showed that operations performed close to the weekend have longer LOS and higher patient morbidity. Our goal was to investigate whether asymptomatic patients undergoing elective carotid endarterectomy (CEA) earlier in the week had a shorter LOS and improved clinical outcomes compared to those treated before the weekend. METHODS: The Vascular Quality Initiative (VQI) database was queried for elective weekday CEAs performed for asymptomatic carotid stenosis from 2005 to 2017...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217353/policy-on-posthumous-sperm-retrieval-survey-of-75-major-academic-medical-centers
#18
Nicholas J Waler, Raul I Clavijo, Nancy L Brackett, Charles M Lynne, Ranjith Ramasamy
OBJECTIVE: To evaluate the presence and content of policies on posthumous sperm retrieval at 75 major academic medical centers in the U.S. METHODS: We surveyed the top 75 major academic medical centers ranked for research in 2016 by U.S. News & World Report using a questionnaire based telephone/web survey. We gathered data on the presence and content of posthumous sperm retrieval policies on the internet. If not published, we contacted the legal counsel, the ethics and compliance offices, the Urology Department, as well as the infertility treatment center associated with each institution...
December 4, 2017: Urology
https://www.readbyqxmd.com/read/29216685/patient-compliance-with-surveillance-colonoscopy-patient-factors-and-the-use-of-a-graded-recall-system
#19
Chahaya Gauci, Rebecca Lendzion, Kim-Chi Phan-Thien, Denis King, Dayashan S Perera
BACKGROUND: Surveillance colonoscopy allows for the early detection and improved treatment outcomes in colorectal neoplasms but compliance rates and factors require further investigation. METHODS: This is a retrospective cohort study examining 816 patients recalled for surveillance colonoscopy at an Australian colorectal practice over a 6-month period. Primary outcome was compliance with colonoscopy within 12 months of recall. The secondary outcome of this study was to identify factors affecting compliance including patient factors and the practices' graded recall system...
December 7, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29216008/adherence-to-growth-hormone-therapy-in-children-and-its-potential-barriers
#20
Shahrzad Mohseni, Zahra Heydari, Mostafa Qorbani, Mania Radfar
BACKGROUND: One of the main concerns in chronic diseases such as growth hormone (GH) deficiency is adherence to the treatment, which significantly affects treatment outcomes. METHODS: This cross-sectional study was conducted among 169 GH recipient children (2-12 years) and teens (13-19 years) referred to a GH distributing teaching pharmacy. The eight-item Morisky Medication Adherence Scale (MMAS) and auto-compliance method were used for the assessment of patients' adherence to GH...
December 7, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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