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https://www.readbyqxmd.com/read/29122798/impact-of-prenatal-diagnosis-on-survival-of-newborns-with-four-congenital-heart-defects-a-prospective-population-based-cohort-study-in-france-the-epicard-study
#1
Babak Khoshnood, Nathalie Lelong, Lucile Houyel, Damien Bonnet, Morgane Ballon, Jean-Marie Jouannic, François Goffinet
OBJECTIVES: (1) Assess the population-level probability of prenatal diagnosis and termination of pregnancy for fetal anomaly for four major congenital heart defects; (2) Examine, using population-based data, the relation between timing of (prenatal vs postnatal) diagnosis and risk of infant (ie, < 1 year) mortality for four major congenital heart defects (CHDs). DESIGN: Population-based cohort (the EPIdémiologie des CARDiopathies congénitales) study. SETTING: Greater Paris area (Paris and its surrounding suburbs)...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29120170/cationic-ti-complexes-with-three-n-o-type-tetrazolyl-ligands-ti%C3%A2-fe-transmetalation-within-fe-metallascorpionate-complexes
#2
Yu Jin Park, Ji Yeon Ryu, Sam Hwang, Ka Hyun Park, Ji Min Lee, Sung Cho, Sunwoo Lee, Manik Lal Saha, Peter J Stang, Junseong Lee
Herein, we report the synthesis of two novel ionic Ti complexes possessing three [N,O]-type bidentate ligands from the reaction of Fe metallascorpionate ligands possessing extended alcohol groups and TiCl4. The reaction of substituted hydroxyphenyl tetrazole and Fe(ClO4)3 in a molar ratio of 3:1 afforded iron scorpionate metalloligands possessing extended arms, which were characterized by IR spectroscopy and ESI-TOF-MS spectrometry. Their molecular structures were also confirmed as neutral Fe-centered scorpionate complexes by X-ray crystallography, in which the extended alcohol groups adopted a tripodal geometry...
November 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29116531/identification-of-surfactants-and-its-correlation-with-physicochemical-parameters-at-the-confluence-region-of-vembanad-lake-in-india
#3
Subha Sasi, Manoj P Rayaroth, Charuvila T Aravindakumar, Usha K Aravind
The present study describes the monitoring of some of the major classes of surfactants in water. The separation, identification, and the quantitative estimation of the compounds were achieved using LC-Q-ToF-MS. The analyses revealed the presence of variety of surfactants including linear alkylbenzene sulfonate (LAS), alcohol ethoxysulfates (AES), and alcohol ethoxylates (AE). Further, emphasis was given to AES as they are one of the most produced and consumed surfactants in the world. And as far as India is concerned, the present study is one of the most significant attempt regarding the identification and quantification of AES...
November 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29111638/synergistic-activity-of-co-and-fe-in-amorphous-cox-fe-b-catalyst-for-efficient-oxygen-evolution-reaction
#4
Huayu Chen, Shuxin Ouyang, Ming Zhao, Yunxiang Li, Jinhua Ye
Water splitting has been greatly limited by the sluggish kinetics of the oxygen evolution reaction (OER). High-oxidation-state metal species are required as the favorable active sites in OER. Here, amorphous Cox-Fe-B (x is the molar ratio of Co/Fe), Co-B, and Fe-B compounds were successfully synthesized as the oxygen evolution electrocatalysts. The calculation of turnover frequency (TOF) indicates that both the Co and Fe sites are active for OER. Cyclic voltammetry, X-ray photoelectron spectroscopy, and long-term stability curves were used to demonstrate that Fe can stabilize Co in a higher oxidation level and meanwhile promote the generation of OOH-like species (the key intermediates for OER)...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29098350/reintervention-burden-and-vessel-growth-after-surgical-reimplantation-of-a-pulmonary-artery-during-childhood
#5
Stephan J Wu, Tacy Downing, Christopher Mascio, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Children requiring reimplantation of a branch pulmonary artery (PA) are at risk for postoperative stenosis and impaired growth of the reimplanted PA. Outcomes and risk factors for reintervention and impaired growth are incompletely described. We reviewed data on patients who underwent reimplantation of a branch PA between 1/1/99 and 5/1/15 at a single center. The primary outcome was reintervention to treat postoperative stenosis. The secondary outcome was "catch-up" growth (faster diameter growth of the affected PA compared with the unaffected PA from the preoperative to follow-up measurements...
