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MHY1485

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https://www.readbyqxmd.com/read/27884298/mhy1485-activates-mtor-and-protects-osteoblasts-from-dexamethasone
#1
Sai Zhao, Caiyun Chen, Shouguo Wang, Feng Ji, Yue Xie
Dexamethasone (Dex) exerts cytotoxic effects to cultured osteoblasts. The potential effect of MHY1485, a small-molecular mammalian target of rapamycin (mTOR) activator, against the process was studied here. In both osteoblastic MC3T3-E1 cells and primary murine osteoblasts, treatment with MHY1485 significantly ameliorated Dex-induced cell death and apoptosis. mTOR inhibition, through mTOR kinase inhibitor OSI-027 or mTOR shRNAs, abolished MHY1485-mediated osteoblast cytoprotection against Dex. Intriguingly, activation of mTOR complex (mTORC1), but not mTORC2, is required for MHY1485's anti-Dex activity...
December 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27600753/liraglutide-attenuates-the-osteoblastic-differentiation-of-mc3t3%C3%A2-e1-cells-by-modulating-ampk-mtor-signaling
#2
Xiong-Ke Hu, Xin-Hua Yin, Hong-Qi Zhang, Chao-Feng Guo, Ming-Xing Tang
Liraglutide, a synthetic analogue of glucagon-like peptide‑1, is utilized in the treatment of type 2 diabetes and obesity. Liraglutide has been previously demonstrated to prevent osteoblastic differentiation of human vascular smooth muscle cells, resulting in the slowing of arterial calcification, however, its effect on bone formation remains unclear. The present study investigated the effect of liraglutide on osteoblastic differentiation using Alizarin Red S staining, and examined the molecular mechanisms underlying the regulatory effect by western blot analysis...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26081285/-pro-renin-receptor-regulates-autophagy-and-apoptosis-in-podocytes-exposed-to-high-glucose
#3
Caixia Li, Helmy M Siragy
High glucose reduces autophagy and enhances apoptosis of podocytes. Previously, we reported that high glucose induced podocyte injury through upregulation of the (pro)renin receptor (PRR). We hypothesized that increasing PRR reduces autophagy and increases apoptosis of mouse podocytes exposed to high glucose via activation of the PI3K/Akt/mTOR signaling pathway. Mouse podocytes were cultured in normal (5 mmol/l) or high (25 mmol/l) d-glucose for 48 h. High glucose significantly increased mRNA and protein levels of PRR, phosphorylation of PI3K/Akt/mTOR, and p62...
August 1, 2015: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25710488/promotion-of-ovarian-follicle-growth-following-mtor-activation-synergistic-effects-of-akt-stimulators
#4
Yuan Cheng, Jaehong Kim, Xiao Xiao Li, Aaron J Hsueh
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and mTOR signaling is important in regulating cell growth and proliferation. Recent studies using oocyte- and granulosa cell-specific deletion of mTOR inhibitor genes TSC1 or TSC2 demonstrated the important role of mTOR signaling in the promotion of ovarian follicle development. We now report that treatment of ovaries from juvenile mice with an mTOR activator MHY1485 stimulated mTOR, S6K1 and rpS6 phosphorylation. Culturing ovaries for 4 days with MHY1485 increased ovarian explant weights and follicle development...
2015: PloS One
https://www.readbyqxmd.com/read/22927967/inhibitory-effect-of-mtor-activator-mhy1485-on-autophagy-suppression-of-lysosomal-fusion
#5
Yeon Ja Choi, Yun Jung Park, Ji Young Park, Hyoung Oh Jeong, Dae Hyun Kim, Young Mi Ha, Ji Min Kim, Yu Min Song, Hyoung-Sam Heo, Byung Pal Yu, Pusoon Chun, Hyung Ryong Moon, Hae Young Chung
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse with lysosomes. In the present study, we investigated the inhibition of autophagy by a synthesized compound, MHY1485, in a culture system by using Ac2F rat hepatocytes. Autophagic flux was measured to evaluate the autophagic activity...
2012: PloS One
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