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Dendritic cell immunotherapy

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https://www.readbyqxmd.com/read/29454038/dendritic-cells-as-cancer-therapeutics
#1
REVIEW
Christian E Bryant, Sarah Sutherland, Benjamin Kong, Michael S Papadimitrious, Derek N J Hart
The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines...
February 14, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29453437/enhancement-of-immunomodulative-effect-of-lactic-acid-bacteria-on-plasmacytoid-dendritic-cells-with-sucrose-palmitate
#2
Masaya Kanayama, Yukiko Kato, Toshikazu Tsuji, Yuki Konoeda, Akiko Hashimoto, Osamu Kanauchi, Toshio Fujii, Daisuke Fujiwara
Plasmacytoid dendritic cells (pDCs) play a key role in the immune response against viruses. In addition, recent research has suggested that pDCs possess direct and indirect tumoricidal activities. We previously found that a lactic acid bacteria strain, Lactococcus lactis JCM 5805 (LC-Plasma), stimulated pDCs and prevented viral infection in mouse and human studies. Meanwhile, emulsifiers have recently been highlighted as candidate adjuvants for some viral vaccines and cancer immunotherapies. In this study, we discovered some specific emulsifiers, mainly consisting of sucrose fatty acid esters, that drastically enhance the potency of LC-Plasma to activate pDCs in vitro...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29435154/efficacy-of-granulocyte-macrophage-colony-stimulating-factor-combined-with-metronomic-paclitaxel-in-the-treatment-of-lewis-lung-carcinoma-transplanted-in-mice
#3
Nengping Zhu, Rongsheng Qin, Qin Zhang, Shaozhi Fu, Shanshan Liu, Yue Chen, Juan Fan, Yunwei Han
Metronomic chemotherapy in combination with immunotherapy is an attractive approach in cancer therapy. The purpose of the present study was to investigate the anti-tumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with metronomic paclitaxel (MET PTX) on Lewis lung carcinoma transplanted in mice. In the present study, tumor-bearing mice survival time and tumor growth were monitored. The day after the end of the treatment, white blood cells were counted, and the number and maturation of dendritic cell were determined by flow cytometry...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434859/silencing-of-suppressor-of-cytokine-signaling-1-enhances-the-immunological-effect-of-mucin-1-calreticulin-primed-4t1-cell-treated-dendritic-cells-in-breast-cancer-treatment
#4
Song Qin, Zhipeng Gao, Yu Liu, Changbai Liu, Jun Wang, Li Li Zou
In cancer immunotherapy, dendritic cell (DC)-based vaccines represent a promising, yet challenging, treatment method. In addition to overcoming the low expression levels of antigenic epitopes on cancer cells, it is also necessary to overcome the inhibitory effect of suppressor of cytokine signaling 1 (SOCS1) on DC self-antigen presentation. Our group previously demonstrated that calreticulin (CRT) translocated type I transmembrane glycoprotein mucin 1 (MUC1), a breast cancer antigen, to the surface of 4T1 cells, and that treatment with MUC1-CRT-primed 4T1 cell-treated DCs induced apoptosis in a breast cancer cell line...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29431693/an-antigen-free-plasmacytoid-dendritic-cell-targeting-immunotherapy-to-bolster-memory-cd8-t-cells-in-nonhuman-primates
#5
Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J Ishii
The priming, boosting, and restoration of memory cytotoxic CD8+ T lymphocytes by vaccination or immunotherapy in vivo is an area of active research. Particularly, nucleic acid-based compounds have attracted attention due to their ability to elicit strong Ag-specific CTL responses as a vaccine adjuvant. Nucleic acid-based compounds have been shown to act as anticancer monotherapeutic agents even without coadministration of cancer Ag(s); however, so far they have lacked efficacy in clinical trials. We recently developed a second-generation TLR9 agonist, a humanized CpG DNA (K3) complexed with schizophyllan (SPG), K3-SPG, a nonagonistic Dectin-1 ligand...
February 5, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29429633/nk-cells-stimulate-recruitment-of-cdc1-into-the-tumor-microenvironment-promoting-cancer-immune-control
#6
Jan P Böttcher, Eduardo Bonavita, Probir Chakravarty, Hanna Blees, Mar Cabeza-Cabrerizo, Stefano Sammicheli, Neil C Rogers, Erik Sahai, Santiago Zelenay, Caetano Reis E Sousa
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in human cancers, intratumoral CCL5, XCL1, and XCL2 transcripts closely correlate with gene signatures of both NK cells and cDC1 and are associated with increased overall patient survival...
February 6, 2018: Cell
https://www.readbyqxmd.com/read/29427678/poly-i-c-enhanced-anti-cervical-cancer-immunities-induced-by-dendritic-cells-derived-exosomes
#7
Shisheng Chen, Mingfen Lv, Shan Fang, Wenxia Ye, Yu Gao, Yunsheng Xu
Dendritic cell (DC)-derived exosomes (Dexo) has been confirmed to be able to induce the specific anti-tumor immune response ex vivo and in vivo. Here, the aim of this study was to evaluate the application of the antigen-pulsed Dexo as a new vaccination platform in immunotherapy for cervical cancer. The immunogenic profile of the different Dexo was assessed by the cell proliferation, cytokines secretion and effector functions of CD8+ T cells and the splenocytes from Dexo-vaccinated mice. Furthermore, the anti-tumor immunity elicited by Dexo was further compared in cervical cancer-bearing mice...
