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TOF Ratio

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https://www.readbyqxmd.com/read/28402450/sudden-cardiac-death-in-adults-with-congenital-heart-disease-does-qrs-complex-fragmentation-discriminate-in-structurally-abnormal-hearts
#1
Jim T Vehmeijer, Zeliha Koyak, Jouke P Bokma, Werner Budts, Louise Harris, Barbara J M Mulder, Joris R de Groot
Aims: Sudden cardiac death (SCD) causes a large portion of all mortality in adult congenital heart disease (ACHD) patients. However, identification of high-risk patients remains challenging. Fragmented QRS-complexes (fQRS) are a marker for SCD in patients with acquired heart disease but data in ACHD patients are lacking. We therefore aim to evaluate the prognostic value of fQRS for SCD in ACHD patients. Methods and results: From a multicentre cohort of 25 790 ACHD patients, we included tachyarrhythmic SCD cases (n = 147), and controls (n = 266) matched by age, gender, congenital defect and (surgical) intervention...
April 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28399799/half-dose-sugammadex-combined-with-neostigmine-is-non-inferior-to-full-dose-sugammadex-for-reversal-of-rocuronium-induced-deep-neuromuscular-blockade-a-cost-saving-strategy
#2
Marie T Aouad, Waseem S Alfahel, Roland N Kaddoum, Sahar M Siddik-Sayyid
BACKGROUND: Sugammadex reverses the effect of rocuronium more rapidly and effectively than neostigmine, at all levels of neuromuscular blockade (NMB). However, its cost is prohibitive. The combination of half dose sugammadex with neostigmine would be non-inferior to full dose sugammadex for the reversal of deep NMB. This approach would reduce the cost of sugammadex while preserving its efficacy. METHODS: Patients were randomly allocated to receive sugammadex 4 mg/kg (Group S) or sugammadex 2 mg/kg with neostigmine 50 μg/kg and glycopyrrolate 10 μg/kg (Group NS) for reversal of rocuronium deep NMB...
April 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28394818/optimization-of-pet-ct-image-quality-using-the-ge-sharp-ir-point-spread-function-reconstruction-algorithm
#3
Nicholas J Vennart, Nicholas Bird, John Buscombe, Heok K Cheow, Ewa Nowosinska, Sarah Heard
OBJECTIVE: The objective of this study was to quantify any improvement with the GE 'Sharp IR' point-spread function (PSF) reconstruction algorithm in addition to ordered subsets expectation maximum (OSEM) and time-of-flight (TOF) reconstruction algorithms and establish the optimum parameters to be used in clinical studies. MATERIALS AND METHODS: We conducted a range of experiments using the National Electrical Manufacturers Association image quality phantom filled with a 4 : 1 signal-to-background ratio...
April 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28394450/effects-of-presynaptic-muscarinic-receptor-blockade-on-neuromuscular-transmission-as-assessed-by-the-train-of-four-and-the-tetanic-fade-response-to-rocuronium
#4
Yong Beom Kim, Sangseok Lee, Kyeong Cheon Lee, Ha Jung Kim, Young Jin Ro, Hong-Seuk Yang
This study investigated the effect of muscarinic M1 and M2 receptor antagonists on the rocuronium-induced train of four (TOF) fade and tetanic fade, respectively. Ex-vivo phrenic nerves/diaphragms were obtained from adult Sprague-Dawley rats and, stabilized in Krebs buffer, and the nerve-stimulated muscle TOF fade was observed at 20 s intervals. For the TOF study, phrenic nerve/diaphragms were incubated with pirenzepine (an M1 blocker) at concentrations of 0 nM (control), 10 nM (PZP10), or 100 nM (PZP100). Rocuronium was then administered incrementally until the first twitch tension (T1) had depressed by >95% during TOF stimulation...
April 10, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28394443/noninvasive-predictors-of-perioperative-atrial-arrhythmias-in-patients-with-tetralogy-of-fallot-undergoing-pulmonary-valve-replacement
#5
Daniel Cortez, Waseem Barham, Emily Ruckdeschel, Nandita Sharma, Anthony C McCanta, Johannes von Alvensleben, William H Sauer, Kathryn K Collins, Joseph Kay, Sonali Patel, Duy T Nguyen
BACKGROUND: Patients with tetralogy of Fallot (TOF) have increased risk of atrial arrhythmias. HYPOTHESIS: A measure of atrial dispersion, the P-wave vector magnitude (Pvm), can identify patients at risk for perioperative atrial flutter (AFL) or intra-atrial re-entrant tachycardia (IART) in a large TOF cohort. METHODS: We performed a blinded, retrospective analysis of 158 TOF patients undergoing pulmonary valve replacement between 1997 and 2015...
