keyword
https://read.qxmd.com/read/37797653/osmotic-demyelination-syndrome-caused-by-rapid-correction-of-hyperammonemia-and-continuous-hyperbilirubinemia-a-case-report-and-review-of-the-literature
#1
Kunwoo Park, Sang Beom Kim, Sung Sang Yoon, Ho Geol Woo
Osmotic demyelination syndrome (ODS) is an acute demyelinating disorder characterized by the loss of myelin in the center of the basis pons, defined as central pontine myelinolysis (CPM), and demyelination in locations outside the pons, defined as extrapontine myelinolysis (EPM). ODS including CPM and EPM is mainly caused by rapid correction of hyponatremia. However, there are several reports of ODS in medical conditions such as malnutrition; alcoholism; liver transplantation; malignancy; sepsis; and electrolyte imbalance including hypernatremia, hypokalemia, hypophosphatemia, and chronic illness...
October 6, 2023: Encephalitis
https://read.qxmd.com/read/37651067/treatment-of-cholestasis-in-infants-and-young-children
#2
REVIEW
Nicole Heinz, Jennifer Vittorio
PURPOSE OF REVIEW: Cholestasis is characterized by a conjugated hyperbilirubinemia secondary to impaired bile synthesis, transport, or excretion from the liver. It is always pathologic and can be indicative of an underlying hepatobiliary, genetic, or metabolic disorder, several of which require timely diagnosis to ensure proper management and optimal outcomes. This review provides an overview of the evaluation of cholestasis with a focus on current and emerging treatment strategies. RECENT FINDINGS: Increased accessibility of next generation sequencing (NGS) allows for utilization of genetic testing early in the diagnostic process...
August 31, 2023: Current Gastroenterology Reports
https://read.qxmd.com/read/36635154/multiple-portions-enteral-nutrition-and-chyme-reinfusion-of-a-blunt-bowel-injury-patient-with-hyperbilirubinemia-undergoing-open-abdomen-a-case-report
#3
Kai Wang, Yun-Xuan Deng, Kai-Wei Li, Xin-Yu Wang, Chao Yang, Wei-Wei Ding
Blunt bowel injury (BBI) is relatively rare but life-threatening when delayed in surgical repair or anastomosis. Providing enteral nutrition (EN) in BBI patients with open abdomen after damage control surgery is challenging, especially for those with discontinuity of the bowel. Here, we report a 47-year-old male driver who was involved in a motor vehicle collision and developed ascites on post-trauma day 3. Emergency exploratory laparotomy at a local hospital revealed a complete rupture of the jejunum and then primary anastomosis was performed...
December 20, 2022: Chinese Journal of Traumatology
https://read.qxmd.com/read/34480466/clinical-profile-of-children-with-cystic-fibrosis-surviving-through-adolescence-and-beyond
#4
JOURNAL ARTICLE
Arvind Kumar, Bhawana Aggarwal, Princy Bamal, Kana Ram Jat, Rakesh Lodha, S K Kabra
OBJECTIVE: To document morbidities in adolescents with cystic fibrosis from India. METHODS: Details of children with cystic fibrosis surviving beyond 15 years of age were extracted from hospital records, and analyzed. Results: 43 children [Median (IQR) age 18.7 (17, 20.6) years, were enrolled. Median (IQR) body mass index was 15.82 (13.5, 19.05) kg/m2. Pseudomonas species were isolated from respiratory specimens of 34 (79%) adolescents. Allergic bronchopulmonary aspergillosis (ABPA) and Cystic fibrosis related diabetes (CFRD) were seen in 12 (28%) and 11 (26%) patients, respectively...
September 4, 2021: Indian Pediatrics
https://read.qxmd.com/read/34134590/novel-oxytocin-receptor-antagonists-for-tocolysis-a-systematic-review-and-meta-analysis-of-the-available-data-on-the-efficacy-safety-and-tolerability-of-retosiban
#5
JOURNAL ARTICLE
Greg Marchand, Richard Blumrick, Alexandra D Ruuska, Kelly Ware, Ahmed Taher Masoud, Alexa King, Stacy Ruther, Giovanna Brazil, Kaitlynne Cieminski, Nicolas Calteux, Hollie Ulibarri, Katelyn Sainz
OBJECTIVE: To assess the efficacy, safety, and tolerability of retosiban-a novel tocolytic unavailable in the US-in the management of preterm labor. METHODS: We searched ClinicalTrials.Gov, MEDLINE, PubMed, SCOPUS, Web of Science, and the Cochrane Library for relevant clinical trials using the terms "retosiban" and "preterm labor" through 09/2020. We included all published randomized clinical trials (three) that compared retosiban to placebo for preterm labor, excluding conferences, books, reviews, posters, case reports, and animal studies...
