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Keywords Dementia prevention nutrition ...

Dementia prevention nutrition exercise

https://read.qxmd.com/read/38362052/south-korean-study-to-prevent-cognitive-impairment-and-protect-brain-health-through-multidomain-interventions-via-face-to-face-and-video-communication-platforms-in-mild-cognitive-impairment-superbrain-meet-protocol-for-a-multicenter-randomized-controlled-trial
#1
JOURNAL ARTICLE
Soo Hyun Cho, Hae Jin Kang, Yoo Kyoung Park, So Young Moon, Chang Hyung Hong, Hae Ri Na, Hong-Sun Song, Muncheong Choi, Sooin Jeong, Kyung Won Park, Hyun Sook Kim, Buong-O Chun, Jiwoo Jung, Jee Hyang Jeong, Seong Hye Choi
BACKGROUND AND PURPOSE: The SoUth Korea study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) proved the feasibility of multidomain intervention for elderly people. One-quarter of the Korean population over 65 years of age has mild cognitive impairment (MCI). Digital health interventions may be cost-effective and have fewer spatial constraints. We aim to examine the efficacy of a multidomain intervention through both face-to-face interactions and video communication platforms using a tablet personal computer (PC) application in MCI...
January 2024: Dementia and neurocognitive disorders
https://read.qxmd.com/read/38356861/enhancing-cognitive-function-in-older-adults-dietary-approaches-and-implications
#2
REVIEW
Baruh Polis, Abraham O Samson
Natural aging encompasses physiological and psychological changes that impact overall health and quality of life. Mitigating these effects requires physical and mental exercise, coupled with proper nutrition. Notably, protein malnutrition emerges as a potential risk factor for senile dementia, with insufficient intake correlating with premature cognitive decline. Adequate protein intake in the elderly positively associates with memory function and lowers cognitive impairment risk. Considering diet as a modifiable risk factor for cognitive decline, extensive research has explored diverse dietary strategies to prevent dementia onset in older adults...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38135320/randomised-controlled-trial-combining-vitamin-e-functionalised-chocolate-with-physical-exercise-to-reduce-the-risk-of-protein-energy-malnutrition-in-predementia-aged-people-study-protocol-for-choko-age
#3
JOURNAL ARTICLE
Anna Pedrinolla, Masoud Isanejad, Cinzia Antognelli, Desirée Bartolini, Consuelo Borras, Valentina Cavedon, Gabriele Di Sante, Anna Migni, Cristina Mas-Bargues, Chiara Milanese, Claudia Baschirotto, Roberto Modena, Alessandra Pistilli, Mario Rende, Federico Schena, Anna Maria Stabile, Nicola Vincenzo Telesa, Sara Tortorella, Kay Hemmings, Jose Vina, Eivind Wang, Anne McArdle, Malcolm J Jackson, Massimo Venturelli, Francesco Galli
OBJECTIVE: Protein-energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly...
December 22, 2023: BMJ Open
https://read.qxmd.com/read/37880167/effects-of-protein-enriched-mediterranean-diet-and-exercise-on-nutritional-status-and-cognition-in-adults-at-risk-of-undernutrition-and-cognitive-decline-the-promed-ex-randomised-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Nicola Ann Ward, Rachel Reid-McCann, Lorraine Brennan, Christopher R Cardwell, Cpgm de Groot, Stefania Maggi, Noel McCaffrey, Bernadette McGuinness, Michelle C McKinley, Marianna Noale, Roisin F O'Neill, Federica Prinelli, Giuseppe Sergi, Caterina Trevisan, Dorothee Volkert, Jayne V Woodside, Claire T McEvoy
INTRODUCTION: Undernutrition leading to unplanned weight loss is common in older age and has been linked to increased dementia risk in later life. Weight loss can precede dementia by a decade or more, providing a unique opportunity for early intervention to correct undernutrition and potentially prevent or delay cognitive impairment. The combined effects of diet and exercise on undernutrition have not yet been evaluated. The objective of this trial is to determine the effect of a protein-enriched Mediterranean diet, with and without exercise, on nutritional status and cognitive performance in older adults at risk of undernutrition and cognitive decline...
