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https://www.readbyqxmd.com/read/28640017/reversal-of-vecuronium-induced-neuromuscular-blockade-with-low-dose-sugammadex-at-train-of-four-count-of-four-a-randomized-controlled-trial
#1
László Asztalos, Zoltán Szabó-Maák, András Gajdos, Réka Nemes, Adrienn Pongrácz, Szabolcs Lengyel, Béla Fülesdi, Edömér Tassonyi
BACKGROUND: Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can be reversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuronium at a similar level of block. METHODS: Sixty-five patients were randomly assigned, and 64 were analyzed in this controlled, superiority study. Participants received general anesthesia with propofol, sevoflurane, fentanyl, and vecuronium...
June 21, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28627098/effect-of-concomitant-birth-defects-and-genetic-anomalies-on-infant-mortality-in-tetralogy-of-fallot
#2
Eric G Jernigan, Paula D Strassle, Rebecca C Stebbins, Robert E Meyer, Jennifer S Nelson
BACKGROUND: A substantial proportion of infants born with tetralogy of Fallot (TOF) die in infancy. A better understanding of the heterogeneity associated with TOF, including extracardiac malformations and chromosomal anomalies is vital to stratifying risk and optimizing outcomes during infancy. METHODS: Using the North Carolina Birth Defects Monitoring Program, infants diagnosed with TOF and born between 2003 and 2012 were included. Kaplan-Meier survival curves were used to estimate cumulative 1-year mortality, stratified by the presence of concomitant birth defects (BDs) and chromosomal anomalies...
June 19, 2017: Birth defects research
https://www.readbyqxmd.com/read/28612431/phlorotannin-composition-of-laminaria-digitata
#3
Anne M Vissers, Augusta Caligiani, Stefano Sforza, Jean-Paul Vincken, Harry Gruppen
INTRODUCTION: Phlorotannins are complex mixtures of phloroglucinol oligomers connected via C-C (fucols) or C-O-C (phlorethols) linkages. Their uniformity in subunits and large molecular weight hamper their structural analysis. Despite its commercial relevance for alginate extraction, phlorotannins in Laminaria digitata have not been studied. OBJECTIVE: To obtain quantitative and structural information on phlorotannins in a methanolic extract from L. digitata. METHODOLOGY: The combined use of (13) C and (1) H NMR spectroscopy allowed characterisation of linkage types and extract purity...
June 13, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28598172/the-feasibility-of-photosensitized-reactions-with-secondary-organic-aerosol-particles-in-the-presence-of-volatile-organic-compounds
#4
Kurtis T Malecha, Sergey A Nizkorodov
The ability of a complex mixture of organic compounds found in secondary organic aerosol (SOA) to act as a photosensitizer in the oxidation of volatile organic compounds (VOCs) was investigated. Different types of SOA were produced in a smog chamber by oxidation of various biogenic and anthropogenic VOCs. The SOA particles were collected from the chamber onto an inert substrate, and the resulting material was exposed to 365 nm radiation in an air flow containing ~200 ppbv of limonene vapor. The mixing ratio of limonene and other VOCs in the flow was observed with a Proton Transfer Reaction Time-of-Flight Mass Spectrometer (PTR-ToF-MS)...
June 9, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28595723/stable-isotope-n-phosphoryl-amino-acids-labeling-for-quantitative-profiling-of-amine-containing-metabolites-using-liquid-chromatography-mass-spectrometry
#5
Shanshan Zhang, Jinwen Shi, Changkai Shan, Chengting Huang, Yile Wu, Rong Ding, Yuhua Xue, Wen Liu, Qiang Zhou, Yufen Zhao, Pengxiang Xu, Xiang Gao
Stable isotope chemical labeling liquid chromatography-mass spectrometry (LC-MS) is a powerful strategy for comprehensive metabolomics profiling, which can improve metabolites coverage and quantitative information for exploration of metabolic regulation in complex biological systems. In the current work, a novel stable isotope N-phosphoryl amino acids labeling strategy (SIPAL) has been successful developed for quantitative profiling of amine-containing metabolites in urine based on organic phosphorus chemistry...