November 2, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29092461/orthogonal-time-of-flight-mass-spectrometry-of-an-ion-beam-with-a-broad-kinetic-energy-profile
#6
S W Miller, B D Prince, R J Bemish
A combined experimental and modeling effort is undertaken to assess a detection system composed of an orthogonal extraction time-of-flight (TOF) mass spectrometer coupled to a continuous ion source emitting an ion beam with kinetic energy of several hundred eV. The continuous ion source comprises an electrospray capillary system employing an undiluted ionic liquid emitting directly into vacuum. The resulting ion beam consists of ions with kinetic energy distributions of width greater than a hundred of eV and mass-to-charge (m/q) ratios ranging from 111 to 500 000 amu/q...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29091994/quantifying-biological-samples-using-linear-poisson-independent-component-analysis-for-maldi-tof-mass-spectra
#7
S Deepaisarn, P D Tar, N A Thacker, A Seepujak, A W McMahon
Motivation: Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI) facilitates the analysis of large organic molecules. However, the complexity of biological samples and MALDI data acquisition leads to high levels of variation, making reliable quantification of samples difficult. We present a new analysis approach that we believe is well-suited to the properties of MALDI mass spectra, based upon an Independent Component Analysis derived for Poisson sampled data...
October 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29083899/nickel-catalyzed-copolymerization-of-ethylene-and-vinyltrialkoxysilanes-catalytic-production-of-cross-linkable-polyethylene-and-elucidation-of-the-chain-growth-mechanism
#8
Zhou Chen, Mark D Leatherman, Olafs Daugulis, Maurice Brookhart
Copolymerizations of ethylene with vinyltrialkoxysilanes using cationic (α-diimine)Ni(Me)(CH3CN)(+) complexes 4a,b/B(C6F5)3 yield high molecular weight copolymers exhibiting highly branched to nearly linear backbones depending on reaction conditions and catalyst choice. Polymerizations are first-order in ethylene pressure and inverse-order in silane concentration. Microstructural analysis of the copolymers reveals both in-chain and chain-end incorporation of -Si(OR)3 groups whose ratios depend on temperature and ethylene pressure...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29081819/cognitive-function-of-artemisia-argyi-h-fermented-by-monascus-purpureus-under-tmt-induced-learning-and-memory-deficits-in-icr-mice
#9
Jin Yong Kang, Du Sang Lee, Seon Kyeong Park, Jeong Su Ha, Jong Min Kim, Gi Jeong Ha, Weon Taek Seo, Ho Jin Heo
The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29068679/understanding-a-hydroformylation-catalyst-that-produces-branched-aldehydes-from-alkyl-alkenes
#10
Paul Dingwall, José A Fuentes, Luke Crawford, Alexandra M Z Slawin, Michael Bühl, Matthew L Clarke
This paper reports experimental and computational studies on the mechanism of a rhodium-catalyzed hydroformylation that is selective for branched aldehyde products from unbiased alkene substrates. This highly unusual selectivity relies on a phospholane-phosphite ligand prosaically called BOBPHOS. Kinetic studies using in situ high pressure IR (HPIR) and the reaction progress kinetic analysis methodology suggested two steps in the catalytic cycle were involved as turnover determining. Negative order in CO and positive orders in alkene and H2 were found and the effect of hydrogen and carbon monoxide partial pressures on selectivity were measured...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29068018/mono-and-binuclear-chiral-n-n-o-scorpionate-zinc-alkyls-as-efficient-initiators-for-the-rop-of-rac-lactide
#11
Antonio Otero, Juan Fernández-Baeza, Luis F Sánchez-Barba, Sonia Sobrino, Andrés Garcés, Agustín Lara-Sánchez, Ana M Rodríguez
The preparation of new chiral bis(pyrazol-1-yl)methane-based N,N,O-donor scorpionate ligands in the form of the alcohol compounds bpzampeH (1) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[4-(dimethylamino)phenyl]ethanol}, bpzaepeH (2) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[4-(diethylamino)phenyl]ethanol}, and bpzimeH (3) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[1-methyl-1H-imidazol-2-yl]ethanol} has been carried out by the 1,2-addition reactions of a series of aldehydes. These new chiral heteroscorpionate ligands reacted with [ZnR2] (R = Me, Et, CH2SiMe3) in a 1 : 1 molar ratio in toluene to give the mononuclear monoalkyl zinc complexes [Zn(R)(κ(3)-NNO)] (4-12)...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29066245/effects-of-neostigmine-or-edrophonium-on-force-of-contraction-when-administered-at-a-train-of-four-ratio-of-0-9-in-anesthetized-dogs
#12
Marta Romano, Manuel Martin-Flores, Daniel M Sakai, Chia T Tseng, Luis Campoy, Robin D Gleed
OBJECTIVE: Anticholinesterase drugs may produce paradoxical neuromuscular block when administered at shallow levels of neuromuscular block. The objective of this study was to evaluate the effects of neostigmine and edrophonium when administered at near-complete reversal from nondepolarizing block in anesthetized dogs. STUDY DESIGN: Incomplete crossover, randomized, blinded experimental study. ANIMALS: A total of 12 Beagle dogs. METHODS: Each dog was anesthetized twice with propofol and maintained with isoflurane and dexmedetomidine...
