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https://www.readbyqxmd.com/read/27704169/hepatic-expression-of-transcription-factors-affecting-developmental-regulation-of-ugt1a1-in-the-han-chinese-population
#1
Ya-Li Nie, Hang He, Jiang-Feng Li, Xiang-Guang Meng, Liang Yan, Pei Wang, Shu-Jie Wang, Hong-Zheng Bi, Li-Rong Zhang, Quan-Cheng Kan
PURPOSE: Complete or partial inactivity of UGT1A1, the unique enzyme responsible for bilirubin glucuronidation, is commonly associated with hyperbilirubinemia. We investigated the dynamic expression of UGT1A1, and that of the transcription factors (TFs) involved in its developmental regulation, during human hepatic growth in Han Chinese individuals. METHODS: Eighty-eight prenatal, pediatric, and adult liver samples were obtained from Han Chinese individuals. Quantitative real-time polymerase chain reaction was used to evaluate mRNA expression of UGT1A1 and TFs including PXR, CAR, HNF1A, HNF4A, PPARA, etc...
October 5, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27677263/atazanavir-and-cardiovascular-risk-among-human-immunodeficiency-virus-infected-patients-a-systematic-review
#2
Dominic Chow, Cecilia Shikuma, Corey Ritchings, Muxing Guo, Lisa Rosenblatt
INTRODUCTION: Patients with human immunodeficiency virus (HIV) infection have an increased risk of cardiovascular disease (CVD). While viral suppression with antiretroviral therapy decreases CVD risk overall, several studies have suggested that certain antiretrovirals, particularly certain protease inhibitors, may be associated with an increased relative risk of CVD. In AIDS Clinical Trials Group 5260 s, ritonavir-boosted atazanavir (ATV) was associated with slower atherosclerosis progression compared to ritonavir-boosted darunavir and raltegravir, potentially due to hyperbilirubinemia...
September 27, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27631159/the-use-of-erwinia-asparaginase-for-adult-patients-with-acute-lymphoblastic-leukemia-after-pegaspargase-intolerance
#3
Troy Z Horvat, Joshua J Pecoraro, Ryan J Daley, Larry W Buie, Amber C King, Raajit K Rampal, Martin S Tallman, Jae H Park, Dan Douer
Asparaginase administration has become a crucial component of front-line pediatric and pediatric-insipired multi-agent regimens for the treatment of acute lymphoblastic leukemia (ALL). The aim of this retrospective study was to assess the safety and feasibility of switching to Erwinia asparaginase after pegaspargase intolerance in adult ALL patients treated at Memorial Sloan Kettering Cancer Center. Our analysis included 10 patients, with a median age of 39 years (range 20-72), male predominance (90%), and a typical B-cell to T-cell ratio (70:30%) for ALL...
August 26, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27550361/early-bactericidal-activity-of-azd5847-in-pulmonary-tuberculosis
#4
Jennifer J Furin, Jeannine Du Bois, Elana van Brakel, Phalkun Chheng, Amour Venter, Charles A Peloquin, Abdullah Alsultan, Bonnie Thiel, Sara M Debanne, W Henry Boom, Andreas H Diacon, John L Johnson
RATIONALE: AZD5847 is an oxazolidinone antibiotic, with in vitro activity against Mycobacterium tuberculosis OBJECTIVES: To evaluate the antimycobacterial activity, safety, and pharmacokinetics of AZD5847 in patients with pulmonary tuberculosis. METHODS: Groups of 15 treatment-naive, sputum smear-positive adults with pulmonary tuberculosis were randomly assigned to AZD5847 at 4 doses (500 mg once daily, 500 mg twice daily, 1200 mg once daily and 800 mg twice daily) or daily standard chemotherapy...
August 22, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27542957/hypoalbuminemia-is-significantly-associated-with-increased-clearance-time-of-high-dose-methotrexate-in-patients-being-treated-for-lymphoma-or-leukemia
#5
Samantha N Reiss, Larry W Buie, Nelly Adel, Debra A Goldman, Sean M Devlin, Dan Douer
As a weak acid, methotrexate (MTX) is bound to serum albumin and has variable protein binding. The purpose of this study was to assess serum albumin's relationship with MTX pharmacokinetics by comparing MTX clearance and toxicities between patients with normal serum albumin to those with hypoalbuminemia. This single-center retrospective study included adult patients with leukemia or lymphoma who received their first MTX at a dose ≥1 g/m(2). Hypoalbuminemia was defined as serum albumin ≤3.4 g/dL. MTX clearance was defined as the first documented time the MTX level ≤0...
