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https://www.readbyqxmd.com/read/27876610/establishing-reference-intervals-for-hcg-in-postmenopausal-women
#1
Khushbu K Patel, Abraham J Qavi, Karl G Hock, Ann M Gronowski
BACKGROUND: Plasma concentrations of human chorionic gonadotropin (hCG) have been shown to increase with age due to pituitary secretion. We previously recommended that an hCG cutoff of 14.0IU/L be used for women ≥55years of age. However, it remains unknown whether concentrations >14.0IU/L can be expected in women with advanced age. Our objectives were to establish plasma hCG reference intervals and correlate follicle stimulating hormone (FSH) and hCG concentrations in postmenopausal females ≥55years...
November 19, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27836302/efficacy-of-spinal-cord-stimulation-as-an-adjunct-therapy-for-chronic-refractory-angina-pectoris
#2
Tasnim F Imran, Raymond Malapero, Ahmed H Qavi, Zachariah Hasan, Bryan de la Torre, Yash R Patel, R Jason Yong, Luc Djousse, J Michael Gaziano, Marie-Denise Gerhard-Herman
INTRODUCTION: Patients with chronic refractory angina whose symptoms are not controlled with conventional therapies have a poor quality of life. Adjunctive therapies, such as spinal cord stimulation (SCS) may be considered in these cases. We sought to examine whether SCS is associated with changes in exercise capacity and angina severity in these patients. METHODS: We searched Pubmed, Medline and other databases until December 2015. Two reviewers independently extracted data and assessed risk of bias...
November 2, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27684822/disseminated-cysticercosis-clinical-spectrum-toll-like-receptor-4-gene-polymorphisms-and-role-of-albendazole-a-prospective-follow-up-of-60-cases-with-a-review-of-56-published-cases
#3
Abdul Qavi, Ravindra Kumar Garg, Hardeep Singh Malhotra, Amita Jain, Neeraj Kumar, Kiran Preet Malhotra, Pradeep Kumar Srivastava, Rajesh Verma, Praveen Kumar Sharma
In this study, we describe clinical and imaging spectrum, and the natural course of patients with disseminated cysticercosis. How albendazole affects the course of disease has also been evaluated. We assessed the Toll-like receptor-4 gene polymorphisms, to know the reason for the apparently higher prevalence of disseminated cysticercosis in India.Sixty consecutive patients with disseminated cysticercosis were enrolled. Sixty age-and-sex-matched healthy controls were also enrolled for the purpose of genetic study...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26294976/clinical-use-of-diuretics-in-heart-failure-cirrhosis-and-nephrotic-syndrome
#4
REVIEW
Ahmed Hassaan Qavi, Rida Kamal, Robert W Schrier
Diuretics play significant role in pharmacology and treatment options in medicine. This paper aims to review and evaluate the clinical use of diuretics in conditions that lead to fluid overload in the body such as cardiac failure, cirrhosis, and nephrotic syndrome. To know the principles of treatment it is essential to understand the underlying pathophysiological mechanisms that cause the need of diuresis in the human body. Various classes of diuretics exist, each having a unique mode of action. A systemic approach for management is recommended based on the current guidelines, starting from thiazides and proceeding to loop diuretics...
2015: International Journal of Nephrology
https://www.readbyqxmd.com/read/26176878/lidocaine-5-patch-for-treatment-of-acute-pain-after-robotic-cardiac-surgery-and-prevention-of-persistent-incisional-pain-a-randomized-placebo-controlled-double-blind-trial
#5
RANDOMIZED CONTROLLED TRIAL
Bruce Vrooman, Leonardo Kapural, Sheryar Sarwar, Edward J Mascha, Tomislav Mihaljevic, Marc Gillinov, Shahbaz Qavi, Daniel I Sessler
OBJECTIVES: To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery. DESIGN: A randomized, placebo-controlled, double-blind trial. SETTING: Tertiary care academic medical center. SUBJECTS: Patients having robotic cardiac valve surgery. METHODS: Patients having robotic cardiac valve surgery were randomly assigned to 5% lidocaine patches or identical-appearing placebo patches...