August 3, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29022979/the-antibacterial-and-antibiofilm-efficacies-of-a-liposomal-peptide-originating-from-rice-bran-protein-against-listeria-monocytogenes
#13
Chuanfen Pu, Wenting Tang
With the aim of exploring a natural antilisterial peptide from food-derived origin, an antibacterial peptide named as Alpep7 was purified from the bromelain hydrolysate of rice bran protein (RBP) in this study. The resulting amino acid consequence was identified as KVDHFPL (Lys-Val-Asp-His-Phe-Pro-Leu) by ultraperformance liquid chromatography tandem matrix-assisted laser desorption/ionisation quadrupole time-of-flight mass spectrometry (MALDI Q-TOF MS). In addition, to assess the probability of the targeted delivery of liposome encapsulation of the peptide to Listeria biofilm, Alpep7-loaded liposomes were further prepared from a mixture of dipalmitoylphosphatidylcholine, stearylamine and cholesterol in a molar ratio of 10 : 3 : 2 and characterised by the analysis of particle size, zeta potential, microtopography and storage stability...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29022216/initial-evaluation-of-the-celesteion-large-bore-pet-ct-scanner-in-accordance-with-the-nema-nu2-2012-standard-and-the-japanese-guideline-for-oncology-fdg-pet-ct-data-acquisition-protocol-version-2-0
#14
Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue
BACKGROUND: The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) function, in accordance with the NEMA NU-2 2012 standard and version 2.0 of the Japanese guideline for oncology fluorodeoxyglucose PET/CT data acquisition protocol. Spatial resolution, sensitivity, count rate characteristic, scatter fraction, energy resolution, TOF timing resolution, and image quality were evaluated according to the NEMA NU-2 2012 standard...
October 11, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28983784/genetic-variations-of-dna-repair-genes-in-breast-cancer
#15
Asuman Özgöz, Kuyaş Hekimler Öztürk, Ayşegül Yükseltürk, Hale Şamlı, Zuhal Başkan, Fadime Mutlu İçduygu, Mehmet Bacaksız
Genetic variations in DNA repair genes may affect DNA repair capacity therefore increase risk for cancer. In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls. Genotyping of the DNA samples was carried out by multiplex PCR and matrix-assisted laser desorption/ionization mass spectrometry with time of flight measurement (MALDI-TOF) using Sequenom MassARRAY 4 analyzer...
October 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28971338/fourier-transform-ion-cyclotron-resonance-mass-spectrometry-as-a-platform-for-characterizing-multimeric-membrane-protein-complexes
#16
Jennifer L Lippens, Michael Nshanian, Chris Spahr, Pascal F Egea, Joseph A Loo, Iain D G Campuzano
Membrane protein characterization is consistently hampered by challenges with expression, purification, and solubilization. Among several biophysical techniques employed for their characterization, native-mass spectrometry (MS) has emerged as a powerful tool for the analysis of membrane proteins and complexes. Here, two MS platforms, the FT-ICR and Q-ToF, have been explored to analyze the homotetrameric water channel protein, AquaporinZ (AqpZ), under non-denaturing conditions. This 97 kDa membrane protein complex can be readily liberated from the octylglucoside (OG) detergent micelle under a range of instrument conditions on both MS platforms...