February 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29416821/dendritic-cells-loaded-with-tumor-derived-exosomes-for-cancer-immunotherapy
#8
REVIEW
Hongyu Liu, Ling Chen, Yaojun Peng, Songyan Yu, Jialin Liu, Liangliang Wu, Lijun Zhang, Qiyan Wu, Xin Chang, Xinguang Yu, Tianyi Liu
Exosomes are vesicles that can be secreted by many types of cell and released into the extracellular space. Studies have found that tumor derived exosomes (TEXs) can promote tumor growth and metastasis, as well as inhibit immune response through transferring their genetic information to the recipient cells. Given their functions in tumor progression, TEXs are considered as promising biomarkers for early detection of human malignancy. Dendritic cells (DCs), a type of antigen presenting cells, can induce tumor-specific T cell immune responses in carcinogenesis...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416816/comprehensive-immunotherapy-combined-with-intratumoral-injection-of-zoledronate-pulsed-dendritic-cells-intravenous-adoptive-activated-t-lymphocyte-and-gemcitabine-in-unresectable-locally-advanced-pancreatic-carcinoma-a-phase-i-ii-trial
#9
Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takashi Kamigaki, Shigenori Goto, Masashi Takahara, Hidemi Goto
Dendritic cell (DC)-based vaccines prepared using various antigen loading methods have been studied for cancer immunotherapy. The in vivo provocation of immunity by the direct injection of DCs without using tumor-specific antigens into tumors after apoptosis-inducing chemotherapy is more applicable. We previously reported that zoledronate-pulsed DCs (Zol-DCs) may induce tumor-antigen-specific CD8+ T cells by activating Vγ9γδT cells. In this report, we studied the feasibility, safety, and efficacy of a comprehensive immunotherapy involving the combined intratumoral injection of Zol-DC, gemcitabine (GEM) and αβT cells in locally advanced pancreatic carcinoma...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414664/glmeemsal-epitope-common-in-different-isoforms-of-hmena-elicits-in-vitro-activation-of-cytotoxic-t-cells-and-stimulates-specific-antitumor-immunity-in-balb-c-mice
#10
Christian Azucena Don-López, Alberto Monroy-García, Benny Weiss-Steider, Leticia Rocha-Zavaleta, Jorge Hernández-Montes, Rosario García-Rocha, María de Lourdes Mora-García
BACKGROUND: Alternative expression of human ortholog of murine Mena (hMena) hMena/hMena11a and hMena/hMenaΔv6 isoforms regulate the invasiveness and metastatic potential of tumor cells. It is then important to identify epitopes of these proteins that can elicit antitumor immune response to contribute to the elimination of cells with metastatic potential. METHODS: We assayed the capacity of the peptide GLMEEMSAL, common in hMena/hMena11a and hMena/hMenaΔv6 isoforms, to generate an antitumor immune response through an in vitro vaccination system with mature dendritic cells (MDC) loaded with this peptide and in vivo immunization using a tumor model with the mammary adenocarcinoma JC cell line to induce tumors in BALBc mice...
February 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29413757/dendritic-cells-pulsed-with-exosomes-in-combination-with-pd-1-antibody-increase-the-efficacy-of-sorafenib-in-hepatocellular-carcinoma-model
#11
Shengbin Shi, Quan Rao, Chuangnian Zhang, Xiuyuan Zhang, Yibo Qin, Zuoxing Niu
Advanced hepatocellular carcinoma (HCC) has limited therapeutic options. Immunotherapy is a promising treatment, while sorafenib is a first-line drug-based treatment for advanced HCC. However, the efficacy of sorafenib and immunotherapy in combination, have not been clearly evaluated. Sorafenib treatment has been shown to promote immunosuppression by increasing hypoxia in orthotopic HCC models. Here, we found that sorafenib treatment in mice with orthotopic HCC increased the expression of inhibitor programmed death-ligand 1 (PD-L1) and T-regulatory cells in tumor tissues...
January 27, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29409785/high-hydrostatic-pressure-in-cancer-immunotherapy-and-biomedicine
#12
REVIEW
Irena Adkins, Nada Hradilova, Ondrej Palata, Lenka Sadilkova, Lenka Palova-Jelinkova, Radek Spisek
High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases...