August 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26010491/chronic-intermittent-hypoxia-is-independently-associated-with-reduced-postoperative-opioid-consumption-in-bariatric-patients-suffering-from-sleep-disordered-breathing
#6
Alparslan Turan, Jing You, Cameron Egan, Alex Fu, Ashish Khanna, Yashar Eshraghi, Raktim Ghosh, Somnath Bose, Shahbaz Qavi, Lovkesh Arora, Daniel I Sessler, Anthony G Doufas
BACKGROUND: Evidence suggests that recurrent nocturnal hypoxemia may affect pain response and/or the sensitivity to opioid analgesia. We tested the hypothesis that nocturnal hypoxemia, quantified by sleep time spent at an arterial saturation (SaO2) < 90% and minimum nocturnal SaO2 on polysomnography, are associated with decreased pain and reduced opioid consumption during the initial 72 postoperative hours in patients having laparoscopic bariatric surgery. METHODS: With Institutional Review Board approval, we examined the records of all patients who underwent laparoscopic bariatric surgery between 2004 and 2010 and had an available nocturnal polysomnography study...
2015: PloS One
https://www.readbyqxmd.com/read/25869114/physical-chemistry-of-highly-concentrated-emulsions
#7
REVIEW
Reza Foudazi, Sahar Qavi, Irina Masalova, Alexander Ya Malkin
This review explores the physics underlying the rheology of highly concentrated emulsions (HCEs) to determine the relationship between elasticity and HCE stability, and to consider whether it is possible to describe all physicochemical properties of HCEs on the basis of a unique physical approach. We define HCEs as emulsions with a volume fraction above the maximum closest packing fraction of monodisperse spheres, φm=0.74, even if droplets are not of polyhedron shape. The solid-like rheological behavior of HCEs is characterized by yield stress and elasticity, properties which depend on droplet polydispersity and which are affected by caging at volume fractions about the jamming concentration, φj...
June 2015: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/25752462/low-serum-vitamin-d-levels-are-not-associated-with-increased-postoperative-pain-and-opioid-requirements-a-historical-cohort-study
#8
Somnath Bose, Ashish Khanna, Jing You, Lovkesh Arora, Shahbaz Qavi, Alparslan Turan
PURPOSE: Vitamin D deficiency has been associated with chronic non-specific musculoskeletal pain syndromes; however, studies are lacking with respect to its relationship with postoperative pain. We tested the hypothesis that a lower preoperative vitamin D level is associated with increased postoperative pain and/or opioid consumption in morbidly obese patients who had laparoscopic bariatric surgery. METHODS: Data from 185 patients who underwent laparoscopic bariatric surgery at the Cleveland Clinic from 2005-2009 and had a vitamin D level checked within three months of their surgery were included in the analysis...
July 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/25254905/relationship-between-chronic-intermittent-hypoxia-and-intraoperative-mean-arterial-pressure-in-obstructive-sleep-apnea-patients-having-laparoscopic-bariatric-surgery
#9
Alparslan Turan, Jing You, Cameron Egan, Alex Fu, Ignazia Gazmuri, Ashish Khanna, Yashar Eshraghi, Raktim Ghosh, Somnath Bose, Shahbaz Qavi, Lovkesh Arora, Daniel I Sessler, Anthony G Doufas
BACKGROUND: Recurrent nocturnal hypoxemia in obstructive sleep apnea enhances sympathetic function, decreases baroreceptor sensitivity, and weakens peripheral vascular responses to adrenergic signals. The authors hypothesized that the percentage of total sleep time spent at oxyhemoglobin saturation (SaO2) less than 90% and minimum nocturnal SaO2 on preoperative polysomnography are associated with decreased intraoperative mean arterial pressure. METHODS: The authors examined the records of all patients who had laparoscopic bariatric surgery at Cleveland Clinic between 2005 and 2009 and an available polysomnography study...
