Read by QxMD icon Read

Occam's razor

Martin B Whyte
No abstract text is available yet for this article.
April 10, 2017: Medical Teacher
Shashikant L Sholapurkar
Cardiotocography (CTG) has disappointingly failed to show good predictability for fetal acidemia or neonatal outcomes in several large studies. A complete rethink of CTG interpretation will not be out of place. Fetal heart rate (FHR) decelerations are the most common deviations, benign as well as manifestation of impending fetal hypoxemia/acidemia, much more commonly than FHR baseline or variability. Their specific nomenclature is important (center-stage) because it provides the basic concepts and framework on which the complex "pattern recognition" of CTG interpretation by clinicians depends...
April 2017: Journal of Clinical Medicine Research
Tugce B Balci, Taila Hartley, Yanwei Xi, David A Dyment, Chandree L Beaulieu, Francois P Bernier, Lucie Dupuis, Gabriella Horvath, Roberto Mendoza-Londono, Chitra Prasad, Julie Richer, Xiao-Ru Yang, Christine M Armour, Eric Bareke, Bridget A Fernandez, Hugh J McMillan, Ryan Lamont, Jacek Majewski, Jillian Parboosingh, A Narayan Prasad, Tony Rupar, Jeremy Schwartzentruber, Amanda C Smith, Martine Tétreault, A Micheil Innes, Kym M Boycott
Recent clinical whole exome sequencing (WES) cohorts have identified unanticipated multiple genetic diagnoses in single patients. However, the frequency of multiple genetic diagnoses in families is largely unknown. We set out to identify the rate of multiple genetic diagnoses in probands and their families referred for analysis in two national research programs in Canada. We retrospectively analyzed WES results for 802 undiagnosed probands referred over the past five years in either the FORGE or Care4Rare Canada WES sequencing initiatives...
February 7, 2017: Clinical Genetics
Stephanie O Skuby, Eunice Rhee, Elizabeth H Thilo, Eric A F Simões
Tetanus is a rare disease in industrialized countries, largely due to the highly protective effect of immunization. We present a case of tetanus in a formerly preterm infant with myelomeningocele repaired in utero, who presented at 44 days of age with poor feeding, lethargy, and increased tone. His symptoms progressed despite a course of antibiotics for presumed meningitis. At 73 days of age (on 29th day of hospitalization), a clinical diagnosis of tetanus was made based on the presence of risus sardonicus, trismus, and generalized hypertonicity...
November 2016: Pediatrics
Samuel W Ross, Jonathan D Bouchez, Peter E Fischer, Rita A Brintzenhoff, Ronald F Sing, A Britton Christmas, Bradley W Thomas
No abstract text is available yet for this article.
September 2016: American Surgeon
Grace Thompson, Mina John
No abstract text is available yet for this article.
February 2016: Pathology
Samuel W Ross, Jonathan D Bouchez, Peter E Fischer, Rita A Brintzenhoff, Ronald F Sing, A Britton Christmas, Bradley W Thomas
No abstract text is available yet for this article.
September 2016: American Surgeon
John H Noble
There are always rival hypotheses to explain away the one that is posited as the most likely to be true. Context and Occam's razor - the principle that among competing hypotheses, the one with the fewest assumptions should be selected - ultimately point to which hypothesis is the most likely to be true.
September 22, 2016: Indian Journal of Medical Ethics
Andrew J Ghio
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam's razor to asthma, it is proposed that there is one cause underlying the numerous phenotypes of this disease and that the responsible molecular pathway is a deficiency of iron in the lung tissues. This deficiency can be either absolute (e.g. asthma in the neonate and during both pregnancy and menstruation) or functional (e...
October 2016: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Oleg A Raevsky
A detailed analysis of the possibility of using the Multiparameter Optimization approach (MPO) for CNS/non-CNS classification of drugs was carried out. This work has shown that MPO descriptors are able to describe only part of chemical transport in the CNS connected with transmembrane diffusion. Hence the "intuitive" CNS MPO approach with arbitrary selection of descriptors and calculations of score functions, search of thresholds of classification, and absence of any chemometric procedures, leads to rather modest accuracy of CNS/non-CNS classification models...
April 2016: Molecular Informatics
Jacob Feldman
The simplicity principle, traditionally referred to as Occam's razor, is the idea that simpler explanations of observations should be preferred to more complex ones. In recent decades the principle has been clarified via the incorporation of modern notions of computation and probability, allowing a more precise understanding of how exactly complexity minimization facilitates inference. The simplicity principle has found many applications in modern cognitive science, in contexts as diverse as perception, categorization, reasoning, and neuroscience...
