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TOF Ratio

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https://www.readbyqxmd.com/read/28915102/acceleration-selective-arterial-spin-labeling-mr-angiography-used-to-visualize-distal-cerebral-arteries-and-collateral-vessels-in-moyamoya-disease
#1
Osamu Togao, Akio Hiwatashi, Makoto Obara, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei, Ataru Nishimura, Koichi Arimura, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda
Purpose To evaluate and compare the performance of acceleration-selective arterial spin labeling (AccASL) magnetic resonance (MR) angiography in the visualization of cerebral arteries and collateral vessels in patients with Moyamoya disease with that of time-of-flight (TOF) MR angiography, with digital subtraction angiography (DSA) as the reference standard. Materials and Methods Thirty-six cerebral hemispheres from 22 patients with Moyamoya disease underwent TOF and AccASL MR angiography and DSA. Qualitative evaluations included imaging of the terminal internal carotid artery (ICA), distal middle cerebral arteries (MCAs), Moyamoya vessels, and leptomeningeal anastomosis (LMA) collaterals with reference to DSA...
September 15, 2017: Radiology
https://www.readbyqxmd.com/read/28895892/a-robotic-platform-for-corn-seedling-morphological-traits-characterization
#2
Hang Lu, Lie Tang, Steven A Whitham, Yu Mei
Crop breeding plays an important role in modern agriculture, improving plant performance, and increasing yield. Identifying the genes that are responsible for beneficial traits greatly facilitates plant breeding efforts for increasing crop production. However, associating genes and their functions with agronomic traits requires researchers to observe, measure, record, and analyze phenotypes of large numbers of plants, a repetitive and error-prone job if performed manually. An automated seedling phenotyping system aimed at replacing manual measurement, reducing sampling time, and increasing the allowable work time is thus highly valuable...
September 12, 2017: Sensors
https://www.readbyqxmd.com/read/28892000/development-of-a-matrix-solid-phase-dispersion-extraction-combined-with-uplc-q-tof-ms-for-determination-of-phenolics-and-terpenoids-from-the-euphorbia-fischeriana
#3
Wenjing Li, Yu Lin, Yuchun Wang, Bo Hong
A method based on a simplified extraction by matrix solid phase dispersion (MSPD) followed by ultra-performance liquid chromatography coupled with the quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) determination is validated for analysis of two phenolics and three terpenoids in Euphorbia fischeriana. The optimized experimental parameters of MSPD including dispersing sorbent (silica gel), ratio of sample to dispersing sorbent (1:2), elution solvent (water-ethanol: 30-70) and volume of the elution solvent (10 mL) were examined and set down...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28890875/cyanotic-congenital-heart-diseases-among-nigerian-children
#4
Barakat Adeola Animasahun, Akpoembele Deborah Madise-Wobo, Olusola Yejide Kusimo
BACKGROUND: There are only few reports on cyanotic congenital heart diseases (CCHD) among Nigerian and African Children. The current report aim to provide the most recent hospital based data on the distribution of CCHD in children less than 14 years of age, the demographic characteristics and risk factors identified. METHODS: Prospective and cross-sectional involving consecutive cases of CCHD diagnosed with echocardiography at the Lagos State University Teaching Hospital between January 2007 and June 2016...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28887618/diagnostic-value-of-3d-time-of-flight-magnetic-resonance-angiography-for-detecting-intracranial-aneurysm-a-meta-analysis
#5
REVIEW
Liu HaiFeng, Xu YongSheng, Xun YangQin, Dou Yu, Wang ShuaiWen, Lu XingRu, Lei JunQiang
PURPOSE: This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). METHODS: PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value...
