keyword
https://read.qxmd.com/read/38453323/muc1-c-the-occam-razor-of-osimertinib-resistance
#1
EDITORIAL
Anirudh Yalamanchali, Khaled A Hassan
No abstract text is available yet for this article.
March 2024: Journal of Thoracic Oncology
https://read.qxmd.com/read/38371171/horrifying-basal-cell-carcinoma-presenting-as-progressive-pyoderma-gangrenosum-case-report
#2
Jason S Hoellwarth, Taylor J Reif, Shoko Mori, Rachel Kang, Cynthia M Magro
INTRODUCTION: Skin ulcers can be challenging to diagnose and manage, particularly with comorbid autoimmune and gastrointestinal diseases. Occam's razor encourages the simplest explanation to guide care, but reconsideration must occur when intervention proves futile. CASE PRESENTATION: We report the case of a 70-year-old male, with a 17-year history of expanding pretibial skin ulcer, presumed by prior care providers to be pyoderma gangrenosum related to Crohn's disease...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38237526/incident-anti-lgi1-autoimmune-encephalitis-during-dementia-with-lewy-bodies-when-occam-razor-is-a-double-edged-sword
#3
JOURNAL ARTICLE
Denise Cerne, Mattia Losa, Pietro Mattioli, Anastasia Lechiara, Giacomo Rebella, Luca Roccatagliata, Dario Arnaldi, Angelo Schenone, Silvia Morbelli, Luana Benedetti, Federico Massa
In Dementia with Lewy bodies (DLB), rapid cognitive decline and seizures seldom complicate the typical clinical course. Nevertheless, concurrent, treatable conditions may be responsible. We report a case of DLB with superimposed anti-LGI1 encephalitis, emphasizing the importance of thorough diagnostic reasoning beyond the simplest explanation amid distinct clinical cues.
February 15, 2024: Journal of Neuroimmunology
https://read.qxmd.com/read/38226785/extreme-soft-tissue-involvement-preceding-multiple-myeloma-diagnosis-is-occam-s-razor-always-the-answer
#4
JOURNAL ARTICLE
Alicja Rydzewska-Rosołowska, Piotr Tabor, Tomasz Hryszko
No abstract text is available yet for this article.
January 15, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38018886/razor-sharp-the-role-of-occam-s-razor-in-science
#5
JOURNAL ARTICLE
Johnjoe McFadden
Occam's razor-the principle of simplicity-has recently been attacked as a cultural bias without rational foundation. Increasingly, belief in pseudoscience and mysticism is growing. I argue that inclusion of Occam's razor is an essential factor that distinguishes science from superstition and pseudoscience. I also describe how the razor is embedded in Bayesian inference and argue that science is primarily the means to discover the simplest descriptions of our world.
November 29, 2023: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/37946881/hickam-s-suicide-a-case-of-carbon-monoxide-toxicity-compartment-syndrome-rhabdomyolysis-and-renal-failure-from-attempted-dual-suicide
#6
Rachel E Bridwell, Richard R Miles, Sean Griffiths, Robert R Burgin, Brit Long
Suicide pacts among elderly couples afflicted by a terminal disease process present a significant challenge to emergency clinicians. If one member of the pair aborts their attempt, the surviving member of a dual suicide attempt can present a complex case with numerous clinical issues reflected by Hickam's dictum rather than by Occam's razor. Thus, emergency clinicians must keenly search for a multitude of concomitant but compounding conditions, potentially projected onto pre-existing comorbidities in an elderly population...
October 2023: Curēus
https://read.qxmd.com/read/37918039/ptosis-in-a-patient-with-dengue-fever-applying-the-occam-s-razor
#7
JOURNAL ARTICLE
Biona Devi Konsam, Liza Das, Apinderpreet Singh, Pravin Salunke, Pinaki Dutta
No abstract text is available yet for this article.
October 31, 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/37908556/coronary-plaque-assessment-an-argument-for-applying-occam-s-razor
#8
JOURNAL ARTICLE
Maros Ferencik
No abstract text is available yet for this article.
