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Dendritic cell immunotherapy

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https://www.readbyqxmd.com/read/29221729/high-dimensional-phenotypic-mapping-of-human-dendritic-cells-reveals-interindividual-variation-and-tissue-specialization
#1
Marcela Alcántara-Hernández, Rebecca Leylek, Lisa E Wagar, Edgar G Engleman, Tibor Keler, M Peter Marinkovich, Mark M Davis, Garry P Nolan, Juliana Idoyaga
Given the limited efficacy of clinical approaches that rely on ex vivo generated dendritic cells (DCs), it is imperative to design strategies that harness specialized DC subsets in situ. This requires delineating the expression of surface markers by DC subsets among individuals and tissues. Here, we performed a multiparametric phenotypic characterization and unbiased analysis of human DC subsets in blood, tonsil, spleen, and skin. We uncovered previously unreported phenotypic heterogeneity of human cDC2s among individuals, including variable expression of functional receptors such as CD172a...
November 28, 2017: Immunity
https://www.readbyqxmd.com/read/29217528/t-cells-expressing-checkpoint-receptor-tigit-are-enriched-in-follicular-lymphoma-tumors-and-characterized-by-reversible-suppression-of-t-cell-receptor-signaling
#2
Sarah E Josefsson, Kanutte Huse, Arne Kolstad, Klaus Beiske, Daniela Pende, Chloé B Steen, Else Marit Inderberg, Ole Christian Lingjærde, Bjørn Østenstad, Erlend B Smeland, Ronald Levy, Jonathan M Irish, June H Myklebust
PURPOSE: T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet the optimal target for immune checkpoint blockade is unknown. Characterizing co-inhibitory receptor expression patterns and signaling responses in FL T-cell subsets might reveal new therapeutic targets. EXPERIMENTAL DESIGN: Surface expression of 9 co-inhibitory receptors governing T-cell function was characterized in T-cell subsets from FL lymph node tumors and from healthy donor tonsils and peripheral blood samples, using high-dimensional flow cytometry...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29213052/exosomes-from-antigen-pulsed-dendritic-cells-induce-stronger-antigen-specific-immune-responses-than-microvesicles-in-vivo
#3
Casper J E Wahlund, Gözde Güclüler, Stefanie Hiltbrunner, Rosanne E Veerman, Tanja I Näslund, Susanne Gabrielsson
Extracellular vesicles (EV), including exosomes and microvesicles (MV), represent a rapidly expanding field of research with diagnostic and therapeutic applications. Although many aspects of EV function remain to be revealed and broad investigations are warranted, most published findings focus on only one vesicle category or a non-separated mix of EVs. In this paper, we investigated both MVs and exosomes from Ovalbumin (OVA)-pulsed dendritic cells for their immunostimulatory potential side-by-side in vivo. Only exosomes induced antigen-specific CD8+ T-cells, and were more efficient than MVs in eliciting antigen-specific IgG production...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209782/advances-in-immunotherapeutic-research-for-glioma-therapy
#4
REVIEW
Jeremy Tetsuo Miyauchi, Stella E Tsirka
Gliomas are primary malignancies of the brain. Tumors are staged based on malignancy, nuclear atypia, and infiltration of the surrounding brain parenchyma. Tumors are often diagnosed once patients become symptomatic, at which time the lesion is sizable. Glioblastoma (grade IV glioma) is highly aggressive and difficult to treat. Most tumors are diagnosed de novo. The gold standard of therapy, implemented over a decade ago, consists of fractionated radiotherapy and temozolomide, but unfortunately, chemotherapeutic resistance arises...
