Giselle Santos Magalhaes, Juliana Fabiana Gregorio, Vinicius Amorim Beltrami, Franciel Batista Felix, Livia Oliveira-Campos, Caio Santos Bonilha, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério, Frederico B De Sousa, Barbara Maximino Rezende, Andréa Teixeira-Carvalho, Robson As Santos, Maria José Campagnole-Santos, Maria da Gloria Rodrigues-Machado, Mauro Martins Teixeira, Vanessa Pinho
OBJECTIVE: Angiotensin-(1-7) [Ang-(1-7)] is a pro-resolving mediator. It is not known whether the pro-resolving effects of Ang-(1-7) are sustained and protect the lung from a subsequent inflammatory challenge. This study sought to investigate the impact of treatment in face of a second allergic or lipopolysaccharide (LPS) challenge. METHODS: Mice, sensitized and challenged with ovalbumin (OVA), received a single Ang-(1-7) dose at the peak of eosinophilic inflammation, 24 h after the final OVA challenge...
April 24, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]