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https://www.readbyqxmd.com/read/29792191/cost-of-provision-of-opioid-substitution-therapy-provision-in-tijuana-mexico
#1
Jose Luis Burgos, Javier A Cepeda, James G Kahn, Maria Luisa Mittal, Emilio Meza, Raúl Rafael Palacios Lazos, Psyché Calderón Vargas, Peter Vickerman, Steffanie A Strathdee, Natasha K Martin
BACKGROUND: Mexico recently enacted drug policy reform to decriminalize possession of small amounts of illicit drugs and mandated that police refer identified substance users to drug treatment. However, the economic implications of drug treatment expansion are uncertain. We estimated the costs of opioid substitution therapy (OST) provision in Tijuana, Mexico, where opioid use and HIV are major public health concerns. METHODS: We adopted an economic health care provider perspective and applied an ingredients-based micro-costing approach to quantify the average monthly cost of OST (methadone maintenance) provision at two providers (one private and one public) in Tijuana, Mexico...
May 23, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29785888/the-impact-of-oprm1-s-genetic-polymorphisms-on-methadone-maintenance-treatment-in-opioid-addicts-a-systematic-review
#2
Bilel Oueslati, Olfa Moula, Rim Ghachem
AIM: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may affect the efficacy of methadone maintenance treatment (MMT). OBJECTIVE: Our purpose was to identify all relevant published papers dealing with the impact ofOPRM1's SNPs  on MMT's efficacy and to summarize results in order to evaluate the relevance of conducting pretherapeutic genotyping in opioid addicts prior to the onset of MMT...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29778626/factors-underlying-risk-taking-in-heroin-dependent-individuals-feedback-processing-and-environmental-contingencies
#3
Daniella M Saleme, Bruno Kluwe-Schiavon, Abdrabo Soliman, Błażej Misiak, Dorota Frydecka, Ahmed A Moustafa
Evidence suggests that factors influencing risk-taking include whether decisions are made based on emotions (affective systems) or cognitions (deliberative systems), the processing of feedback (e.g., deciding to attend a rehabilitation facility for opioid addiction treatment after an intervention held by a family member), and attention to environmental contingencies (e.g., considering the probability of an outcome such as the likelihood of contracting tetanus from a shared needle; or the gains and losses associated with a decision, such as the benefits and costs of taking drugs)...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29763278/implantable-buprenorphine-probuphine-for-maintenance-treatment-of-opioid-dependence
#4
Nancy Hope Goodbar, Katherine E Hanlon
No abstract text is available yet for this article.
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29738425/a-pilot-open-label-8-week-study-evaluating-desvenlafaxine-for-treatment-of-major-depression-in-methadone-maintained-individuals-with-opioid-use-disorder
#5
Cynthia El Hage, Maykel F Ghabrash, Simon Dubreucq, Suzanne Brissette, François Lespérance, Paul Lespérance, Clairélaine Ouellet-Plamondon, Julie Bruneau, Didier Jutras-Aswad
Depression is one of the most prevalent psychiatric disorders among opioid-dependent individuals. Clinical trials testing selective serotonin reuptake inhibitors among depressed patients on methadone maintenance therapy (MMT) failed to show efficacy, whereas those on tricyclic antidepressants produced mixed results with potential for cardiotoxicity. Desvenlafaxine (DESV) is a SNRI with minimal cardiotoxicity and drug interactions. This study sought to assess feasibility and tolerability of using DESV in depressed patients on MMT...
May 7, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29733373/substance-use-and-recidivism-outcomes-for-prison-based-drug-and-alcohol-interventions
#6
Dominique de Andrade, Jessica Ritchie, Michael Rowlands, Emily Mann, Leanne Hides
We conducted a systematic review to examine the substance use and recidivism outcomes of prison-based substance use interventions. We searched public health, criminology, and psychology databases, and conducted forward and backward snowballing methods to identify additional studies. Studies were included if they were published between January 1, 2000 and June 30, 2017; were published in English; and reported substance use and/or recidivism outcomes of prison-based substance use interventions. Studies were reviewed for methodological rigor using the Effective Public Health Practice Project's Quality Assessment Tool for Quantitative Studies...
May 4, 2018: Epidemiologic Reviews
https://www.readbyqxmd.com/read/29727755/are-patients-pejorative-representations-of-buprenorphine-associated-with-their-level-of-addiction-and-of-misuse
#7
Paul Vanderkam, Stéphanie Gagey, Pierre Ingrand, Marie-Christine Perault-Pochat, Yann Brabant, Clara Blanchard, Benoit Tudrej, Nassir Messaadi, Philippe Binder
BACKGROUND: In France, buprenorphine is at once the most widely prescribed and the most commonly misused opioid maintenance treatment (OMT). Unlike other medicines, it is seldom prescribed as a generic drug. Several studies have underlined the influence of the patient's representations when choosing brand-name rather than generic forms. We aim to prove a link between these pejorative representations and misuse, a higher degree of addiction and a preference for brand-name products. METHODS: An observational study carried out at 11 sites in France using self-assessment questionnaires filled out in dispensing pharmacies by patients having come to them for buprenorphine delivery...
