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https://www.readbyqxmd.com/read/29656624/health-care-burden-of-spinal-diseases-in-the-republic-of-korea-analysis-of-a-nationwide-database-from-2012-through-2016
#1
Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim, Ji-Woong Kwon
OBJECTIVE: This study aimed to determine the incidence and analyze trends related to spinal diseases based on a national database in the Republic of Korea (ROK) and to elucidate the healthcare burden that will serve as a useful resource for researchers, clinicians, and patients. METHODS: This study was a retrospective analysis of data obtained from Healthcare Bigdata Hub, the Korean Statistical Information Service, and Open Data Portal from 2012 through 2016. The main disease codes for spinal diseases (M40-M54) were used for identification of these conditions...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656623/superior-and-middle-cluneal-nerve-entrapment-as-a-cause-of-low-back-pain
#2
REVIEW
Toyohiko Isu, Kyongsong Kim, Daijiro Morimoto, Naotaka Iwamoto
Low back pain (LBP) is encountered frequently in clinical practice. The superior and the middle cluneal nerves (SCN and MCN) are cutaneous nerves that are purely sensory. They dominate sensation in the lumbar area and the buttocks, and their entrapment around the iliac crest can elicit LBP. The reported incidence of SCN entrapment (SCN-E) in patients with LBP is 1.6%-14%. SCN-E and MCN entrapment (MCN-E) produce leg symptoms in 47%-84% and 82% of LBP patients, respectively. In such patients, pain is exacerbated by lumbar movements, and the symptoms mimic radiculopathy due to lumbar disorder...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656560/a-preoperative-criterion-identifying-a-low-risk-group-for-lymph-node-metastasis-in-intrahepatic-cholangiocarcinoma
#3
Tomoaki Yoh, Etsuro Hatano, Satoru Seo, Hiroaki Terajima, Yoichiro Uchida, Kojiro Taura, Kentaro Yasuchika, Shinji Uemoto
BACKGROUND: Imaging study cannot identify patients with potential low-risk for LN metastasis in intrahepatic cholangiocarcinoma (ICC). The purpose of this study was to identify a low-risk group for lymph node (LN) metastasis in ICC using preoperatively available factors. METHODS: Data from 127 consecutive patients, who underwent curative intent surgery for ICC at Kyoto University Hospital and Kitano Hospital between 2002 and 2016, were retrospectively analyzed. By using only preoperative data, multiple linear regression model for predicting LN metastasis was developed...
April 14, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29656552/better-performance-of-four-dimension-computed-tomography-as-a-localization-procedure-in-normocalcemic-primary-hyperparathyroidism
#4
Phelipe Cunha-Bezerra, Ricardo Vieira, Fernando Amaral, Henrique Cartaxo, Túlio Lima, Ulisses Montarroyos, Francisco Bandeira
INTRODUCTION: The multi-phase or four-dimensional computed tomography (4D CT) has emerged as a promising technique for preoperative localization of parathyroid lesions in patients with primary hyperparathyroidism (PHPT), but little is known about its accuracy in patients with normocalcemic primary hyperparathyroidism (NPHPT). METHODS: A total of 18 patients diagnosed with PHPT underwent three methods of preoperative localization (4D CT, TC-99-Sestamibi scintigraphy and ultrasonography)...
April 15, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#5
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29656541/a-novel-herpesvirus-associated-with-chronic-superficial-keratitis-and-proliferative-conjunctivitis-in-a-great-horned-owl-bubo-virginianus
#6
Molly D Gleeson, Bret A Moore, Sydney G Edwards, Sarah Stevens, April L Childress, James F X Wellehan, Jessica Robertson, Christopher J Murphy, Michelle G Hawkins, Joanne Paul-Murphy
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29656446/hemodynamic-response-function-hrf-variability-confounds-resting-state-fmri-functional-connectivity
#7
D Rangaprakash, Guo-Rong Wu, Daniele Marinazzo, Xiaoping Hu, Gopikrishna Deshpande
PURPOSE: fMRI is the convolution of the hemodynamic response function (HRF) and unmeasured neural activity. HRF variability (HRFv) across the brain could, in principle, alter functional connectivity (FC) estimates from resting-state fMRI (rs-fMRI). Given that HRFv is driven by both neural and non-neural factors, it is problematic when it confounds FC. However, this aspect has remained largely unexplored even though FC studies have grown exponentially. We hypothesized that HRFv confounds FC estimates in the brain's default-mode-network...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656408/in-silico-tracking-of-individual-species-accelerating-progress-in-macromolecular-engineering-and-design
#8
Dagmar R D'hooge
The beneficial use of computer simulations to track the microstructural evolution of individual species is highlighted in view of macromolecular engineering and design, considering two case studies on catalytic polymerization, and both "low" (<100) and "high" (>100) chain lengths, that is, i) atom transfer radical copolymerization of n-butyl acrylate and styrene aiming at the synthesis of functional macrospecies of "identical' chain length; and ii) chain shuttling polymerization of ethylene and 1-octene toward the production of segmented block copolymers with "soft" and "hard" segments...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656376/human-genetics-of-sclerosing-bone-disorders
#9
REVIEW
Raphaël De Ridder, Eveline Boudin, Geert Mortier, Wim Van Hul
PURPOSE OF REVIEW: The group of sclerosing bone disorders encompasses a variety of disorders all marked by increased bone mass. In this review, we give an overview of the genetic causes of this heterogeneous group of disorders and briefly touch upon the value of these findings for the development of novel therapeutic agents. RECENT FINDINGS: Advances in the next-generation sequencing technologies are accelerating the molecular dissection of the pathogenic mechanisms underlying skeletal dysplasias...