October 2023: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/37902772/from-cardiorenal-syndrome-to-chronic-cardiovascular-and-kidney-disorder-a-conceptual-transition
#9
JOURNAL ARTICLE
Carmine Zoccali, Francesca Mallamaci, Jean-Michel Halimi, Patrick Rossignol, Pantelis Sarafidis, Raffaele De Caterina, Robert Giugliano, Faiez Zannad
The association between cardiac and kidney dysfunction has received attention over the past two decades. A putatively unique syndrome, the cardiorenal syndrome, distinguishing five subtypes on the basis of the chronology of cardiac and kidney events, has been widely adopted. This review discusses the methodologic and practical problems inherent to the current classification of cardiorenal syndrome. The term "disorder" is more appropriate than the term "syndrome" to describe concomitant cardiovascular and kidney dysfunction and/or damage...
October 30, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/37887786/septic-obturation-of-a-knee-endoprosthesis-caused-by-aspergillus-clavatus
#10
Robert Kuthan, Gabriel Lawrence Zaremba-Wróblewski, Flynn Ott, Dorsa Soltaninia
Aspergillus clavatus is a rare opportunistic fungal pathogen that can be isolated from various environmental sources, including soil and animal feces. Although infrequent, infections caused by A. clavatus can be severe in immunocompromised patients. Here, we present a case of a prosthetic joint infection (PJI) in a 74-year-old female patient caused by A. clavatus . The patient presented with left knee pain, and septic loosening of the left knee endoprosthesis was diagnosed. She underwent surgical revision with the implantation of an antibiotic spacer and microbiologic testing...
October 23, 2023: Pathogens
https://read.qxmd.com/read/37851682/distilling-identifiable-and-interpretable-dynamic-models-from-biological-data
#11
JOURNAL ARTICLE
Gemma Massonis, Alejandro F Villaverde, Julio R Banga
Mechanistic dynamical models allow us to study the behavior of complex biological systems. They can provide an objective and quantitative understanding that would be difficult to achieve through other means. However, the systematic development of these models is a non-trivial exercise and an open problem in computational biology. Currently, many research efforts are focused on model discovery, i.e. automating the development of interpretable models from data. One of the main frameworks is sparse regression, where the sparse identification of nonlinear dynamics (SINDy) algorithm and its variants have enjoyed great success...
October 18, 2023: PLoS Computational Biology
https://read.qxmd.com/read/37842758/remembering-the-occam-s-razor-could-simple-electrocardiographic-findings-provide-relevant-predictions-for-current-hemodynamic-criteria-of-pulmonary-hypertension
#12
JOURNAL ARTICLE
Hacer Ceren Tokgöz, Bahadır Erdem Öcal, Yiğit Cengiz Erkuş, Seda Tanyeri, Barkın Kültürsay, Ayhan Tosun, Berhan Keskin, Aykun Hakgör, Dicle Sırma, Çağdaş Buluş, Ali Karagöz, İbrahim Halil Tanboğa, Şeyhmus Külahçıoğlu, Zübeyde Bayram, Ahmet Sekban, Nihal Özdemir, Cihangir Kaymaz
BACKGROUND: We evaluated the predictive value of electrocardiographic (ECG) findings for pulmonary hemodynamics assessed by right heart catheterization (RHC). METHODS: Our study population comprised 562 retrospectively evaluated patients who underwent RHC between 2006 and 2022. Correlations between ECG measures and pulmonary arterial systolic and mean pressures (PASP and PAMP) and pulmonary vascular resistance (PVR) were investigated. Moreover, receiver operating characteristic (ROC) curve analysis assessed the predictive value of ECG for pulmonary hypertension (PH) and precapillary PH...
October 16, 2023: Anatolian Journal of Cardiology
https://read.qxmd.com/read/37781142/description-length-guided-nonlinear-unified-granger-causality-analysis
#13
JOURNAL ARTICLE
Fei Li, Qiang Lin, Xiaohu Zhao, Zhenghui Hu
Most Granger causality analysis (GCA) methods still remain a two-stage scheme guided by different mathematical theories; both can actually be viewed as the same generalized model selection issues. Adhering to Occam's razor, we present a unified GCA (uGCA) based on the minimum description length principle. In this research, considering the common existence of nonlinearity in functional brain networks, we incorporated the nonlinear modeling procedure into the proposed uGCA method, in which an approximate representation of Taylor's expansion was adopted...
