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https://www.readbyqxmd.com/read/28102875/prevalence-of-abnormal-electrocardiograms-in-swiss-elite-athletes-detected-with-modern-screening-criteria
#1
Tilman Perrin, Lukas Daniel Trachsel, Simon Schneiter, Andrea Menafoglio, Silvia Albrecht, Tony Pirrello, Prisca Eser, Laurent Roten, Boris Gojanovic, Matthias Wilhelm
AIMS OF THE STUDY: Sudden cardiac arrest in athletes is a rare but dramatic event. The value of a routine electrocardiogram (ECG) during preparticipation screening (PPS) remains controversial, partly because of the relatively high number of false positive findings. Our study aimed to evaluate the prevalence of abnormal ECGs in consecutive Swiss elite athletes, overall and with regard to different sports classes, using modern screening criteria. METHODS: We analysed the 12-lead resting ECGs of high-level elite athletes (age ≥14 years) recorded at the Swiss Olympic Medical Centre Magglingen between 2013 and 2016 during routine PPS...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28100655/furosemide-depresses-the-presynaptic-fiber-volley-and-modifies-frequency-dependent-axonal-excitability-in-rat-hippocampus
#2
Mogens Andreasen, Steen Nedergaard
The loop diuretic furosemide is known to have anticonvulsant effects, believed to be exerted through blockade of glial Na-K-Cl cotransport causing altered volume regulation in brain tissue. The possibility that direct effects of furosemide on neuronal properties could also be involved is supported by previous observations, but such effects have not been thoroughly investigated. In the present study we show that furosemide has two opposing effects on stimulus-induced postsynaptic excitation in the non-epileptic rat hippocampal slice: i) an enhancement of e-s coupling, which depended on intact GABAA transmission and was partially mimicked by selective blockade of K-Cl cotransport, and ii) a decrement of fEPSPs...
January 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28099192/aerobic-exercise-training-in-very-severe-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#3
Mara Paneroni, Carla Simonelli, Michele Vitacca, Nicolino Ambrosino
OBJECTIVE: To evaluate the effectiveness of exercise training in patients with very severe chronic obstructive pulmonary disease (COPD). DESIGN: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing and Allied Health Literature databases using the following as search terms: COPD, Chronic Obstructive Pulmonary Disease, Exercise, and Pulmonary Rehabilitation. We included randomized controlled trials (RCTs) of subjects with forced expiratory volume in the first second of less than 35% of the predicted normal value enrolled in in-patient, outpatient, or home- or community-based training programs lasting at least 4 weeks with respect to usual care...
January 17, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28097413/when-surgical-resources-are-severely-constrained-who-receives-care-determinants-of-access-to-orthopaedic-trauma-surgery-in-uganda
#4
Trina Stephens, Alexander Mezei, Nathan N O'Hara, Jeffrey Potter, Rodney Mugarura, Piotr A Blachut, Peter J O'Brien, Tito Beyeza, Gerard P Slobogean
BACKGROUND: In low- and middle-income countries, the volume of traumatic injuries requiring orthopaedic intervention routinely exceeds the capacity of available surgical resources. The objective of this study was to identify predictors of surgical care for lower extremity fracture patients at a high-demand, resource-limited public hospital in Uganda. METHODS: Skeletally mature patients admitted with the intention of definitive surgical treatment of an isolated tibia or femur fractures to the national referral hospital in Uganda were recruited to participate in this study...
January 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28087136/global-general-pediatric-surgery-partnership-the-ucla-mozambique-experience
#5
Vanda Amado, Deborah B Martins, Abraar Karan, Brittni Johnson, Shant Shekherdimian, Lee T Miller, Atanasio Taela, Daniel A DeUgarte
BACKGROUND/PURPOSE: There has been increasing recognition of the disparities in surgical care throughout the world. Increasingly, efforts are being made to improve local infrastructure and training of surgeons in low-income settings. The purpose of this study was to review the first 5-years of a global academic pediatric general surgery partnership between UCLA and the Eduardo Mondlane University in Maputo, Mozambique. METHODS: A mixed-methods approach was utilized to perform an ongoing needs assessment...
