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https://www.readbyqxmd.com/read/29333464/comparison-of-tof-pet-and-bremsstrahlung-spect-images-of-yttrium-90-a-monte-carlo-simulation-study
#1
Akihiko Takahashi, Kazuhiko Himuro, Shingo Baba, Yasuo Yamashita, Masayuki Sasaki
Objectives: Yttrium-90 (90Y) is a beta particle nuclide used in targeted radionuclide therapy which is available to both single-photon emission computed tomography (SPECT) and time-of-flight (TOF) positron emission tomography (PET) imaging. The purpose of this study was to assess the image quality of PET and Bremsstrahlung SPECT by simulating PET and SPECT images of 90Y using Monte Carlo simulation codes under the same conditions and to compare them. Methods: In-house Monte Carlo codes, MCEP-PET and MCEP-SPECT, were employed to simulate images...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#2
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29312717/predictors-of-ventricular-tachyarrhythmia-occurring-late-after-intracardiac-repair-of-tetralogy-of-fallot-combination-of-qrs-duration-change-rate-and-tricuspid-regurgitation-pressure-gradient
#3
Shuichi Shiraishi, Masashi Takahashi, Ai Sugimoto, Masanori Tsuchida
Background: To determine potential predictors of ventricular tachyarrhythmia and sudden cardiac death (SCD) occurring late after repair of tetralogy of Fallot (TOF). Methods: Since 1964, 415 patients had undergone total repair for TOF at Niigata University Hospital. Of these, 89 patients who were followed for more than 10 years at our institute were retrospectively reviewed. Results: The mean follow-up period was 24.3 years. During the study period, one patient died of cerebral bleeding, and two patients had SCD...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29298644/interaction-of-cu-2-with-%C3%AE-crystallin-a-biophysical-and-mass-spectrometric-study
#4
Srabani Karmakar, Kali P Das
α-Crystallin, the major eye lens protein in mammals is known to behave as a molecular chaperone. It is a member of the small heat shock protein family and is known to be linked with aging and cataract. Copper homeostasis, oxidative stress and interaction of Cu+2+ with α-crystallin are related to aging related neurodegenerative diseases. In order to understand the role of such interaction, we have studied the chaperone function and stability of α-crystallin by spectroscopic methods and detected the binding of Cu2+ by MALDI TOF mass spectrometry...
December 29, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29297948/coalescence-and-self-bunching-observed-in-commercial-high-resolution-mass-spectrometry-instrumentation
#5
Anton Kaufmann, Stephan Walker
RATIONALE: Self-bunching and coalescence are well-known effects in Fourier transform ion cyclotron resonance (FTICR) and multi-reflection time-of-flight (TOF) mass spectrometry. These detrimental effects can also be observed in currently more frequently used high-resolution mass spectrometry (HRMS) instruments, such as the Orbitrap and single-reflection TOF. METHODS: A modern single-reflection TOF and a Q-Orbitrap were used to produce conditions in which self-bunching and coalescence were observed...
January 3, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29297944/solvent-effects-on-differentiation-of-mouse-brain-tissue-using-laser-microdissection-cut-and-drop-sampling-with-direct-mass-spectral-analysis
#6
John F Cahill, Vilmos Kertesz, Tiffany Porta, J C Yves LeBlanc, Ron M A Heeren, Gary J Van Berkel
RATIONALE: Laser microdissection-liquid vortex capture/electrospray ionization mass spectrometry (LMD-LVC/ESI-MS) has potential for on-line classification of tissue but an investigation into what analytical conditions provide best spectral differentiation has not been conducted. The effects of solvent, ionization polarity, and spectral acquisition parameters on differentiation of mouse brain tissue regions are described. METHODS: Individual 40 × 40 μm microdissections from cortex, white, grey, granular, and nucleus regions of mouse brain tissue were analyzed using different capture/ESI solvents, in positive and negative ion mode ESI, using time-of-flight (TOF)-MS and sequential window acquisitions of all theoretical spectra (SWATH)-MS (a permutation of tandem-MS), and combinations thereof...
January 3, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29287135/pulmonary-hypoplasia-in-fetuses-with-congenital-conotruncal-defects
#7
Qian Wang, Ying Zhao, Ling Han, Ye Zhang, Shuping Ge, Yihua He
OBJECTIVES: We sought to investigate pulmonary hypoplasia (PH) and associated risk factors in fetuses with congenital conotruncal defect (CTD). METHODS: A total of 75 fetuses with CTD (gestational age (GA): 22-32 weeks) and 150 normal GA-matched fetuses as the control group were studied. We measured diameters of aorta (Ao); main, left, and right pulmonary artery (PA); and their Z-scores by fetal echocardiography (FE). We also measured the lung area, lung area/chest area ratio (LCR), lung-to-head circumference ratio (LHR), right lung area/head circumference2 (quantitative lung index, QLI), and Z-scores...