2023: Network Neuroscience
https://read.qxmd.com/read/37420349/statistical-significance-testing-for-mixed-priors-a-combined-bayesian-and-frequentist-analysis
#14
JOURNAL ARTICLE
Jakob Robnik, Uroš Seljak
In many hypothesis testing applications, we have mixed priors, with well-motivated informative priors for some parameters but not for others. The Bayesian methodology uses the Bayes factor and is helpful for the informative priors, as it incorporates Occam's razor via the multiplicity or trials factor in the look-elsewhere effect. However, if the prior is not known completely, the frequentist hypothesis test via the false-positive rate is a better approach, as it is less sensitive to the prior choice. We argue that when only partial prior information is available, it is best to combine the two methodologies by using the Bayes factor as a test statistic in the frequentist analysis...
September 21, 2022: Entropy
https://read.qxmd.com/read/37361877/-cdc-cindy-and-david-s-conversations-game-advising-president-to-survive-pandemic
#15
JOURNAL ARTICLE
Zhanshan Sam Ma, Liexun Yang
Ongoing debates on anti-COVID19 policies have been focused on coexistence-with vs . zero-out (virus) strategies, which can be simplified as "always open (AO)" vs . "always closed (AC)." We postulate that a middle ground, dubbed LOHC (low-risk-open and high-risk-closed), is likely favorable, precluding obviously irrational HOLC (high-risk-open and low-risk-closed). From a meta-strategy perspective, these four policies cover the full spectrum of anti-pandemic policies. By emulating the reality of anti-pandemic policies today, the study aims to identify possible cognitive gaps and traps by harnessing the power of evolutionary game-theoretic analysis and simulations, which suggest that ( i ) AO and AC seems to be "high-probability" events (0...
June 9, 2023: IScience
https://read.qxmd.com/read/37328974/occam-s-razor-on-the-mechanism-of-resistive-wall-mode-induced-%C3%AE-limits-in-diverted-tokamaks
#16
JOURNAL ARTICLE
D Brunetti, J P Graves, C J Ham, S Saarelma
External kink modes, believed to be the drive of the β-limiting resistive wall mode, are strongly stabilized by the presence of a separatrix. We thus propose a novel mechanism explaining the appearance of long-wavelength global instabilities in free boundary high-β diverted tokamaks, retrieving the experimental observables within a physical framework dramatically simpler than most of the models employed for the description of such phenomena. It is shown that the magnetohydrodynamic stability is worsened by the synergy of β and plasma resistivity, with wall effects significantly screened in an ideal, i...
May 2023: Physical Review. E
https://read.qxmd.com/read/37307068/a-middle-aged-male-with-aortic-regurgitation-and-anaemia-the-occam-s-razor
#17
JOURNAL ARTICLE
Ramanathan Velayutham, A Shaheer Ahmed, Bheemanathi Hanuman Srinivas, Mohamed Bilal Azam
No abstract text is available yet for this article.
June 12, 2023: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/37276252/occam-s-razor-two-arrhythmias-in-a-single-heart
#18
JOURNAL ARTICLE
Aviram Hochstadt, Michael Geist, Sami Viskin
No abstract text is available yet for this article.
June 6, 2023: Circulation
https://read.qxmd.com/read/37155526/occam-s-razor-or-hickam-s-dictum-covid-19-is-not-a-textbook-aetiology-of-acute-pancreatitis-a-modified-naranjo-score-appraisal
#19
JOURNAL ARTICLE
Thomas Zheng Jie Teng, Branden Qi Yu Chua, Puay Khim Lim, Kai Siang Chan, Vishal G Shelat
BACKGROUND: Acute pancreatitis (AP) is a disease spectrum ranging from mild to severe disease. During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of AP have been published, with most authors concluding a causal relationship between COVID-19 and AP. Retrospective case reports or small case series are unable to accurately determine the cause-effect relationship between COVID-19 and AP. AIM: To establish whether COVID-19 is a cause of AP using the modified Naranjo scoring system...
April 7, 2023: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/37147080/editorial-commentary-in-patients-with-hip-spine-syndrome-a-single-simple-solution-may-not-apply-occam-s-razor-becomes-blunt
#20
EDITORIAL
Thomas C Edwards, Rima Nasser
The importance of hip-spine syndrome in a nonarthritic population, in which patients present with coexisting symptoms in both the hip and lumbar spine, is becoming more clear. Several studies have shown inferior outcomes in patients undergoing treatment for femoral acetabular impingement syndrome with coexisting spinal symptoms. The most important factor when treating HSS patients is understanding each patient's pathology. A history and physical examination with provocative tests for spinal and hip pathology often provide the answer...
June 2023: Arthroscopy
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