April 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28393856/toward-a-scientific-understanding-of-the-effectiveness-material-basis-and-prescription-compatibility-of-a-chinese-herbal-formula-dan-hong-injection
#6
Panlin Li, Weiwei Su, Sha Yun, Yiqiu Liao, Yinyin Liao, Hong Liu, Peibo Li, Yonggang Wang, Wei Peng, Hongliang Yao
Since traditional Chinese medicine (TCM) is a complex mixture of multiple components, the application of methodologies for evaluating single-components Western medicine in TCM studies may have certain limitations. Appropriate strategies that recognize the integrality of TCM and connect to TCM theories remain to be developed. Here we use multiple unique approaches to study the scientific connotation of a TCM formula Dan-hong injection (DHI) without undermining its prescription integrity. The blood circulation improving and healing promoting effects of DHI were assessed by a qi stagnation blood stasis rat model and a mouse model of laser irradiation induced cerebral microvascular thrombosis...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393779/the-utility-of-preoperative-level-of-erythrocytosis-in-the-prediction-of-postoperative-blood-loss-and-30-day-mortality-in-patients-with-tetralogy-of-fallot
#7
Jhon Harold Guevara, Andres Zorrilla-Vaca, Gloria C Silva-Gordillo
BACKGROUND: Postoperative major bleeding is a relatively common complication of patients undergoing corrective surgery of tetralogy of Fallot (TOF). Life-threatening blood losses can lead to aggressive transfusions or reoperation. Little is known about the risk factors associated with a bleeding tendency in TOF patients. This study aimed to establish predictive models for postoperative blood loss and mortality in TOF patients. METHODS: We conducted a retrospective observational study involving patients with TOF who were posted for corrective cardiac surgery in a single hospital between 2010 and 2015...
April 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28391849/analysis-of-small-biomolecules-and-xenobiotic-metabolism-using-converted-graphene-like-monolayer-plates-and-laser-desorption-ionization-time-of-flight-mass-spectrometry
#8
Hyunook Kang, Hoyeol Yun, Sang Wook Lee, Woon-Seok Yeo
We report a method of small molecule analysis using a converted graphene-like monolayer (CGM) plate and laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF MS) without organic matrices. The CGM plate was prepared from self-assembled monolayers of biphenyl-4-thiol on gold using electron beam irradiation followed by an annealing step. The above plate was utilized for the LDI-TOF MS analyses of various small molecules and their mixtures, e.g., amino acids, sugars, fatty acids, oligoethylene glycols, and flavonoids...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28389916/a-direct-label-free-maldi-tof-mass-spectrometry-based-assay-for-the-characterization-of-inhibitors-of-protein-lysine-methyltransferases
#9
Karine Guitot, Thierry Drujon, Fabienne Burlina, Sandrine Sagan, Sandra Beaupierre, Olivier Pamlard, Robert H Dodd, Catherine Guillou, Gérard Bolbach, Emmanuelle Sachon, Dominique Guianvarc'h
Histone lysine methylation is associated with essential biological functions like transcription activation or repression, depending on the position and the degree of methylation. This post-translational modification is introduced by protein lysine methyltransferases (KMTs) which catalyze the transfer of one to three methyl groups from the methyl donor S-adenosyl-L-methionine (AdoMet) to the amino group on the side chain of lysines. The regulation of protein lysine methylation plays a primary role not only in the basic functioning of normal cells but also in various pathologies and KMT deregulation is associated with diseases including cancer...
April 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28389847/a-pilot-study-of-salivary-n-glycome-in-hbv-induced-chronic-hepatitis-cirrhosis-and-hepatocellular-carcinoma
#10
Yannan Qin, Yaogang Zhong, Tianran Ma, Jiaxu Zhang, Ganglong Yang, Feng Guan, Zheng Li, Baozhen Li
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV), which can lead to chronic liver disease and put people at high risk of death from cirrhosis of the liver and liver cancer. However, little is known about the correlation of salivary N-linked glycans related to HBV-infected liver diseases. Here we investigated N-linked glycome in saliva from 200 subjects (50 healthy volunteers (HV), 40 HBV-infected patients (HB), 50 cirrhosis patients (HC), and 60 hepatocellular carcinoma patients (HCC) using MALDI-TOF/TOF-MS...
