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https://www.readbyqxmd.com/read/29150086/the-ex-vivo-toll-like-receptor-7-tolerance-induction-in-donor-lymphocytes-prevents-murine-acute-graft-versus-host-disease
#1
Nikolaos Zogas, Garyfalia Karponi, Fotios Iordanidis, Stylianos Malasidis, Vasilios Paraskevas, Anastasia Papadopoulou, Zaharias George Scouras, Achilles Anagnostopoulos, Evangelia Yannaki
BACKGROUND AIMS: Acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation, mediated by alloreactive donor T cells. Toll-like receptors (TLRs), a family of conserved pattern-recognition receptors (PRRs), represent key players in donors' T-cell activation during aGVHD; however, a regulatory, tolerogenic role for certain TLRs has been recognized in a different context. We investigated whether the ex vivo-induced TLR-2,-4,-7 tolerance in donor cells could prevent alloreactivity in a mismatched transplantation model...
November 14, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29148105/experiences-of-nurse-case-managers-within-a-central-discharge-planning-role-of-collaboration-between-physicians-patients-and-other-healthcare-professionals-a-sociocultural-qualitative-study
#2
Jorun E Thoma, Marion A Waite
AIMS AND OBJECTIVES: Purpose of this study was to gain knowledge of Nurse Case Managers' (NCM) experiences within the German acute care context of collaboration with patients and physicians in a discharge planning role. Further to learn about patients' assignment to the management of the NCMs. Explicitly, to explore critical incidences of interactions between NCM, patients and health care practitioner in discharge planning to understand the factor that contributes to effective collaboration...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29130725/-eighth-jes%C3%A3%C2%BAs-culebras-lecture-critical-care-nutrition-and-hyperglycemia-a-close-relationship
#3
Alfonso Mesejo
Critically ill patients show a metabolic response to injury that affects carbohydrate metabolism, causing hyperglycemia and an increase in glycemic variability that makes the critically ill patient susceptible to infection, resulting in morbidity and mortality increase. Also, severe hypoglycemia was detected as a consequence of intensive insulin treatment that provokes deleterious effects in their clinical evolution, so a correct monitoring of plasma glucose would contribute to reduce morbidity and mortality...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29105022/homozygous-dkk1-knockout-mice-exhibit-high-bone-mass-phenotype-due-to-increased-bone-formation
#4
Michelle M McDonald, Alyson Morse, Aaron Schindeler, Kathy Mikulec, Lauren Peacock, Tegan Cheng, Justin Bobyn, Lucinda Lee, Paul A Baldock, Peter I Croucher, Patrick P L Tam, David G Little
Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1 (+/-) heterozygous mice display a high bone mass phenotype. Complete loss of Dkk1 function disrupts embryonic head development. Homozygous Dkk1 (-/-) mice that were heterozygous for Wnt3 loss of function mutation (termed Dkk1 KO) are viable and allowed studying the effects of homozygous inactivation of Dkk1 on bone formation. Dkk1 KO mice showed a high bone mass phenotype exceeding that of heterozygous mice as well as a high incidence of polydactyly and kinky tails...
November 6, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29077390/lab-on-chip-devices-gaining-ground-losing-size
#5
Veronica C Romao, Sofia A M Martins, Jose Germano, Filipe A Cardoso, Susana Cardoso, Paulo P Freitas
Portable analytical devices are notably gaining relevance in the panorama of urgent testing. Such devices have the potential to play an important role as easy-to-handle tools in critical situations. Epidemic infectious disease agents (e.g., Ebola virus, Coronavirus, Zika virus) could be controlled more easily by testing travelers on-site at the country borders to prevent outbreaks from spreading. The increasing incidence of hospital-acquired infections caused by antibiotic resistant pathogens could be minimized by point-of-care microbial analysis as well as rapid screening tests of bacteria resistance...
October 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29072915/preserving-spin-states-upon-reflection-linear-and-nonlinear-responses-of-a-chiral-meta-mirror
#6
Lei Kang, Sean P Rodrigues, Mohammad Taghinejad, Shoufeng Lan, Kyu-Tae Lee, Yongmin Liu, Douglas H Werner, Augustine Urbas, Wenshan Cai
Conventional metallic mirrors flip the spin of a circularly polarized wave upon normal incidence by inverting the direction of the propagation vector. Altering or maintaining the spin state of light waves carrying data is a critical need to be met at the brink of photonic information processing. In this work, we report a chiral metamaterial mirror that strongly absorbs a circularly polarized wave of one spin state and reflects that of the opposite spin in a manner conserving the circular polarization. A circular dichroic response in reflection as large as ∼0...
