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Critical Incident Response

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https://www.readbyqxmd.com/read/28622118/imaging-spectrum-of-invasive-fungal-and-fungal-like-infections
#1
Hilary L P Orlowski, Sebastian McWilliams, Vincent M Mellnick, Sanjeev Bhalla, Meghan G Lubner, Perry J Pickhardt, Christine O Menias
Invasive fungal and fungal-like infections contribute to substantial morbidity and mortality in immunocompromised individuals. The incidence of these infections is increasing-largely because of rising numbers of immunocompromised patients, including those with neutropenia, human immunodeficiency virus, chronic immunosuppression, indwelling prostheses, burns, and diabetes mellitus, and those taking broad-spectrum antibiotics. Invasive fungal pathogens include primary mycotic organisms such as Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis, and Paracoccidioides brasiliensis, which are true pathogens and inherently virulent...
June 16, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28611969/anastomotic-strictures-after-esophageal-atresia-repair-incidence-investigations-and-management-including-treatment-of-refractory-and-recurrent-strictures
#2
REVIEW
Renato Tambucci, Giulia Angelino, Paola De Angelis, Filippo Torroni, Tamara Caldaro, Valerio Balassone, Anna Chiara Contini, Erminia Romeo, Francesca Rea, Simona Faraci, Giovanni Federici di Abriola, Luigi Dall'Oglio
Improved surgical techniques, as well as preoperative and postoperative care, have dramatically changed survival of children with esophageal atresia (EA) over the last decades. Nowadays, we are increasingly seeing EA patients experiencing significant short- and long-term gastrointestinal morbidities. Anastomotic stricture (AS) is the most common complication following operative repair. An esophageal stricture is defined as an intrinsic luminal narrowing in a clinically symptomatic patient, but no symptoms are sensitive or specific enough to diagnose an AS...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28607211/consensus-statement-of-the-indian-academy-of-pediatrics-on-newborn-hearing-screening
#3
Abraham Paul, Chhaya Prasad, S S Kamath, Samir Dalwai, M K C Nair, Waheeda Pagarkar
JUSTIFICATION: Hearing impairment is one of the most critical sensory impairments with significant social and psychological consequences. Reported incidence of congenital hearing loss is 30 per 10,000 children. Evidence-based, standardized national guidelines are needed for professionals to screen for hearing impairment during the neonatal period. PROCESS: The meeting on formulation of national consensus guidelines on developmental disorders was organized by Indian Academy of Pediatrics in Mumbai, on 18th and 19th December, 2015...
June 4, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28585791/-pediatric-traumatic-brain-injury-due-to-civil-gunshot-wounds-at-a-general-hospital-in-cali-colombia
#4
L Parrado Sánchez, C Gómez, J A Valderrama Chaparro, L D Beltrán Osorio, M Sierra Ruiz, A Enríquez Marulanda, J Lobato Polo
OBJECTIVES: Traumatic brain injury (TBI) due to gunshot-wounds (GSW) is a critical situation in the pediatric population. The aim of this study is to characterize TBI in this population since there are few reports that describe it especially in Colombia where its incidence is high, also to determine which were the main mortality predictor within our population. MATERIAL AND METHODS: We conducted a retrospective cross-sectional study in which we reviewed pediatric medical records of patients that had consulted at the Fundacion Valle del Lili pediatric Emergency Room between January of 2011 and December of 2015 because of TBI due to GSW...
January 25, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28582027/restenosis-of-the-coronary-arteries-past-present-future-directions
#5
REVIEW
Julius B Elmore, Emile Mehanna, Sahil A Parikh, David A Zidar
Restenosis is a pathologic response to vascular injury, characterized by neointimal hyperplasia and progressive narrowing of a stented vessel segment. Although advances in stent design have led to a dramatic reduction in the incidence of restenosis, it continues to represent the most common cause of target lesion failure following percutaneous coronary intervention. Efforts to maximize restenosis prevention, through careful consideration of modifiable risk factors and an individualized approach, are critical, as restenosis, once established, can be particularly difficult to treat...
