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experience of implementing HPV vaccination

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https://www.readbyqxmd.com/read/29016596/experiences-of-operational-costs-of-hpv-vaccine-delivery-strategies-in-gavi-supported-demonstration-projects
#1
Siobhan Botwright, Taylor Holroyd, Shreya Nanda, Paul Bloem, Ulla K Griffiths, Anissa Sidibe, Raymond C W Hutubessy
From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries to conduct small-scale demonstration projects for the introduction of the human papillomavirus vaccine, with the aim of determining which human papillomavirus vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on the operational costs and cost determinants of different vaccination delivery strategies within these projects across twelve countries using a standardized micro-costing tool...
2017: PloS One
https://www.readbyqxmd.com/read/28663791/human-papillomavirus-vaccination-the-population-impact
#2
REVIEW
Lai-Yang Lee, Suzanne M Garland
We currently have the knowledge and experience to prevent much of human papillomavirus (HPV)-related disease burden globally. In many countries where prophylactic HPV vaccination programs have been adopted as highly effective public health programs with good vaccine coverage, we are already seeing, in real-world settings, reduction of vaccine-related HPV-type infections, genital warts and cervical pre-cancers with potential reductions in vulvar, vaginal and anal pre-cancers. Moreover, we are seeing a change in cervical screening paradigms, as HPV-based screening programs now have strong evidence to support their use as more sensitive ways to detect underlying cervical abnormalities, as compared with conventional cervical cytology...
2017: F1000Research
https://www.readbyqxmd.com/read/28419156/school-nurses-attitudes-towards-and-experiences-of-the-swedish-school-based-hpv-vaccination-programme-a-repeated-cross-sectional-study
#3
Maria Grandahl, Margareta Larsson, Tanja Tydén, Christina Stenhammar
The aim was to investigate school nurses' attitudes towards, and experiences of vaccination against human papillomavirus (HPV), and compare the results with a similar study three years earlier. School nurses (n = 736) from all counties in Sweden completed a questionnaire in spring 2016, four years after the implementation of the national HPV vaccination programme, and three years after the previous survey. Overall, the school nurses had more favourable attitudes towards the HPV vaccination programme compared to the study in 2013 (p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28291647/health-professional-feedback-on-hpv-vaccination-roll-out-in-a-developing-country
#4
Collette Venturas, Kanayo Umeh
BACKGROUND: Worldwide, Zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). The human papilloma virus (HPV) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-Saharan countries, such as Zambia. Past research suggests health professionals' experiences with HPV vaccination rollout can have practical implications for effective delivery. OBJECTIVE: To explore health professionals' perspectives on the HPV vaccination programme in Zambia...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28279264/introduction-of-molecular-hpv-testing-as-the-primary-technology-in-cervical-cancer-screening-acting-on-evidence-to-change-the-current-paradigm
#5
Joseph E Tota, James Bentley, Jennifer Blake, François Coutlée, Máire A Duggan, Alex Ferenczy, Eduardo L Franco, Michael Fung-Kee-Fung, Walter Gotlieb, Marie-Hélène Mayrand, Meg McLachlin, Joan Murphy, Gina Ogilvie, Sam Ratnam
Since being introduced in the 1940s, cervical cytology - despite its limitations - has had unequivocal success in reducing cervical cancer burden in many countries. However, we now know that infection with human papillomavirus (HPV) is a necessary cause of cervical cancer and there is overwhelming evidence from large-scale clinical trials, feasibility studies and real-world experience that supports the introduction of molecular testing for HPV as the primary technology in cervical cancer screening (i.e., "HPV primary screening")...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/27887796/vaccine-strategies-optimising-outcomes
#6
Karin Hardt, Paolo Bonanni, Susan King, Jose Ignacio Santos, Mostafa El-Hodhod, Gregory D Zimet, Scott Preiss
Successful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine...
