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Critical Incident Response

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https://www.readbyqxmd.com/read/28191998/the-effects-of-confrontation-and-avoidance-coping-in-response-to-workplace-incivility
#1
M Sandy Hershcovis, Ann-Frances Cameron, Loie Gervais, Jennifer Bozeman
Workplace incivility has significant adverse consequences for targets. However, we know remarkably little about how targets of incivility cope and even less about which coping strategies are effective. Drawing on the coping process of the transactional model of stress, we examine confrontation as a form of problem-focused coping and avoidance as a form of emotion-focused coping in response to incivility. We examine the effects of these coping strategies on reoccurrence of incivility, incivility enacted by targets, psychological forgiveness, and emotional exhaustion...
February 13, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28190430/delirium-in-critically-ill-patients
#2
A J C Slooter, R R Van De Leur, I J Zaal
Delirium is common in critically ill patients and associated with increased length of stay in the intensive care unit (ICU) and long-term cognitive impairment. The pathophysiology of delirium has been explained by neuroinflammation, an aberrant stress response, neurotransmitter imbalances, and neuronal network alterations. Delirium develops mostly in vulnerable patients (e.g., elderly and cognitively impaired) in the throes of a critical illness. Delirium is by definition due to an underlying condition and can be identified at ICU admission using prediction models...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28181276/modulation-of-autonomic-nervous-activity-in-the-termination-of-paroxysmal-atrial-fibrillation
#3
Jen-Hung Huang, Yung-Kuo Lin, Ming-Hsiung Hsieh, Shih-Ann Chen, Wan-Chun Chiu, Yi-Jen Chen
BACKGROUND: Autonomic nervous activity plays a critical role in the genesis of paroxysmal atrial fibrillation (AF, PAF). However, the role of autonomic nervous activity on AF termination has not been elucidated. Heart rate variability (HRV) is widely used to evaluate autonomic nervous activity in humans. The purpose of this study was to assess whether autonomic nervous activity assessed by HRV contributes to AF termination. METHODS: Electrocardiograms (ECGs) and HRV were studied in patients with termination of sustained (>30 s) PAF by 24-h ambulatory Holter monitoring...
February 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28178654/hepatitis-b-virus-surface-proteins-accelerate-cholestatic-injury-and-tumor-progression-in-abcb4-knockout-mice
#4
Daniel Zahner, Hannah Glimm, Tomomitsu Matono, Yuri Churin, Diran Herebian, Ertan Mayatepek, Kernt Köhler, Stefan Gattenlöhner, Anne Stinn, Annette Tschuschner, Martin Roderfeld, Elke Roeb
: Understanding of the pathophysiology of cholestasis associated carcinogenesis could challenge the development of new personalized therapeutic approaches and thus improve prognosis. Simultaneous damage might aggravate hepatic injury, induce chronic liver disease and even promote carcinogenesis. We aimed to study the effect of Hepatitis B virus surface protein (HBsAg) on cholestatic liver disease and associated carcinogenesis in a mouse model combining both impairments. Hybrids of Abcb4-/- and HBsAg transgenic mice were bred on fibrosis susceptible background BALB/c...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28163912/the-benefits-of-youth-are-lost-on-the-young-cardiac-arrest-patient
#5
REVIEW
Brian Griffith, Patrick Kochanek, Cameron Dezfulian
Children and young adults tend to have reduced mortality and disability after acquired brain injuries such as trauma or stroke and across other disease processes seen in critical care medicine. However, after out-of-hospital cardiac arrest (OHCA), outcomes are remarkably similar across age groups. The consistent lack of witnessed arrests and a high incidence of asphyxial or respiratory etiology arrests among pediatric and young adult patients with OHCA account for a substantial portion of the difference in outcomes...
2017: F1000Research
https://www.readbyqxmd.com/read/28152053/evaluation-of-absorbent-materials-for-use-as-ad-hoc-dry-decontaminants-during-mass-casualty-incidents-as-part-of-the-uk-s-initial-operational-response-ior
#6
Nick Kassouf, Sara Syed, Joanne Larner, Richard Amlôt, Robert P Chilcott
The UK's Initial Operational Response (IOR) is a revised process for the medical management of mass casualties potentially contaminated with hazardous materials. A critical element of the IOR is the introduction of immediate, on-scene disrobing and decontamination of casualties to limit the adverse health effects of exposure. Ad hoc cleansing of the skin with dry absorbent materials has previously been identified as a potential means of facilitating emergency decontamination. The purpose of this study was to evaluate the in vitro oil and water absorbency of a range of materials commonly found in the domestic and clinical environments and to determine the effectiveness of a small, but representative selection of such materials in skin decontamination, using an established ex vivo model...
