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https://www.readbyqxmd.com/read/27913834/key-role-of-pacing-site-as-determinant-factor-of-exercise-testing-performance-in-pediatric-patients-with-chronic-ventricular-pacing
#1
Michel Cabrera Ortega, Hiram Tápanes Duamy, Dunia B Benítez Ramos
Chronic right ventricular (RV) apical pacing has been associated with deterioration of functional capacity and chronotropic incompetence during exercise testing in children. The effects of alternative pacing site on exercise performance in pediatric population remain unknown. We evaluated the influence of ventricular pacing site on exercise capacity in pediatric patients with complete congenital atrioventricular block requiring permanent pacemaker therapy. Sixty-four children paced from RV apex (n = 26), RV midseptum (n = 15) and left ventricular (LV) apex (n = 23) were studied cross-sectionally...
December 2, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27913377/optimization-and-assessment-of-three-different-high-performance-liquid-chromatographic-systems-for-the-combinative-fingerprint-analysis-and-multi-ingredients-quantification-of-sangju-ganmao-tablet
#2
Meng-Zhe Guo, Jie Han, Dan-Dan He, Jia-Hui Zou, Zheng Li, Yan Du, Dao-Quan Tang
Chromatographic separation is still a critical subject for the quality control of traditional Chinese medicine. In this study, three different high performance liquid chromatographic (HPLC) systems employing commercially available columns packed with 1.8, 3.5 and 5.0 μm particles were respectively developed and optimized for the combinative fingerprint analysis and multi-ingredients quantification of Sangju Ganmao tablet (SGT). Chromatographic parameters including the repeatability of retention time and peak area, symmetry factor, resolution, number of theoretical plates and peak capacity were used to assess the chromatographic performance of different HPLC systems...
December 1, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27913345/facial-age-estimation-with-age-difference
#3
Zhenzhen Hu, Yonggang Wen, Jianfeng Wang, Meng Wang, Richang Hong, Shuicheng Yan
Age estimation based on the human face remains a significant problem in computer vision and pattern recognition. In order to estimate an accurate age or age group of a facial image, most of the existing algorithms require a huge face data set attached with age labels. This imposes a constraint on the utilization of the immensely unlabeled or weakly labeled training data, e.g. the huge amount of human photos in the social networks. These images may provide no age label, but it is easily to derive the age difference for an image pair of the same person...
December 1, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27913343/a-frequency-shift-method-to-measure-shear-wave-attenuation-in-soft-tissues
#4
Simon Bernard, Siavash Kazemirad, Guy Cloutier
In vivo quantification of shear wave attenuation in soft tissues may help to better understand human tissue rheology and lead to new diagnostic strategies. Attenuation is difficult to measure in acoustic radiation force elastography because the shear wave amplitude decreases due to a combination of diffraction and viscous attenuation. Diffraction correction requires assuming a cylindrical wavefront and an isotropic propagation medium, which may not be the case in some applications. In this study, the frequency shift method, used in ultrasound imaging and seismology, was adapted for shear wave attenuation measurement in elastography...
December 1, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27913338/intracardiac-vortex-dynamics-by-high-frame-rate-doppler-vortography-i-in-vivo-i-comparison-with-vector-flow-mapping-and-4-d-flow-mri
#5
Julia Faurie, Mathilde Baudet, Kondo Claude Assi, Dominique Auger, Guillaume Gilbert, Francois Tournoux, Damien Garcia
Recent studies have suggested that intracardiac vortex flow imaging could be of clinical interest to early diagnose the diastolic heart function. Doppler vortography has been intro-duced as a simple color Doppler method to detect and quantify intraventricular vortices. This method is able to locate a vortex core based on the recognition of an antisymmetric pattern in the Doppler velocity field. Because the heart is a fast-moving organ, high frame rates are needed to decipher the whole blood vortex dynamics during diastole...