January 2015: Anesthesiology
https://www.readbyqxmd.com/read/24561169/choroidal-analysis-in-healthy-eyes-using-swept-source-optical-coherence-tomography-compared-to-spectral-domain-optical-coherence-tomography
#10
COMPARATIVE STUDY
Mehreen Adhi, Jonathan J Liu, Ahmed H Qavi, Ireneusz Grulkowski, Chen D Lu, Kathrin J Mohler, Daniela Ferrara, Martin F Kraus, Caroline R Baumal, Andre J Witkin, Nadia K Waheed, Joachim Hornegger, James G Fujimoto, Jay S Duker
PURPOSE: To compare analyses of choroidal thickness and volume in healthy eyes measured concurrently with prototype long-wavelength swept-source optical coherence tomography (OCT) and commercially available spectral-domain optical coherence tomography (OCT) with and without enhanced depth imaging (EDI). DESIGN: Prospective cross sectional study. METHODS: The study included 19 healthy subjects (19 eyes), who were prospectively recruited to undergo 2 consecutive imaging sessions on the same randomly selected eye using spectral domain OCT and a prototype long-wavelength swept-source OCT...
June 2014: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/24220884/enhanced-visualization-of-the-choroido-scleral-interface-using-swept-source-oct
#11
Mehreen Adhi, Jonathan J Liu, Ahmed H Qavi, Ireneusz Grulkowski, James G Fujimoto, Jay S Duker
An accurate analysis of the thickness and volume of choroid using optical coherence tomography (OCT) requires precise visualization of the choroido-scleral interface. Results of studies that use spectral-domain OCT (SD-OCT) to look at the percent visualization of the choroido-scleral interface for accurate analysis of choroidal thickness show varying success rates. This study assessed the visualization of choroido-scleral interface in 19 healthy participants (19 eyes) prospectively recruited for consecutive high-definition raster scanning with an SD-OCT system with and without enhanced depth imaging (EDI) and a prototype long-wavelength swept-source OCT (SS-OCT) system...
November 2013: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/24171505/subpicogram-per-milliliter-detection-of-interleukins-using-silicon-photonic-microring-resonators-and-an-enzymatic-signal-enhancement-strategy
#12
Jared T Kindt, Matthew S Luchansky, Abraham J Qavi, So-Hyun Lee, Ryan C Bailey
The detection of biomolecules at ultralow (low to subpicogram per milliliter) concentrations and within complex, clinically relevant matrices is a formidable challenge that is complicated by limitations imposed by the Langmuir binding isotherm and mass transport, for surface-based affinity biosensors. Here we report the integration of an enzymatic signal enhancement scheme onto a multiplexable silicon photonic microring resonator detection platform. To demonstrate the analytical value of this combination, we simultaneously quantitated levels of the interleukins IL-2, IL-6, and IL-8 in undiluted cerebrospinal fluid in an assay format that is multiplexable, relatively rapid (90 min), and features a 3 order of magnitude dynamic range and a limit of detection ≤1 pg/mL...
November 19, 2013: Analytical Chemistry
https://www.readbyqxmd.com/read/23882341/treatment-and-pathogenesis-of-acute-hyperkalemia
#13
Yelena Mushiyakh, Harsh Dangaria, Shahbaz Qavi, Noorjahan Ali, John Pannone, David Tompkins
This article focuses on the pathogenesis, clinical manifestations, and various treatment modalities for acute hyperkalemia and presents a systematic approach to selecting a treatment strategy. Hyperkalemia, a life-threatening condition caused by extracellular potassium shift or decreased renal potassium excretion, usually presents with non-specific symptoms. Early recognition of moderate to severe hyperkalemia is vital in preventing fatal cardiac arrhythmias and muscle paralysis. Management of hyperkalemia includes the elimination of reversible causes (diet, medications), rapidly acting therapies that shift potassium into cells and block the cardiac membrane effects of hyperkalemia, and measures to facilitate removal of potassium from the body (saline diuresis, oral binding resins, and hemodialysis)...
2011: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/22665972/a-nonsense-mutation-in-s-antigen-p-glu306-causes-oguchi-disease
#14
Nadia K Waheed, Ahmed H Qavi, Sarah N Malik, Maleeha Maria, Moeen Riaz, Frans P M Cremers, Maleeha Azam, Raheel Qamar
PURPOSE: Genetic studies were performed to identify the causative mutation in a 15-year-old girl diagnosed with congenital stationary night blindness (CSNB) presenting Mizuo-Nakamura phenomenon, a typical Oguchi disease symptom. The patient also had dural sinus thrombosis (DST), thrombocytopenia, and systemic lupus erythematosus (SLE). METHODS: Mutation analysis was done by sequencing two candidate genes, S-antigen (SAG; arrestin 1), associated with Oguchi type 1, and rhodopsin kinase (GRK1), associated with Oguchi type 2...