2017: PloS One
https://www.readbyqxmd.com/read/28150874/the-caspase-3-p120-rasgap-stress-sensing-module-reduces-liver-cancer-incidence-but-does-not-affect-overall-survival-in-gamma-irradiated-and-carcinogen-treated-mice
#7
Güliz Vanli Jaccard, Christine Sempoux, Christian Widmann
Activation of oncogenes is the initial step in cellular transformation. Oncogenes favor aberrant proliferation and this initially also induces cellular stress. This oncogenic stress can act a safeguard mechanism against further transformation by inducing senescence or apoptosis. Yet, the few premalignant cells that tolerate and escape these senescent or apoptotic responses are those that will ultimately generate tumors. The caspase-3/p120 RasGAP module is a stress-sensing device that promotes survival under mild stress conditions...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28149511/the-development-and-role-of-microbial-host-interactions-in-gut-mucosal-immune-development
#8
REVIEW
C R Stokes
At birth the piglet's immune system is immature and it is dependent upon passive maternal protection until weaning. The piglet's mucosal immune system develops over the first few weeks but has not reached maturity at weaning ages which are common on commercial farms. At weaning piglets are presented with a vast and diverse range of microbial and dietary/environmental antigens. Their ability to distinguish between antigens and mount a protective response to potential pathogens and to develop tolerance to dietary antigens is critical to their survival and failure to do so is reflected in the high incidence of morbidity and mortality in the post-weaning period...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28137293/adapting-the-local-response-for-malaria-elimination-through-evaluation-of-the-1-3-7-system-performance-in-the-china-myanmar-border-region
#9
Duoquan Wang, Chris Cotter, Xiaodong Sun, Adam Bennett, Roly D Gosling, Ning Xiao
BACKGROUND: Assessing the essential components of '1-3-7' strategy along the China-Myanmar border is critical to identify gaps and challenges to support evidence-based decision making. METHODS: A mixed-method retrospective study including quantitative and qualitative analysis of the 1-3-7 system components was conducted. Sampled counties were chosen based on malaria incidence from 1 January 2012 to 31 December 2014. RESULTS: All 260 confirmed malaria cases from sampled counties were reported within 1 day and had completed case investigations...
January 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28135826/-you-didn-t-tell-us-what-to-do-trauma-2-and-critical-incident-responses-in-remote-indigenous-settings
#10
Ernest Hunter
OBJECTIVE: The aim of this paper is to outline engagement and practice principles for psychiatrists contributing to responses to critical incidents, based on three decades of experience in remote Indigenous Australia. CONCLUSION: Psychiatrists have important roles in these settings and situations, which should be considered in advance and informed by cultivated relationships.
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28131515/critical-incidents-and-judicial-response-during-medium-security-treatment
#11
Inge Jeandarme, Ciska Wittouck, Freya Vander Laenen, Claudia Pouls, Henri Heimans, T I Oei, Stefan Bogaerts
This study examined inpatient incidents in three Flemish forensic medium security units and analyzed the subsequent judicial reactions to these incidents. During medium security treatment, incidents were reported for more than half of the participants. The most frequently registered incidents were non-violent in nature, such as absconding and treatment non-compliance. The base rate for physically violent incidents was low. Although crime-related incidents during medium security treatment were rarely prosecuted and adjudicated, the base rate of revocation - and hence drop-out from treatment - as a result of these incidents was high...
January 25, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28126203/skin-derived-tslp-systemically-expands-regulatory-t-cells
#12
Theresa M Leichner, Atsushi Satake, Victor Sanoe Harrison, Yukinori Tanaka, Angela S Archambault, Brian S Kim, Mark C Siracusa, Warren J Leonard, Ali Naji, Gregory F Wu, David Artis, Taku Kambayashi
Regulatory T cells (Tregs) are a subset of CD4(+) T cells with suppressive function and are critical for limiting inappropriate activation of T cells. Hence, the expansion of Tregs is an attractive strategy for the treatment of autoimmune diseases. Here, we demonstrate that the skin possesses the remarkable capacity to systemically expand Treg numbers by producing thymic stromal lymphopoietin (TSLP) in response to vitamin D receptor stimulation. An ∼2-fold increase in the proportion and absolute number of Tregs was observed in mice treated topically but not systemically with the Vitamin D3 analog MC903...
January 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28122507/drought-stress-had-a-predominant-effect-over-heat-stress-on-three-tomato-cultivars-subjected-to-combined-stress
#13
Rong Zhou, Xiaqing Yu, Carl-Otto Ottosen, Eva Rosenqvist, Liping Zhao, Yinlei Wang, Wengui Yu, Tongmin Zhao, Zhen Wu
BACKGROUND: Abiotic stresses due to environmental factors could adversely affect the growth and development of crops. Among the abiotic stresses, drought and heat stress are two critical threats to crop growth and sustainable agriculture worldwide. Considering global climate change, incidence of combined drought and heat stress is likely to increase. The aim of this study was to shed light on plant growth performance and leaf physiology of three tomatoes cultivars ('Arvento', 'LA1994' and 'LA2093') under control, drought, heat and combined stress...
January 25, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28120514/ultraviolet-radiation-induced-down-regulation-of-serca2-mediates-activation-of-nlrp3-inflammasome-in-basal-cell-carcinoma
#14
Israr Ahmad, Kashiff M Muneer, Michelle E Chang, Hana M Nasr, Jacqueline M Clay, Conway C Huang, Nabiha Yusuf
Basal cell carcinomas (BCCs) account for majority of skin malignancies in the United States. The incidence of BCCs is strongly associated with exposure of ultraviolet (UV) radiation. Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome plays an important role in innate immune responses. Different stimuli such as toxins, microorganisms, and particles released from injured cells activate the NLRP3 inflammasome. Activated NLRP3 results in activation of caspase-1, which cleaves pro-IL-1β to active IL-1β...
