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Capsule endoscope

Wen-Guo Chen, Guo-Dong Shan, Hong Zhang, Ming Yang, Lin L, Min Yue, Guang-Wu Chen, Qing Gu, Hua-Tuo Zhu, Guo-Qiang Xu, Li-Hua Chen
The aim of the study was to evaluate the diagnostic and therapeutic value of double-balloon entoroscopy (DBE) in small bowel diseases (SBDs) in China.A retrospective review of 674 consecutive patients who underwent DBE between January 2007 and November 2015 was conducted. Patients were divided into 3 groups by age, young group (<45 years), middle-aged group (45-65 years), and elderly group (>65 years). Data were collected with regard to demographics, clinical, endoscopic findings, complications, diagnostic yield, and management...
October 2016: Medicine (Baltimore)
José Francisco Juanmartiñena Fernández, Iñaki Fernández-Urién, Rosa Iglesias Picazo, María Rosario Aznárez Barrio, Marta Montes Díaz, Alba Cebrian García, Juan José Vila Costas
No abstract text is available yet for this article.
October 12, 2016: Gastroenterología y Hepatología
Koushik Herle, Susan Jehangir
Wireless capsule endoscopy (WCE) is one of the great milestones in the field of gastroenterology. It is versatile in image acquisition, painless and can reach parts of the small bowel not amenable to conventional endoscopy. The commonest complication with WCE is retention of the capsule. We report a case of retained capsule in a child who was being investigated for obscure gastrointestinal bleeding (OGIB). Operative intervention was required for its retrieval after two weeks of expectant management.
September 2016: APSP Journal of Case Reports
Dan Carter, Rami Eliakim
Diseases affecting the colon are common worldwide and can cause a major health problem. Colorectal cancer (CRC) as well as Inflammatory bowel diseases represent a major cause of morbidity and mortality in western countries. PillCam colon capsule endoscopy (PCCE) is a novel and promising technology that can be useful for the screening and monitoring of colonic diseases. In the recent years many articles examined the use of various versions of PCCE-the 1st and 2nd generation versus various other endoscopic or radiologic modalities both for detection of colonic polyps or cancer and in both ulcerative colitis (UC) and Crohn's disease...
August 2016: Annals of Translational Medicine
Marisol Luján-Sanchis, Laura Sanchis-Artero, Laura Larrey-Ruiz, Laura Peño-Muñoz, Paola Núñez-Martínez, Génesis Castillo-López, Lara González-González, Carlos Boix Clemente, Cecilia Albert Antequera, Ana Durá-Ayet, Javier Sempere-Garcia-Argüelles
Capsule endoscopy (CE) currently plays an important role in Crohn's disease (CD). It is a noninvasive technique that has led to a breakthrough in the endoscopic diagnosis of diseases of the small intestine. Its superior diagnostic performance and excellent safety profile lead to its considerable acceptance on the part of the patient. This paper reviews current indications of CE in three stages of clinical practice: Suspected CD, unclassified colitis and its extensive role in diagnosed CD. The diagnostic and therapeutic impact of the results of CE on the monitoring of this disease is also reviewed...
September 16, 2016: World Journal of Gastrointestinal Endoscopy
Jonathan A Leighton, Debra J Helper, Ian M Gralnek, Iris Dotan, Ignacio Fernandez-Urien, Adi Lahat, Pramod Malik, Gerard E Mullin, Bruno Rosa
BACKGROUND AND AIMS: Crohn's disease (CD) is typically diagnosed by ileocolonoscopy (IC); however, when inflammation is localized solely in the small bowel, visualization of the entire small-bowel mucosa can be challenging. The aim of this study was to compare the diagnostic yield of a pan-enteric video capsule endoscope (small-bowel colon [SBC] capsule) versus IC in patients with active CD. METHODS: This was a prospective, multicenter study. Patients with known active CD and proven bowel luminal patency underwent a standardized colon cleansing protocol followed by ingestion of the capsule...
September 19, 2016: Gastrointestinal Endoscopy
Joel A Friedlander, Quin Y Liu, Benjamin Sahn, Koorosh Kooros, Catharine M Walsh, Robert E Kramer, Jenifer R Lightdale, Julie Khlevner, Mark McOmber, Jacob Kurowski, Matthew J Giefer, Harpreet Pall, David M Troendle, Elizabeth C Utterson, Herbert Brill, George M Zacur, Richard A Lirio, Diana G Lerner, Carrie Reynolds, Troy E Gibbons, Michael Wilsey, Chris A Liacouras, Douglas S Fishman
Wireless capsule endoscopy (CE) was introduced in 2000 as a less invasive method to visualize the distal small bowel in adults. As this technology has advanced it has been adapted for use in pediatric gastroenterology. Several studies have described its clinical use, utility, and various training methods but pediatric literature regarding capsule endoscopy is limited. This clinical report developed by the Endoscopic and Procedures Committee of the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition outlines the current literature, and describes the recommended current role, use, training, and future areas of research for CE in pediatrics...