December 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29209562/collagen-i-enhances-the-efficiency-and-anti-tumor-activity-of-dendritic-tumor-fusion-cells
#5
Jian He, Rong Zheng, Zhenghua Zhang, Jie Tan, Chaofan Zhou, Guoqing Zhang, Xinglu Jiang, Qianyi Sun, Sufang Zhou, Duo Zheng, Yong Huang, Lige Wu, Zongqiang Lai, Jieping Li, Nuo Yang, Xiaoling Lu, Yongxiang Zhao
Low fusion efficiency and nominal activity of fusion cells (FCs) restrict the clinical application of dendritic cell (DC)/tumor fusion cells. Collagen I (Col I) is an interstitial collagen with a closely-knit structure used to repair damaged cell membranes. This study evaluated whether Col I could improve the fusion efficiency of polyethylene glycol (PEG)-induction and enhance the immunogenicity of fusion vaccine. DC/B16 melanoma and controlled DC/H22 hepatoma cell fusions were induced by PEG with or without Col I...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29209327/strategies-to-improve-the-efficacy-of-dendritic-cell-based-immunotherapy-for-melanoma
#6
REVIEW
Kristian M Hargadon
Melanoma is a highly aggressive form of skin cancer that frequently metastasizes to vital organs, where it is often difficult to treat with traditional therapies such as surgery and radiation. In such cases of metastatic disease, immunotherapy has emerged in recent years as an exciting treatment option for melanoma patients. Despite unprecedented successes with immune therapy in the clinic, many patients still experience disease relapse, and others fail to respond at all, thus highlighting the need to better understand factors that influence the efficacy of antitumor immune responses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29209309/new-directions-for-natural-killer-t-cells-in-the-immunotherapy-of-cancer
#7
Luc Teyton
Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic cell and B cell maturation through direct membrane contacts and initiate productive responses. As such, NKT cells are the cellular adjuvant of many immune reactions and have functions that go much beyond what their name encapsulates. In addition, the initial discovery of the ligands of NKT cells is deeply linked to cancer biology and therapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207589/tolerogenic-dendritic-cell-based-immunotherapy
#8
EDITORIAL
Kiyuk Chang, Jie-Young Song, Dae-Seog Lim
No abstract text is available yet for this article.
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29196724/hierarchically-porous-and-cu-and-zn-containing-%C3%AE-alooh-mesostrands-as-adjuvants-for-cancer-immunotherapy
#9
Xia Li, Mohamed A Shenashen, Xiupeng Wang, Atsuo Ito, Akiyoshi Taniguchi, Sherif A Ei-Safty
Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we fabricated hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands (Cu- and Zn-AMSs) with randomly wrinkled morphology, mesoscale void- or cave-like pockets, high-exposed surface coverage sites, and positive charge streams in saline...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194124/humanized-mouse-models-to-study-pathophysiology-and-treatment-of-hiv-infection
#10
Guillemette Masse-Ranson, Hugo Mouquet, James P Di Santo
PURPOSE OF REVIEW: Immunodeficient mice that lack all lymphocyte subsets and have phagocytic cells that are tolerant of human cells can be stably xenografted with human hematopoietic stem cell as well as other human tissues (fetal liver and thymus) creating 'human immune system' (HIS) mice. HIS mice develop all major human lymphocyte classes (B, T, natural killer, and innate lymphoid cell) and their specialized subsets as well as a variety of myeloid cells (dendritic cell, monocytes, and macrophages) thereby providing a small animal model in which to interrogate human immune responses to infection...
November 30, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29190690/development-of-effective-tumor-immunotherapy-using-a-novel-dendritic-cell-targeting-toll-like-receptor-ligand
#11
Nadeeka H De Silva, Takashi Akazawa, Viskam Wijewardana, Norimitsu Inoue, Maremichi Oyamada, Atsuko Ohta, Yuki Tachibana, Daluthgamage Patsy H Wijesekera, Mitsuru Kuwamura, Yasuko Nishizawa, Kazuyuki Itoh, Takeshi Izawa, Shingo Hatoya, Tetsuya Hasegawa, Jyoji Yamate, Toshio Inaba, Kikuya Sugiura
Although dendritic cell (DC)-based immunotherapy shows little toxicity, improvements should be necessary to obtain satisfactory clinical outcome. Using interferon-gamma injection along with DCs, we previously obtained significant clinical responses against small or early stage malignant tumors in dogs. However, improvement was necessary to be effective to largely developed or metastatic tumors. To obtain effective methods applicable to those tumors, we herein used a DC-targeting Toll-like receptor ligand, h11c, and examined the therapeutic effects in murine subcutaneous and visceral tumor models and also in the clinical treatment of canine cancers...