December 20, 2016: Vaccine
https://www.readbyqxmd.com/read/27737666/experiences-and-lessons-learned-from-29-hpv-vaccination-programs-implemented-in-19-low-and-middle-income-countries-2009-2014
#7
Joël Ladner, Marie-Hélène Besson, Etienne Audureau, Mariana Rodrigues, Joseph Saba
BACKGROUND: Cervical cancer is the greatest cause of age-weighted years of life lost in the developing world. Human papillomavirus (HPV) infection is associated with a high proportion of cervical cancers, and HPV vaccination may help to reduce the incidence of cancer. The aim of the study was to identify barriers, obstacles, and strategies and to analyze key concerns and lessons learned with respect to the implementation of HPV vaccination program in low- and middle-income countries. METHODS: The Gardasil Access Program (GAP) is a donation program established to enable organizations and institutions in eligible low-resource countries to gain operational experience designing and implementing HPV vaccination programs...
October 13, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27637758/challenges-in-cost-effectiveness-analysis-modelling-of-hpv-vaccines-in-low-and-middle-income-countries-a-systematic-review-and-practice-recommendations
#8
REVIEW
Obinna I Ekwunife, James F O'Mahony, Andreas Gerber Grote, Christoph Mosch, Tatjana Paeck, Stefan K Lhachimi
BACKGROUND: Low- and middle-income countries (LMICs) face a number of challenges in implementing cervical cancer prevention programmes that do not apply in high-income countries. OBJECTIVE: This review assessed how context-specific challenges of implementing cervical cancer prevention strategies in LMICs were accounted for in existing cost-effectiveness analysis (CEA) models of human papillomavirus (HPV) vaccination. METHODS: The databases of MEDLINE, EMBASE, NHS Economic Evaluation Database, EconLit, Web of Science, and the Center for the Evaluation of Value and Risk in Health (CEA) Registry were searched for studies published from 2006 to 2015...
January 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/27446557/control-of-cervical-cancer-in-peru-current-barriers-and-challenges-for-the-future
#9
Alfredo Aguilar, Joseph A Pinto, Jhajaira Araujo, Williams Fajardo, Leny Bravo, Luis Pinillos, Carlos Vallejos
Cervical cancer is the leading malignant neoplasm in Peruvian women. This malignancy is a public health problem and several efforts were previously performed to develop cancer control plans. Geographical, cultural, structural, infrastructural and procedural barriers can limit the implementation of such strategies. Several previous studies have characterized human papilloma virus (HPV) epidemiology, where prevalence of high-risk HPV in adult females is ~12% and the prevalence in cervical cancer is 90-95%. The predominant barriers for the control of cervical cancer are lack of specialists in remote villages, education/cultural issues, loss of patients in follow-up, lack of access to HPV testing and lack of compliance for HPV vaccination...
August 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27412177/knowledge-attitudes-and-awareness-of-the-human-papillomavirus-amongst-primary-care-practice-nurses-an-evaluation-of-current-training-in-england
#10
H Patel, K Austin-Smith, S M Sherman, D Tincello, E L Moss
Background: The incorporation of Human papillomavirus (HPV) testing into the English cervical screening programme has been met with fear and anxiety. Healthcare professionals need to be adequately informed about HPV to help alleviate patient concerns. The aim of this study was to evaluate the HPV training provided to practice nurses (PNs) and determine their level of HPV knowledge. Method: A web-based survey was distributed to 147 General Practice surgeries in the Leicester, Leicestershire and Rutland regions, between May and July 2015...
September 1, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/27159786/the-value-of-demonstration-projects-for-new-interventions-the-case-of-human-papillomavirus-vaccine-introduction-in-low-and-middle-income-countries
#11
N Howard, S Mounier-Jack, K E Gallagher, S Kabakama, U K Griffiths, M Feletto, D S LaMontagne, H E D Burchett, D Watson-Jones
Demonstration projects or pilots of new public health interventions aim to build learning and capacity to inform country-wide implementation. Authors examined the value of HPV vaccination demonstration projects and initial national programmes in low-income and lower-middle-income countries, including potential drawbacks and how value for national scale-up might be increased. Data from a systematic review and key informant interviews, analyzed thematically, included 55 demonstration projects and 8 national programmes implemented between 2007-2015 (89 years' experience)...