October 2, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28969991/spect-imaging-evaluation-of-111-indium-chelated-cetuximab-for-diagnosing-egfr-positive-tumor-in-an-hct-15-induced-colorectal-xenograft
#17
Bin-Bin Shih, Yi-Fang Chang, Chun-Chia Cheng, Hao-Jhih Yang, Kang-Wei Chang, Ai-Sheng Ho, Hua-Ching Lin, Chun Yeh, Chun-Chao Chang
BACKGROUND: Epidermal growth factor receptor (EGFR) overexpressed in colorectal cancer (CRC) is a tumor target for developing the anti-tumor theranostic agents. Cetuximab, an anti-EGFR monoclonal antibody against EGFR-positive tumors, inhibits cell proliferation and growth was labeled with radioactive (111)indium ((111)In) in this study for diagnosing EGFR-positive CRC. The aim of this study was to evaluate the efficacy of noninvasive nuclear imaging agent (111)In-cetuximab and investigate the biological distribution of (111)In-cetuximab in the HCT-15-induced EGFR-positive CRC tumor xenografts...
September 29, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28967478/partial-neuromuscular-block-impairs-arytenoid-abduction-during-hypercarbic-challenge-in-anesthetized-dogs
#18
Chia T Tseng, Daniel M Sakai, Madeline Libin, Monika Mostowy, Jonathan Cheetham, Luis Campoy, Robin D Gleed, Manuel Martin-Flores
OBJECTIVE: To evaluate the effect of two levels of partial neuromuscular block (NMB) on arytenoid abduction, tidal volume (VT) and peak inspiratory flow (PIF) in response to a hypercarbic challenge in anesthetized dogs. STUDY DESIGN: Prospective laboratory study. ANIMALS: Eleven healthy male Beagle dogs aged 3-5 years. METHODS: Dogs were anesthetized with propofol and dexmedetomidine infusions. The rima glottidis was observed via an endoscope placed through a laryngeal mask airway...
June 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28958530/adding-functionality-to-milk-based-protein-preparation-and-physico-chemical-characterization-of-%C3%AE-lactoglobulin-phenolic-conjugates
#19
Ahmed A Abd El-Maksoud, Ismail H Abd El-Ghany, Hossam S El-Beltagi, Sampson Anankanbil, Chiranjib Banerjee, Steen V Petersen, Bianca Pérez, Zheng Guo
Multi-functional phenolic emulsifiers were prepared by covalently coupling β-Lactoglobulin (βLg) to caffeic acid (CA) using crosslinker chemistry at different pH conditions (pH 2.5, 6.0, and 8.5). The resulting bioconjugates were characterized by MALDI-TOF MS, differential scanning calorimetry (DSC), fluorescence-quenching, infrared and circular dichroism spectroscopies. Furthermore, the emulsifying and antioxidant properties of βLg-CA conjugates were evaluated and compared to native β-Lactoglobulin and the non-covalent β-lactoglobulin/caffeic complex (βLg/CA)...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28937750/active-site-metal-identity-alters-histone-deacetylase-8-substrate-selectivity-a-potential-novel-regulatory-mechanism
#20
Carol Ann Castaneda, Jeffrey E Lopez, Caleb G Joseph, Michael D Scholle, Milan Mrksich, Carol A Fierke
Histone deacetylase 8 (HDAC8) is a well-characterized member of the class I acetyl-lysine deacetylase (HDAC) family. Previous work has shown that the efficiency of HDAC8-catalyzed deacetylation of a methylcoumarin peptide varies depending on the identity of the divalent metal ion in the HDAC8 active site. Here we demonstrate that both HDAC8 activity and substrate selectivity for a diverse range of peptide substrates depend on the identity of the active site metal ion. Varied deacetylase activities of Fe(II)- and Zn(II)-HDAC8 toward an array of peptide substrates were identified using self-assembled monolayers for matrix-assisted laser desorption ionization (SAMDI) mass spectrometry...
October 24, 2017: Biochemistry
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