December 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27519946/favism-the-commonest-form-of-severe-hemolytic-anemia-in-palestinian-children-varies-in-severity-with-three-different-variants-of-g6pd-deficiency-within-the-same-community
#6
N Scott Reading, Mahmoud M Sirdah, Mohammad E Shubair, Benjamin E Nelson, Mustafa S Al-Kahlout, Jamal M Al-Tayeb, Lina N Aboud, Maysaa Abu Shaban, Lucio Luzzatto, Josef T Prchal
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic abnormality known to predispose to acute hemolytic anemia (AHA), which can be triggered by certain drugs or infection. However, the commonest trigger is fava beans (Vicia faba) ingestion, causing AHA (favism), which may be life-threatening especially in children. G6PD deficiency is genetically highly heterogeneous, as nearly 200 different mutations have been observed. We have investigated the hematological features of acute favism in the Palestinian Gaza community that is characterized by the polymorphic coexistence of three different G6PD deficiency genes (G6PD A-, G6PD Cairo, G6PD Med)...
September 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27509944/incidence-and-management-of-toxicity-associated-with-lasparaginase-in-the-treatment-of-all-and-nk-tcell-lymphoma-an-observational-study
#7
Shu Hui Yeang, Alexandre Chan, Chuen Wen Tan, Soon Thye Lim, Heng Joo Ng
BACKGROUND: Lasparaginase (ASNase) is commonly used in the treatment of acute lymphoblastic leukemia (ALL) and natural killer (NK)/Tcell lymphoma. This study was designed to describe the incidence of toxicity associated with ASNase in Asian adults. Secondary objectives were to investigate the management and impact of toxicity on subsequent ASNase use, and to compare the actual management against current recommendations. MATERIALS AND METHODS: In this retrospective, multicenter, observational study, Asian patients ≥ 18 years old who received ≥ 1 dose of the native E...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27465587/risk-of-hemophagocytic-lymphohistiocytosis-in-adults-with-fevers-of-unknown-origin-the-clinical-utility-of-a-new-scoring-system-on-early-detection
#8
Hao-Yuan Wang, Ching-Fen Yang, Tzeon-Jye Chiou, Sheng-Hsiang Yang, Jyh-Pyng Gau, Yuan-Bin Yu, Po-Min Chen, Hui-Chi Hsu, Chang-Phone Fung, Hsiao-Yi Lin, Cheng-Hwai Tzeng, Jin-Hwang Liu, Liang-Tsai Hsiao
The diagnosis of hemophagocytic lymphohistiocytosis (HLH) is delayed by most physicians. This study aimed to identify early parameters and suitable scoring systems for the risk of HLH. Clinical and laboratory data collected ≤3 days after admission were defined as early parameters and used to calculate the number of HLH-2004 criteria met and bone marrow (BM) score. Between January 2006 and February 2016, 233 immunocompetent adults with naïve fever of unknown origin who underwent a BM study were enrolled to mimic patients at risk of HLH and randomly assigned into the developmental or validation cohort...
July 28, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27358786/higher-plasma-bilirubin-predicts-veno-occlusive-disease-in-early-childhood-undergoing-hematopoietic-stem-cell-transplantation-with-cyclosporine
#9
Kwi Suk Kim, Aree Moon, Hyoung Jin Kang, Hee Young Shin, Young Hee Choi, Hyang Sook Kim, Sang Geon Kim
AIM: To analyze the association between plasma bilirubin levels and veno-occlusive disease (VOD) in non-adult patients undergoing hematopoietic stem cell transplantation (HSCT) during cyclosporine therapy. METHODS: A total of 123 patients taking cyclosporine were evaluated using an electronic medical system at the Seoul National University Children's Hospital from the years 2004 through 2011. Patients were grouped by age and analyzed for incidence and type of adverse drug reactions (ADRs) including VOD...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27326811/patterns-of-early-allograft-dysfunction-in-adult-live-donor-liver-transplantation-the-a2all-experience
#10
James J Pomposelli, Nathan P Goodrich, Jean C Emond, Abhinav Humar, Talia B Baker, David R Grant, Robert A Fisher, John P Roberts, Kim M Olthoff, Brenda W Gillespie, Robert M Merion
BACKGROUND: Early allograft dysfunction (EAD) after living donor liver transplantation (LDLT) has often been attributed to inadequate graft size, and termed small-for-size syndrome. Early allograft dysfunction definitions include a variable constellation of findings, including hyperbilirubinemia, coagulopathy, encephalopathy, and ascites formation. Among putative causes of EAD after LDLT are excessive portal pressure and/or flow. Our objective was to evaluate patterns of EAD after LDLT...