September 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/26684658/implementation-of-a-national-school-based-human-papillomavirus-hpv-vaccine-campaign-in-fiji-knowledge-vaccine-acceptability-and-information-needs-of-parents
#12
S F La Vincente, D Mielnik, K Jenkins, F Bingwor, L Volavola, H Marshall, P Druavesi, F M Russell, K Lokuge, E K Mulholland
BACKGROUND: In 2008 Fiji implemented a nationwide Human Papillomavirus (HPV) vaccine campaign targeting all girls aged 9-12 years through the existing school-based immunisation program. Parents of vaccine-eligible girls were asked to provide written consent for vaccination. The purpose of this study was to describe parents' knowledge, experiences and satisfaction with the campaign, the extent to which information needs for vaccine decision-making were met, and what factors were associated with vaccine consent...
2015: BMC Public Health
https://www.readbyqxmd.com/read/26346895/public-health-value-of-universal-hpv-vaccination
#13
REVIEW
Riccardo A Audisio, Giancarlo Icardi, Andrea M Isidori, Carlo A Liverani, Alberto Lombardi, Luciano Mariani, Francesco Saverio Mennini, David A Mitchell, Andrea Peracino, Sergio Pecorelli, Giovanni Rezza, Carlo Signorelli, Giovanni Vitali Rosati, Gian Vincenzo Zuccotti
BACKGROUND: The story of Human Papillomavirus vaccination demands reflection not only for its public health impact on the prophylactic management of HPV disease, but also for its relevant economic and social outcomes. Greater than ever data confirm the efficacy and support the urge for effective vaccination plans for both genders before sexual debut. METHODS: A review of previous experience in gender-restricted vaccination programs has demonstrated a lower effectiveness...
January 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26343194/gavi-hpv-programs-application-to-implementation
#14
REVIEW
Celina M Hanson, Linda Eckert, Paul Bloem, Tania Cernuschi
Developing countries disproportionately suffer from the burden of cervical cancer yet lack the resources to establish systematic screening programs that have resulted in significant reductions in morbidity and mortality in developed countries. Human Papillomavirus (HPV) vaccination provides an opportunity for primary prevention of cervical cancer in low-resource settings through vaccine provision by Gavi The Vaccine Alliance. In addition to the traditional national introduction, countries can apply for a demonstration program to help them make informed decisions for subsequent national introduction...
May 20, 2015: Vaccines
https://www.readbyqxmd.com/read/26170394/robust-in-vitro-and-in-vivo-neutralization-against-multiple-high-risk-hpv-types-induced-by-a-thermostable-thioredoxin-l2-vaccine
#15
Hanna Seitz, Lis Ribeiro-Müller, Elena Canali, Angelo Bolchi, Massimo Tommasino, Simone Ottonello, Martin Müller
Current prophylactic virus-like particle (VLP) human papillomavirus (HPV) vaccines are based on the L1 major capsid protein and provide robust but virus type-restricted protection. Moreover, VLP vaccines have a high production cost, require cold-chain storage, and are thus not readily implementable in developing countries, which endure 85% of the cervical cancer-related death burden worldwide. In contrast with L1, immunization with minor capsid protein L2 elicits broad cross-neutralization, and we previously showed that insertion of a peptide spanning amino acids 20-38 of L2 into bacterial thioredoxin (Trx) greatly enhances its immunogenicity...
October 2015: Cancer Prevention Research
https://www.readbyqxmd.com/read/26149158/the-views-of-young-women-on-hpv-vaccine-communication-in-four-european-countries
#16
Dafina Petrova, Carol Gray Brunton, Moritz Jaeger, Anita Lenneis, Rocio Munoz, Rocio Garcia-Retamero, Irina Todorova
The Human Papilloma Virus (HPV) is the most common sexually transmitted infection (STI) and can cause cervical cancer. Two vaccines are available to protect against the most common strands of the virus. Vaccination programs differ across Europe but most neglect young adults, who are the group with the highest risk of contracting STIs. Our aim was to explore the views of young women from four European countries—Scotland, Spain, Serbia, and Bulgaria - about the HPV vaccine communication strategy. These countries are characterized by different cervical cancer prevalence and vaccine implementation policies...