July 25, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28573344/-residual-neuromuscular-blockade
#6
T Fuchs-Buder, D Schmartz
Even small degrees of residual neuromuscular blockade, i. e. a train-of-four (TOF) ratio >0.6, may lead to clinically relevant consequences for the patient. Especially upper airway integrity and the ability to swallow may still be markedly impaired. Moreover, increasing evidence suggests that residual neuromuscular blockade may affect postoperative outcome of patients. The incidence of these small degrees of residual blockade is relatively high and may persist for more than 90 min after a single intubating dose of an intermediately acting neuromuscular blocking agent, such as rocuronium and atracurium...
June 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28567705/diagnostic-value-of-doppler-echocardiography-for-identifying-hemodynamic-significant-pulmonary-valve-regurgitation-in-tetralogy-of-fallot-comparison-with-cardiac-mri
#7
Niek E G Beurskens, Thomas M Gorter, Petronella G Pieper, Elke S Hoendermis, Beatrijs Bartelds, Tjark Ebels, Rolf M F Berger, Tineke P Willems, Joost P van Melle
Quantification of pulmonary regurgitation (PR) is essential in the management of patients with repaired tetralogy of Fallot (TOF). We sought to evaluate the accuracy of first-line Doppler echocardiography in comparison with cardiac magnetic resonance imaging (MRI) to identify hemodynamic significant PR. Paired cardiac MRI and echocardiographic studies (n = 97) in patients with repaired TOF were retrospectively analyzed. Pressure half time (PHT) and pulmonary regurgitation index (PRi) were measured using continuous wave Doppler...
May 31, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28537193/isolated-potato-virus-a-coat-protein-possesses-unusual-properties-and-forms-different-short-virus-like-particles
#8
Alexander L Ksenofontov, Eugeny N Dobrov, Natalia V Fedorova, Marina V Serebryakova, Andrei N Prusov, Ludmila A Baratova, Viiu Paalme, Lilian Järvekülg, Eleonora V Shtykova
In our previous study, we have observed that the isolated coat proteins (CP) of the Potyvirus Potato Virus A (PVA) virions exhibit an intrinsic tendency to self-associate into various multimeric forms containing some fractions of cross-β-structure. In this report, we studied the effect of solution conditions on the structure and dissociation of isolated PVA CP using a number of complementary physicochemical methods. Analysis of the structure of PVA CP in solution was performed by limited proteolysis with MALDI-TOF mass spectrometry analysis, transmission electron microscopy, intrinsic fluorescence spectroscopy, and synchrotron small angle X-ray scattering (SAXS)...
June 8, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28532539/-detection-of-serum-peptides-in-patients-with-lung-squamous-cell-carcinoma-by-maldi-tof-ms-and-analysis-of-their-correlation-with-chemotherapy-efficacy
#9
Guanhua Zhao, Bin Xu, Xiaoyan Li, Chuanhao Tang, Haifeng Qin, Hong Wang, Shaoxing Yang, Weixia Wang, Hongjun Gao, Kun He, Xiaoqing Liu
BACKGROUND: Treatment options for patients with squamous cell carcinoma of the lung (SCC) are limited in chemotherapy. However, not all patients could benefit form standard platinum regimen. Considering the dismal prognosis of patients with advanced SCC, a greater focus on selecting sensitive chemotherapy regimens remains of upmost importance to improve outcomes in this disease. In this study, we used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to detect pre-chemotherapy serum peptides in advanced lung squamous cell carcinoma patients accepting paclitaxel combined with platinum chemotherapy and to analyze the correlation between serum peptides and chemotherapy efficacy...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28520473/a-new-method-and-mass-spectrometric-instrument-for-extraterrestrial-microbial-life-detection-using-the-elemental-composition-analyses-of-martian-regolith-and-permafrost-ice
#10
G G Managadze, A A Safronova, K A Luchnikov, E A Vorobyova, N S Duxbury, P Wurz, N G Managadze, A E Chumikov, R Kh Khamizov
We propose a new technique for the detection of microorganisms by elemental composition analyses of a sample extracted from regolith, permafrost, and ice of extraterrestrial bodies. We also describe the design of the ABIMAS instrument, which consists of the onboard time-of-flight laser mass-reflectron (TOF LMR) and the sample preparation unit (SPU) for biomass extraction. This instrument was initially approved to fly on board the ExoMars 2020 lander mission. The instrument can be used to analyze the elemental composition of possible extraterrestrial microbial communities and compare it to that of terrestrial microorganisms...
