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https://www.readbyqxmd.com/read/29767569/teaching-tip-development-of-veterinary-anesthesia-simulations-for-pre-clinical-training-design-implementation-and-evaluation-based-on-student-perspectives
#1
Jana L Jones, Jim Rinehart, Jacqueline Jordan Spiegel, Ryane E Englar, Brian K Sidaway, Joie Rowles
Anesthesia simulations have been used in pre-clinical medical training for decades to help learners gain confidence and expertise in an operating room environment without danger to a live patient. The authors describe a veterinary anesthesia simulation environment (VASE) with anesthesia scenarios developed to provide a re-creation of a veterinarian's task environment while performing anesthesia. The VASE uses advanced computer technology with simulator inputs provided from standard monitoring equipment in common use during veterinary anesthesia and a commercial canine training mannequin that allows intubation, ventilation, and venous access...
2018: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29762742/effects-of-reduced-digestible-lysine-density-on-myopathies-of-the-pectoralis-major-muscles-in-broiler-chickens-at-48-and-62-days-of-age
#2
K J Meloche, B I Fancher, D A Emmerson, S F Bilgili, W A Dozier
Quantitative control of nutrient intake may decrease the incidence of wooden breast (WB) and white striping (WS) myopathies with some impairment of live performance. Two experiments (Exp) utilizing Yield Plus × Ross 708 male broilers were conducted to determine if a reduction in myopathies may be obtained through a qualitative approach by reducing digestible lysine (dLys) density. All birds received an identical starter diet until 11 d of age. In Exp 1 (63 pens; 22 birds/pen), each pen was then randomly assigned to 1 of the following 7 dietary treatments (TRT) for a 47 d production period...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29760798/a-multicenter-retrospective-comparison-of-sequential-versus-sandwich-chemoradiotherapy-for-stage-ie-iie-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#3
Jin Li, Yajun Li, Meizuo Zhong, Wei Liu, Xianling Liu, Jiwei Li, Kunlun Li, Pingyong Yi
Background: Chemotherapy and radiotherapy are critical for treating early-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL); however, the optimal therapy sequence remains unclear. Therefore, we performed this study to compare the efficacy of L-asparaginase/pegaspargase-based sequential versus sandwich chemoradiotherapy for patients newly diagnosed with stage IE-IIE ENKTL. Methods: Patients were categorized into sequential ( N = 111) and sandwich ( N = 104) groups. Chemotherapy regimens included GELOX, SMILE, and VLP...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29756070/reducing-severe-hypoglycaemia-in-hospitalised-patients-with-diabetes-early-outcomes-of-standardised-reporting-and-management
#4
Katherine A Araque, Deepak K Kadayakkara, Nino Gigauri, Diane Sheehan, Sachin Majumdar, Gregory Buller, Clare A Flannery
Background: Severe hypoglycaemic events (HGEs) in hospitalised patients are associated with poor outcomes and prolonged hospitalization. Systematic, coordinated care is required for acute management and prevention of HGEs; however, studies evaluating quality control efforts are scarce. Objective: To investigate the effectiveness of system-based interventions to improve management response to HGEs. Methods: System-based interventions were designed and implemented following a root cause analysis of HGE in adult patients with diabetes from two general medical wards with the highest incidence of HGE...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29749425/understanding-singaporean-medical-students-stress-and-coping
#5
Li Wu, Julia Farquhar, Jackie Ma, Arpana R Vidyarthi
Medical school is intrinsically stressful, and high levels of stress have untoward effects. Although surveys have revealed some sources of stress among medical students, little is known about the qualitative aspects of these stressors and their associated coping behaviours, particularly among medical students in Singapore. Our exploratory pilot study found that relationship issues and examinations were the major sources of stress for medical students. The respondents described multiple context-sensitive coping styles, as well as reported 'avoidance' or 'wishful thinking' coping strategies as ineffective...
April 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29742108/lemur-species-specific-metapopulation-responses-to-habitat-loss-and-fragmentation
#6
Travis S Steffens, Shawn M Lehman
Determining what factors affect species occurrence is vital to the study of primate biogeography. We investigated the metapopulation dynamics of a lemur community consisting of eight species (Avahi occidentalis, Propithecus coquereli, Microcebus murinus, Microcebus ravelobensis, Lepilemur edwardsi, Cheirogaleus medius, Eulemur mongoz, and Eulemur fulvus) within fragmented tropical dry deciduous forest habitat in Ankarafantsika National Park, Madagascar. We measured fragment size and isolation of 42 fragments of forest ranging in size from 0...