2015: Current HIV Research
https://www.readbyqxmd.com/read/26115523/access-and-attitudes-to-hpv-vaccination-amongst-hard-to-reach-populations-in-kenya
#17
Deborah Watson-Jones, Nelly Mugo, Shelley Lees, Muthoni Mathai, Sophie Vusha, Gathari Ndirangu, David A Ross
BACKGROUND: Sub-Saharan Africa bears the greatest burden of cervical cancer. Human papillomavirus (HPV) vaccination programmes to prevent the disease will need to reach vulnerable girls who may not be able access health and screening services in the future. We conducted formative research on facilitators and barriers to HPV vaccination and potential acceptability of a future HPV vaccination programme amongst girls living in hard-to-reach populations in Kenya. METHODS: Stakeholder interviews with Ministry of Health staff explored barriers to and support for the uptake of HPV vaccination...
2015: PloS One
https://www.readbyqxmd.com/read/26101366/immunogenicity-and-safety-of-a-9-valent-hpv-vaccine
#18
RANDOMIZED CONTROLLED TRIAL
Pierre Van Damme, Sven Eric Olsson, Stanley Block, Xavier Castellsague, Glenda E Gray, Teobaldo Herrera, Li-Min Huang, Dong Soo Kim, Punnee Pitisuttithum, Joshua Chen, Susan Christiano, Roger Maansson, Erin Moeller, Xiao Sun, Scott Vuocolo, Alain Luxembourg
OBJECTIVES: Prophylactic vaccination of youngwomen aged 16 to 26 years with the 9-valent (6/11/16/18/31/33/45/52/58) human papillomavirus (HPV) virus-like particle (9vHPV) vaccine prevents infection and disease. We conducted a noninferiority immunogenicity study to bridge the findings in young women to girls and boys aged 9 to 15 years. METHODS: Subjects (N = 3066) received a 3-dose regimen of 9vHPV vaccine administered at day 1, month 2, and month 6. Anti-HPV serologic assays were performed at day 1 and month 7...
July 2015: Pediatrics
https://www.readbyqxmd.com/read/25749310/design-of-a-large-outcome-trial-for-a-multivalent-human-papillomavirus-l1-virus-like-particle-vaccine
#19
MULTICENTER STUDY
Alain Luxembourg, Oliver Bautista, Erin Moeller, Michael Ritter, Joshua Chen
BACKGROUND: The 9-valent human papillomavirus (HPV) (9vHPV) vaccine targets the four HPV types (6/11/16/18) covered by the licensed quadrivalent HPV (qHPV) vaccine and five additional types (31/33/45/52/58). A large outcome trial of 9vHPV vaccine was conducted. METHODS: An active control (qHPV vaccine) was used because a placebo is not ethically acceptable. Since qHPV vaccine is (and 9vHPV vaccine was anticipated to be) highly efficacious against HPV 6/11/16/18, low incidence of HPV 6/11/16/18-associated disease was expected...
May 2015: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/25606080/current-issues-facing-the-introduction-of-human-papillomavirus-vaccine-in-malaysia
#20
REVIEW
Lp Wong, Ic Sam
Certain human papillomavirus (HPV) types are strongly associated with cervical cancer. Recently-described effective vaccines against these HPV types represent a great medical breakthrough in preventing cervical cancer. In Malaysia, the vaccine has just received regulatory approval. We are likely to face similar barriers to implementing HPV vaccination as reported by countries where vaccination has been introduced. Most women have poor understanding of HPV and its link to cervical cancer. Physicians who will be recommending HPV vaccines may not have extensive knowledge or experience with HPV-related disease...
2007: Malaysian Family Physician
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