May 2017: Astrobiology
https://www.readbyqxmd.com/read/28520413/temporal-characteristics-of-brown-carbon-over-the-central-indo-gangetic-plain
#11
Rangu Satish, Puthukkadan Shamjad, Navaneeth Thamban, Sachchida Tripathi, Neeraj Rastogi
Recent global models estimate that light absorption by brown carbon (BrC) in several regions of the world is ∼30-70% of that due to black carbon (BC). It is, therefore, important to understand its sources and characteristics on temporal and spatial scales. In this study, we conducted semicontinuous measurements of water-soluble organic carbon (WSOC) and BrC using particle-into-liquid sampler coupled with a liquid waveguide capillary cell and total organic carbon analyzer (PILS-LWCC-TOC) over Kanpur (26.5°N, 80...
May 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28512230/differential-proteomic-analysis-of-gender-dependent-hepatic-tumorigenesis-in-hras12v-transgenic-mice
#12
Zhuona Rong, Tingting Fan, Huiling Li, Juan Li, Kangwei Wang, Xinxin Wang, Jianyi Dong, Jun Chen, Fujin Wang, Jingyu Wang, Aiguo Wang
Male prevalence is an outstanding characteristic of hepatocellular carcinoma (HCC), and the underlying mechanisms for this have remained largely unknown. In the present study, Hras12V transgenic mice, in which hepatocyte-specific expression of the ras oncogene induces male-biased hepatic tumorigenesis, were studied, and altered proteins were detected by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Protein samples from hepatic tumor tissues (T) and peri-tumor tissues (P) of transgenic males and females and the corresponding normal liver tissues (Wt) of non-transgenic males and females were subjected to pairwise comparisons based on proteomic analysis...
May 16, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28497926/plasma-lte4-pgf2%C3%AE-ratio-and-blood-eosinophil-count-are-increased-in-elderly-asthmatics-with-previous-asthma-exacerbation
#13
Ga Young Ban, Young Min Ye, Sang Ha Kim, Gyu Young Hur, Joo Hee Kim, Jae Jung Shim, Kumsun Cho, Joo Youn Cho, Hae Sim Park
The tools for asthma control assessment recommended by the current guideline are cognitive function- and effort-dependent, which is substantially impaired in the elderly. The aim of this study is to investigate objective assessment tools of asthma control status and previous asthma exacerbation (AE) in elderly subjects. Asthmatics aged >60 years who were treated with step 2 or 3 by the Global Initiative for Asthma (GINA) guideline were enrolled. During the 12-week study period, the subjects used either 400 μg of budesonide plus 10 mg of montelukast or 800 μg of inhaled budesonide...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497418/assessing-time-of-flight-signal-to-noise-ratio-gains-within-the-myocardium-and-subsequent-reductions-in-administered-activity-in-cardiac-pet-studies
#14
Ian S Armstrong, Christine M Tonge, Parthiban Arumugam
BACKGROUND: Time-of-flight (TOF) is known to increase signal-to-noise ratio (SNR) and facilitate reductions in administered activity. Established measures of SNR gain are derived from areas of uniform uptake, which is not applicable to the heterogeneous uptake in cardiac PET images using fluoro-deoxyglucose (FDG). This study aimed to develop a technique to quantify SNR gains within the myocardium due to TOF. METHODS: Reference TOF SNR gains were measured in 88 FDG oncology patients...