January 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28086959/e-learning-programs-in-oncology-a-nationwide-experience-from-2005-to-2014
#6
Jan Degerfält, Staffan Sjöstedt, Per Fransson, Elisabeth Kjellén, Mads U Werner
BACKGROUND: E-learning is an established concept in oncological education and training. However, there seems to be a scarcity of long-term assessments of E-learning programs in oncology vis-á-vis their structural management and didactic value. This study presents descriptive, nationwide data from 2005 to 2014. E-learning oncology programs in chemotherapy, general oncology, pain management, palliative care, psycho-social-oncology, and radiotherapy, were reviewed from our databases. Questionnaires of self-perceived didactic value of the programs were examined 2008-2014...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28074571/screening-brief-intervention-and-referral-to-treatment-sbirt-implementation-barriers-facilitators-and-model-migration
#7
Janice Vendetti, Amanda Gmyrek, Donna Damon, Manu Singh, Bonnie McRee, Frances Del Boca
AIMS: To identify barriers and facilitators associated with initial implementation of a US alcohol and other substance use Screening, Brief Intervention, and Referral to Treatment (SBIRT) grant program, and to identify modifications in program design that addressed implementation challenges. DESIGN: A mixed-method approach used quantitative and qualitative data, including SBIRT provider ratings of implementation barriers and facilitators, staff interview responses and program documentation...
February 2017: Addiction
https://www.readbyqxmd.com/read/28069159/developing-a-new-pi-rads-v2-based-nomogram-for-forecasting-high-grade-prostate-cancer
#8
X-K Niu, W-F He, Y Zhang, S K Das, J Li, Y Xiong, Y-H Wang
AIM: To establish a predictive nomogram for high-grade prostate cancer (HGPCa) in biopsy-naive patients based on the Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2), magnetic resonance imaging (MRI)-based prostate volume (PV), MRI-based PV-adjusted prostate-specific antigen density (PSAD), and other classical parameters. MATERIAL AND METHODS: Between August 2014 and August 2015, 158 men who were eligible for analysis were included as the training cohort...
January 6, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28068484/informatics-and-data-analytics-to-support-exposome-based-discovery-for-public-health
#9
Arjun K Manrai, Yuxia Cui, Pierre R Bushel, Molly Hall, Spyros Karakitsios, Carolyn J Mattingly, Marylyn Ritchie, Charles Schmitt, Denis A Sarigiannis, Duncan C Thomas, David Wishart, David M Balshaw, Chirag J Patel
The complexity of the human exposome-the totality of environmental exposures encountered from birth to death-motivates systematic, high-throughput approaches to discover the environmental determinants of disease. In this review, we describe the state of science in analyzing the human exposome and provide recommendations for the public health community to consider in dealing with analytic challenges of exposome-based biomedical research. We describe extant and novel analytic methods needed to associate the exposome with critical health outcomes and contextualize the data-centered challenges by drawing parallels to other research endeavors such as human genomics research...
December 23, 2016: Annual Review of Public Health
https://www.readbyqxmd.com/read/28054296/staple-line-reinforcement-in-laparoscopic-sleevegastrectomy-experience-in-1023-consecutive-cases
#10
Matías Sepúlveda, Cristián Astorga, Juan P Hermosilla, Munir Alamo
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric procedures performed worldwide. However, staple line-related complications have become a major challenge for bariatric surgeons. The aim of this study was to evaluate the morbidity in a cohort of patients who underwent LSG with imbricated oversewing of the staple line at a single high-volume center. MATERIALS AND METHODS: We retrospectively reviewed prospectively collected data for all patients who underwent LSG to treat obesity at our institution from January 2010 to September 2016...
January 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28048638/tu-d-201-04-veracity-of-data-elements-in-radiation-oncology-incident-learning-systems
#11
A Kapur, S Evans, D Brown, G Ezzell, D Hoopes, S Dieterich, K Kapetanovic, C Tomlinson
PURPOSE: Incident learning systems encompass volumes, varieties, values, and velocities of underlying data elements consistent with the V's of big data. Veracity, the 5th V however exists only if there is high inter-rater reliability (IRR) within the data elements. The purpose of this work was to assess IRR in the nationally deployed RO-ILS: Radiation Oncology-Incident Learning System (R) sponsored by the American Society for Radiation Oncology (ASTRO) and the American Association of Physicists in Medicine (AAPM)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048255/su-d-brb-04-nomogram-for-prediction-comparison-and-evaluation-of-dose-to-normal-tissue-in-srs-planning
#12
A Templeton, Y Liao, A Diaz, J Turian
PURPOSE: Radiosurgery of brain metastases is a unique treatment planning subset in which the treatment approach, high conformality and steep dose gradients are relatively invariant with varying location, size and shape of the target. Prescription doses are generally limited by the size of tumor or amount of surrounding normal brain receiving intermediate doses. We tabulated our treatment plans to establish a nomogram which provides planning expectations, useful for patient scheduling, planning efficiency, and training purposes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#13