April 8, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28388696/the-use-of-serine-protease-from-yarrowia-lipolytica-yeast-in-the-production-of-biopeptides-from-denatured-egg-white-proteins
#11
Marta Pokora, Aleksandra Zambrowicz, Agnieszka Zabłocka, Anna Dąbrowska, Marek Szołtysik, Konrad Babij, Ewelina Eckert, Tadeusz Trziszka, Józefa Chrzanowska
Deriving non-conventional enzymes from cheaper sources than those used for commercially available enzymes may result in the production of hydrolysates with beneficial features, while drastically reducing the cost of hydrolysis. This is especially significant for enzymatic hydrolysis as a method of protein waste utilization. We have previously described the ability of non-commercial serine protease from Yarrowia lipolytica yeast to produce/release bioactive peptides from egg white protein by-products (EP). The enzymatic hydrolysis of EP was carried out for 24 h using the serine protease at an enzyme: substrate ratio of 1:30 (w/w)...
April 7, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28383318/quantitative-comparison-between-regularized-time-of-flight-and-osem-pet-reconstructions-for-small-18f-fdg-avid-lesions
#12
Charles B Chism, Gregory C Ravizzini, Homer A Macapinlac, Tinsu Pan
OBJECTIVE: We seek to quantitatively assess the relationship between lesion size and maximum standard uptake value (SUVmax) differences for small fluorine-18-fluorodeoxyglucose-avid lesions through the comparison of regularized time-of-flight (R-ToF) PET and standard ordered subset expectation maximization (OSEM) PET reconstructions. PATIENTS AND METHODS: Data from 30 patients (male to female ratio 8 : 7, 15 different primary malignancies) who underwent noncontrast PET-CT in October 2015 through February 2016 were evaluated...
April 5, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28359858/surface-immobilized-antibody-orientation-determined-using-tof-sims-and-multivariate-analysis
#13
Nicholas G Welch, Robert M T Madiona, Thomas B Payten, Christopher D Easton, Luisa Pontes-Braz, Narelle Brack, Judith A Scoble, Benjamin W Muir, Paul J Pigram
Antibody orientation at solid phase interfaces plays a critical role in the sensitive detection of biomolecules during immunoassays. Correctly oriented antibodies with solution-facing antigen binding regions have improved antigen capture as compared to their randomly oriented counterparts. Direct characterization of oriented proteins with surface analysis methods still remains a challenge however surface sensitive techniques such as Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) provide information-rich data that can be used to probe antibody orientation...
March 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28357461/association-between-proximal-internal-carotid-artery-steno-occlusive-disease-and-diffuse-wall-thickening-in-its-petrous-segment-a-magnetic-resonance-vessel-wall-imaging-study
#14
Xiaoyi Chen, Huilin Zhao, Zhensen Chen, Huiyu Qiao, Yuanyuan Cui, Dongye Li, Zechen Zhou, Le He, Rui Li, Chun Yuan, Xihai Zhao
PURPOSE: Significant stenosis or occlusion in carotid arteries may lead to diffuse wall thickening (DWT) in the arterial wall of downstream. This study aimed to investigate the correlation between proximal internal carotid artery (ICA) steno-occlusive disease and DWT in ipsilateral petrous ICA. METHODS: Symptomatic patients with atherosclerotic stenosis (>0%) in proximal ICA were recruited and underwent carotid MR vessel wall imaging. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) was acquired for characterizing the wall thickness and longitudinal extent of the lesions in petrous ICA and the distance from proximal lesion to the petrous ICA...
March 29, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28351536/highly-selective-enrichment-of-phosphopeptides-by-titanium-iv-attached-monodisperse-porous-poly-vinylphosphonic-acid-co-ethylene-dimethacrylate-microspheres
#15
Kouroush Salimi, Duygu Deniz Usta, Ömür Çelikbıçak, Aslı Pınar, Bekir Salih, Ali Tuncel
A seeded polymerization protocol was developed for the synthesis of monodisperse-porous poly(vinylphosphonic acid-co-ethylene dimethacrylate), [poly(VPA-co-EDMA)] microspheres with superior porous properties. The protocol allowed the direct synthesis of phosphonic acid functionalized porous microspheres with the mean size of ∼4μm and the specific surface area of 420m(2)g(-1) without applying any complicated post-derivatization protocol for the attachment of phosphonic acid group. The phosphonic acid content of poly(VPA-co-EDMA) microspheres was determined as 1...