May 11, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28489210/sugammadex-ed90-dose-to-reverse-the-rocuronium-neuromuscular-blockade-in-obese-patients
#15
Mauro Prado DA Silva, Christiano Matsui, Daniel Dongiou Kim, Joaquim Edson Vieira, Carlos Alberto Malheiros, Ligia Andrade Silva Telles Mathias
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery. Methods: we conducted a prospective study with the biased coin up-and-down sequential design. We chosen the following doses: 2.0mg/Kg, 2.2mg/Kg, 2.4mg/Kg, 2.6mg/Kg, 2.8mg/Kg. The complete reversal of rocuronium-induced NMB considered a T4/T1 ratio ≥0...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28479750/serum-protein-profile-in-women-with-pregnancy-morbidity-associated-with-antiphospholipid-syndrome
#16
Angela M Alvarez, Stefan Neubeck, Sergio Parra, Udo R Markert, Angela P Cadavid
CONTEXT: Antiphospholipid antibodies (aPL) are related with a high risk of pregnancy morbidity (PM) and also of vascular thrombosis. On the basis of recent studies, we expect that in women with PM associated with antiphospholipid syndrome (APS), further factors may be deregulated and involved in pathophysiology of the disease. Such factors may have the potential to become novel biomarkers for APS and its stages. SETTINGS AND DESIGN: Descriptive study from a recurrent pregnancy loss program...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28476377/nodal-metastasis-signatures-in-breast-cancer
#17
Kyeongmee Park, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho
Although the molecular taxonomy of invasive breast cancer is based on heterogeneous histologic types, pathologic nodal (pN) stage remains one of the most important independent prognostic factors. Although node-positive number (NPN) has been widely as an accepted staging algorithm of pN stage, the node-positive ratio (NPR) in totally resected axillary nodes has been considered as another reasonable indicator. We aimed to identify signatures to play a predictive role in nodal metastasis for analytic validation between the primary breast cancers with positive node metastasis and those with negative node metastasis...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28470792/super-resolution-intracranial-quiescent-interval-slice-selective-magnetic-resonance-angiography
#18
Ioannis Koktzoglou, Robert R Edelman
PURPOSE: To evaluate the combination of nonenhanced quiescent-interval slice-selective (QISS) magnetic resonance angiography (MRA) with super-resolution reconstruction for portraying the intracranial arteries. METHODS: The intracranial arteries of seven volunteers were imaged at 3T using QISS MRA acquired with a flow-compensated fast low-angle shot (FLASH) readout and thin overlapping slices. The impacts of super-resolution reconstruction and various acquisition parameters on the delineation of intracranial arteries were quantified using four metrics: arterial-to-background contrast-to-noise ratio (CNR), arterial-to-background contrast, arterial sharpness, and arterial full-width-at-half-maximum (FWHM)...
May 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28465033/newborn-screening-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-based-on-parylene-matrix-chip
#19
Jo-Il Kim, Joo-Yoon Noh, Mira Kim, Jong-Min Park, Hyun-Woo Song, Min-Jung Kang, Jae-Chul Pyun
Newborn screening for diagnosis of phenylketonuria, homocystinuria, and maple syrup urine disease have been conducted by analyzing the concentration of target amino acids using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) based on parylene-matrix chip. Parylene-matrix chip was applied to MALDI-ToF MS analysis reducing the matrix peaks significantly at low mass-to-charge ratio range (m/z < 500). Reproducibility of inter-spot and intra-spot analyses of amino acids was less than 10%...
April 29, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28464615/mg-corrosion-hydroxyapatite-and-bone-healing
#20
Håkan Nygren, Narmin Bigdeli, Lars Ilver, Per Malmberg
The different capacities of magnesium in the metallic form (Mg-metal) and magnesium oxide (MgO) to stimulate bone healing are possible clues in the search for products that may promote bone healing. Since both Mg-metal and MgO can be assumed to release comparable amounts of Mg(2+) ions during their reactions in the tissue where they have been implanted, it is of some importance to follow this process and analyze the resulting mineral formation in the tissue at the implantation site. Implants of MgO were inserted into rat tibia, and the bone healing was compared with sham-operated controls...
May 2, 2017: Biointerphases
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