July 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28578177/the-impact-of-uterine-immaturity-on-obstetrical-syndromes-during-adolescence
#6
Ivo Brosens, Joanne Muter, Caroline Gargett, Patrick Puttemans, Giuseppe Benagiano, Jan J Brosens
Pregnant nulliparous adolescents are at increased risk - inversely proportional to their age - of major obstetric syndromes, including preeclampsia, fetal growth restriction and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28577719/personalized-therapy-in-hepatocellular-carcinoma-molecular-markers-of-prognosis-and-therapeutic-response
#7
REVIEW
Richard A Burkhart, Sean M Ronnekleiv-Kelly, Timothy M Pawlik
Hepatocellular carcinoma (HCC) represents a growing worldwide health crisis with rising incidence, limited effective therapies and persistently poor prognosis. Five-year survival remains less than 20% despite decades of research. One byproduct of research efforts is the identification of numerous biomarkers of disease. From prognosis to therapeutic response, biomarker identification parallels a deeper molecular understanding of the disease that to date has generated limited gain in clinical outcomes. As one example, the classical prognostic biomarkers of tumor Ki-67 protein expression and TP53 gene mutation have been repeatedly demonstrated to correlate with poor prognosis...
June 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28576233/disaster-preparedness-and-response-for-the-burn-mass-casualty-incident-in-the-twenty-first-century
#8
REVIEW
Randy D Kearns, David E Marcozzi, Noran Barry, Lewis Rubinson, Charles Scott Hultman, Preston B Rich
The effective and efficient coordination of emergent patient care at the point of injury followed by the systematic resource-based triage of casualties are the most critical factors that influence patient outcomes after mass casualty incidents (MCIs). The effectiveness and appropriateness of implemented actions are largely determined by the extent and efficacy of the planning and preparation that occur before the MCI. The goal of this work was to define the essential efforts related to planning, preparation, and execution of acute and subacute medical care for disaster burn casualties...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28570990/preparation-for-workplace-adversity-student-narratives-as-a-stimulus-for-learning
#9
Julie Hanson, Margaret McAllister
Nursing students are not always well prepared for the kind of adverse events they may experience in the workplace and yet it seems apparent that future students could benefit from learning about such experiences so that they can be avoided, or their impact minimised. This research aimed to identify nursing students' experiences of adversity, collaborate with students to discern important lessons for future students in their experiences, and make recommendations for other educators on how to use these adversity stories as lessons...
May 24, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28569437/tumor-necrosis-factor-alpha-role-in-development-of-insulin-resistance-and-pathogenesis-of-type-2-diabetes-mellitus
#10
Muhammad Sajid Hamid Akash, Kanwal Rehman, Aamira Liaqat
Pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance are characterized by multi-stimuli factors notably glucolipotoxicity, generation of reactive oxygen species (ROS), epigenetic factors, activation of various transcriptional mediated pathways along with the augmented levels of various pro-inflammatory cytokines. Among the various pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) is one the most important pro-inflammatory mediator that is critically involved in the development of insulin resistance and pathogenesis of T2DM...
June 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28554028/the-effects-of-low-level-ionizing-radiation-and-copper-exposure-on-the-incidence-of-antibiotic-resistance-in-lentic-biofilm-bacteria
#11
J Vaun McArthur, Christian A Dicks, A Lawrence Bryan, R Cary Tuckfield
Environmental reservoirs of antibiotic resistant bacteria are poorly understood. Understanding how the environment selects for resistance traits in the absence of antibiotics is critical in developing strategies to mitigate this growing menace. Indirect or co-selection of resistance by environmental pollution has been shown to increase antibiotic resistance. However no attention has been given to the effects of low-level ionizing radiation or the interactions between radiation and heavy metals on the maintenance or selection for antibiotic resistance (AR) traits...