October 25, 2023: BMJ Open
https://read.qxmd.com/read/37635980/alzheimer-s-disease-and-its-associated-risk-of-bone-fractures-a-narrative-review
#5
REVIEW
Bing-Na Zhou, Qian Zhang, Mei Li
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder that is the major cause of dementia in the aged population. Recent researches indicate that patients with AD have a significantly increased fracture risk, but the pathological mechanisms are still unclear. OBJECTIVE: We systematically reviewed studies regarding bone fracture risk in AD to uncover links between the pathologies of osteoporosis and AD. METHODS: We searched the literature using the databases of PubMed, Web of Science, Embase and Cochrane Library...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37635661/understanding-cognitive-frailty-in-aging-adults-prevalence-risk-factors-pathogenesis-and-non-pharmacological-interventions
#6
REVIEW
Livia Gajdosova, Vladimir Jakus, Jana Muchova
The worldwide increase in the aged population raises health concerns for elderly individuals. Cognitive frailty of the elderly (apart from those suffering from Alzheimer´s disease or other type of dementia) is a complex construct associated with aging, which is composed of physical and cognitive components, while physical frailty and cognitive impairment mutually affect each other. Although the prevalence of cognitive frailty in community-dwelling older adults without neurodegenerative disease is low, it can rise dramatically in clinical settings...
2023: Bratislavské Lekárske Listy
https://read.qxmd.com/read/37273649/exercise-program-to-reduce-the-risk-of-cognitive-decline-and-physical-frailty-in-older-adults-study-protocol-for-an-open-label-double-arm-clinical-trial
#7
JOURNAL ARTICLE
Moeko Noguchi-Shinohara, Kunihiko Yokoyama, Junji Komatsu, Kazumi Masuda, Mitsunobu Kouno, Mitsuhiro Yoshita, Kenjiro Ono
OBJECTIVE: It is a big problem that many older adults are physically inactive. Well-known benefits of physical exercise include a decrease in the risk of cognitive decline and physical frailty. Therefore, this study aims to examine whether our proposed exercise program can prevent cognitive decline and improve physical function in the elderly. METHODS: This study will include nondemented older adults ( n  = 103) without regular exercise habits. The trial will include a physical exercise training program (once a week) and nutritional lectures (once a month) over 5 months and follow-up for ≥1 year...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37081555/leveraging-the-glymphatic-and-meningeal-lymphatic-systems-as-therapeutic-strategies-in-alzheimer-s-disease-an-updated-overview-of-nonpharmacological-therapies
#8
REVIEW
Douglas A Formolo, Jiasui Yu, Kangguang Lin, Hector W H Tsang, Haining Ou, Georg S Kranz, Suk-Yu Yau
Understanding and treating Alzheimer's disease (AD) has been a remarkable challenge for both scientists and physicians. Although the amyloid-beta and tau protein hypothesis have largely explained the key pathological features of the disease, the mechanisms by which such proteins accumulate and lead to disease progression are still unknown. Such lack of understanding disrupts the development of disease-modifying interventions, leaving a therapeutic gap that remains unsolved. Nonetheless, the recent discoveries of the glymphatic pathway and the meningeal lymphatic system as key components driving central solute clearance revealed another mechanism underlying AD pathogenesis...
April 20, 2023: Molecular Neurodegeneration
https://read.qxmd.com/read/36892103/how-can-physical-activity-facilitate-a-sustainable-future-reducing-obesity-and-chronic-disease
#9
REVIEW
David J Stensel
This review examines the ways in which physical activity can contribute to a sustainable future by addressing significant public health issues. The review begins by identifying obesity and ageing as two major challenges facing societies around the world due to the association of both with the risk of chronic disease. Recent developments in the understanding and treatment of obesity are examined followed by an appraisal of the role of exercise alone and in combination with other therapies in preventing and managing obesity...