November 29, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27913304/effects-of-nongenetic-factors-on-immune-cell-dynamics-in-early-childhood-the-generation-r-study
#6
Diana van den Heuvel, Michelle A E Jansen, Kazem Nasserinejad, Willem A Dik, Ellen G van Lochem, Liesbeth E Bakker-Jonges, Halima Bouallouch-Charif, Vincent W V Jaddoe, Herbert Hooijkaas, Jacques J M van Dongen, Henriëtte A Moll, Menno C van Zelm
BACKGROUND: . Numbers of blood leukocyte subsets are highly dynamic in childhood and differ greatly between individuals. Inter-individual variation is only partly accounted for by genetic factors. OBJECTIVE: Determine which nongenetic factors affect the dynamics of innate leukocytes, and naive and memory lymphocyte subsets. METHODS: . We performed six-color flow cytometry and linear mixed effect modeling to define the dynamics of 62 leukocyte subsets from birth to 6 years of age in 1,182 children with one to five measurements per individual...
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27913131/using-phenomenological-models-for-forecasting-the-2015-ebola-challenge
#7
Bruce Pell, Yang Kuang, Cecile Viboud, Gerardo Chowell
BACKGROUND: The rising number of novel pathogens threatening the human population has motivated the application of mathematical modeling for forecasting the trajectory and size of epidemics. MATERIALS AND METHODS: We summarize the real-time forecasting results of the logistic equation during the 2015 Ebola challenge focused on predicting synthetic data derived from a detailed individual-based model of Ebola transmission dynamics and control. We also carry out a post-challenge comparison of two simple phenomenological models...
November 19, 2016: Epidemics
https://www.readbyqxmd.com/read/27913076/biofilm-production-and-beta-lactamic-resistance-in-brazilian-staphylococcus-aureus-isolates-from-bovine-mastitis
#8
Viviane Figueira Marques, Cássia Couto da Motta, Bianca da Silva Soares, Dayanne Araújo de Melo, Shana de Mattos de Oliveira Coelho, Irene da Silva Coelho, Helene Santos Barbosa, Miliane Moreira Soares de Souza
Staphylococcus spp. play an important role in the etiology of bovine mastitis. Staphylococcus aureus is considered the most relevant species due to the production of virulence factors such as slime, which is required for biofilm formation. This study aimed to evaluate biofilm production and its possible relation to beta-lactamic resistance in 20 S. aureus isolates from bovine mastitic milk. The isolates were characterized by pheno-genotypic and MALDI TOF-MS assays and tested for genes such as icaA, icaD, bap, agr RNAIII, agr I, agr II, agr III, and agr IV, which are related to slime production and its regulation...
October 18, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27912154/limb-dominance-foot-orientation-and-functional-asymmetry-during-walking-gait
#9
John D Polk, Rebecca M Stumpf, Karl S Rosengren
While healthy gait is often characterized as, or assumed to be symmetric, consistent asymmetries often exist. In this study, we test the hypotheses that asymmetries in lower limb function, as measured by ground reaction force characteristics, may be explained by differences in foot orientation or limb dominance. Peak ground reaction force (GRF) measurements, and impulses were obtained for thirty-six healthy subjects with simultaneous kinematic estimates of foot posture. Three gait tasks were performed: subjects walked i) with normal foot orientation, ii) with feet laterally rotated (outward), and iii) with feet aligned in the direction of movement (straight)...