May 26, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28552356/canine-brachycephaly-is-associated-with-a-retrotransposon-mediated-missplicing-of-smoc2
#12
Thomas W Marchant, Edward J Johnson, Lynn McTeir, Craig I Johnson, Adam Gow, Tiziana Liuti, Dana Kuehn, Karen Svenson, Mairead L Bermingham, Michaela Drögemüller, Marc Nussbaumer, Megan G Davey, David J Argyle, Roger M Powell, Sérgio Guilherme, Johann Lang, Gert Ter Haar, Tosso Leeb, Tobias Schwarz, Richard J Mellanby, Dylan N Clements, Jeffrey J Schoenebeck
In morphological terms, "form" is used to describe an object's shape and size. In dogs, facial form is stunningly diverse. Facial retrusion, the proximodistal shortening of the snout and widening of the hard palate is common to brachycephalic dogs and is a welfare concern, as the incidence of respiratory distress and ocular trauma observed in this class of dogs is highly correlated with their skull form. Progress to identify the molecular underpinnings of facial retrusion is limited to association of a missense mutation in BMP3 among small brachycephalic dogs...
June 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28542874/comparison-of-ixekizumab-with-ustekinumab-in-moderate-to-severe-psoriasis-24-week-results-from-ixora-s-a-phase-3-study
#13
K Reich, A Pinter, J P Lacour, C Ferrandiz, G Micali, L E French, M Lomaga, Y Dutronc, C Henneges, S Wilhelm, S Hartz, C Paul
BACKGROUND: The interleukin (IL)-23/IL-17 axis has been shown critical in the pathogenesis of psoriasis. OBJECTIVES: To present the primary endpoint (Week 12) and safety/efficacy data up to Week 24 from a head-to-head trial (IXORA-S) of the IL-17A inhibitor, ixekizumab (IXE), vs. the IL-12/23 inhibitor ustekinumab (UST). METHODS: Randomised patients received IXE (160-mg starting dose, then 80 mg every two weeks for 12 weeks, then 80 mg every four weeks, N=136) or UST (45 mg/90 mg weight-based dosing per label, N=166)...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28539355/xanthine-oxidase-inhibition-protects-against-western-diet-induced-aortic-stiffness-and-impaired-vasorelaxation-in-female-mice
#14
Guido Lastra, Camila Manrique, Guanghong Jia, Annayya R Aroor, Melvin R Hayden, Brady J Barron, Brett Niles, Jaume Padilla, James R Sowers
Consumption of a high-fat high-fructose diet (western diet, [WD]) promotes vascular stiffness, a critical factor in the development of cardiovascular disease (CVD). Obese and diabetic women exhibit greater arterial stiffness than men, which contributes to the increased incidence of CVD in women. Further, high-fructose diets result in elevated plasma concentrations of uric acid via xanthine oxidase (XO) activation, and are also associated with vascular stiffness. In turn, uric acid levels lead to vascular stiffness and CVD in women...
May 24, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28525808/characterization-of-post-disaster-environmental-management-for-hazardous-materials-incidents-lessons-learnt-from-the-tianjin-warehouse-explosion-china
#15
Hui Zhang, Huabo Duan, Jian Zuo, MingWei Song, Yukui Zhang, Bo Yang, Yongning Niu
Hazardous Materials Incidents (HMIs) have attracted a growing public concern worldwide. The health risks and environmental implications associated with HMIs are almost invariably severe, and underscore the urgency for sound management. Hazardous Materials Explosion incidents (HMEIs) belong to a category of extremely serious HMIs. Existing studies placed focuses predominately on the promptness and efficiency of emergency responses to HMIs and HMEIs. By contrast, post-disaster environmental management has been largely overlooked...