July 2016: Transplantation
https://www.readbyqxmd.com/read/27255829/adult-onset-hemophagocytic-lymphohistiocytosis-prognosis-is-affected-by-underlying-disease-and-coexisting-viral-infection-analysis-of-a-single-institution-series-of-35-patients
#11
Chiara Cattaneo, Margherita Oberti, Cristina Skert, Angela Passi, Mirko Farina, Alessandro Re, Paola Tozzi, Erika Borlenghi, Giuseppe Rossi
Adult onset hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which can develop as a complication of many disorders. Early diagnosis is essential in order to avoid a fatal outcome. To confirm the diagnosis of acquired HLH made in a single institution series of adult patients with HLH-04 criteria, we applied the HScore and evaluated prognostic factors associated with clinical outcome. The median age of 35 patients was 54 (range 17-81), M/F ratio was 20/15. In 26/35 (74.3%) patients, an underlying haematological disease was present (2 Multicentric Castleman Disease, 10 B-cell Non-Hodgkin Lymphoma [NHL] and 14 T/NK-cell NHL); an autoimmune disorder was observed in four (11...
June 3, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27171984/phase-2-study-of-intensified-chemotherapy-and-allogeneic-hematopoietic-stem-cell-transplantation-for-older-patients-with-acute-lymphoblastic-leukemia
#12
Amir T Fathi, Daniel J DeAngelo, Kristen E Stevenson, Jonathan E Kolitz, Julie D Asch, Philip C Amrein, Eyal C Attar, David P Steensma, Martha Wadleigh, Julia Foster, Christine Connolly, Ilene Galinsky, Craig E Devoe, Richard M Stone, Donna S Neuberg, Karen K Ballen
BACKGROUND: Outcomes among older patients with acute lymphoblastic leukemia remain poor. This study sought to determine the efficacy of an intensified, multi-agent approach derived from a Dana-Farber consortium trial in younger adults for patients older than 50 years (trial identifier NCT00973752). METHODS: The primary endpoint was overall survival (OS) at 1 year. Patients received induction chemotherapy with vincristine, prednisone, doxorubicin, and pegylated asparaginase...
August 1, 2016: Cancer
https://www.readbyqxmd.com/read/27154793/severe-direct-hyperbilirubinemia-as-a-consequence-of-right-heart-failure-in-congenital-heart-disease
#13
Joseph Philip, Ravi S Samraj, Dalia Lopez-Colon, Regino Gonzalez-Peralta, Arun Chandran, Mark S Bleiwies
Adult literature documents increased cholestasis in right heart failure yet is poorly documented in the pediatric population. We describe three infants with congenital heart disease who developed significantly elevated direct bilirubin levels of 43, 23, and 12 mg/dL, respectively, in the absence of hepatic dysfunction. The common hemodynamic pathophysiology in these infants is right heart dysfunction with moderate to severe tricuspid regurgitation in the setting of low perfusion state. Right heart dysfunction in infants can result in severe conjugated bilirubin, likely as a consequence of venous congestion and can be used as an indirect marker of right heart dynamics...
May 6, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/26841296/l-carnitine-for-treatment-of-pegasparaginase-induced-hepatotoxicity
#14
Ruham Alshiekh-Nasany, Dan Douer
INTRODUCTION: Similar to pediatric regimens, multiple doses of L-asparaginase (PEG-Asp) are being increasingly used in adults with newly diagnosed acute lymphoblastic leukemia (ALL) with promising results. One of the most common side effects of the drug in adults is high-grade hyperbilirubinemia and transaminitis. Despite being almost always reversible and may not recur, clinicians may still be reluctant to continue with PEG-Asp in patients with liver toxicity, losing the benefit from multiple doses of the drug...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/26714506/a-prospective-study-from-south-india-to-compare-the-severity-of-malaria-caused-by-plasmodium-vivax-p-falciparum-and-dual-infection
#15
Shubhanker Mitra, Kpp Abhilash, Shalabh Arora, Angel Miraclin
BACKGROUND & OBJECTIVES: Traditionally, Plasmodium falciparum has been attributed to cause severe malaria, whereas P. vivax is considered to cause "benign" tertian malaria. Recently, there has been an increasing body of evidence challenging this conviction. However, the spectrum and degree of severity of the disease caused by P. vivax, as per World Health Organization (2012) remains unclear. Thus, in this prospective study, we aimed at comparing the severity of malaria caused by P. vivax, P...