January 30, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29403496/recent-advances-in-targeting-cd8-t-cell-immunity-for-more-effective-cancer-immunotherapy
#13
REVIEW
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI). Cytotoxic T lymphocytes (CTL) eliminate malignant cells through recognition by the T-cell receptor (TCR) of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29399576/distinct-features-of-dendritic-cell-based-immunotherapy-as-cancer-vaccines
#14
REVIEW
Chaelin Lee, Myungmi Lee, Inmoo Rhee
Dendritic cells (DCs) are the most professional antigen presenting cells that play important roles in connection between innate and adaptive immune responses. Numerous studies revealed that the functions of DCs are related with the capture and processing of antigen as well as the migration to lymphoid tissues for the presenting antigens to T cells. These unique features of DCs allow them to be considered as therapeutic vaccines that can induce immune responses and anti-tumor activity. Here, we discuss and understand the immunological basis of DCs and presume the possibilities of DC-based vaccines for the promising cancer therapy...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399401/a-safe-and-highly-efficient-tumor-targeted-type-i-interferon-immunotherapy-depends-on-the-tumor-microenvironment
#15
Anje Cauwels, Sandra Van Lint, Geneviève Garcin, Jennyfer Bultinck, Franciane Paul, Sarah Gerlo, José Van der Heyden, Yann Bordat, Dominiek Catteeuw, Lode De Cauwer, Elke Rogge, Annick Verhee, Gilles Uzé, Jan Tavernier
Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized immunocytokines that, when injected in mice, only reveal their activity upon cell-specific impact. We here show that type I IFN-derived AcTaferon targeted to the tumor displays strong antitumor activity without any associated toxicity, in contrast with wild type IFN. Treatment with CD20-targeted AcTaferon of CD20+ lymphoma tumors or melanoma tumors engineered to be CD20+, drastically reduced tumor growth...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29397689/dual-roles-of-graphene-oxide-to-attenuate-inflammation-and-elicit-timely-polarization-of-macrophage-phenotypes-for-cardiac-repair
#16
Jin Han, Yong Sook Kim, Min-Young Lim, Han Young Kim, Saerom Kong, Mikyung Kang, Yeon Woong Choo, Ju Hee Jun, Seungmi Ryu, Hye-Yun Jeong, Jooyeon Park, Gun-Jae Jeong, Jong-Chan Lee, Gwang Hyeon Eom, Youngkeun Ahn, Byung-Soo Kim
Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the regulation of inflammation by M1 macrophages and their timely polarization toward regenerative M2 macrophages suggest an immunotherapy. Particularly, controlling cellular generation of reactive oxygen species (ROS), which cause M1 differentiation, and developing M2 macrophage phenotypes in macrophages propose a therapeutic approach. Previously, stem or dendritic cells were used in MI for their anti-inflammatory and cardioprotective potentials and showed inflammation modulation and M2 macrophage progression for cardiac repair...
February 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29395859/role-of-tumor-infiltrating-lymphocytes-in-patients-with-solid-tumors-can-a-drop-dig-a-stone
#17
REVIEW
Giuseppe Badalamenti, Daniele Fanale, Lorena Incorvaia, Nadia Barraco, Angela Listì, Rossella Maragliano, Bruno Vincenzi, Valentina Calò, Juan Lucio Iovanna, Viviana Bazan, Antonio Russo
In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in different clinical studies. Currently, immunotherapy was clinically validated as effective treatment option for many tumors such as melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC). Some surface receptors of immune cells, called immune checkpoint receptors, may inhibit activity of proinflammatory lymphocytes, following binding with specific ligands. Cancer cells exploit these mechanisms to inactivate tumor-infiltrating lymphocytes (TILs) to escape from immunosurveillance...
January 30, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29393209/therapeutic-role-for-tsp-2-antibody-in-a-murine-asthma-model
#18
Kai Li, En Ping Huang, Jin Su, Ping Zhu, Jun Lin, Shen Qiu Luo, Cui Lan Yang
BACKGROUND: Specific immunotherapy, including agonists for Toll-like receptor 2 (TLR2), have been shown to protect from allergies and to have a high immunomodulatory capacity. METHODS: A new antibody, TSP-2, reactive against an epitope of the extracellular domain of TLR2, was identified. The effect of the antibody on dendritic cells was assessed by immunohistochemistry, Western blot, and flow cytometric analysis. The effect of TSP-2 in a murine asthma model induced with ovalbumin (OVA) was assessed...
January 27, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29391795/design-and-immunological-evaluation-of-anti-cd205-tailored-plga-based-nanoparticulate-cancer-vaccine
#19
Sheikh Tasnim Jahan, Sams Ma Sadat, Azita Haddadi
The aim of this research was to develop a targeted antigen-adjuvant assembled delivery system that will enable dendritic cells (DCs) to efficiently mature to recognize antigens released from tumor cells. It is important to target the DCs with greater efficiency to prime T cell immune responses. In brief, model antigen, ovalbumin (OV), and monophosphoryl lipid A adjuvant were encapsulated within the nanoparticle (NP) by double emulsification solvent evaporation method. Targeted NPs were obtained through ligand incorporation via physical adsorption or chemical conjugation process...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29389978/dendritic-cell-immunotherapy-followed-by-cart-interruption-during-hiv-1-infection-induces-plasma-protein-markers-of-cellular-immunity-and-neutrophil-recruitment
#20
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert D M E Osterhaus, Rob A Gruters, Arno C Andeweg
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level. DESIGN: An autologous dendritic cell (DC) therapeutic vaccine was administered to HIV-infected individuals, stable on cART. The effect of vaccination was evaluated at the plasma protein level during the period preceding cART interruption, during analytical therapy interruption and at viral reactivation...
2018: PloS One
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