September 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28885753/study-of-gas-phase-reactions-of-no2-with-aromatic-compounds-using-proton-transfer-reaction-time-of-flight-mass-spectrometry
#6
Jianquan Li, Xubing Du, Teng Guo, Zhen Peng, Li Xu, Junguo Dong, Ping Cheng, Zhen Zhou
The study of ion chemistry involving the NO2(+) is currently the focus of considerable fundamental interest and is relevant in diverse fields ranging from mechanistic organic chemistry to atmospheric chemistry. A very intense source of NO2(+) was generated by injecting the products from the dielectric barrier discharge (DBD) of a nitrogen and oxygen mixture upstream into the drift tube of a proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS) apparatus with H3 O(+) as the reagent ion. The NO2(+) intensity is controllable and related to the DBD operation conditions and ratio of oxygen to nitrogen...
September 8, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28872133/peptide-and-protein-quantification-using-automated-immuno-maldi-imaldi
#7
Huiyan Li, Robert Popp, Bjorn Frohlich, Michael X Chen, Christoph H Borchers
Mass spectrometry (MS) is one of the most commonly used technologies for quantifying proteins in complex samples, with excellent assay specificity as a result of the direct detection of the mass-to-charge ratio of each target molecule. However, MS-based proteomics, like most other analytical techniques, has a bias towards measuring high-abundance analytes, so it is challenging to achieve detection limits of low ng/mL or pg/mL in complex samples, and this is the concentration range for many disease-relevant proteins in biofluids such as human plasma...
August 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28863124/quantification-and-reduction-of-respiratory-induced-artifacts-in-positron-emission-tomography-computed-tomography-using-the-time-of-flight-technique
#8
Roya Sharifpour, Pardis Ghafarian, Arman Rahmim, Mohammad R Ay
OBJECTIVE: The aim of this study was to investigate the impact of time-of-flight (TOF) on quantification and reduction of respiratory artifacts. PATIENTS AND METHODS: The National Electrical Manufacturers Association phantom was used for optimization of reconstruction parameters. Twenty seven patients with lesions located in the diaphragmatic region were evaluated. The PET images were retrospectively reconstructed using non-TOF (routine protocol in our department) and TOF algorithms with different reconstruction parameters...
August 31, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28854786/determining-the-limit-of-detection-of-surface-bound-antibody
#9
Robert M T Madiona, Nicholas G Welch, Judith A Scoble, Benjamin W Muir, Paul J Pigram
Determination of a limit of detection (LoD) for surface bound antibodies is crucial for the development and deployment of sensitive bioassays. The measurement of very low concentrations of surface bound antibodies is also important in the manufacturing of pharmaceutical products such as antibody-conjugated pharmaceuticals. Low concentrations are required to avoid an immune response from the target host. Enzyme-linked immunosorbent assay (ELISA), x-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used to determine the LoD for the surface bound antibody (antiepidermal growth factor receptor antibody) on silicon substrates...
August 11, 2017: Biointerphases
https://www.readbyqxmd.com/read/28846666/interleukin-6-il-6-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-single-nucleotide-polymorphisms-snps-inflammation-and-metabolism-in-gestational-diabetes-mellitus-in-inner-mongolia
#10
Jie Zhang, Haiyi Chi, Huiying Xiao, Xiaoyan Tian, Yilin Wang, Xia Yun, Yancheng Xu
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on the association of IL-65-72C/G and TNF-α -857C/T single nucleotide polymorphisms (SNPs), inflammatory biomarkers, and metabolic indexes in women with GDM, especially in the Inner Mongolia population. The aim of this study was to investigate the associations of IL-65-72C/G and TNF-α -857C/T SNPs, and inflammation and metabolic biomarkers in women with GDM pregnancies...
August 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28831634/using-maldi-tof-ms-typing-method-to-decipher-outbreak-the-case-of-staphylococcus-saprophyticus-causing-urinary-tract-infections-utis-in-marseille-france
#11
K D Mlaga, G Dubourg, C Abat, H Chaudet, L Lotte, S M Diene, D Raoult, R Ruimy, J-M Rolain
Staphylococcus saprophyticus is one of the leading causes of urinary tract infections (UTI). In December 2014, our surveillance system identified an abnormal increase in S. saprophyticus causing UTIs in four university hospitals in Marseille, indicating a suspected community S. saprophyticus UTI outbreak. This was detected by our surveillance system BALYSES (Bacterial real-time Laboratory-based Surveillance System). S. saprophyticus/ Escherichia coli UTI ratio increased three-fold from 0.0084 in 2002 to 0.025 in December 2015 in Marseille with an abnormal peak in December 2014, and with an annual estimated ratio trend of 5...