December 2017: Echocardiography
https://www.readbyqxmd.com/read/29286544/direct-analysis-by-time-of-flight-secondary-ion-mass-spectrometry-tof-sims-reveals-action-of-bacterial-laccase-mediator-system-on-both-hardwood-and-softwood-samples
#8
Robyn E Goacher, Erick J Braham, Courtney L Michienzi, Robert M Flick, Alexander F Yakunin, Emma R Master
The modification and degradation of lignin play a vital role in carbon cycling as well as production of biofuels and bioproducts. The possibility of using bacterial laccases for the oxidation of lignin offers a route to utilize existing industrial protein expression techniques. However, bacterial laccases are most frequently studied on small model compounds that do not capture the complexity of lignocellulosic materials. This work studied the action of laccases from Bacillus subtilis and Salmonella typhimurium (EC 1...
December 29, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29243479/size-dependent-catalytic-activity-of-monodispersed-nickel-nanoparticles-for-the-hydrolytic-dehydrogenation-of-ammonia-borane
#9
Kun Guo, Hailong Li, Zhixin Yu
Nickel (Ni) nanoparticles (NPs) with controlled sizes in the range of 4.9-27.4 nm are synthesized by tuning the ratio of nickel acetylacetonate precursor and trioctylphosphine in the presence of oleylamine. X-ray diffraction and transmission electron microscopy confirm the formation of metallic Ni crystal phase and their monodispersed nature. These Ni NPs are found to be effective catalysts for the hydrolytic dehydrogenation of ammonia borane, and their catalytic activities are size-dependent. A volcano-type activity trend is observed with 8...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29242649/dose-reversal-effect-relationship-of-three-different-doses-of-neostigmine-in-obese-patients-a-randomised-clinical-trial
#10
Satyen Parida, Venkatesan Kausalya, Sandeep Kumar Mishra, Sethuramachandran Adinarayanan
Background and Aims: Previous studies suggest that administration of vecuronium based on total body weight rather than ideal body weight (IBW) in obesity results in overdosing with prolonged recovery times. We hypothesised that larger doses of neostigmine could result in faster recovery in obese patients administered vecuronium based on total body weight. Methods: Forty-five obese American Society of Anesthesiologists' II patients undergoing elective surgery under general anaesthesia were randomised into 3 groups to receive neostigmine 30, 40 and 50 μg/kg...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#11
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29234137/ratiometric-mass-spectrometry-for-cell-identification-and-quantitation-using-intracellular-dual-biomarkers
#12
Xiaoming Chen, Fangjie Wo, Jiang Chen, Jie Tan, Tao Wang, Xiao Liang, Jianmin Wu
This study proposed an easy-to-use method for cell identification and quantitation by ratiometric matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Two pairs of MS peaks in the molecular fingerprint of cells were selected as intracellular dual-biomarkers due to the stability and specificity of their ratio values in different types of hepatocellular cancer (HCC) cell lines. Five types of HCC cells can be thereafter differentiated based on these two pairs of intracellular peptides/proteins...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232875/optimization-of-ultrasound-assisted-extraction-hplc-and-uhplc-esi-q-tof-ms-ms-analysis-of-main-macamides-and-macaenes-from-maca-cultivars-of-lepidium-meyenii-walp
#13
Shu-Xiao Chen, Ke-Ke Li, Duoji Pubu, Si-Ping Jiang, Bin Chen, Li-Rong Chen, Zhen Yang, Chao Ma, Xiao-Jie Gong
Ultrasound-assisted extraction (UAE), using petroleum ether as the solvent, was systematically applied to extract main macamides and macaenes from Maca hypocotyls. Extraction yield was related with four variables, including ratio of solution to solid, extraction temperature, extraction time, and extraction power. On the basis of response surface methodology (RSM), the optimal conditions were determined to be the ratio of solution to solid as 10:1 (mL/g), the extraction temperature of 40 °C, the extraction time of 30 min, and the extraction power of 200 W...
December 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29217492/the-potential-role-of-ideal-mri-for-identification-of-lipids-and-hemorrhage-in-carotid-artery-plaques
#14
Faisal Khosa, Rachel E Clough, Xiaoen Wang, Ananth J Madhuranthakam, Robert L Greenman
Hemorrhage and lipid deposits contribute to instability in atherosclerotic plaques. Unstable carotid artery plaques can lead to cerebral ischemic events. While MRI studies have shown the ability to identify plaque components, the identification of hemorrhage and lipids has proven to be problematic. The purpose of this study was to quantitatively evaluate the potential of the MRI fat/water separation method known as iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL) to complement and improve existing methods for the identification of hemorrhage and lipids in carotid artery plaques...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29215168/decreased-signal-intensity-ratio-on-mra-reflects-misery-perfusion-on-spect-in-patients-with-intracranial-stenosis
#15
Masatomo Miura, Makoto Nakajima, Akiko Fujimoto, Shinya Shiraishi, David S Liebeskind, Yukio Ando
BACKGROUND AND PURPOSE: Acetazolamide reactivity on 123 I-IMP SPECT is used to detect misery perfusion due to intracranial atherosclerosis. Noninvasive fractional flow assessed by signal intensity ratio (SIR) on time of flight-magnetic resonance angiography (TOF-MRA) might offer a feasible alternative to identify high-risk intracranial stenosis. METHODS: Data from consecutive patients with unilateral middle cerebral artery (MCA) stenosis who underwent both TOF-MRA and acetazolamide reactivity on 123 I-IMP SPECT were retrospectively analyzed...