January 25, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28116028/characteristics-of-real-time-non-critical-incident-debriefing-practices-in-the-emergency-department
#15
Nur-Ain Nadir, Suzanne Bentley, Dimitrios Papanagnou, Komal Bajaj, Stephan Rinnert, Richard Sinert
INTRODUCTION: Benefits of post-simulation debriefings as an educational and feedback tool have been widely accepted for nearly a decade. Real-time, non-critical incident debriefing is similar to post-simulation debriefing; however, data on its practice in academic emergency departments (ED), is limited. Although tools such as TeamSTEPPS® (Team Strategies and Tools to Enhance Performance and Patient Safety) suggest debriefing after complicated medical situations, they do not teach debriefing skills suited to this purpose...
January 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28101750/mortuary-operations-following-mass-fatality-natural-disasters-a-review
#16
REVIEW
Madelyn Anderson, Jodie Leditschke, Richard Bassed, Stephen M Cordner, Olaf H Drummer
This is a critical review to discuss the best practice approaches to mortuary operations in preparation for and the response to natural, mass fatality, disaster events, as identified by a review of published articles. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) Statement guided the identification of potential articles to use in this critical review. Subsequent searches were also conducted to identify articles relating to heat wave, and flood mortality. All identified peer-reviewed studies published in English which discussed the preparation and response of mortuaries to mass fatality natural disasters occurring in developed countries were included...
March 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28096293/the-role-of-mdm2-and-mdm4-in-breast-cancer-development-and-prevention
#17
REVIEW
Sue Haupt, Reshma Vijayakumaran, Jeffreena Panimaya, Andrew Burgess, Elgene Lim, Ygal Haupt
The major cause of death from breast cancer is not the primary tumour, but relapsing, drug-resistant, metastatic disease. Identifying factors that contribute to aggressive cancer offers important leads for therapy. Inherent defense against carcinogens depends on the individual molecular make-up of each person. Important molecular determinants of these responses are under the control of the mouse double minute (MDM) family: comprised of the proteins MDM2 and MDM4. In normal, healthy adult cells, the MDM family functions to critically regulate measured, cellular responses to stress and subsequent recovery...
January 17, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28094319/helminth-induced-ly6c-hi-monocyte-derived-alternatively-activated-macrophages-suppress-experimental-autoimmune-encephalomyelitis
#18
Cesar Terrazas, Juan de Dios Ruiz-Rosado, Stephanie A Amici, Kyle A Jablonski, Diana Martinez-Saucedo, Lindsay M Webb, Hanna Cortado, Frank Robledo-Avila, Steve Oghumu, Abhay R Satoskar, Miriam Rodriguez-Sosa, Luis I Terrazas, Mireia Guerau-de-Arellano, Santiago Partida-Sánchez
Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. Alternatively activated macrophages (AAMϕs) have been suggested as the anti-inflammatory effector cells during helminth infections. Here, we define the origin of AAMϕs during infection with Taenia crassiceps, and their disease-modulating activity on the Experimental Autoimmune Encephalomyelitis (EAE)...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079728/surveying-resident-and-faculty-physician-knowledge-attitudes-and-experiences-in-response-to-public-lead-contamination
#19
D Kay Taylor, Brenda Lovegrove Lepisto, Nicolas Lecea, Ranine Ghamrawi, Ghassan Bachuwa, Jenny LaChance, Mona Hanna-Attisha
Environmental health crises can appear anywhere and without warning. After research revealed a significant incidence of elevated pediatric blood lead levels following a water source change, Genesee County declared a public health emergency in Flint, Michigan. Hospital patients and family members began approaching Hurley Medical Center's physicians with questions regarding the health implications of the lead contamination. Many of the physicians voiced concerns about responding appropriately to patient needs and increasing demands for information...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28074555/pediatric-stress-from-neuroendocrinology-to-contemporary-disorders
#20
REVIEW
Stavroula Stavrou, Nicolas C Nicolaides, Elena Critselis, Christina Darviri, Evangelia Charmandari, George P Chrousos
BACKGROUND: Stress is defined as a state of threatened or perceived as threatened homeostasis. A broad spectrum of extrinsic or intrinsic, real or perceived stressful stimuli, called "stressors", activates a highly conserved system, the "stress system", which adjusts homeostasis through central and peripheral neuroendocrine responses. Inadequate, excessive or prolonged adaptive responses to stress may underlie the pathogenesis of several disease states prevalent in modern societies. The development and severity of these conditions primarily depend on the genetic vulnerability of the individual, the exposure to adverse environmental factors and the timing of the stressful event(s), given that prenatal life, infancy, childhood and adolescence are critical periods characterized by increased vulnerability to stressors...
January 11, 2017: European Journal of Clinical Investigation
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