2018: PloS One
https://www.readbyqxmd.com/read/29741657/cancers-attributable-to-tobacco-smoking-in-france-in-2015
#7
Bochen Cao, Catherine Hill, Christophe Bonaldi, Maria E León, Gwenn Menvielle, Pierre Arwidson, Freddie Bray, Isabelle Soerjomataram
Background: The evidence on the carcinogenicity of tobacco smoking has been well established. An assessment of the population-attributable fraction (PAF) of cancer due to smoking is needed for France, given its high smoking prevalence. Methods: We extracted age- and sex-specific national estimates of population and cancer incidence for France, and incidence rates of lung cancer among never smokers and relative risk (RR) estimates of smoking for various cancers from the American Cancer Prevention Study (CPS II)...
May 7, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29740543/quorum-sensing-signaling-and-quenching-in-the-multidrug-resistant-pathogen-stenotrophomonas-maltophilia
#8
REVIEW
Pol Huedo, Xavier Coves, Xavier Daura, Isidre Gibert, Daniel Yero
Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations and act as major regulatory mechanisms of pathogenesis in both pure cultures and poly-microbial communities. Disruption of QS systems, a phenomenon known as Quorum Quenching (QQ), represents a new promising paradigm for the design of novel antimicrobial strategies...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29738328/persistent-postsurgical-pain-pathophysiology-and-preventative-pharmacologic-considerations
#9
Philippe Richebé, Xavier Capdevila, Cyril Rivat
The development of chronic pain is considered a major complication after surgery. Basic science research in animal models helps us understand the transition from acute to chronic pain by identifying the numerous molecular and cellular changes that occur in the peripheral and central nervous systems. It is now well recognized that inflammation and nerve injury lead to long-term synaptic plasticity that amplifies and also maintains pain signaling, a phenomenon referred to as pain sensitization. In the context of surgery in humans, pain sensitization is both responsible for an increase in postoperative pain via the expression of wound hyperalgesia and considered a critical factor for the development of persistent postsurgical pain...
May 7, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29732473/thermoregulatory-responses-and-reproductive-traits-in-composite-beef-bulls-raised-in-a-tropical-climate
#10
Narian Romanello, José de Brito Lourenço Junior, Waldomiro Barioni Junior, Felipe Zandonadi Brandão, Cintia Righetti Marcondes, José Ricardo Macedo Pezzopane, Messy Hannear de Andrade Pantoja, Daniela Botta, Alessandro Giro, Ana Beatriz Bossois Moura, Andréa do Nascimento Barreto, Alexandre Rossetto Garcia
It is believed that increased livestock production is limited by tropical climate. Thermal imbalance in bulls can lead to hyperthermia and alter testicular metabolism, causing subfertility or infertility. Therefore, the thermoregulation of composite Canchim bulls (5/8 Charolais × 3/8 Zebu) raised in tropical climate as well as their consequences in the physiological, hematological, hormonal, and andrological parameters were evaluated monthly. The bulls (n = 18; 30.0 ± 1.5 months; 503.8 ± 23...
May 7, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29725260/micrornas-associated-with-therapy-of-non-small-cell-lung-cancer
#11
REVIEW
Junmi Lu, Yuting Zhan, Juan Feng, Jiadi Luo, Songqing Fan
The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel precise diagnosis and effective treatment approach for NSCLC patients. MicroRNAs (MiRNAs) are a class of 18-25nt non-coding small RNAs, which have been shown to be involved profoundly in the pathogenesis such as cellular proliferation, differentiation, development, apoptosis and tumorigenesis in many human tumors including of NSCLC...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29723009/operators-who-readily-acquire-patterns-and-cues-risk-being-miscued-in-routinized-settings
#12
Sue Brouwers, Mark Wiggins, Barbara Griffin
The detection of critical cues is a hallmark of expert performance, and in high-risk settings, it can prevent serious incidents. A sensitivity to cues and a proclivity to rapidly acquire patterns during routinized tasks, however, can miscue performance when these patterns change. In the present study, 75 university students undertook an assessment of cue utilization and engaged in a 24-min rail control simulation. The rail control task involved monitoring with periodic interventions to reroute trains, according to a train-track matching rule...