April 14, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29656245/individual-differences-in-socioemotional-sensitivity-are-an-index-of-salience-network-function
#10
Gianina Toller, Jesse Brown, Marc Sollberger, Suzanne M Shdo, Laura Bouvet, Paul Sukhanov, William W Seeley, Bruce L Miller, Katherine P Rankin
Connectivity in intrinsically connected networks (ICNs) may predict individual differences in cognition and behavior. The drastic alterations in socioemotional awareness of patients with behavioral variant frontotemporal dementia (bvFTD) are presumed to arise from changes in one such ICN, the salience network (SN). We examined how individual differences in SN connectivity are reflected in overt social behavior in healthy individuals and patients, both to provide neuroscientific insight into this key brain-behavior relationship, and to provide a practical tool to diagnose patients with early bvFTD...
February 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29656234/intramasseteric-schwanoma-mimicking-an-isolated-cheek-mass-case-report-and-review-of-literature
#11
Nazir El Khatib, Antoine Nehme, Selim Nasser, Nabil Moukarzel, Houssam Khodor Abtar
INTRODUCTION: Schwannoma is a benign well circumscribed tumor of the nerve sheath and it is mostly localized in the head and neck. Intramasseteric schwannoma represents a very rare entity and a few cases have been described in the literature. PRESENTATION OF CASE: We present a case of an isolated, asymptomatic and slowly progressive right cheek tumor in a middle aged man. Although multiple investigations, including neck scanner and fine needle aspiration, were done, the diagnosis was obscure and difficult before definite surgical resection...
April 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29656225/biodegradation-of-acrylamide-by-a-novel-isolate-cupriavidus-oxalaticus-ictdb921-identification-and-characterization-of-the-acrylamidase-produced
#12
Dattatray K Bedade, Rekha S Singhal
Acrylamide is neurotoxic, genotoxic, teratogenic and carcinogenic. Its widespread use in various industrial processes leads to environmental contamination. Acrylamidase produced by certain bacteria degrade acrylamide to acrylic acid and ammonia. The present study details the isolation and identification of soil bacterium which could degrade acrylamide. Among the 18 acrylamide-degrading isolates tested, isolate ICTDB921 demonstrated superior acrylamide degradation which was confirmed by HPLC, FTIR and GC-MS...
April 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29656166/identification-of-molt-inhibiting-hormone-and-ecdysteroid-receptor-cdna-sequences-in-gammarus-pulex-and-variations-after-endocrine-disruptor-exposures
#13
Eric Gismondi
In amphipods, growth, development and reproduction are mediated by the molt, which is a hormonally controlled process and which, therefore, could be impacted by endocrine disruption compounds (EDC). The molt process is controlled by both X-organ (XO) and Y-organ (YO) through a variety of hormones and receptors including the molt-inhibiting hormone (MIH) and the ecdysteroid receptor (EcR). However, although many studies were devoted to characterize MIH and EcR in crustaceans, only few works evaluated their variations under EDCs exposures...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29656136/streptococcous-gallolyticus-subsp-pasteurianus-meningitis-complicated-by-venous-sinus-thrombosis-a-case-report
#14
Martin Wardle, Andre Mu, Steven Y C Tong
We describe a case of Streptococcus gallolyticus subsp pasteurianus meningitis, unusually occurring in a splenectomised patient and complicated by cerebral venous thrombosis. Following presentation with meningism and diagnosis and management of S. gallolyticus meningitis, the patient represented with a further four days of fevers and subsequently developed left sided paresthesias. Cerebral imaging revealed venous thrombus in the right frontal cortical veins and left sigmoid sinus. The patient recovered following four weeks of intravenous ceftriaxone and anticoagulation with enoxaparin and then warfarin...