October 30, 2017: Nano Letters
https://www.readbyqxmd.com/read/29062902/the-interplay-between-th17-and-t-regulatory-responses-as-well-as-adipokines-in-the-progression-of-non-alcoholic-fatty-liver-disease
#7
REVIEW
Magdalena Świderska, Jerzy Jaroszewicz, Agnieszka Stawicka, Anna Parfieniuk-Kowerda, Adrian Chabowski, Robert Flisiak
Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease, coupled with metabolic syndrome, which may progress to non-alcoholic steatohepatitis (NASH). Diabetes, obesity, hypertension, hypercholesterolemia, and hypertriglyceridemia are considered to be the most common causes leading to the incidence of NAFLD. It is assumed that the accumulation of lipid deposits in hepatocytes leads to production of proinflammatory cytokines that triggers the development of liver inflammation. Regulatory T cells (Tregs) play a critical role in regulating inflammatory processes in NASH, while T helper type 17 (Th17) might functionally oppose Treg-mediated responses...
September 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/29058967/a-public-health-preparedness-logic-model-assessing-preparedness-for-cross-border-threats-in-the-european-region
#8
Michael A Stoto, Christopher Nelson, Elena Savoia, Irina Ljungqvist, Massimo Ciotti
Improving preparedness in the European region requires a clear understanding of what European Union (EU) member states should be able to do, whether acting internally or in cooperation with each other or the EU and other multilateral organizations. We have developed a preparedness logic model that specifies the aims and objectives of public health preparedness, as well as the response capabilities and preparedness capacities needed to achieve them. The capabilities, which describe the ability to effectively use capacities to identify, characterize, and respond to emergencies, are organized into 5 categories...
September 2017: Health Security
https://www.readbyqxmd.com/read/29057608/current-immunogenetic-predisposition-to-tuberculosis-in-the-moroccan-population
#9
REVIEW
M Qrafli, M Najimi, R Elaouad, K Sadki
Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment...
October 22, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29055271/neurocysticercosis-as-an-infectious-acquired-epilepsy-worldwide
#10
REVIEW
Doodipala Samba Reddy, Randy Volkmer
Aside from brain injury and genetic causes, there is emerging information on brain infection and inflammation as a common cause of epilepsy. Neurocysticercosis (NCC), the most common cause of epilepsy worldwide, is caused by brain cysts from the Taenia solium tapeworm. In this article, we provide a critical analysis of current and emerging information on the relationship between NCC infection and epilepsy occurrence. We searched PubMed and other databases for reports on the prevalence of NCC and incidence of epilepsy in certain regions worldwide...
November 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29049138/graph-theoretical-analysis-of-genome-scale-data-examination-of-gene-activation-occurring-in-the-setting-of-community-acquired-pneumonia
#11
Octavia M Peck Palmer, Gary Rogers, Sachin Yende, Derek C Angus, Michael A Langston, Gilles Clermont
INTRODUCTION: We have previously reported evidence that black individuals appear to have a significantly higher incidence of infection-related hospitalizations compared to white individuals. It is possible that the host immune response is responsible for this vital difference. In support such a hypothesis, the aim of this study was to determine whether black and white individuals exhibit differential whole blood gene network activation. METHODS: We examined whole blood network activation in a subset of patients (n = 22 pairs, propensity score matched (1:1) black and white patients) with community-acquired pneumonia (CAP) from the Genetic and Inflammatory Markers of Sepsis study...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29045912/the-lived-experience-of-first-year-undergraduate-student-nurses-a-hermeneutic-phenomenological-study
#12
Debra J Porteous, Alison Machin
INTRODUCTION: This study gives insight into the experiences and perceptions of one group of undergraduate nursing students as they make the transition into Higher Education and the nursing profession, during the first year, of their three-year programme. Research has shown that first year undergraduate experience is complex and challenging for any student. For undergraduate nursing students, the process of achieving additional professional practice competencies required for United Kingdom nursing registration adds additional responsibility and potentially, more pressure...