March 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28347634/ten-year-outcomes-of-monomorphic-ventricular-tachycardia-catheter-ablation-in-repaired-tetralogy-of-fallot
#16
Mikaël Laredo, Robert Frank, Xavier Waintraub, Estelle Gandjbakhch, Laurence Iserin, Sebastien Hascoët, Caroline Himbert, Yves Gallais, Françoise Hidden-Lucet, Guillaume Duthoit
BACKGROUND: Monomorphic ventricular tachycardia (MVT) is common in adults with repaired tetralogy of Fallot (TOF), and is associated with sudden cardiac death. Management of MVT is not defined, and results of catheter ablation (CA) are limited. AIMS: To evaluate long-term outcomes of MVT CA in repaired TOF. METHODS: Thirty-four patients (mean age 32±10.3 years; 59% male) with repaired TOF underwent CA for symptomatic MVT between 1990 and 2012 in our centre; direct-current ablation (DCA) was used in 6%, radiofrequency followed by DCA in 29% and radiofrequency alone in 65%...
March 24, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28336781/quantitative-evaluation-of-two-scatter-correction-techniques-for-18-f-fdg-brain-pet-mr-imaging-in-regard-to-mr-based-attenuation-correction
#17
Jarmo Teuho, Virva Saunavaara, Tuula Tolvanen, Terhi Tuokkola, Antti Karlsson, Jouni Tuisku, Mika Teräs
In positron emission tomography (PET), corrections for photon scatter and attenuation are essential for visual and quantitative consistency. Magnetic resonance attenuation correction (MRAC) is generally conducted by image segmentation and assignment of discrete attenuation coefficients, which offers limited accuracy compared to computed tomography attenuation correction (CTAC). Potential inaccuracies in MRAC may affect scatter correction, as the attenuation image (µ-map) is used in single scatter simulation (SSS) to calculate the scatter estimate...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28328038/superbasic-alkyl-substituted-bisphosphazene-proton-sponges-a-new-class-of-deprotonating-matrices-for-negative-ion-matrix-assisted-ionization-laser-desorption-mass-spectrometry-of-low-molecular-weight-hardly-ionizable-analytes
#18
C D Calvano, T R I Cataldi, J F Kögel, A Monopoli, F Palmisano, J Sundermeyer
RATIONALE: Here hardly ionizable and low molecular weight compounds are detected in negative ion mode by using novel superbasic proton sponges based on 1,8-bisphosphazenylnaphthalene (PN) as MALDI matrices. Among the selected proton sponges, 1,8-bis(trispyrrolidinophosphazenyl)naphthalene (TPPN) has shown the best behaviour as matrix since it allows the direct detection of intact cholesterol without derivatization also in real challenging samples. METHODS: Very weakly acidic compounds such as sterols, steroids, fatty alcohols and saccharides were detected in reflectron negative ion mode by a MALDI TOF/TOF system equipped with a neodymium-doped yttrium lithium fluoride (Nd:YLF) laser (345 nm) with typical mass accuracy of 10 ppm...
July 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28302216/-association-of-indoor-air-pollution-single-nucleotide-polymorphism-of-hif-1%C3%AE-gene-with-susceptibility-to-lung-cancer-in-han-population-in-fujian-province
#19
Fei He, Qi Qi, Xu Li, Rendong Xiao, Qiuping Xu, Weimin Xiong, Zhiqiang Liu, Lin Cai
BACKGROUND: Hypoxia inducible factor-1α (HIF-1α) is associated with the progression and metastasis of lung cancer. There are, however, few studies on the relationship between the single nucleotide polymorphisms of HIF-1α and susceptibility to lung cancer. Therefore, we aimed to investigate the relationship between indoor air pollution, HIF-1α rs2057482, and the susceptibility to primary lung cancer of the Fujian Han population. METHODS: The present study is a hospital-based case-control study...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28287470/the-application-of-curve-fitting-on-the-voltammograms-of-various-isoforms-of-metallothioneins-metal-complexes
#20
Miguel Angel Merlos Rodrigo, Jorge Molina-López, Ana Maria Jimenez Jimenez, Elena Planells Del Pozo, Pavlina Adam, Tomas Eckschlager, Ondrej Zitka, Lukas Richtera, Vojtech Adam
The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, with multiple isoforms within each class. The main aim of this study was to determine the behavior of MT in dependence on various externally modelled environments, using electrochemistry. In our study, the mass distribution of MTs was characterized using MALDI-TOF. After that, adsorptive transfer stripping technique with differential pulse voltammetry was selected for optimization of electrochemical detection of MTs with regard to accumulation time and pH effects...
March 11, 2017: International Journal of Molecular Sciences
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