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JOURNAL ARTICLE
Randhall B Carteri, Mateus Padilha, Silvaine Sasso de Quadros, Eder Kroeff Cardoso, Mateus Grellert
BACKGROUND: The increase in severe traumatic brain injury (sTBI) incidence is a worldwide phenomenon, resulting in a heavy disease burden in the public health systems, specifically in emerging countries. The shock index (SI) is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock, which is increased in sTBI. Considering the high mortality of sTBI, scrutinizing the predictive potential of SI and its variants is vital...
March 9, 2024: World Journal of Critical Care Medicine
#2
JOURNAL ARTICLE
Ambuj Mishra, Rajman Gupta, Rajendra Kr Joshi, Satish Chandra Garkoti
Due to substantial topographic variations in the Himalaya, incident solar radiation in the forest canopy is highly unequal. This results in significant environmental differences at finer scales and may lead to considerable differences in photosynthetic productivity in montane forests. Therefore, local-scale ecophysiological investigations, may be more effective and instructive than landscape-level inventories and models. We investigated leaf ecophysiological differences and related adaptations between two Quercus semecarpifolia forests in aspect-mediated, significantly varying light regimes in the same mountain catchment...
March 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
#3
JOURNAL ARTICLE
Aya R Mohammed, Esmat I El-Said, Salah F Abd ElAal, Rania M Kamal
BACKGROUND: Food safety is a serious challenge in the face of increasing population and diminishing resources. Staphylococcus aureus is a critical foodborne pathogen characterized by its capability to secret a diverse range of heat-resistant enterotoxins. Antibiotic usage in dairy herds resulted in the occurrence of antimicrobial resistance (AMR) patterns among bacterial species, which were consequently transmitted to humans via dairy products. Lactic acid bacteria (LAB) produce bacteriocins, which provide an excellent source of natural antimicrobials with the further advantage of being environmentally friendly and safe...
January 2024: Open Veterinary Journal
#4
JOURNAL ARTICLE
Matthew J Levy, Remle P Crowe, Heidi Abraham, Anna Bailey, Matt Blue, Reinhard Ekl, Eric Garfinkel, Joshua B Holloman, Jeff Hutchens, Ryan Jacobsen, Colin Johnson, Asa Margolis, Ruben Troncoso, Jefferson G Williams, J Brent Myers
OBJECTIVES: Emergency medical services (EMS) systems increasingly grapple with rising call volumes and workforce shortages, forcing systems to decide which responses may be delayed. Limited research has linked dispatch codes, on-scene findings, and emergency department (ED) outcomes. This study evaluated the association between dispatch categorizations and time-critical EMS responses defined by prehospital interventions and ED outcomes. Secondarily, we proposed a framework for identifying dispatch categorizations that are safe or unsafe to hold in queue...
April 16, 2024: Prehospital Emergency Care
#5
JOURNAL ARTICLE
Karin F Hoth, Patrick Ten Eyck, Karisa K Harland, Anusha Krishnadasan, Robert M Rodriguez, Juan Carlos C Montoy, Linder H Wendt, William Mower, Kelli Wallace, Scott Santibañez, David A Talan, Nicholas M Mohr
OBJECTIVES: The COVID-19 pandemic placed health care personnel (HCP) at risk for stress, anxiety, burnout, and post-traumatic stress disorder (PTSD). To address this, hospitals developed programs to mitigate risk. The objectives of the current study were to measure the availability and use of these programs in a cohort of academic emergency departments (EDs) in the United States early in the pandemic and identify factors associated with program use. METHODS: Cross-sectional survey of ED HCP in 21 academic EDs in 15 states between June and September 2020...
2024: PloS One
#6
JOURNAL ARTICLE
Takuya Takahashi, Takehiro Takahashi, Tetsuya Ikawa, Hitoshi Terui, Toshiya Takahashi, Yuichiro Segawa, Hayakazu Sumida, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients...
April 15, 2024: Journal of Dermatology
#7
JOURNAL ARTICLE
Lisa J Cohen, Yinan Liang, Devon Peterkin, Kamryn McGibbon, Frank Rappa, Megan L Rogers, Sungeun You, Ksenia Chistopolskaya, Sergey Enikolopov, Shira Barzilay, Vikas Menon, M Ishrat Husain, Manuela Dudeck, Judith Streb, Elif Çinka, Fatma Kantas Yilmaz, Oskar Kuśmirek, Samira S Valvassori, Yarden Blum, Igor Galynker
OBJECTIVE: The COVID-19 pandemic has had a globally devastating psychosocial impact. A detailed understanding of the mental health implications of this worldwide crisis is critical for successful mitigation of and preparation for future pandemics. Using a large international sample, we investigated in the present study the relationship between multiple COVID-19 parameters (both disease characteristics and government responses) and the incidence of the suicide crisis syndrome (SCS), an acute negative affect state associated with near-term suicidal behavior...