February 28, 2023: Proceedings of the Nutrition Society
https://read.qxmd.com/read/36791973/effects-of-community-based-frailty-preventing-intervention-on-all-cause-and-cause-specific-functional-disability-in-older-adults-living-in-rural-japan-a-propensity-score-analysis
#10
JOURNAL ARTICLE
Yu Nofuji, Satoshi Seino, Takumi Abe, Yuri Yokoyama, Miki Narita, Hiroshi Murayama, Shoji Shinkai, Akihiko Kitamura, Yoshinori Fujiwara
Preventing frailty is crucial in aging societies. We examined the effectiveness of a community-based frailty-prevention program for delaying the onset of functional disability among community-dwelling older adults. From 2014 to 2019, 48 community-based frailty prevention classes (FPC, 60 min/session, once a week), comprising resistance exercise and nutritional or psychosocial programs, were established in Yabu City, Japan. We conducted a baseline survey in 2012 and followed up with participants for up to 6...
February 13, 2023: Preventive Medicine
https://read.qxmd.com/read/36675177/rationale-for-a-multi-factorial-approach-for-the-reversal-of-cognitive-decline-in-alzheimer-s-disease-and-mci-a-review
#11
REVIEW
Rammohan V Rao, Kaavya G Subramaniam, Julie Gregory, Aida L Bredesen, Christine Coward, Sho Okada, Lance Kelly, Dale E Bredesen
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement...
January 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36435582/-papps-update-on-older-people-2022
#12
JOURNAL ARTICLE
Miguel Ángel Acosta Benito, Rosa Ana García Pliego, José Miguel Baena Díez, Ana Gorroñogoitia Iturbe, Yolanda Herreros Herreros, M Del Canto De Hoyos Alonso, Purificación Magán Tapia, Iñaki Martin Lesende
This article examines the latest available evidence on preventive activities in the elderly, including sleep disorders, physical exercise, deprescription, cognitive disorders and dementias, nutrition, social isolation and frailty.
October 2022: Atencion Primaria
https://read.qxmd.com/read/36337728/promoting-healthy-cardiovascular-aging-emerging-topics
#13
JOURNAL ARTICLE
Zachary S Clayton, Daniel H Craighead, Sanna Darvish, McKinley Coppock, Katelyn R Ludwig, Vienna E Brunt, Douglas R Seals, Matthew J Rossman
The development of age-related cardiovascular (CV) dysfunction increases the risk of CV disease as well as other chronic age-associated disorders, including chronic kidney disease, and Alzheimer's disease and related dementias. Major manifestations of age-associated CV dysfunction that increase disease risk are vascular dysfunction, primarily vascular endothelial dysfunction and arterial stiffening, and elevated systolic blood pressure. Declines in nitric oxide bioavailability secondary to increased oxidative stress and inflammation are established mechanisms of CV dysfunction with aging...
2022: The journal of cardiovascular aging
https://read.qxmd.com/read/36102762/effectiveness-of-a-complex-intervention-of-group-based-nutrition-and-physical-activity-to-prevent-frailty-in-pre-frail-older-adults-super-a-randomised-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Ruth Teh, Daniel Barnett, Richard Edlin, Ngaire Kerse, Debra L Waters, Leigh Hale, Esther Tay, Evelingi Leilua, Avinesh Pillai
BACKGROUND: The increasing prevalence of frailty with age is becoming a public health priority in countries with ageing populations. Pre-frailty presents a window of opportunity to prevent the development of frailty in community-dwelling older adults. This study aimed to examine the effectiveness of a complex intervention that combined a nutrition-based intervention and a physical activity intervention, along with the effectiveness of each intervention individually, to reduce physical frailty in pre-frail older adults over 2 years...
August 2022: The Lancet. Healthy longevity
https://read.qxmd.com/read/36088747/the-japan-multimodal-intervention-trial-for-prevention-of-dementia-prime-tamba-j-mint-prime-tamba-study-protocol-of-a-randomised-controlled-multi-domain-intervention-trial
#15
JOURNAL ARTICLE
Ryoko Kumagai, Tohmi Osaki, Yutaro Oki, Shunsuke Murata, Kazuaki Uchida, Haruhi Encho, Rei Ono, Hisatomo Kowa
The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba) is a randomised controlled trial to prevent cognitive decline in community-dwelling cognitively ordinary older people at risk of dementia. Participants are aged 65-85 years living in a rural area in Japan, aware of very mild decline in cognitive function or abilities of activities of daily living, have at least one vascular risk (e.g. hypertension or diabetes), and have a Mini-Mental State Examination score of 24 or higher...