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047176/su-c-bra-05-delineating-high-dose-clinical-target-volumes-for-head-and-neck-tumors-using-machine-learning-algorithms
#14
C Cardenas, A Wong, A Mohamed, J Yang, L Court, A Rao, C Fuller, M Aristophanous
PURPOSE: To develop and test population-based machine learning algorithms for delineating high-dose clinical target volumes (CTVs) in H&N tumors. Automating and standardizing the contouring of CTVs can reduce both physician contouring time and inter-physician variability, which is one of the largest sources of uncertainty in H&N radiotherapy. METHODS: Twenty-five node-negative patients treated with definitive radiotherapy were selected (6 right base of tongue, 11 left and 9 right tonsil)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046484/we-ab-209-05-development-of-an-ultra-fast-high-quality-whole-breast-radiotherapy-treatment-planning-system
#15
Y Sheng, T Li, S Yoo, F Yin, R Blitzblau, J Horton, M Palta, C Hahn, Y Ge, Q Wu
PURPOSE: To enable near-real-time (<20sec) and interactive planning without compromising quality for whole breast RT treatment planning using tangential fields. METHODS: Whole breast RT plans from 20 patients treated with single energy (SE, 6MV, 10 patients) or mixed energy (ME, 6/15MV, 10 patients) were randomly selected for model training. Additional 20 cases were used as validation cohort. The planning process for a new case consists of three fully automated steps:1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045051/randomized-trial-on-the-effects-of-a-combined-physical-cognitive-training-in-aged-mci-subjects-the-train-the-brain-study
#16
(no author information available yet)
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043434/aortic-root-surgery-does-high-surgical-volume-and-a-consistent-perioperative-approach-improve-outcome
#17
Rajdeep Bilkhu, Pouya Youssefi, Gopal Soppa, Rajan Sharma, Anne Child, Mark Edsell, Jean-Pierre van Besouw, Marjan Jahangiri
There is evidence that high surgical volume and team consistency improve outcomes. Mortality of 4%-12% for aortic root surgery has been reported in the United States and UK. We aim to assess outcomes of patients undergoing aortic root surgery by a consistent, high-volume team. Data on patients undergoing elective or urgent aortic root replacement (ARR) were collected prospectively. Patients undergoing emergency surgery were excluded. A standardized perioperative approach was maintained and was achieved by delivering training to team members, including surgical trainees, anesthetic, nursing, and perfusion staff, whenever there was a change of team...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28042838/a-comparison-study-of-classifier-algorithms-for-cross-person-physical-activity-recognition
#18
Yago Saez, Alejandro Baldominos, Pedro Isasi
Physical activity is widely known to be one of the key elements of a healthy life. The many benefits of physical activity described in the medical literature include weight loss and reductions in the risk factors for chronic diseases. With the recent advances in wearable devices, such as smartwatches or physical activity wristbands, motion tracking sensors are becoming pervasive, which has led to an impressive growth in the amount of physical activity data available and an increasing interest in recognizing which specific activity a user is performing...
December 30, 2016: Sensors
https://www.readbyqxmd.com/read/28035015/case-studies-in-physiology-maximal-oxygen-consumption-and-performance-in-a-centenarian-cyclist
#19
Veronique Louise Billat, Gilles Dhonneur, Laurence Mille-Hamard, Laurence Le Moyec, Iman Momken, Thierry Launay, Jean-Pierre Koralsztein, Sophie Besse
: The purpose of this study was to examine the physiological characteristics of an elite centenarian cyclist who, at 101 years old, established the one-hour cycling record for individuals ≥ 100 years old (24.25 km) and to determine the physiological factors associated with his performance improvement two years later at 103 years old (26.92 km; +11%). Before each record, he performed an incremental test on a cycling ergometer. For two years, he trained 5,000 km a year with a polarized training that involved cycling 80% of mileage at "light" RPE ≤ 12 and 20% at "hard" RPE ≥ 15 at a cadence between 50 and 70 rpm...
December 29, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28032435/effects-of-rest-intervals-and-training-loads-on-metabolic-stress-and-muscle-hypertrophy
#20
Julius Fink, Naoki Kikuchi, Koichi Nakazato
We investigated the effects of volume-matched resistance training (RT) with different training loads and rest intervals on acute responses and long-term muscle and strength gains. Ten subjects trained with short rest (30 s) combined with low load (20 RM) (SL) and ten subjects performed the same protocol with long rest (3 min) and high load (8 RM) (LH). Cross-sectional area (CSA) of the upper arm was measured by magnetic resonance imaging before and after 8 weeks of training. Acute stress markers such as growth hormone (GH) and muscle thickness (MT) changes have been assessed pre and post a single RT session...
December 28, 2016: Clinical Physiology and Functional Imaging
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