August 22, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28830363/recovery-and-prediction-of-postoperative-muscle-power-is-it-still-a-problem
#12
Martin Zoremba, Dennis Kornmann, Benjamin Vojnar, Rene Burchard, Thomas Wiesmann, Hinnerk Wulf, Thomas Kratz
BACKGROUND: In the postoperative period, immediate recovery of muscular power is essential for patient safety, but this can be affected by anaesthetic drugs, opioids and neuromuscular blocking agents (NMBA). In this cohort study, we evaluated anaesthetic and patient-related factors contributing to reduced postoperative muscle power and pulse oximetric saturation. METHODS: We prospectively observed 615 patients scheduled for minor surgery. Premedication, general anaesthesia and respiratory settings were standardized according to standard operating procedures (SOP)...
August 22, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28826708/occlusion-status-on-magnetic-resonance-angiography-is-associated-with-risk-of-delayed-ischemic-events-in-cerebral-aneurysms-treated-with-stent-assisted-coiling
#13
Takayuki Kikuchi, Akira Ishii, Hideo Chihara, Daisuke Arai, Mitsushige Ando, Yohei Takenobu, Tomohisa Okada, Yasushi Takagi, Susumu Miyamoto
OBJECTIVE: Management after stent-assisted coiling (SAC) for unruptured intracranial aneurysm is sometimes difficult because close monitoring for ischemic events for a long period of time after the procedure is necessary. The purpose of this study was to clarify the usefulness of magnetic resonance angiography (MRA) at follow-up after SAC. METHODS: Sixty-six consecutive cases of SAC for unruptured intracranial aneurysm in our institute and affiliated hospitals were retrospectively reviewed for a delayed ischemic event...
August 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28820955/integration-of-an-in-situ-maldi-based-high-throughput-screening-process-a-case-study-with-receptor-tyrosine-kinase-c-met
#14
Katrin Beeman, Jens Baumgärtner, Manuel Laubenheimer, Karlheinz Hergesell, Martin Hoffmann, Ulrich Pehl, Frank Fischer, Jan-Carsten Pieck
Mass spectrometry (MS) is known for its label-free detection of substrates and products from a variety of enzyme reactions. Recent hardware improvements have increased interest in the use of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS for high-throughput drug discovery. Despite interest in this technology, several challenges remain and must be overcome before MALDI-MS can be integrated as an automated "in-line reader" for high-throughput drug discovery. Two such hurdles include in situ sample processing and deposition, as well as integration of MALDI-MS for enzymatic screening assays that usually contain high levels of MS-incompatible components...
August 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28805852/the-effect-of-sub-zero-temperature-on-the-formation-and-composition-of-secondary-organic-aerosol-from-ozonolysis-of-alpha-pinene
#15
K Kristensen, L N Jensen, M Glasius, M Bilde
This study presents a newly constructed temperature controlled cold-room smog chamber at Aarhus University, Denmark. The chamber is herein utilized to study the effect of sub-zero temperature on the formation and chemical composition of secondary organic aerosol (SOA) from ozone initiated oxidation of α-pinene. The chemical composition of α-pinene SOA formed from dark ozonolysis of α-pinene at 293 K and 258 K was investigated using High-Resolution Time-of-Flight Aerosol Mass Spectrometry (HR-ToF-AMS) and Ultra-High Performance Liquid Chromatography/Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry (UHPLC/ESI-qToF-MS)...