September 16, 2016: Journal of Pediatric Gastroenterology and Nutrition
Ilja Tachecí, Petr Bradna, Tomáš Douda, Drahomíra Baštecká, Marcela Kopáčová, Stanislav Rejchrt, Martin Lutonský, Tomáš Soukup, Jan Bureš
INTRODUCTION: The aim of our prospective study was to define endoscopy appearance of the small bowel in healthy volunteers. METHOD: Forty-two healthy volunteers underwent wireless capsule endoscopy, clinical investigation, laboratory tests, and completed a health-status questionnaire. All subjects were available for a 36-month clinical follow-up. RESULTS: Eleven subjects (26%) had fully normal endoscopy findings. Remaining 31 persons (74%), being asymptomatic, with normal laboratory results, had some minor findings at wireless capsule endoscopy...
September 8, 2016: Acta Medica (Hradec Králové)
Henrique Augusto Cantareira Sabino, Fabiana Cardoso Pereira Valera, Davi Casale Aragon, Marina Zilio Fantucci, Carolina Carneiro Titoneli, Roberto Martinez, Wilma T Anselmo-Lima, Edwin Tamashiro
BACKGROUND: The management of acute exacerbation of chronic rhinosinusitis (AECRS) is still under debate, especially because there are no adequate studies to support a best-evidence treatment for this condition. Antibiotic use for AECRS has been recommended based on extrapolation of data from acute rhinosinusitis (ARS) or non-placebo-controlled studies. This study aimed to evaluate whether antibiotic therapy modifies the course of AECRS in a randomized, placebo-controlled study. METHODS: Patients with AECRS were randomized in a double-blinded manner (2:1 ratio) to receive either amoxicillin-clavulanate 875 mg/125 mg twice daily (BID) (AMX-CLAV, n = 21) or placebo capsules (n = 11) during 14 days...
September 9, 2016: International Forum of Allergy & Rhinology
J F Juanmartiñena Fernández, I Fernández-Urién, C Saldaña Dueñas, A Elosua González, A Borda Martín, J J Vila Costas
Obscure gastrointestinal bleeding accounts for approximately 5-10% of patients presenting with gastrointestinal haemorrhage. The majority of lesions responsible were found to be located in the small bowel. Currently, capsule en-doscopy is the first-line tool to investigate the small bowel as it is a non-invasive, feasible and simple procedure. Howe-ver, capsule endoscopy sometimes identifies the source of bleeding outside the small bowel and within the reach of conventional endoscopy. We present the case of a 46 year-old man with few prior negative endoscopic procedures and iron-deficiency anaemia due to gastric GIST...
2016: Anales del Sistema Sanitario de Navarra
Zibing Woodward, J Lucas Williams, Amnon Sonnenberg
BACKGROUND: The number of procedures utilized in the general management of gastrointestinal bleeding (GIB) has not been investigated previously. We used the National Endoscopic Database of the Clinical Outcomes Research Initiative for an observational study to analyze the average length of workup in GIB. METHODS: The electronic database was queried for all patients aged 18 years and older who underwent an endoscopic evaluation for any bleeding indication between 2000 and 2014...
October 2016: European Journal of Gastroenterology & Hepatology
Uri Kopylov, Eyal Klang, Doron Yablecovitch, Adi Lahat, Benjamin Avidan, Sandra Neuman, Nina Levhar, Tomer Greener, Noa Rozendorn, Arkadi Beytelman, Henit Yanai, Iris Dotan, Yehuda Chowers, Batya Weiss, Shomron Ben-Horin, Marianne M Amitai, Rami Eliakim
BACKGROUND: Video capsule endoscopy (VCE) and magnetic resonance enterography (MRE) are the prime modalities for the evaluation of small bowel (SB) Crohn's disease (CD). Mucosal inflammation on VCE is quantified using the Lewis score (LS). Diffusion-weighted (DW) magnetic resonance imaging (MRI) allows for accurate assessment of SB inflammation without administration of intravenous contrast material. The Magnetic Resonance Index of Activity (MaRiA) and the Clermont index are quantitative activity indices validated for contrast-enhanced MRE and DW-MRE, respectively...
September 2016: Therapeutic Advances in Gastroenterology
Kelly R Haisley, James P Dolan, Susan B Olson, Sergio A Toledo-Valdovinos, Kyle D Hart, Gene Bakis, Brintha K Enestvedt, John G Hunter
INTRODUCTION: Sponge cytology is a novel screening tool for esophageal cancer but has been unable to be validated for widespread use. Our aim was to apply fluorescent in situ hybridization to sponge cytology samples in order to evaluate the safety and efficacy of this modality in screening for esophageal cancer. MATERIALS AND METHODS: At a single, multidisciplinary, NCI-designated cancer center, patients completed sponge cytology sampling prior to upper endoscopy...