2012: Molecular Vision
https://www.readbyqxmd.com/read/22541813/label-free-multiplexed-detection-of-bacterial-tmrna-using-silicon-photonic-microring-resonators
#15
Ott Scheler, Jared T Kindt, Abraham J Qavi, Lauris Kaplinski, Barry Glynn, Thomas Barry, Ants Kurg, Ryan C Bailey
A label-free biosensing method for the sensitive detection and identification of bacterial transfer-messenger RNA (tmRNA) is presented employing arrays of silicon photonic microring resonators. Species specific tmRNA molecules are targeted by complementary DNA capture probes that are covalently attached to the sensor surface. Specific hybridization is monitored in near real-time by observing the resonance wavelength shift of each individual microring. The sensitivity of the biosensing platform allowed for detection down to 53 fmol of Streptococcus pneumoniae tmRNA, equivalent to approximately 3...
June 2012: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/22174955/nanostructured-substrates-for-optical-sensing
#16
Jonathan W Kemling, Abraham J Qavi, Ryan C Bailey, Kenneth S Suslick
Sensors that change color have the advantages of versatility, ease of use, high sensitivity, and low cost. The recent development of optically based chemical sensing platforms has increasingly employed substrates manufactured with advanced processing or fabrication techniques to provide precise control over shape and morphology of the sensor micro- and nano-structure. New sensors have resulted with improved capabilities for a number of sensing applications, including the detection of biomolecules and environmental monitoring...
November 17, 2011: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/21834517/isothermal-discrimination-of-single-nucleotide-polymorphisms-via-real-time-kinetic-desorption-and-label-free-detection-of-dna-using-silicon-photonic-microring-resonator-arrays
#17
Abraham J Qavi, Thomas M Mysz, Ryan C Bailey
We report a sensitive, label-free method for detecting single-stranded DNA and discriminating between single nucleotide polymorphisms (SNPs) using arrays of silicon photonic microring resonators. In only a 10 min assay, DNA is detected at subpicomole levels with a dynamic range of 3 orders of magnitude. Following quantitation, sequence discrimination with single nucleotide resolution is achieved isothermally by monitoring the dissociation kinetics of the duplex in real-time using an array of SNP-specific capture probes...
September 1, 2011: Analytical Chemistry
https://www.readbyqxmd.com/read/21711056/anti-dna-rna-antibodies-and-silicon-photonic-microring-resonators-increased-sensitivity-for-multiplexed-microrna-detection
#18
Abraham J Qavi, Jared T Kindt, Martin A Gleeson, Ryan C Bailey
In this paper, we present a method for the sensitive detection of microRNAs (miRNAs) utilizing an antibody that specifically recognizes DNA:RNA heteroduplexes and a silicon photonic microring resonator array transduction platform. Microring resonator arrays are covalently functionalized with DNA capture probes that are complementary to solution phase miRNA targets. Following hybridization on the sensor, the anti-DNA:RNA antibody is introduced and binds selectively to the heteroduplexes, giving a larger signal than the original miRNA hybridization due to the increased mass of the antibody, as compared to the 22-mer oligoribonucleotide...
August 1, 2011: Analytical Chemistry
https://www.readbyqxmd.com/read/20680616/sizing-up-the-future-of-microrna-analysis
#19
REVIEW
Abraham J Qavi, Jared T Kindt, Ryan C Bailey
In less than 20 years, our appreciation for micro-RNA molecules (miRNAs) has grown from an original, curious observation in worms to their current status as incredibly important global regulators of gene expression that play key roles in many transformative biological processes. As our understanding of these small, non-coding transcripts continues to evolve, new approaches for their analysis are emerging. In this critical review we describe recent improvements to classical methods of detection as well as innovative new technologies that are poised to help shape the future landscape of miRNA analysis...
November 2010: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/20491114/multiplexed-detection-and-label-free-quantitation-of-micrornas-using-arrays-of-silicon-photonic-microring-resonators
#20
Abraham J Qavi, Ryan C Bailey
No abstract text is available yet for this article.
June 21, 2010: Angewandte Chemie
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