April 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29709732/treatment-initiation-strategies-for-syringe-exchange-referrals-to-methadone-maintenance-a-randomized-clinical-trial
#8
Michael Kidorf, Robert K Brooner, Jeannie-Marie Leoutsakos, Jessica Peirce
This randomized clinical trial evaluated the efficacy of three treatment initiation strategies for improving retention to methadone maintenance for opioid-dependent individuals referred from a syringe exchange program (SEP). New admissions (n = 212) were randomly assigned to one of three 3-month initiation strategies: 1) Low Threshold (LTI), 2) Voucher Reinforcement (VRI), or 3) Standard Care (SCI). LTI was modeled on interim methadone maintenance to transition SEP admissions to the structure of medication-assisted treatment while maximizing exposure to methadone pharmacotherapy...
April 16, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29681324/expectancy-modulation-of-opioid-neurotransmission
#9
Marta Pecina, Jon-Kar Zubieta
Expectancies are powerful modulators of cognitive and emotional experiences, as well as the neurobiological responses linked to these processes. In medicine, placebo effects are a clear example of how expectancies activate opioid neurotransmission in a treatment context, leading to the experience of analgesia and the improvement of emotional states, among other symptoms. Molecular neuroimaging techniques using positron emission tomography (PET) and the selective μ-opioid receptor tracer [11 C]carfentanil have significantly contributed to our understanding of the neurobiological systems involved in the formation of placebo effects...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29671681/sexual-dysfunctions-are-predicted-by-childhood-sexual-abuse-in-women-with-opioid-use-disorder
#10
Ruken Ağaçhanlı, İzgi Alnıak, Cuneyt Evren
BACKGROUND: Studies on sexual functioning of populations with substance use disorders (SUDs) are mostly conducted with male substance users. We have very limited information about the sexuality and related factors in women with opioid use disorder (OUD). OBJECTIVES: We aimed to evaluate the relationship between childhood traumatic experiences (CTEs) and sexual dysfunctions (SDs) of women with OUD and to compare it with a sample of women who do not have SUD. METHODS: Participants included 51 outpatient women with OUD who were on opioid maintenance treatment (OMT) with Buprenorphine/Naloxone and 48 women without SUD...
April 19, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29671504/buprenorphine-therapy-for-opioid-use-disorder
#11
Roger Zoorob, Alicia Kowalchuk, Maria Mejia de Grubb
Opioid misuse, including the use of heroin and the overprescribing, misuse, and diversion of opioid pain medications, has reached epidemic proportions in the United States. As a result, there has been a dramatic increase in opioid use disorder and associated overdoses and deaths. Addiction is a chronic brain disease with a genetic component that affects motivation, inhibition, and cognition. Patient characteristics associated with successful buprenorphine maintenance treatment include stable or controlled medical or psychiatric comorbidities and a safe, substance-free environment...
March 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29668645/coverage-of-medications-that-treat-opioid-use-disorder-and-opioids-for-pain-management-in-marketplace-plans-2017
#12
Haiden A Huskamp, Lauren E Riedel, Colleen L Barry, Alisa B Busch
BACKGROUND: Efficacious medications to treat opioid use disorders (OUDs) have been slow to diffuse into practice, and insurance coverage limits may be one important barrier. OBJECTIVES: To compare coverage for medications used to treat OUDs and opioids commonly prescribed for pain management in plans offered on the 2017 Health Insurance Marketplace exchanges. RESEARCH DESIGN: We identified a sample of 100 plans offered in urban and in rural counties on the 2017 Marketplaces, weighting by population...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29657696/comparing-effectiveness-of-mindfulness-based-relapse-prevention-with-treatment-as-usual-on-impulsivity-and-relapse-for-methadone-treated-patients-a-randomized-clinical-trial
#13
Mehdi Yaghubi, Fatemeh Zargar, Hossein Akbari
Background: Impulsivity is one of the causes of relapse that can affect treatment outcomes. Studies have shown that addiction treatments can reduce impulsivity in drug-dependent individuals. Studies also have suggested that mindfulness is associated with impulsivity. However, no study has investigated the effectiveness of the mindfulness-based intervention on impulsivity in opioid-dependent individuals. This study aimed to compare the effectiveness of mindfulness-based relapse prevention (MBRP) with treatment as usual (TAU) in terms of impulsivity and relapse for methadone-treated patients...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29626742/dissatisfaction-with-opioid-maintenance-treatment-partly-explains-reported-side-effects-of-medications
#14
Ashley Elizabeth Muller, Ronny Bjørnestad, Thomas Clausen
BACKGROUND: Drop-out is a core problem in opioid maintenance treatment (OMT), but patients' reactions to and acceptance of the various OMT medications are insufficiently investigated. In Norway, there has been vocal patient resistance to the newest medication, buprenorphine-naloxone (BNX), and complaints have focused on the side effect profile. There has been no comparison of patient satisfaction and side effects of the three most common OMT medications. AIM: To compare patient satisfaction with OMT and side effects of BNX, buprenorphine monopreparate (BUP), and methadone (MET) as reported by patients...