August 25, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Eduardo Rodrigues-Pinto, Helder Cardoso, Bruno Rosa, João Santos-Antunes, Susana Rodrigues, Margarida Marques, Susana Lopes, Andreia Albuquerque, Pedro Carvalho, Maria Moreira, José Cotter, Guilherme Macedo
BACKGROUND AND STUDY AIMS: One of the indications for capsule endoscopy (CE) is the detection of proximal small bowel (SB) involvement in Crohn's disease (CD) patients. Our aim was to assess clinical, laboratory and endoscopic predictors associated with proximal SB involvement in CD patients submitted to CE. PATIENTS AND METHODS: Retrospective multicenter study in which Lewis score (LS) was systematically determined in 190 CE of patients diagnosed with CD between 2003 and 2014...
June 2016: Endoscopy International Open
Edgar R Naut
Occult gastrointestinal bleeding is not visible and may present with a positive fecal occult blood test or iron deficiency anemia. Obscure bleeding can be overt or occult, with no source identified despite an appropriate diagnostic workup. A stepwise approach to this evaluation after negative upper and lower endoscopy has been shown to be cost effective. This includes repeat endoscopies if warranted, followed by video capsule endoscopy (VCE) if no obstruction is present. If the VCE is positive then specific endoscopic intervention may be possible...
September 2016: Medical Clinics of North America
Noboru Yatagai, Hiroya Ueyama, Tomoyoshi Shibuya, Keiichi Haga, Masahito Takahashi, Osamu Nomura, Naoto Sakamoto, Taro Osada, Takashi Yao, Sumio Watanabe
BACKGROUND: Small intestinal lipomas are rare, usually asymptomatic, and most commonly encountered incidentally during investigation of the gastrointestinal tract for another reason. However, they may cause obscure gastrointestinal bleeding. CASE PRESENTATION: We report a case of obscure gastrointestinal bleeding due to a small intestinal lipoma. A 69-year-old Japanese man on antiplatelet therapy presented to our department with tarry stools and anemic symptoms...
2016: Journal of Medical Case Reports
Petros C Benias, Lionel S D'Souza, Haris Papafragkakis, Joseph Kim, Manju Harshan, Neil D Theise, David L Carr-Locke
BACKGROUND AND AIMS: Current modalities for lymph node staging in cancer can be limited. We sought to evaluate the feasibility of needle-based confocal laser endomicroscopy (nCLE) at the time of endoscopic ultrasound (EUS) and to describe the nCLE features that distinguish between benign, malignant, and inflammatory lymph nodes. METHODS: We collected data on 28 consecutive patients during EUS staging of malignancy or assessment of enlarged lymph nodes. Patients underwent nCLE at the time of EUS followed by fine needle biopsy...
October 2016: Endoscopy
Salman Muzammil, John R Mabus, Philip R Cooper, Randall J Brezski, Courtney B Bement, Rob Perkinson, Norman D Huebert, Suzanne Thompson, Dalia Levine, Connie Kliwinski, Dino Bradley, Pamela J Hornby
Although much speculation has surrounded intestinally expressed FcRn as a means for systemic uptake of orally administered immunoglobulin G (IgG), this has not been validated in translational models beyond neonates or in FcRn-expressing cells in vitro. Recently, IgG1 intestinal infusion acutely in anesthetized cynomolgus resulted in detectable serum monoclonal antibody (mAb) levels. In this study, we show that IgG2 has greater protease resistance to intestinal enzymes in vitro and mice in vivo, due to protease resistance in the hinge region...
June 2016: Pharmacology Research & Perspectives
Anna L Paterson, Pierre Lao-Sirieix, Maria O'Donovan, Irene Debiram-Beecham, Massimiliano di Pietro, Ahmad Miremadi, Stephen E Attwood, Fiona M Walter, Peter D Sasieni, Rebecca C Fitzgerald
AIMS: Reflux symptoms are highly prevalent and non-specific hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non-endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms. METHODS AND RESULTS: Two complementary cohorts were recruited: 1) Patients with reflux symptoms and no prior endoscopy (n=409); 2) Patients with reflux symptoms referred for endoscopy (n=411)...
July 15, 2016: Histopathology
Billy H K Leung, Carmen C Y Poon, Ruikai Zhang, Y L Zheng, C K W Chan, Philip W Y Chiu, James Y W Lau, Joseph J Y Sung
: Wireless capsule endoscope (WCE) is a revolutionary approach to diagnose small bowel pathologies. Currently available WCEs are mostly passive devices with image capturing function only, while on-going efforts have been placed on robotizing WCEs or to enhance them with therapeutic functions. In this paper, the authors present a novel inflatable WCE for haemostasis in the gastrointestinal tracts by balloon tamponade effect. METHODS: The proposed wireless capsule consists of a balloon that can be inflated using the endothermic reaction of acid and base...
July 13, 2016: IEEE Transactions on Bio-medical Engineering
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