August 31, 2022: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/36045102/protein-enriched-mediterranean-diet-to-combat-undernutrition-and-promote-healthy-neurocognitive-ageing-in-older-adults-the-promed-cog-consortium-project
#16
JOURNAL ARTICLE
Roisin F O'Neill, Lorraine Brennan, Federica Prinelli, Giuseppe Sergi, Caterina Trevisan, Lisette C P G M De Groot, Dorothee Volkert, Stefania Maggi, Marianna Noale, Silvia Conti, Fulvio Adorni, Jayne V Woodside, Michelle C McKinley, Bernadette McGuinness, Chris Cardwell, Claire T McEvoy
Dementia is a major public health challenge owing to its increasing prevalence and recognised impact on disability among older adults. Observational data indicate that weight loss is associated with increased dementia risk of 30%-40% and precedes a diagnosis of cognitive impairment or dementia by at least one decade. Although relatively little is known about the mechanisms of unintentional weight loss in dementia, this provides a window of opportunity to intervene with strategies to counteract undernutrition and delay, or prevent, the onset of dementia...
September 2022: Nutrition Bulletin
https://read.qxmd.com/read/35814120/the-nuance-of-bilingualism-as-a-reserve-contributor-conveying-research-to-the-broader-neuroscience-community
#17
JOURNAL ARTICLE
Toms Voits, Vincent DeLuca, Jubin Abutalebi
The neurological notion of "reserve" arises from an individually observable dissociation between brain health and cognitive status. According to the cognitive reserve hypothesis, high-reserve individuals experience functional compensation for neural atrophy and, thus, are able to maintain relatively stable cognitive functioning with no or smaller-than-expected impairment. Several lifestyle factors such as regular physical exercise, adequate and balanced nutrition, and educational attainment have been widely reported to contribute to reserve and, thus, lead to more successful trajectories of cognitive aging (CA)...
2022: Frontiers in Psychology
https://read.qxmd.com/read/35719157/applications-of-medium-chain-triglycerides-in-foods
#18
REVIEW
Shinji Watanabe, Shougo Tsujino
In the 1950s, the production of processed fats and oils from coconut oil was popular in the United States. It became necessary to find uses for the medium-chain fatty acids (MCFAs) that were byproducts of the process, and a production method for medium-chain triglycerides (MCTs) was established. At the time of this development, its use as a non-fattening fat was being studied. In the early days MCFAs included fatty acids ranging from hexanoic acid (C6:0) to dodecanoic acid (C12:0), but today their compositions vary among manufacturers and there seems to be no clear definition...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/35718870/the-ketogenic-diet-and-alzheimer-s-disease
#19
REVIEW
H Hersant, G Grossberg
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the most common form of dementia. There are currently FDA-approved symptomatic therapies for AD and a recently approved, potentially disease-modifying drug, Aducanumab; however, there are no curative or preventative therapies. Research suggests that diet may play a role in AD, but it is inconclusive relative to which dietary approach provides the most neuroprotective effects. There are other life-style approaches that have been found to possibly play a role in AD prevention/treatment...
2022: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/35617704/examining-the-cognitive-benefits-of-probiotic-supplementation-in-physically-active-older-adults-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Victoria Sanborn, Mashael Aljumaah, M Andrea Azcarate-Peril, John Gunstad
The prevalence of dementia is projected to increase with the growing older adult population and prevention strategies are urgently needed. Two promising interventions include physical activity (PA) and probiotic supplementation, with initial findings suggesting their combined use may confer greater cognitive benefits than either intervention alone. However, no study has yet examined the effects of probiotic supplementation on cognitive function in healthy, physically active older adults. The present study used archival data from a randomized clinical trial including 127 physically active, middle-aged to older adults (average age 64...
August 1, 2022: Applied Physiology Nutrition and Metabolism
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