2017: PloS One
https://www.readbyqxmd.com/read/29187401/delivering-type-i-interferon-to-dendritic-cells-empowers-tumor-eradication-and-immune-combination-treatments
#12
Anje Cauwels, Sandra Van Lint, Franciane Paul, Genevieve Garcin, Stefaan De Koker, Alexander Van Parys, Thomas Wueest, Sarah Gerlo, José Van der Heyden, Yann Bordat, Dominiek Catteeuw, Elke Rogge, Annick Verhee, Bart Vandekerckhove, Niko Kley, Gilles Uzé, Jan Tavernier
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as these are only available in a limited set of malignancies. Despite approval for treatment of various cancers, clinical application of cytokines is still impeded by their multiple toxic side effects. Type I interferon (IFN) has a long history in the treatment of cancer, but its multifaceted activity pattern and complex side effects prevent its clinical use...
November 29, 2017: Cancer Research
https://www.readbyqxmd.com/read/29185391/current-status-of-immunotherapy-for-sarcomas
#13
Shinji Miwa, Hideji Nishida, Hiroyuki Tsuchiya
Although the development of anticancer drugs has improved the outcomes of bone and soft tissue sarcomas, the clinical outcome of patients with relapsed sarcomas remains unsatisfactory due to therapeutic toxicities and resistance to anticancer drugs. Therefore, novel therapeutic modalities are needed to improve the outcome of patients with bone and soft tissue sarcomas. Dendritic cells present tumor antigens and stimulate immune responses, and immune cells, such as cytotoxic T lymphocytes, kill tumor cells by recognizing tumor antigens...
December 2017: Immunotherapy
https://www.readbyqxmd.com/read/29181186/enhanced-antitumor-effects-and-improved-immune-status-of-dendritic-cell-and-cytokine-induced-killer-cell-infusion-in-advanced-cancer-patients
#14
Feng Chen, Menghan Yang, Qingkun Song, Jiangping Wu, Xiaoli Wang, Xinna Zhou, Yanhua Yuan, Yuguang Song, Ni Jiang, Yanjie Zhao, Lei Zhou, Jun Ren
Little progress has been made in the treatment of advanced cancer. Dendritic cells (DCs) plus cytokine-induced killer (CIK) cells have exhibited antitumor effects. Thus, the aim of the present study was to evaluate the clinical efficacy of DC-CIK cell treatment in patients with advanced cancer. A paired study including 57 patients treated with DC-CIK cells (DC-CIK group) and 33 patients treated with best supportive care alone (BSC group) was performed. The patients in the DC-CIK group were matched to those in the control group in terms of sex, age, tumor type and clinical stage...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29180849/adjuvant-immunotherapy-of-dendritic-cells-and-cytokine-induced-killer-cells-is-safe-and-enhances-chemotherapy-efficacy-for-multiple-myeloma-in-china-a-meta-analysis-of-clinical-trials
#15
Yan Wang, Benji Lv, Ke Li, Anqi Zhang, Hong Liu
Objective: The aim of this study was to systematically evaluate the efficacy and safety of the combination of dendritic cells and cytokine-induced killer cells (DC-CIK) adjuvant immunotherapy and chemotherapy in the treatment of multiple myeloma (MM). Methods: Clinical trials were gathered by searching Web of Science, PubMed, Embase, Cochrane Library, Wanfang, and CNKI database. Outcome measurements including therapeutic efficacy, prognosis, immune function, and adverse events were extracted and evaluated...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29180626/mitochondrial-dynamics-controls-anti-tumour-innate-immunity-by-regulating-chip-irf1-axis-stability
#16
Zhengjun Gao, Yiyuan Li, Fei Wang, Tao Huang, Keqi Fan, Yu Zhang, Jiangyan Zhong, Qian Cao, Tong Chao, Junling Jia, Shuo Yang, Long Zhang, Yichuan Xiao, Ji-Yong Zhou, Xin-Hua Feng, Jin Jin
Macrophages, dendritic cells and other innate immune cells are involved in inflammation and host defense against infection. Metabolic shifts in mitochondrial dynamics may be involved in Toll-like receptor agonist-mediated inflammatory responses and immune cell polarization. However, whether the mitochondrial morphology in myeloid immune cells affects anti-tumor immunity is unclear. Here we show that FAM73b, a mitochondrial outer membrane protein, has a pivotal function in Toll-like receptor-regulated mitochondrial morphology switching from fusion to fission...