September 2021: Current Medical Research and Opinion
https://read.qxmd.com/read/29985210/features-of-adult-hyperammonemia-not-due-to-liver-failure-in-the-icu
#6
JOURNAL ARTICLE
Amra Sakusic, Moldovan Sabov, Amanda J McCambridge, Alejandro A Rabinstein, Tarun D Singh, Kumar Mukesh, Kianoush B Kashani, David Cook, Ognjen Gajic
OBJECTIVES: To evaluate the epidemiology of hyperammonemia unrelated to liver failure in the critical care setting. DESIGN: Retrospective case series. SETTING: Critically ill patients admitted to ICUs at Mayo Clinic, Rochester, MN (medical ICU, two mixed medical-surgical ICUs, coronary care unit, or the cardiosurgical ICU) between July 1, 2004, and October 31, 2015. PATIENTS: Adult critically ill patients with hyperammonemia not related to acute or chronic liver failure...
September 2018: Critical Care Medicine
https://read.qxmd.com/read/26722008/delirium-frequency-and-risk-factors-among-patients-with-cancer-in-palliative-care-unit
#7
JOURNAL ARTICLE
Gülcin Şenel, Neşe Uysal, Gonca Oguz, Mensure Kaya, Nihal Kadioullari, Nesteren Koçak, Serife Karaca
Introductıon: Delirium is a complex but common disorder in palliative care with a prevalence between 13% and 88% but a particular frequency at the end of life yet often remains insufficiently diagnosed and managed. The aim of our study is to determine the frequency of delirium and identify factors associated with delirium at palliative care unit. METHODS: Two hundred thirteen consecutive inpatients from October 1, 2012, to March 31, 2013, were studied prospectively. Age, gender, Palliative Performance Scale (PPS), Palliative Prognostic Index (PPI), length of stay in hospital, and delirium etiology and subtype were recorded...
April 2017: American Journal of Hospice & Palliative Care
https://read.qxmd.com/read/25528833/-state-of-homeostasis-links-in-the-children-with-intestinal-colic
#8
JOURNAL ARTICLE
O M Horlenko, U H Dubinina
The state of homeostasis links in the children with intestinal colic is represented by the following parameters and clinical characteristics. The data of investigated children's contingent with intestinal colic prevailed by following comorbidities: SARS--12 (18.18% ± 4.78%), protein-energy malnutrition--9 (12.85% ± 3.82%), pneumonia--6 (8.57% ± 3.57%), atopic dermatitis--7 (10.00% ±.3.57%). All children have a next complaints: flatulence (100%), in the 62 children (88.57% ± 3.82%) were identificated frequent regurgitation, in the 48 (80...
November 2014: Likars'ka Sprava
https://read.qxmd.com/read/25318617/a-descriptive-study-of-16-severe-plasmodium-vivax-cases-from-three-municipalities-of-colombia-between-2009-and-2013
#9
JOURNAL ARTICLE
Anthony T O'Brien, Jesica F Ramírez, Sandra P Martínez
BACKGROUND: Plasmodium vivax, the most geographically distributed cause of malaria, accounts for more than 70% of cases in the Americas. In Colombia, P. vivax was responsible for 67.3% of cases in the last five years. Despite vivax malaria impact worldwide, historically it has been neglected and considered to be a benign disease. In the last decade medical literature reports have emerged countering this benign outlook. This study pretends to describe the clinical and paraclinical profile of severe vivax malaria cases hospitalized in Tumaco, Cali, Buenaventura between 2009 and 2013, to contribute to the knowledge regarding the behaviour and clinical expression of this disease...