September 2016: Wiley Interdisciplinary Reviews. Cognitive Science
Ciara Conduit, Ashutosh Hardikar, Ritam Prasad, Louise Nott
No abstract text is available yet for this article.
July 20, 2016: Journal of Thoracic Oncology
Ram V Nampoothiri, Arjun Lakshman, Ashish Bhalla, Subhash Varma
No abstract text is available yet for this article.
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Arjun Lakshman, Ram V Nampoothiri, Arjun Datt Law, Pankaj Malhotra, Subhash C Varma
Hypereosinophilia is an uncommon clinical problem encountered in hematology practice. While most of such cases are secondary or reactive, a significant fraction of cases are due to clonal myeloproliferative disorders. We report a young patient who presented with marked hypereosinophilia and was investigated extensively for its cause. Finally a common tropical infection was responsible for such marked eosinophilia fulfilling the principle of Occam's razor. The case emphasizes the need to search for treatable reactive causes even in presence of marked hypereosinophilia in a tropical country...
June 2016: Indian Journal of Hematology & Blood Transfusion
Uday Yanamandra, Kamal Kant Sahu, Alka Khadwal, Gaurav Prakash, Subhash Chander Varma, Pankaj Malhotra
We present a patient of acute promyelocytic leukaemia managed with all-trans-retinoic-acid and arsenic trioxide who developed hypercalcemia with target organ damage. The patient also was simultaneously discovered to be symptomatic from hyperparathyroidism, which was unmasked after ATRA administration. Patient was successfully managed without any interruption of ATRA therapy and parathyroidectomy. We discuss the mechanisms of ATRA in causing hypercalcemia and its possible role in index case in unmasking hyperparathyroidism...
June 2016: Indian Journal of Hematology & Blood Transfusion
R Miller, S Appleton
Postoperative complications can pose a significant obstacle in the ongoing management of surgical patients. However, it is pertinent to remember that postoperative events are not always complications of the preceding operation. We present the case of a patient with calculous cholecystitis and gallbladder empyema who underwent laparoscopic cholecystectomy. Postoperatively, he continued to have right upper quadrant pain associated with abnormal liver function tests. Ultimately, the cause of his postoperative symptoms was rather prosaic and ran counter to Occam's razor, the relevance of which is discussed below...
September 2016: Annals of the Royal College of Surgeons of England
Atsuhisa Tamura
The occurrence of pulmonary tuberculosis (PTB) and lung cancer as comorbidities has been extensively discussed in many studies. In the past, it was well known that lung cancer is a specific epidemiological successor of PTB and that lung cancer often develops in scars caused by PTB. In recent years, the relevance of the two diseases has drawn attention in terms of the close epidemiological connection and chronic inflammation-associated carcinogenesis. In Japanese case series studies, most lung cancer patients with tuberculous sequelae received supportive care alone in the past, but more recently, the use of aggressive lung cancer treatment is increasing...
January 2016: Kekkaku: [Tuberculosis]
Ian S Boon, Dilani Perera, John Ayuk
No abstract text is available yet for this article.
April 7, 2016: BMJ Case Reports
Anish Desai, Alexander Fe, Amishi Desai, Jonathan Ilowite, Burke A Cunha, Joseph P Mathew
Adult T-cell leukemia/lymphoma (ATLL) is usually preceded by infection with human T-cell lymphotropic virus I (HTLV-I). Patients with ATLL frequently get opportunistic infections of the lungs, intestines, and central nervous system. Pneumocystis pneumonia is commonly known as an AIDS defining illness. Grocott's methenamine silver stain of bronchoalveolar lavage (BAL) samples obtained via bronchoscopy remain the gold standard for diagnosis. Pulmonary cryptococcosis is seen in patients with T-cell deficiencies and a diagnosis is made by culture of sputum, BAL, or occasionally of pleural fluid...
February 2016: Connecticut Medicine
Mathias Garny, McCullen Sandora, Martin S Sloth
The standard model could be self-consistent up to the Planck scale according to the present measurements of the Higgs boson mass and top quark Yukawa coupling. It is therefore possible that new physics is only coupled to the standard model through Planck suppressed higher dimensional operators. In this case the weakly interacting massive particle miracle is a mirage, and instead minimality as dictated by Occam's razor would indicate that dark matter is related to the Planck scale, where quantum gravity is anyway expected to manifest itself...
March 11, 2016: Physical Review Letters
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"