April 15, 2024: Disaster Medicine and Public Health Preparedness
#8
JOURNAL ARTICLE
Yijiao Fang, Bo Xiong, Xue Shang, Fan Yang, Yuehao Yin, Zhirong Sun, Xin Wu, Jun Zhang, Yi Liu
BACKGROUND: Inflammation and stress response may be related to the occurrence of sepsis-associated acute kidney injury (SA-AKI) in patients with sepsis.Insulin resistance (IR) is closely related to the stress response, inflammatory response, immune response and severity of critical diseases. We assume that the triglyceride-glucose (TyG) index, an alternative indicator for IR, is associated with the occurrence of SA-AKI in patients with sepsis. METHODS: Data were obtained from The Medical Information Mart for Intensive Care-IV(MIMIC-IV) database in this retrospective cohort study...
April 15, 2024: Heliyon
#9
JOURNAL ARTICLE
Gastrointestinal Acute Radiation Syndrome: Mechanisms, Models, Markers, and Medical Countermeasures.
Thomas A Winters, Libero Marzella, Olivia Molinar-Inglis, Paul W Price, Nyun Calvin Han, Jonathan E Cohen, Sue-Jane Wang, Anthony F Fotenos, Julie M Sullivan, John Esker, Paula J Lapinskas, Andrea L DiCarlo
There have been a number of reported human exposures to high dose radiation, resulting from accidents at nuclear power plants (e.g., Chernobyl), atomic bombings (Hiroshima and Nagasaki), and mishaps in industrial and medical settings. If absorbed radiation doses are high enough, evolution of acute radiation syndromes (ARS) will likely impact both the bone marrow as well as the gastrointestinal (GI) tract. Damage incurred in the latter can lead to nutrient malabsorption, dehydration, electrolyte imbalance, altered microbiome and metabolites, and impaired barrier function, which can lead to septicemia and death...
April 15, 2024: Radiation Research
#10
JOURNAL ARTICLE
Ronan Lordan
INTRODUCTION: Over the last two decades research has grown regarding dairy intake and health. It has been reported by many that yogurt intake may be associated with reduced risk of type 2 diabetes mellitus (T2D). In this report, the United States Food and Drug Administration (FDA) decision to announce a qualified health claim for yogurt products regarding reduced risk of T2D in response to a Danone North America petition is discussed. METHODS: Relevant literature cited in the petition along with supporting evidence from PubMed and Google Scholar databases until April 1st, 2024 were used...
April 10, 2024: Diabetes & Metabolic Syndrome
#11
JOURNAL ARTICLE
Birte von der Beck, Andreas Wissmann, Rene H Tolba, Philip Dammann, Gero Hilken
Laboratory animal facility managers must ensure that animal experiments can be carried out under optimal scientific conditions, that all legal requirements are met, and that animal welfare is maximized. Animal experimentation is stressful not only for the animals involved but also for the people who maintain these animals or carry out the experiments. Many of those involved find themselves in a constant conflict between scientific necessity, care, and harm. Under the term Culture of Care , procedures have been developed to reduce the burden of animal experimentation on the animals and the staff involved...
April 8, 2024: Animals: An Open Access Journal From MDPI
#12
JOURNAL ARTICLE
Addison E Barnett, Ahmad Ozair, Anas S Bamashmos, Hong Li, David S Bosler, Gabrielle Yeaney, Assad Ali, David M Peereboom, Justin D Lathia, Manmeet S Ahluwalia
Introduction : Sex differences in glioblastoma (GBM) have been observed in incidence, genetic and epigenetic alterations, and immune response. These differences have extended to the methylation of the MGMT promoter, which critically impacts temozolomide resistance. However, the association between sex, MGMT methylation, and survival is poorly understood, which this study sought to evaluate. Methods : A retrospective cohort study was conducted and reported following STROBE guidelines, based on adults with newly diagnosed GBM who received their first surgical intervention at Cleveland Clinic (Ohio, USA) between 2012 and 2018...
March 31, 2024: Cancers
#13
JOURNAL ARTICLE
Sulagna Chakraborty, Annalisa Fama, William E Sander
Increased incidence of zoonoses, coupled with veterinarians' occupational exposure, led to this study examining the knowledge of licensed US veterinarians on zoonoses and their disease prevention practices. This online survey supported by the National Association of State Public Health Veterinarians received 466 responses from 36 US states; 67% of the respondents were female, and 72.5% were small animal medicine practitioners. The One Health concept was familiar among 82% of respondents, 51.3% knew of continuing education training on zoonoses, and 68% had attended such a training in the last 5 years...
April 12, 2024: Journal of the American Veterinary Medical Association
#14
JOURNAL ARTICLE
Mohamed Abdelmonem, Alex Dussaq, Kathy Papakonstantino, Muharrem Yunce, Mrigender Singh Virk
OBJECTIVES: Identifying antibodies to red blood cell antigens is one of transfusion medicine's critical responsibilities. The International Society of Blood Transfusion recognizes 354 red blood cell antigens. Accurate identification of clinically significant alloantibodies is imperative for preventing hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. We compared the performance of the tube (polyethylene glycol-indirect antiglobulin test [PEG-IAT]) and solid-phase red cell adherence assay techniques...