October 15, 2014: Malaria Journal
https://read.qxmd.com/read/24951989/metabolic-disorders-of-liver-and-iron-in-diabetic-and-non-diabetic-patients-bmi-35-or-35-before-gastric-bypass
#10
JOURNAL ARTICLE
Manuel Garcíacaballero, Alexander Reyes-Ortiz, José Manuel Martínez-Moreno, José Antonio Toval-Mata
INTRODUCTION: The presence of abnormalities in the metabolic pathways of iron and liver functioning can produce insulin resistance or metabolic syndrome. Therefore, it is important to examine those alterations that may lead to the development of diseases. Nutritional status is another important factor that is intimately linked to diabetes and obesity. PATIENTS AND METHODS: We studied 131 patients (78 nondiabetic patients and 53 diabetic), 37 patients BMI ≤35 (3 BMI < 25, 18 BMI 25-29...
May 1, 2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/24593282/impact-of-nutritional-status-of-egyptian-patients-with-end-stage-liver-disease-on-their-outcomes-after-living-donor-liver-transplantation
#11
MULTICENTER STUDY
Ayman Yosry, Dalia Omran, Mohamad Said, Waleed Fouad, Osama Fekry
OBJECTIVE: Malnutrition is prevalent among patients with end-stage liver disease (ESLD) awaiting liver transplantation. Our aim was to examine prospectively the impact of patients' nutritional status on their outcomes after living donor liver transplantation (LDLT). METHODS: In all, 30 patients scheduled for LDLT were subjected to a preoperative nutritional status assessment through subjective global assessment (SGA), nutritional risk screening (NRS 2002) and anthropometric measurements...
June 2014: Journal of Digestive Diseases
https://read.qxmd.com/read/22271646/four-hundred-thirty-consecutive-pediatric-living-donor-liver-transplants-variables-associated-with-posttransplant-patient-and-graft-survival
#12
JOURNAL ARTICLE
Joao Seda Neto, Renata Pugliese, Eduardo A Fonseca, Rodrigo Vincenzi, Vincenzo Pugliese, Helry Candido, Alberto B Stein, Marcel Benavides, Bernardo Ketzer, Hsiang Teng, Gilda Porta, Irene K Miura, Vera Baggio, Teresa Guimaraes, Adriana Porta, Celso Arrais Rodrigues, Francisco C Carnevale, Eduardo Carone, Mario Kondo, Paulo Chapchap
The availability of living donors allows transplant teams to indicate living donor liver transplantation (LDLT) early in the course of liver disease before the occurrence of life-threatening complications. Late referral to transplant centers is still a problem and can compromise the success of the procedure. The aim of this study was to examine the perioperative factors associated with patient and graft survival for 430 consecutive pediatric LDLT procedures at Sirio-Libanes Hospital/A. C. Camargo Hospital (São Paulo, Brazil) between October 1995 and April 2011...
May 2012: Liver Transplantation
https://read.qxmd.com/read/19382077/-peritoneal-dialysis-in-cirrhotic-patients
#13
REVIEW
A F De Vecchi
Renal failure and the need for dialysis worsen the prognosis of patients with combined liver and kidney disease. The choice of an appropriate dialysis technique should improve the life expectancy of these patients. Hypotension, impaired defence against infections, electrolyte and acid-base imbalance, severe protein and caloric malnutrition, hyperammonemia, hyperbilirubinemia, and inadequate response to diuretics present a number of clinical problems in patients with liver insufficiency. Liver failure is therefore considered an important risk factor for any type of dialysis...
March 2009: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/17542291/gastrointestinal-problems-at-high-altitude
#14
REVIEW
A C Anand, V K Sashindran, Latika Mohan
Gastrointestinal (GI) problems at high altitude are commonplace. The manifestations differ considerably in short-term visitors, long-term residents and native highlanders. Ethnic food habits and social norms also play a role in causing GI dysfuntion. Symptoms like nausea and vomiting are common manifestations of acute mountain sickness and are seen in 81.4% short-term visitors like mountaineers. Anorexia is almost universal and has a mutifactorial causation including effect of hormones like leptin and cholecystokinin and also due to hypoxia itself...
October 2006: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
https://read.qxmd.com/read/9623033/metabolic-and-immune-effects-of-dietary-arginine-glutamine-and-omega-3-fatty-acids-supplementation-in-immunocompromised-patients
#15
COMPARATIVE STUDY
C Chuntrasakul, S Siltharm, S Sarasombath, C Sittapairochana, W Leowattana, S Chockvivatanavanit, A Bunnak
To evaluate the nutritional, metabolic and immune effects of dietary arginine, glutamine and omega-3 fatty acids (fish oil) supplementation in immunocompromised patients, we performed a prospective study on the effect of immune formula administered to 11 severe trauma patients (average ISS = 24), 10 burn patients (average % TBSA = 48) and 5 cancer patients. Daily calorie and protein administration were based on the patient's severity (Stress factor with the range of 35-50 kcal/kg/day and 1.5-2.5 g/kg/day, respectively) Starting with half concentration liquid immune formula through nasogastric tube by continuous drip at 30 ml/h and increasing to maximum level within 4 days...