August 14, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28802619/sugammadex-efficacy-for-reversal-of-rocuronium-and-vecuronium-induced-neuromuscular-blockade-a-pooled-analysis-of-26-studies
#16
William Joseph Herring, Tiffany Woo, Christopher A Assaid, Robert J Lupinacci, Hendrikus J Lemmens, Manfred Blobner, Karin S Khuenl-Brady
STUDY OBJECTIVE: To summarize and compare efficacy of sugammadex with neostigmine or placebo for reversal of rocuronium- or vecuronium-induced neuromuscular blockade (NMB), and to demonstrate consistency of sugammadex results across various patient populations. DESIGN: Pooled analysis on data from 26 multicenter, randomized, Phase II and III studies. SETTING: Operating room. PATIENTS: 1855 adults undergoing surgery under general anesthesia and receiving rocuronium or vecuronium for NMB...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28801138/cadmium-exposure-in-newborn-rats-ovary-induces-developmental-disorders-of-primordial-follicles-and-the-differential-expression-of-scf-c-kit-gene
#17
Wenchang Zhang, Tingting Wu, Chenyun Zhang, Lingfeng Luo, Meimei Xie, Huiling Huang
Since the 1990s, the rising problem that gonad reproductive toxicity on adult female after exposing to cadmium (Cd), an environmental endocrine disruptor, has attracted high attention at home and abroad,and was systematically studied. Our research focuses on a further problem is that early cadmium exposure (during birth to before puberty) impact on development and function of ovarian cells and its possible mechanism. Our research focuses on the changes of ovarian cells growth and development after the newborn rat ovaries with cadmium exposure in vitro, and different expression of ovarian cells development-related factors, SCF/c-kit and changes of their DNA methylation status...
August 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28799210/whole-brain-arteriography-and-venography-using-improved-velocity-selective-saturation-pulse-trains
#18
Wenbo Li, Feng Xu, Michael Schär, Jing Liu, Taehoon Shin, Yansong Zhao, Peter C M van Zijl, Bruce A Wasserman, Ye Qiao, Qin Qin
PURPOSE: To develop velocity-selective (VS) MR angiography (MRA) protocols for arteriography and venography with whole-brain coverage. METHODS: Tissue suppression using velocity-selective saturation (VSS) pulse trains is sensitive to radiofrequency field (B1 +) inhomogeneity. To reduce its sensitivity, we replaced the low-flip-angle hard pulses in the VSS pulse train with optimal composite (OCP) pulses. Additionally, new pulse sequences for arteriography and venography were developed by placing spatially selective inversion pulses with a delay to null signals from either venous or arterial blood...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28795964/neuromuscular-monitoring-in-the-perioperative-period
#19
Glenn S Murphy
Neuromuscular monitoring devices were introduced into clinical practice in the 1970s. Qualitative neuromuscular monitors, or peripheral nerve stimulators, provide an electrical stimulus to a motor nerve and the response of corresponding muscle subjectively evaluated. A standard peripheral nerve stimulator provides several patterns of nerve stimulation, including train-of-four (TOF), double-burst, tetanic, and post-tetanic count. Qualitative (and quantitative) monitors are needed to determine onset of neuromuscular blockade, maintain the required depth of muscle relaxation during the surgical procedure, and assess an appropriate dose of reversal agent...
August 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28791652/fabrication-of-yolk-shell-cu-c-nanocomposites-as-high-performance-catalysts-in-oxidative-carbonylation-of-methanol-to-dimethyl-carbonate
#20
Juan Wang, Panpan Hao, Ruina Shi, Leilei Yang, Shusen Liu, Jinxian Zhao, Jun Ren, Zhong Li
A facile way was developed to fabricate yolk-shell composites with tunable Cu cores encapsulated within hollow carbon spheres (Cu@C) with an average diameter about 210 nm and cavity size about 80 nm. During pyrolysis, the confined nanospace of hollow cavity ensures that the nucleation-and-growth process of Cu nanocrystals take place exclusively inside the cavities. The size of Cu cores can be easily tuned from 30 to 55 nm by varying the copper salt concentration. By deliberately creating shell porosity through KOH chemical activation, at an optimized KOH/HCS mass ratio of 1/4, the catalytic performance for the oxidative carbonylation of methanol to dimethyl carbonate (DMC) of the activated sample is enhanced remarkably with TOF up to 8...
August 8, 2017: Nanoscale Research Letters
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