December 7, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29211926/heterotelechelic-polymers-via-ring-opening-metathesis-and-regioselective-chain-transfer
#16
Andreas F M Kilbinger, Peng Liu, Mohammad Yasir, Albert Ruggi
Heterotelechelic polymers were synthesized via a kinetic telechelic ring opening metathesis polymerization method relying on the regioselective cross metathesis of the propagating Grubbs' first generation catalyst with cinnamyl alcohol derivatives. This procedure allowed the synthesis of hetero-bis-end-functional polymers in a one-pot setup. The molecular weight of the polymers could be controlled by varying the ratio between cinnamyl alcohol derivatives and monomer. The end functional groups can be changed using different aromatically substituted cinnamyl alcohol derivatives...
December 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29199149/ultra-high-mass-multimer-analysis-of-protein-1a-capping-domains-by-a-silicon-nanomembrane-detector
#17
H C Shin, D Deterra, J Park, H Kim, M Nishikiori, Ch Uetrecht, P G Ahlquist, M Arbulu, R H Blick
Conventional time of flight ion detectors are based on secondary electron multipliers encountering a significant loss in detection efficiency, sensitivity and resolution with protein mass above 50kDa. In this work we employ a silicon nanomembrane detector in a Matrix-Assisted Laser Desorption/Ionization coupled to time of flight (MALDI-TOF) mass spectrometer. The operating principle relies on phonon-assisted field emission with excellent performance in the high mass range from 0.001-2MDa. In addition to the analysis of standard proteins the nanomembrane detector (NMD) has the potential for the detection and structural investigation of complex macromolecular assemblies through non-covalent interactions...
November 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29198447/fabrication-and-evaluation-of-magnetic-phosphodiesterase-5-linked-nanoparticles-as-adsorbent-for-magnetic-dispersive-solid-phase-extraction-of-inhibitors-from-chinese-herbal-medicine-prior-to-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight
#18
Yi Tao, Xianghui Gu, Weidong Li, Baochang Cai
In the present study, the preparation of the magnetic phosphodiesterase-5 linked Fe3O4@ SiO2 nanoparticles was successfully achieved by amide reaction and the magnetic phosphodiesterase-5 linked Fe3O4@SiO2 nanoparticles were evaluated as a new adsorbent for magnetic dispersive solid-phase extraction of ligands from medicinal plant samples before the analysis by UHPLC-Q-TOF/MS. The prepared phosphodiesterase-5 linked Fe3O4@SiO2 nanoparticles were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, vibration sample magnetometer and potential laser particle size analyzer...
November 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29193956/native-ms-analysis-of-monoclonal-antibody-conjugates-by-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#19
Iain David Grant Campuzano, Chawita Netirojjanakul, Michael Nshanian, Jennifer L Lippens, David Peter Alexander Kilgour, Steven L Van Orden, Joseph Loo
Antibody drug conjugates (ADCs) are an important class of therapeutic molecule currently being used to treat HER2-positive metastatic breast cancer, relapsed or refractory Hodgkin lymphoma, and systemic anaplastic large cell lymphoma. An ADC typically consists of a small molecule or peptide-based cytotoxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (mAb) scaffold. Mass spectrometric (MS) characterization of these molecules afford highly accurate molecular weight (MW) and drug-to-antibody ratio (DAR) determination, and is typically performed using orthogonal acceleration time-of-flight (oa-ToF) analysers and more recently Orbitrap instruments...
December 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29192283/chemical-changes-in-layered-ferroelectric-semiconductors-induced-by-helium-ion-beam
#20
Alex Belianinov, Matthew J Burch, Holland E Hysmith, Anton V Ievlev, Vighter Iberi, Michael A Susner, Michael A McGuire, Peter Maksymovych, Marius Chyasnavichyus, Stephen Jesse, Olga S Ovchinnikova
Multi-material systems interfaced with 2D materials, or entirely new 3D heterostructures can lead to the next generation multi-functional device architectures. Physical and chemical control at the nanoscale is also necessary tailor these materials as functional structures approach physical limit. 2D transition metal thiophosphates (TPS), with a general formulae Cu1-xIn1+x/3P2S6, have shown ferroelectric polarization behavior with a T c above the room temperature, making them attractive candidates for designing both: chemical and physical properties...
November 30, 2017: Scientific Reports
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