November 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29179719/effect-of-dendritic-cell-cytokine-induced-killer-cells-in-patients-with-advanced-colorectal-cancer-combined-with-first-line-treatment
#17
Yunqing Xie, Lijie Huang, Luchuan Chen, Xiaowei Lin, Li Chen, Qiuhong Zheng
BACKGROUND: Surgical resection combined with adjuvant chemotherapy is considered as the gold-standard treatment for advanced colorectal cancer patients. These patients have a poor 5-year survival rate of 5% or less. Furthermore, a large dose of chemotherapy can produce adverse side effects and severe toxicity. Therefore, this retrospective study aimed to evaluate the efficacy of dendritic cell-cytokine-induced killer (DC-CIK) cell infusion as an adjuvant therapy in patients with advanced colorectal cancer combined with first-line treatment...
November 28, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29179132/rational-incorporation-of-molecular-adjuvants-into-a-hybrid-nanoparticle-based-nicotine-vaccine-for-immunotherapy-against-nicotine-addiction
#18
Zongmin Zhao, Brian Harris, Yun Hu, Theresa Harmon, Paul R Pentel, Marion Ehrich, Chenming Zhang
Current clinically-tested nicotine vaccines have yet shown enhanced smoking cessation efficacy due to their low immunogenicity. Achieving a sufficiently high immunogenicity is a necessity for establishing a clinically-viable nicotine vaccine. This study aims to facilitate the immunogenicity of a hybrid nanoparticle-based nicotine vaccine by rationally incorporating toll-like receptor (TLR)-based adjuvants, including monophosphoryl lipid A (MPLA), Resiquimod (R848), CpG oligodeoxynucleotide 1826 (CpG ODN 1826), and their combinations...
November 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/29177671/creation-of-recombinant-chaperone-vaccine-using-large-heat-shock-protein-for-antigen-targeted-cancer-immunotherapy
#19
Chunqing Guo, John R Subjeck, Xiang-Yang Wang
Large heat shock proteins (HSPs) or stress proteins, including Hsp110 and Grp170, are unique molecular chaperones with superior capability of shuttling tumor protein antigens into professional antigen-presenting cells, such as dendritic cells, for highly efficient cross-presentation and T cell priming. Reconstituted chaperone complexes of large HSP and tumor protein antigen have been demonstrated to generate a robust antigen-specific T lymphocyte response with therapeutic potency against multiple cancer types in preclinical models...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29177268/advanced-manufacturing-of-microdisk-vaccines-for-uniform-control-of-material-properties-and-immune-cell-function
#20
Qin Zeng, Peipei Zhang, Xiangbin Zeng, Lisa H Tostanoski, Christopher M Jewell
The continued challenges facing vaccines in infectious disease and cancer highlight a need for better control over the features of vaccines and the responses they generate. Biomaterials offer unique advantages to achieve this goal through features such as controlled release and co-delivery of antigens and adjuvants. However, many synthesis strategies lead to particles with heterogeneity in diameter, shape, loading level, or other properties. In contrast, advanced manufacturing techniques allow precision control of material properties at the micro- and nano-scale...
November 27, 2017: Biomaterials Science
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