May 3, 2018: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/29716663/organization-or-community-based-outbreak-responding-to-cases-of-meningitis-under-epidemiologic-uncertainty
#13
Tea Burmaz, Vittorio Selle, Vincenzo Baldo, Elena Savoia
Six cases of serogroup C invasive meningococcal disease were identified in Treviso district, Veneto region, Italy between December 13 and 15, 2007. The afflicted patients were found to have attended the same Latin-dance clubs on the same nights, and chemoprophylaxis was provided to potentially exposed individuals. Despite these efforts, 2 cases caused by the same meningococcal strain subsequently occurred in the same area, without any apparent epidemiological correlation to the initial cases. This may have resulted from a failure to neutralize the meningococcal carrier/s...
May 2, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29709630/space-time-clusters-and-co-occurrence-of-chikungunya-and-dengue-fever-in-colombia-from-2015-to-2016
#14
M R Desjardins, A Whiteman, I Casas, E Delmelle
Vector-borne diseases (VBDs) infect over one billion people and are responsible for over one million deaths each year, globally. Chikungunya (CHIK) and Dengue Fever (DENF) are emerging VBDs due to overpopulation, increases in urbanization, climate change, and other factors. Colombia has recently experienced severe outbreaks of CHIK AND DENF. Both viruses are transmitted by the Aedes mosquitoes and are preventable with a variety of surveillance and vector control measures (e.g. insecticides, reduction of open containers, etc...
April 27, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29701145/a-potential-therapeutic-target-rna-binding-protein-arid5a-for-the-treatment-of-inflammatory-disease-associated-with-aberrant-cytokine-expression
#15
Kazuya Masuda, Tadamitsu Kishimoto
BACKGROUND: Infection, tissue damage and aging can cause inflammation with high levels of inflammatory cytokines. Overproduction of inflammatory cytokines often leads to systemic inflammatory response syndrome (SIRS), severe sepsis, and septic shock. However, prominent therapeutic targets have not been found, although the incidence of sepsis is likely to increase annually. Our recent studies indicate that some RNA-binding proteins, which control gene expression of inflammatory cytokines at the post-transcriptional level, may play a critical role in inflammatory diseases such as sepsis...
April 25, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29695301/health-in-yemen-losing-ground-in-war-time
#16
Charbel El Bcheraoui, Aisha O Jumaan, Michael L Collison, Farah Daoud, Ali H Mokdad
BACKGROUND: The effect of the ongoing war in Yemen on maternal and child health (MCH) has not been comprehensively assessed. Providing a situational analysis at the governorate level is critical to assist in planning a response and allocating resources. METHODS: We used multiple national- and governorate-level data sources to provide estimates of 12 relevant MCH indicators in 2016 around child vaccination, and child and maternal nutritional status, and the change in these estimates for the period 2013-2016 based on shock variables including change in gross domestic product, burden of airstrikes per 1000 population, change in access to untreated water sources and unimproved toilets, and change in wheat flour prices...
April 25, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29694303/cannabinoid-receptor-2-a-potential-novel-therapeutic-target-for-sepsis
#17
Qianwen He, Fei Xiao, Qinghong Yuan, Jingjing Zhang, Jia Zhan, Zongze Zhang
OBJECTIVE: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is the most common cause of death among critically ill patients in non-coronary intensive care units and the incidence continues to rise. Although advanced management was applied, the prognosis of sepsis patients remains poor. As a G-protein coupled receptor, cannabinoid receptor 2 (CB2R) was implicated in a wide variety of diseases. In this study, we aimed to investigate the role of CB2R in sepsis...
April 25, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29691437/immunological-responses-following-administration-of-a-genotype-1a-1b-2-3a-quadrivalent-hcv-vlp-vaccine
#18
D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, D C Jackson, Z Y Keck, S K H Foung, H E Drummer, E J Gowans, J Torresi
The significant public health problem of Hepatitis C virus (HCV) has been partially addressed with the advent of directly acting antiviral agents (DAAs). However, the development of an effective preventative vaccine would have a significant impact on HCV incidence and would represent a major advance towards controlling and possibly eradicating HCV globally. We previously reported a genotype 1a HCV viral-like particle (VLP) vaccine that produced neutralizing antibodies (NAb) and T cell responses to HCV. To advance this approach, we produced a quadrivalent genotype 1a/1b/2a/3a HCV VLP vaccine to produce broader immune responses...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29687904/unitary-physiology
#19
John S Torday, William B Miller
The common relationships among a great variety of biological phenomena seem enigmatic when considered solely at the level of the phenotype. The deep connections in physiology, for example, between the effects of maternal food restriction in utero and the subsequent incidence of metabolic syndrome in offspring, the effects of microgravity on cell polarity and reproduction in yeast, stress effects on jellyfish, and their endless longevity, or the relationship between nutrient abundance and the colonial form in slime molds, are not apparent by phenotypic observation...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#20
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
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