December 2015: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/26699814/postoperative-neutrophil-to-lymphocyte-ratio-of-living-donor-liver-transplant-association-with-graft-size
#16
Hironori Hayashi, Hiroyuki Takamura, Yoshinao Ohbatake, Shinichi Nakanuma, Isamu Makino, Hisatoshi Nakagawara, Tomoharu Miyashita, Hidehiro Tajima, Sachio Fushida, Tetsuo Ohta
Issues related to small-for-size grafts in living donor liver transplantation (LDLT) are highly important. The neutrophil lymphocyte ratio (NLR) has been reported to be an inexpensive index of systemic inflammation for various diseases. We retrospectively evaluated the relationship between NLR and clinical course of 61 adult LDLT recipients in our institute until post-operative day 14. Patients were classified into two groups based on the graft volume divided by standard liver volume, as over 35% of graft volume divided by standard liver volume (GV/SLV) (Group L; n = 55) and under 35% of GV/SLV (Group S; n = 6)...
April 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/26595259/optimal-dose-of-gemcitabine-for-the-treatment-of-biliary-tract-or-pancreatic-cancer-in-patients-with-liver-dysfunction
#17
Takashi Shibata, Tomoki Ebata, Ken-ichi Fujita, Tomoya Shimokata, Osamu Maeda, Ayako Mitsuma, Yasutsuna Sasaki, Masato Nagino, Yuichi Ando
A clear consensus does not exist about whether the initial dose of gemcitabine, an essential anticancer antimetabolite, should be reduced in patients with liver dysfunction. Adult patients with biliary tract or pancreatic cancer were divided into three groups according to whether they had mild, moderate, or severe liver dysfunction, evaluated on the basis of serum bilirubin and liver transaminase levels at baseline. As anticancer treatment, gemcitabine at a dose of 800 or 1000 mg/m(2) was given as an i.v. infusion once weekly for 3 weeks of a 4-week cycle...
February 2016: Cancer Science
https://www.readbyqxmd.com/read/26354310/bilirubin-encephalopathy-in-a-domestic-shorthair-cat-with-increased-osmotic-fragility-and-cholangiohepatitis
#18
E T Contreras, U Giger, J L Malmberg, J M Quimby, P A Schaffer
A 7-month-old female domestic shorthair cat was diagnosed with chronic regenerative hemolytic anemia characterized by increased osmotic fragility of unknown etiology. At 13 months of age, the cat was evaluated for acute collapse. The cat was icteric with severe hyperbilirubinemia but no hematocrit changes. Severe obtundation and lateral recumbency progressed to tetraparesis and loss of proprioception in all 4 limbs, and a cerebellar or brainstem lesion was suspected. Postmortem examination revealed suppurative cholangiohepatitis and acute neuronal necrosis in the nuclei of the brainstem and cerebellum, consistent with bilirubin encephalopathy...
May 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/26129885/crimean-congo-hemorrhagic-fever-with-hyperbilirubinemia-and-ascites-an-unusual-presentation
#19
Zeynep Ture, Ayşegül Ulu Kılıç, Ilhami Celik, Tugba Tok, Dilek Yağcı-Çağlayık
Crimean-Congo hemorrhagic fever (CCHF) is a fatal systemic viral infection which is an important health problem in Turkey. Many systemic symptoms have been reported including fever, hemorrhage, headache, fatigue, muscle ache, abdominal pain, nausea and vomiting. A 45-year-old male farmer with CCHF presented with massive peritoneal effusion and hyperbilirubinemia. To our knowledge, this is the first case of peritoneal effusion and hyperbilirubinemia in an adult patient with CCHF. His clinical symptoms successfully improved with supportive therapy...
January 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/26101675/marked-direct-hyperbilirubinemia-due-to-ceftriaxone-in-an-adult-with-sickle-cell-disease
#20
Daniyeh Khurram, Leonid Shamban, Robert Kornas, Maryann Paul
Drugs are a significant cause of liver injury. Drug-induced liver injury (DILI) can cause acute hepatitis, cholestasis, or a mixed pattern. Ceftriaxone is a commonly used antibiotic and has been associated with reversible biliary sludge, pseudolithiasis, and cholestasis. A 32-year-old male with sickle cell disease was admitted to the hospital for acute sickle cell crisis. On the second day of hospitalization, he developed cough and rhonchi with chest X-ray revealing right middle lobe infiltrates. Ceftriaxone and azithromycin were initiated...
2015: Case Reports in Gastrointestinal Medicine
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