April 12, 2024: American Journal of Clinical Pathology
#15
JOURNAL ARTICLE
Y Cortes-Araya, S Cheung, W Ho, C Stenhouse, C J Ashworth, C L Esteves, F X Donadeu
Intrauterine growth restriction (IUGR) occurs both in humans and domestic species. It has a particularly high incidence in pigs, and is a leading cause of neonatal morbidity and mortality as well as impaired postnatal growth. A key feature of IUGR is impaired muscle development, resulting in decreased meat quality. Understanding the developmental origins of IUGR, particularly at the molecular level, is important for developing effective strategies to mitigate its economic impact on the pig industry and animal welfare...
April 11, 2024: Scientific Reports
#16
REVIEW
Asif Ahmad Bhat, Muhammad Afzal, Ahsas Goyal, Gaurav Gupta, Riya Thapa, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Moyad Shahwan, Keshav Raj Paudel, Haider Ali, Deepak Sahu, Parteek Prasher, Sachin Kumar Singh, Kamal Dua
Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates of morbidity and death across many demographic groups. An industrial chemical and common environmental contaminant, formaldehyde (FA) presents serious health concerns to the respiratory system, including the onset and aggravation of lung inflammatory disorders. Epidemiological studies have shown significant associations between FA exposure levels and the incidence and severity of several respiratory diseases...
April 9, 2024: Chemico-biological Interactions
#17
EDITORIAL
Murad Ali
Muslims practice fasting during the ''holy month of Ramadan'', which poses special difficulties for those who have diabetes. Studies show that a sizable fraction of people with type 1 and type 2 diabetes fast despite the health hazards that come with the condition. This indicates that the incidence of diabetes among Muslims who fast is noteworthy. An increased vulnerability to acute problems, such as hypoglycemia, hyperglycemia, and diabetic ketoacidosis, is caused by extended fasting periods, irregular eating and sleeping routines, and changes in medication regimens...
March 2024: Curēus
#18
JOURNAL ARTICLE
Steven T Chen, Yevgeniy R Semenov, Allireza Alloo, Daniel Q Bach, Allison Betof Warner, Amina Bougrine, Leeann Burton, Laura C Cappelli, Mariana Castells, Justine Cohen, Anna K Dewan, Riley Fadden, Lauren Guggina, Aparna Hegde, Victor Huang, Douglas B Johnson, Benjamin Kaffenberger, Daniela Kroshinsky, Shawn Kwatra, Bernice Kwong, Mario E Lacouture, Cecilia Larocca, Jonathan Leventhal, Alina Markova, Jon McDunn, Meghan J Mooradian, Jarushka Naidoo, Jennifer Choi, Vinod Nambudiri, Caroline A Nelson, Anisha B Patel, Julia Pimkina, Johnathan Rine, Krista M Rubin, Maxwell Sauder, Sheila Shaigany, Afreen Shariff, Ryan J Sullivan, Leyre Zubiri, Kerry L Reynolds, Nicole R LeBoeuf
With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often with important downstream consequences for the patient. Current guidelines lack clarity in terms of diagnostic criteria for D-irAEs. The goal of this project is to better define D-irAE for the purposes of identification, diagnosis, and future study of this important group of diseases...
April 10, 2024: Journal for Immunotherapy of Cancer
#19
JOURNAL ARTICLE
Guofu Li, Ziyu Xiong, Ying Li, Cong Yan, Yingying Cheng, Yuwen Wang, Jingwei Li, Zifeng Dai, Dongdong Zhang, Wenzhong Du, Chunyang Men, Changbin Shi
OBJECTIVE: Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked to hypoxic glioma cell-released exosomes. In light of this, the present study aimed to investigate the role of exosomal pyruvate kinase M2 (PKM2) in glioma cells that exhibit resistance to TMZ. METHODS: Sensitive and TMZ-resistant glioma cells were subjected to either a normoxic or hypoxic environment, and the growth patterns and enzymatic activity of glycolysis enzymes were subsequently measured...
April 10, 2024: Discover. Oncology
#20
JOURNAL ARTICLE
Matthew Gibb, James Y Liu, Christie M Sayes
Environmental contaminants are ubiquitous in the air we breathe and can potentially cause adverse immunological outcomes such as respiratory sensitization, a type of immune-driven allergic response in the lungs. Wood dust, latex, pet dander, oils, fragrances, paints, and glues have all been implicated as possible respiratory sensitizers. With the increased incidence of exposure to chemical mixtures and the rapid production of novel materials, it is paramount that testing regimes accounting for sensitization are incorporated into development cycles...
April 8, 2024: Cell Biology and Toxicology
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