March 29, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29617066/the-mixed-opioid-receptor-antagonist-naltrexone-mitigates-stimulant-induced-euphoria-a-double-blind-placebo-controlled-trial-of-naltrexone
#15
Thomas J Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone, Maura Fitzgerald, Amy M Yule, Mai Uchida, Andrea E Spencer, Anna M Hall, Ariana J Koster, Leah Feinberg, Sarah Kassabian, Barbara Storch, Joseph Biederman
OBJECTIVE: Supratherapeutic doses of methylphenidate activate μ-opioid receptors, which are linked to euphoria. This study assessed whether naltrexone, a mixed μ-opioid antagonist, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential in subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: We conducted a 6-week, double-blind, placebo-controlled, randomized clinical trial of naltrexone in adults with DSM-IV ADHD receiving open treatment with a long-acting formulation of methylphenidate (January 2013 to June 2015)...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29609153/the-effect-of-housing-first-on-adherence-to-methadone-maintenance-treatment
#16
Milad Parpouchi, Akm Moniruzzaman, Stefanie N Rezansoff, Angela Russolillo, Julian M Somers
BACKGROUND: Opioid overdose deaths have become a public health crisis in North America, and those who are homeless are particularly vulnerable. Methadone maintenance treatment (MMT) may prevent overdose and death among homeless people with opioid dependence, but suboptimal medication adherence is a common limitation. Previous research found that Housing First (HF) increases antipsychotic medication adherence among formerly homeless people. However, no experimental trials have examined whether HF has a significant impact on MMT adherence...
March 30, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29601303/the-opioid-epidemic-and-pregnancy-implications-for-anesthetic-care
#17
Britany L Raymond, Bradley T Kook, Michael G Richardson
PURPOSE OF REVIEW: This review summarizes evolving knowledge regarding adverse maternal, fetal, and neonatal effects of opioid exposure during pregnancy, and current treatment options for opioid use disorder (OUD). Maternal and fetal implications of maternal opioid maintenance with methadone and buprenorphine are described. Finally, acute and chronic pain management strategies in opioid-tolerant parturients are reviewed. RECENT FINDINGS: Opioid use among parturients has risen dramatically, with opioid use during pregnancy as high as 20%...
March 29, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29595995/barriers-and-facilitators-of-breastfeeding-reported-by-postpartum-women-in-methadone-maintenance-therapy
#18
Jennifer Hicks, Elizabeth Morse, David K Wyant
INTRODUCTION: This study utilized a cross-sectional qualitative and quantitative interview-based survey to capture the infant feeding practices and barriers to exclusive breastfeeding for women in methadone maintenance therapy. Participants were recruited from an opioid dependence treatment center in an urban setting in the Southeastern United States. MATERIALS AND METHODS: A convenience sample of women in treatment (n = 30) were interviewed using an adapted instrument designed to capture decisions and intentions to formula feed or breastfeed; support from friends and family; hospital experience; support from healthcare personnel; and maternal knowledge of breastfeeding while taking methadone...
March 29, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29595410/a-novel-approach-to-treating-adolescents-with-opioid-use-disorder-in-pediatric-primary-care
#19
Sharon Levy, Shannon Mountain-Ray, Jason Reynolds, Steven J Mendes, Jonas Bromberg
BACKGROUND: Medication treatment for opioid use disorder is effective, and recommended for adolescents, though very few adolescents with opioid use disorder ever receive medications. Reasons include lack of trained medication prescribers for this age group and difficulty in identifying adolescents with substance use disorders. This manuscript examines a novel implementation model of identifying and providing treatment for substance use disorders, including opioid use disorder, in a pediatric primary care practice...
March 29, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29589873/cost-effectiveness-of-hydromorphone-for-severe-opioid-use-disorder-findings-from-the-salome-randomized-clinical-trial
#20
Nick Bansback, Daphne Guh, Eugenia Oviedo-Joekes, Suzanne Brissette, Scott Harrison, Amin Janmohamed, Michael Krausz, Scott MacDonald, David C Marsh, Martin T Schechter, Aslam H Anis
BACKGROUND AND AIMS: Previous research has found diacetylmorphine, delivered under supervision, to be cost-effective in the treatment of severe opioid use disorder, but diacetylmorphine is not available in many settings. The Study to Assess Long-term Opioid Maintenance Effectiveness (SALOME) randomized controlled trial provided evidence that injectable hydromorphone is non-inferior to diacetylmorphine. The current study aimed to compare the cost-effectiveness of hydromorphone directly with diacetylmorphine and indirectly with methadone maintenance treatment...
March 28, 2018: Addiction
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