September 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28521721/the-importance-of-military-conscripts-for-surveillance-of-human-immunodeficiency-virus-infection-and-risk-behavior-in-thailand
#16
Aladdin Shadyab, Kenrad Nelson, Ram Rangsin
BACKGROUND: The epidemic of human immunodeficiency virus (HIV) infection in Thailand began in 1988 among injection drug users (IDUs) in Bangkok. It soon spread to other populations, especially female sex workers (FSWs) and men attending STD clinics. Routine serologic surveillance for HIV began among military conscripts in 1991. The HIV seroprevalence data from military conscripts provided national surveillance data, since the entire population of 21 year old men were conscripted for 2 years' service in the military by a random process during which 10% of men were selected...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28520616/pediatric-cancer-burden-and-treatment-resources-within-the-pediatric-iedea-consortium
#17
Steven A Brown, Salma Abbas, Mary-Ann Davies, Torsak Bunupuradah, Annette H Sohn, Karl-Günter Technau, Lorna Renner, Valériane Leroy, Andrew Edmonds, Marcel Yotebieng, Catherine C McGowan, Stephany N Duda, Lynne Mofenson, Beverly Musick, Kara Wools-Kaloustian
INTRODUCTION: The incidence and treatment of cancer in HIV-infected children from resource-limited settings has not been extensively studied. OBJECTIVES: Develop and implement a cross-sectional survey to evaluate pediatric cancer burden, diagnostic modalities in use, and treatment availability as perceived by HIV clinic staff at regional International Epidemiology Databases to Evaluate AIDS (IeDEA) sites. METHODS: IeDEA regional investigators developed a cross-sectional clinical site survey which included questions on the numbers and types of pediatric cancers observed, modalities used to treat identified cancers and treatment options available at individual sites in the Asia-Pacific, Latin America, Central Africa, East Africa, West Africa, and Southern Africa regions...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28510736/go-no-go-decision-in-anaesthesia-wide-variation-in-risk-tolerance-amongst-anaesthetists
#18
P R Greig, H E Higham, J L Darbyshire, C Vincent
Background: The variability in risk tolerance in medicine is not well understood. Parallels are often drawn between aviation and anaesthesia. The aviation industry is perceived as culturally risk averse, and part of preflight checks involves a decision on whether the flight can operate. This is sometimes termed a go/no-go decision. This questionnaire study was undertaken to explore the equivalent go/no-go decision in anaesthesia. We presented anaesthetists with a range of situations in which additional risk might be expected and asked them to decide whether they would proceed with the case...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28499095/trpm7-is-involved-in-volume-regulation-in-salivary-glands
#19
J M Kim, S Choi, K Park
Under hypotonic conditions, the regulatory volume decrease (RVD) is essential to maintain physiological homeostasis and functions in diverse biological systems. Intracellular Ca(2+) has been reported as an important mediator of this response, but the underlying Ca(2+) mechanism responsible for RVD is still controversial. Here we investigate the role of Ca(2+) in the RVD response using live-cell imaging, microspectrofluorimetry, and a patch-clamp technique. A typical RVD was observed in submandibular gland acinar cells after swelling in a hypotonic solution, whereas intracellular Ca(2+) chelation completely inhibited the RVD response...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28489942/biotunable-nanoplasmonic-filter-on-few-layer-mos2-for-rapid-and-highly-sensitive-cytokine-optoelectronic-immunosensing
#20
Younggeun Park, Byunghoon Ryu, Bo-Ram Oh, Yujing Song, Xiaogan Liang, Katsuo Kurabayashi
Monitoring of the time-varying immune status of a diseased host often requires rapid and sensitive detection of cytokines. Metallic nanoparticle-based localized surface plasmon resonance (LSPR) biosensors hold promise to meet this clinical need by permitting label-free detection of target biomolecules. These biosensors, however, continue to suffer from relatively low sensitivity as compared to conventional immunoassay methods that involve labeling processes. Their response speeds also need to be further improved to enable rapid cytokine quantification for critical care in a timely manner...
May 16, 2017: ACS Nano
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