October 3, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29041671/tailoring-the-plasmon-induced-transparency-resonances-in-terahertz-metamaterials
#13
Meng Liu, Zhen Tian, Xueqian Zhang, Jianqiang Gu, Chunmei Ouyang, Jiaguang Han, Weili Zhang
We experimentally demonstrate that a coupled metamaterial composed of sub-wavelength split-ring-resonators (SRRs) and closed-ring-resonators (CRRs) can tailor the plasmon-induced-transparency (PIT) resonances when the external electric field is parallel to the gaps of SRRs. Rotating or moving SRRs in vertical direction plays a critical role in the EIT functionality, while an excellent robust performance can be acquired via moving SRRs in the horizontal direction. Based on the results, a polarization-independent and polarization-dependent planar metamaterial are designed, fabricated and measured...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29040626/a-dose-response-meta-analysis-of-chronic-arsenic-exposure-and-incident-cardiovascular-disease
#14
Katherine A Moon, Shilpi Oberoi, Aaron Barchowsky, Yu Chen, Eliseo Guallar, Keeve E Nachman, Mahfuzar Rahman, Nazmul Sohel, Daniela D'Ippoliti, Timothy J Wade, Katherine A James, Shohreh F Farzan, Margaret R Karagas, Habibul Ahsan, Ana Navas-Acien
Background: Consistent evidence at high levels of water arsenic (≥100 µg/l), and growing evidence at low-moderate levels (<100 µg/l), support a link with cardiovascular disease (CVD). The shape of the dose-response across low-moderate and high levels of arsenic in drinking water is uncertain and critical for risk assessment. Methods: We conducted a systematic review of general population epidemiological studies of arsenic and incident clinical CVD (all CVD, coronary heart disease (CHD) and stroke) with three or more exposure categories...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29034127/socio-demographic-factors-which-significantly-relate-to-the-prediction-of-burns-severity-in-children
#15
Khalid Alnababtah, Salim Khan
BACKGROUND: Burns are considered one of the biggest wounds and the most devastating injuries humans can receive as they have prolonged consequences which are not only physical, but psychological in addition to the cost of treatment. The aim of the study was to explore the relationships between socio-demographic factors (SDF) and the incidence and mechanisms of burn injuries in children. The objectives were to identify the multiple and various factors responsible for the occurrence of significant burns in children; to explore and investigate the relationship between these factors; to critically analyse SDF on the incidence and mechanisms of burns and to develop a contextual model with a view to informing future health care policy and health promotion programmes...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29033719/epidemiology-and-characteristics-of-nosocomial-infections-in-critically-ill-patients-in-a-tertiary-care-intensive-care-unit-of-northern-india
#16
Anirban Hom Choudhuri, Mitali Chakravarty, Rajeev Uppal
BACKGROUND AND AIMS: The prevalence of nosocomial infection is higher in the Intensive Care Unit (ICU) than other areas of the hospital. The present observational study was undertaken to describe the epidemiology and characteristics of nosocomial infections acquired in a tertiary care ICU and the impact of the various risk factors in their causation. MATERIALS AND METHODS: A retrospective study was conducted on the prospectively collected data of 153 consecutive patients admitted in a tertiary care ICU between July 2014 and December 2015...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29023584/intravenous-fluid-prescribing-errors-in-children-mixed-methods-analysis-of-critical-incidents
#17
Richard L Conn, Steven McVea, Angela Carrington, Tim Dornan
INTRODUCTION: Recent National Institute for Health and Care Excellence (NICE) guidelines aim to improve intravenous (IV) fluid prescribing for children, but existing evidence about how and why fluid prescribing errors occur is limited. Studying this can lead to more effective implementation, through education and systems design. AIMS: Identify types of IV fluid prescribing errors reported in practiceAnalyse factors that contribute to errorsProvide guidance to educators and those responsible for designing systems...
2017: PloS One
https://www.readbyqxmd.com/read/28990401/reactive-oxygen-species-and-their-implications-on-cd4-t-cells-in-type-1-diabetes
#18
Dana M Previte, Jon D Piganelli
Previous work has indicated that Type 1 diabetes (T1D) pathology is highly driven by reactive oxygen species (ROS). One way in which ROS shape the autoimmune response demonstrated in T1D is by promoting CD4+ T cell activation and differentiation. As CD4+ T cells are a significant contributor to pancreatic cell destruction in T1D, understanding how ROS impact their development, activation, and differentiation is critical. Recent advances: CD4+ T cells themselves generate ROS via NADPH oxidase expression and electron transport chain activity...
October 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28986573/activin-in-acute-pancreatitis-potential-risk-stratifying-marker-and-novel-therapeutic-target
#19
Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachristou, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung
Acute Pancreatitis is a substantial health care challenge with increasing incidence. Patients who develop severe disease have considerable mortality. Currently, no reliable predictive marker to identify patients at risk for severe disease exists. Treatment is limited to rehydration and supporting care suggesting an urgent need to develop novel approaches to improve standard care. Activin is a critical modulator of inflammatory responses, but has not been assessed in pancreatitis. Here, we demonstrate that serum activin is elevated and strongly correlates with disease severity in two established murine models of acute pancreatitis induced by either cerulein or IL-12 + IL-18...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28980509/hospital-workplace-violence-prevention-in-california-new-regulations
#20
Patricia Pidge Gooch
In response to startling statistics in the increasing number of workplace violence (WPV) incidents against health care workers, California employers across the continuum of care are preparing their organizations to comply with California Occupational Safety and Health Administration (CAL/OSHA) regulation SB 1299. This groundbreaking legislation requires hospitals and other health care settings to implement written strategic prevention plans and broaden the identification and reporting of incidents related to WPV...
October 1, 2017: Workplace Health & Safety
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