November 18, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27911900/clinical-and-pharmacological-investigation-of-myotoxicity-in-sri-lankan-russell-s-viper-daboia-russelii-envenoming
#10
Anjana Silva, Christopher Johnston, Sanjaya Kuruppu, Daniela Kneisz, Kalana Maduwage, Oded Kleifeld, A Ian Smith, Sisira Siribaddana, Nicholas A Buckley, Wayne C Hodgson, Geoffrey K Isbister
BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antivenom and the toxins responsible for myotoxicity. METHODOLOGY AND FINDINGS: Clinical features of myotoxicity were assessed in authenticated Russell's viper bite patients admitted to a Sri Lankan teaching hospital...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27910771/induction-of-flavin-containing-monooxygenase-in-mice-by-oral-administration-of-phellinus-baumii-agaricomycetes-extract
#11
Batbayar Sainkhuu, Beom Su Park, Ha Won Kim
Phellinus baumii is a yellow mushroom long used in alternative medicine in Korea and other central Asian countries. To identify genes affected by a single or 7-day oral administration of a water extract of Ph. Baumii, mouse liver tissue was analyzed using microarrays. The results showed that 8 and 23 genes were upregulated and 3 and 11 genes downregulated more than 3-fold by single and multiple oral administrations of 100 mg/kg PBE, respectively. Among the upregulated genes, the expression of 3 flavin-containing monooxygenase (Fmo) family genes, Fmo2-4, was upregulated in a concentration-dependent manner...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910309/spatial-resolution-measurements-of-the-advanced-radiographic-capability-x-ray-imaging-system-at-energies-relevant-to-compton-radiography
#12
G N Hall, N Izumi, O L Landen, R Tommasini, J P Holder, D Hargrove, D K Bradley, A Lumbard, J G Cruz, K Piston, J J Lee, E Romano, P M Bell, A C Carpenter, N E Palmer, B Felker, V Rekow, F V Allen
Compton radiography provides a means to measure the integrity, ρR and symmetry of the DT fuel in an inertial confinement fusion implosion near peak compression. Upcoming experiments at the National Ignition Facility will use the ARC (Advanced Radiography Capability) laser to drive backlighter sources for Compton radiography experiments and will use the newly commissioned AXIS (ARC X-ray Imaging System) instrument as the detector. AXIS uses a dual-MCP (micro-channel plate) to provide gating and high DQE at the 40-200 keV x-ray range required for Compton radiography, but introduces many effects that contribute to the spatial resolution...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910305/comparison-of-polystyrene-scintillator-fiber-array-and-monolithic-polystyrene-for-neutron-imaging-and-radiography
#13
R Simpson, T E Cutler, C R Danly, M A Espy, J H Goglio, J F Hunter, A C Madden, D R Mayo, F E Merrill, R O Nelson, A L Swift, C H Wilde, T G Zocco
The neutron imaging diagnostic at the National Ignition Facility has been operating since 2011 generating neutron images of deuterium-tritium (DT) implosions at peak compression. The current design features a scintillating fiber array, which allows for high imaging resolution to discern small-scale structure within the implosion. In recent years, it has become clear that additional neutron imaging systems need to be constructed in order to provide 3D reconstructions of the DT source and these additional views need to be on a shorter line of sight...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909885/kinematics-and-muscle-activation-patterns-during-a-maximal-voluntary-rate-activity-in-healthy-elderly-and-young-adults
#14
Eva Chadnova, Nancy St-Onge, Richard Courtemanche, Robert D Kilgour
BACKGROUND: Maximal voluntary rate (MVR) performance tasks can provide important age-related information to the limiting factors associated with movement and the development of fatigue. AIM: To determine whether kinematic and muscle activation patterns during an MVR task differ between young and older adults. METHODS: We continuously measured frequency, amplitude, peak velocity, index of co-contraction and median frequencies of the index finger flexors and extensors during a 20-s MVR task in 10 young and 10 older subjects...
December 1, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27909862/combined-characterization-of-bovine-polyhemoglobin-microcapsules-by-uv-vis-absorption-spectroscopy-and-cyclic-voltammetry
#15
Marcos Camargo Knirsch, Filippo Dell'Anno, Marco Salerno, Claudio Larosa, Bronislaw Polakiewicz, Roberto Eggenhöffner, Attilio Converti
Polyhemoglobin produced from pure bovine hemoglobin by reaction with PEG bis(N-succynimidil succinate) as a cross-linking agent was encapsulated in gelatin and dehydrated by freeze-drying. Free carboxyhemoglobin and polyhemoglobin microcapsules were characterized by UV-Vis spectroscopy in the absorption range 450-650 nm and cyclic voltammetry in the voltage range from -0.8 to 0.6 mV to evaluate the ability to break the bond with carbon monoxide and to study the carrier's affinity for oxygen, respectively...