May 1998: Journal of the Medical Association of Thailand
https://read.qxmd.com/read/8856579/growth-hormone-insensitivity-in-children-with-biliary-atresia
#16
JOURNAL ARTICLE
J C Bucuvalas, J A Horn, J Slusher, M P Alfaro, S D Chernausek
Malnutrition is a critical predictor of mortality and morbidity in children with biliary atresia who undergo orthotopic liver transplantation. Growth hormone (GH) enhances nitrogen retention in patients with chronic obstructive lung disease, sepsis, and in fasted adult volunteers. The goal of this study was to assess the acute response to recombinant human GH (rhGH) treatment in children with biliary atresia to determine whether GH therapy was likely to improve pretransplant nutritional status. Five children, aged 10-32 months, with biliary atresia and persistent cholestasis despite surgical attempts to reestablish bile flow, were studied...
August 1996: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/8128361/effect-of-route-of-nutrition-on-recovery-of-hepatic-organic-anion-clearance-after-fasting
#17
JOURNAL ARTICLE
B Waters, K A Kudsk, E J Jarvi, R O Brown, T C Fabian, G C Wood
BACKGROUND: Previous work documented a 40% depression of hepatic indocyanine green (ICG) clearance (ClICG) in pigs fasted to 20% weight loss, with return to normal within 12 days of food refeeding. ClICG in pigs is insensitive to changes in hepatic blood flow but very sensitive to changes in hepatic function (HF). Serial ClICG determinations were performed to quantify the effect of route of nutrient delivery on recovery of HF. METHODS: Fourteen pigs were fasted to 20% weight loss (12...
March 1994: Surgery
https://read.qxmd.com/read/3751957/changes-in-nutritional-status-associated-with-obstructive-jaundice-and-biliary-drainage-in-rats
#18
JOURNAL ARTICLE
D J Gouma, P T Roughneen, S Kumar, F G Moody, B J Rowlands
Effect of bile duct ligation (BDL) and internal biliary drainage on food intake and nutritional status was studied in rats and compared with sham and pair-fed animals. During week 1, food intake of BDL animals was reduced (p less than 0.05), resulting in weight loss (p less than 0.05). In weeks 2 and 3, food intake, nitrogen balance, and weight gain were similar in all groups. Internal biliary drainage or sham operation after 3 wk produced transient changes in food intake and N2 balance. Serum albumin fell in all groups, returned to normal in sham (3...
September 1986: American Journal of Clinical Nutrition
https://read.qxmd.com/read/3463238/paediatric-liver-disorders-in-singapore
#19
JOURNAL ARTICLE
H B Wong
The liver in an infant or child is as liable to the same pathologies afflicting the adult liver but with certain differences in prevalence and causes. Genetic disorders are more likely to present in the paediatric age group where many involve metabolic processes such as galactosemia, phenylketonuria, glycogen storage disease and others. Many of these present in the newborn period. However, neoplasms and hamartomas also present in the newborn period, such as congenital neuroblastoma with an enormously enlarged liver, hepatoblastoma and haemangioma...
April 1986: Annals of the Academy of Medicine, Singapore
https://read.qxmd.com/read/3122016/-clinical-analysis-of-postoperative-hyperbilirubinemia-following-resection-of-esophageal-cancer
#20
JOURNAL ARTICLE
T Tsujinaka, Y Kido, Y Ogawa, T Mori
Postoperative hyperbilirubinemia (Bil greater than or equal to 2, II greater than or equal to 15) was observed in 46.9% of 239 cases of esophageal cancer, since 1969. The incidence increased significantly from 31 to 55.9% after introducing total parenteral nutrition (TPN) for pre-postoperative nutritional support. In retrosternal reconstruction it was significantly higher (57.8%) than any other operative procedures. Further investigation was done in recent 128 cases since 1979. Postoperative hyperbilirubinemia was observed in 59%...
August 1987: Nihon Geka Gakkai Zasshi
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