April 12, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29656124/development-of-an-improved-rapid-bacpro%C3%A2-protocol-and-a-method-for-direct-identification-from-blood-culture-positive-bottles-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#15
Takatoshi Yonezawa, Tomohisa Watari, Kazuho Ashizawa, Daisuke Hanada, Takako Yanagiya, Naoki Watanabe, Takashi Terada, Yutaka Tomoda, Satoshi Fujii
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been incorporated into pathogenic bacterial identification methods and has improved their rapidity. Various methods have been reported to directly identify bacteria with MALDI-TOF MS by pretreating culture medium in blood culture bottles. Rapid BACpro® (Nittobo Medical Co., Ltd.) is a pretreatment kit for effective collection of bacteria with cationic copolymers. However, the Rapid BACpro® pretreatment kit is adapted only for MALDI Biotyper (Bruker Daltonics K...
April 12, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29656107/statistical-testing-and-power-analysis-for-brain-wide-association-study
#16
Weikang Gong, Lin Wan, Wenlian Lu, Liang Ma, Fan Cheng, Wei Cheng, Stefan Grünewald, Jianfeng Feng
The identification of connexel-wise associations, which involves examining functional connectivities between pairwise voxels across the whole brain, is both statistically and computationally challenging. Although such a connexel-wise methodology has recently been adopted by brain-wide association studies (BWAS) to identify connectivity changes in several mental disorders, such as schizophrenia, autism and depression, the multiple correction and power analysis methods designed specifically for connexel-wise analysis are still lacking...
April 5, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29656082/ultra-high-performance-supercritical-fluid-chromatography-hyphenated-to-atmospheric-pressure-chemical-ionization-high-resolution-mass-spectrometry-for-the-characterization-of-fast-pyrolysis-bio-oils
#17
Julien Crepier, Agnès Le Masle, Nadège Charon, Florian Albrieux, Pascal Duchene, Sabine Heinisch
Extensive characterization of complex mixtures requires the combination of powerful analytical techniques. A Supercritical Fluid Chromatography (SFC) method was previously developed, for the specific case of fast pyrolysis bio oils, as an alternative to gas chromatography (GC and GC × GC) or liquid chromatography (LC and LC × LC), both separation methods being generally used prior to mass spectrometry (MS) for the characterization of such complex matrices. In this study we investigated the potential of SFC hyphenated to high resolution mass spectrometry (SFC-HRMS) for this characterization using Negative ion Atmospheric Pressure Chemical ionization ((-)APCI) for the ionization source...
April 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29656020/odorant-binding-protein-based-identification-of-natural-spatial-repellents-for-the-african-malaria-mosquito-anopheles-gambiae
#18
Thomas Kröber, Konstantinos Koussis, Martine Bourquin, Panagiota Tsitoura, Maria Konstantopoulou, Taiwo Sam Awolola, Francesca R Dani, Huili Qiao, Paolo Pelosi, Kostas Iatrou, Patrick M Guerin
There is increasing interest in the development of effective mosquito repellents of natural origin to reduce transmission of diseases such as malaria and yellow fever. To achieve this we have employed an in vitro competition assay involving odorant-binding proteins (OBPs) of the malaria mosquito, Anopheles gambiae, with a predominantly female expression bias to identify plant essential oils (EOs) containing bioactive compounds that target mosquito olfactory function. EOs and their fractions capable of binding to such OBPs displayed repellence against female mosquitoes in a laboratory repellence assay...
April 12, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29656019/proteomic-identification-of-virulence-related-factors-in-young-and-aging-c-elegans-infected-with-pseudomonas-aeruginosa
#19
Christina D King, Daljeet Singh, Kyle Holden, Annie B Govan, Scott A Keith, Arjumand Ghazi, Renã A S Robinson
The molecular mechanisms that distinguish immunosenescence from general age-related decline are poorly understood. We addressed this by exposing Day 1 and Day 5 adults of Caenorhabditis elegans to Pseudomonas aeruginosa strain PA01, an opportunistic pathogen. Day 5 adult C. elegans exhibited greater vulnerability to infection as compared to Day 1 C. elegans. Using TMT6 -plex isobaric labeling and reductive dimethylation, we identified 55 proteins whose levels were altered following infection of Day 1 and Day 5 adults...
April 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#20
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
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