December 1, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27909859/sofa-score-and-left-ventricular-systolic-function-as-predictors-of-short-term-outcome-in-patients-with-sepsis
#16
Francesca Innocenti, Vittorio Palmieri, Aurelia Guzzo, Valerio Teodoro Stefanone, Chiara Donnini, Riccardo Pini
In a group of septic patients, we assess the short-term prognostic value of LV systolic performance, evaluated through conventional left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LV GLS). One hundred forty-seven patients with sepsis were recruited; LVEF by planimetry and peak GLS by 2D speckle tracking could be assessed within 24 h. The study population was stratified according to SOFA tertiles assessed at the time of the echocardiogram (G1: SOFA score <5; G2: SOFA score 5-7; G3: SOFA score >7)...
December 1, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27909701/immunological-quality-and-performance-of-tumor-vessel-targeting-car-t-cells-prepared-by-mrna-ep-for-clinical-research
#17
Kanako Inoo, Ryo Inagaki, Kento Fujiwara, Shigemi Sasawatari, Takashi Kamigaki, Shinsaku Nakagawa, Naoki Okada
We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular endothelial growth factor receptor 2 (VEGFR2), demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP) and analyzed their immunological characteristics and functions for use in clinical research. The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6-12 hours after mRNA-EP...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/27909408/reliability-validity-and-usefulness-of-30-15-intermittent-fitness-test-in-female-soccer-players
#18
Nedim Čović, Eldin Jelešković, Haris Alić, Izet Rađo, Erduan Kafedžić, Goran Sporiš, Daniel T McMaster, Zoran Milanović
PURPOSE: The aim of this study was to examine the reliability, validity and usefulness of the 30-15IFT in competitive female soccer players. METHODS: Seventeen elite female soccer players participated in the study. A within subject test-retest study design was utilized to assess the reliability of the 30-15 intermittent fitness test (IFT). Seven days prior to 30-15IFT, subjects performed a continuous aerobic running test (CT) under laboratory conditions to assess the criterion validity of the 30-15IFT. End running velocity (VCT and VIFT), peak heart rate (HRpeak) and maximal oxygen consumption (VO2max) were collected and/or estimated for both tests...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27909373/exercise-telemonitoring-and-telerehabilitation-compared-with-traditional-cardiac-and-pulmonary-rehabilitation-a-systematic-review-and-meta-analysis
#19
Christen Chan, Cristiane Yamabayashi, Nafeez Syed, Ashley Kirkham, Pat G Camp
Background: Despite exercise capacity and quality-of-life benefits, pulmonary rehabilitation (PR) and cardiac rehabilitation (CR) programmes are not easily accessed because of several barriers. A solution may be telerehabilitation (TR), in which patients exercise in their communities while they are monitored via teletechnology. However, the benefits of TR for the purposes of PR and CR have not been systematically reviewed. Objective: To determine whether the benefits of the exercise component of PR and CR using TR are comparable to usual-care (UC) programmes...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27909231/influence-of-dietary-nitrate-supplementation-on-physiological-and-muscle-metabolic-adaptations-to-sprint-interval-training
#20
Christopher Thompson, Lee J Wylie, Jamie R Blackwell, Jonathan Fulford, Matthew I Black, James Kelly, Sinead T J McDonagh, James Carter, Stephen J Bailey, Anni Vanhatalo, Andrew M Jones
We hypothesized that 4 weeks of dietary nitrate supplementation would enhance exercise performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty six recreationally-active subjects, matched on key variables at baseline, completed a series of exercise tests before and following a 4 week period in which they were allocated to one of the following groups: 1) SIT and NO3(-)-depleted beetroot juice as a placebo (SIT+PL); 2) SIT and NO3(-)-rich beetroot juice (~13mmol NO3(-)/day; SIT+BR); or 3) no training and NO3(-)-rich beetroot juice (NT+BR)...
December 1, 2016: Journal of Applied Physiology
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