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https://www.readbyqxmd.com/read/28926968/weakening-pin-bone-attachment-in-fish-fillets-using-high-intensity-focused-ultrasound
#1
Martin H Skjelvareid, Svein Kristian Stormo, Kristín Anna Þórarinsdóttir, Karsten Heia
High Intensity Focused Ultrasound (HIFU) can be used for the localized heating of biological tissue through the conversion of sound waves into heat. Although originally developed for human medicine, HIFU may also be used to weaken the attachment of pin bones in fish fillets to enable easier removal of such bones. This was shown in the present study, where a series of experiments were performed on HIFU phantoms and fillets of cod and salmon. In thin objects such as fish fillets, the heat is mainly dissipated at the surfaces...
September 18, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28926769/experimental-study-of-time-response-of-bending-deformation-of-bone-cantilevers-in-an-electric-field
#2
Huimin Kang, Zhende Hou, Qing-Hua Qin
Bone is a complex composite material with hierarchical structures and anisotropic mechanical properties. Bone also processes electromechanical properties, such as piezoelectricity and streaming potentials, which termed as stress generated potentials. Furthermore, the electrostrictive effect and flexoelectric effect can also affect electromechanical properties of the bone. In the present work, time responses of bending deflections of bone cantilever in an external electric field are measured experimentally to investigate bone's electromechanical behavior...
September 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28926628/application-of-raman-spectroscopy-in-type-2-diabetes-screening-in-blood-using-leucine-and-isoleucine-amino-acids-as-biomarkers-and-in-comparative-anti-diabetic-drugs-efficacy-studies
#3
Zephania Birech, Peter Waweru Mwangi, Fredrick Bukachi, Keith Makori Mandela
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes symptoms are noticed. The objective of this work was first to explore the potential of leucine and isoleucine amino acids as diabetes type 2 biomarkers using their Raman spectroscopic signatures. Secondly, we wanted to explore whether Raman spectroscopy can be applied in comparative efficacy studies between commercially available anti-diabetic drug pioglitazone and the locally used anti-diabetic herbal extract Momordica spinosa (Gilg...
2017: PloS One
https://www.readbyqxmd.com/read/28926513/pharmacokinetics-and-safety-profile-of-single-dose-administration-of-an-estrogen-receptor-%C3%AE-selective-phytoestrogenic-phytoserm-formulation-in-perimenopausal-and-postmenopausal-women
#4
Gerson Hernandez, Liqin Zhao, Adrian A Franke, Yu-Ling Chen, Wendy J Mack, Roberta D Brinton, Lon S Schneider
OBJECTIVE: Selected estrogen receptor β-selective phytoestrogen (phytoSERM), a preparation of genistein, daidzein, and S-equol, has an 83-fold selective affinity for estrogen receptor (ER) β, and may promote neuronal survival and estrogenic mechanisms in the brain without exerting feminizing activity in the periphery. The aim of this study was to assess the safety, tolerability, and single-dose pharmacokinetics of the phytoSERM formulation in perimenopausal and postmenopausal women...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28926393/trends-in-the-treatment-of-single-and-multilevel-cervical-stenosis-a-review-of-the-american-board-of-orthopaedic-surgery-database
#5
Alfredo Arrojas, J Benjamin Jackson, Gregory Grabowski
BACKGROUND: In order to identify any changes in the utilization of new and old techniques, we investigated trends in the operative management of cervical stenosis by orthopaedic surgeons applying for board certification. METHODS: We queried the American Board of Orthopaedic Surgery database from 1998 to 2013 to identify all of the cervical spine procedures for stenosis that had been performed by candidates taking Part II of the licensing examination. Longitudinal trends were determined for the utilized approach, the individual procedures that had been performed, and whether a motion-preserving technique had been employed...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926137/metabolic-profile-of-rhizoma-coptidis-in-human-plasma-determined-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry
#6
Qing-Shan Zhang, Gao-Wa Wang, Zhi-Qiang Han, Xiang-Mei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
RATIONALE: Rhizoma coptidis extract and its alkaloids show various pharmacological activities, but its metabolic profile in human plasma has not been thoroughly investigated. In the present research, the metabolism of Rhizoma coptidis at a clinical dose (5 g/60 kg/day) was systematically analyzed to determine its biotransformation processes in human plasma. METHODS: In this research, the metabolites of Rhizoma coptidis in human plasma after oral administration of Rhizoma coptidis extract at a clinical dose were investigated using ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometry...
September 19, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28925969/caffeine-improves-basketball-performance-in-experienced-basketball-players
#7
Carlos Puente, Javier Abián-Vicén, Juan José Salinero, Beatriz Lara, Francisco Areces, Juan Del Coso
The aim of this study was to determine the effect of caffeine intake on overall basketball performance in experienced players. A double-blind, placebo-controlled, randomized experimental design was used for this investigation. In two different sessions separated by one week, 20 experienced basketball players ingested 3 mg of caffeine/kg of body mass or a placebo. After 60 min, participants performed 10 repetitions of the following sequence: Abalakov jump, Change-of-Direction and Acceleration Test (CODAT) and two free throws...
September 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28925810/ube3a-mediated-regulation-of-imprinted-genes-and-epigenome-wide-marks-in-human-neurons
#8
S Jesse Lopez, Keith Dunaway, M Saharul Islam, Charles Mordaunt, Annie Vogel Ciernia, Makiko Meguro-Horike, Shin-Ichi Horike, David J Segal, Janine LaSalle
The dysregulation of genes in neurodevelopmental disorders that lead to social and cognitive phenotypes is a complex, multilayered process involving both genetics and epigenetics. Parent-of-origin effects of deletion and duplication of the 15q11-q13 locus leading to Angelman, Prader-Willi, and Dup15q syndromes are due to imprinted genes, including UBE3A, which is maternally expressed exclusively in neurons. UBE3A encodes a ubiquitin E3 ligase protein with multiple downstream targets, including RING1B, which in turn monoubiquitinates histone variant H2A...
September 19, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28925749/cardiac-telerehabilitation-a-novel-cost-efficient-care-delivery-strategy-that-can-induce-long-term-health-benefits
#9
Ines Frederix, Francesca Solmi, Massimo F Piepoli, Paul Dendale
Background Finding innovative and cost-efficient care strategies that induce long-term health benefits in cardiac patients constitutes a big challenge today. The aim of this Telerehab III follow-up study was to assess whether a 6-month additional cardiac telerehabilitation programme could induce long-term health benefits and remain cost-efficient after the tele-intervention ended. Methods and results A total of 126 cardiac patients first completed the multicentre, randomised controlled telerehabilitation trial (Telerehab III, time points t0 to t1)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28925354/dynamic-representation-of-partially-occluded-objects-in-primate-prefrontal-and-visual-cortex
#10
Amber M Fyall, Yasmine El-Shamayleh, Hannah Choi, Eric Shea-Brown, Anitha Pasupathy
Successful recognition of partially occluded objects is presumed to involve dynamic interactions between brain areas responsible for vision and cognition, but neurophysiological evidence for the involvement of feedback signals is lacking. Here, we demonstrate that neurons in the ventrolateral prefrontal cortex (vlPFC) of monkeys performing a shape discrimination task respond more strongly to occluded than unoccluded stimuli. In contrast, neurons in visual area V4 respond more strongly to unoccluded stimuli...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28924947/development-of-a-rapid-maldi-tof-ms-based-epidemiological-screening-method-using-mrsa-as-a-model-organism
#11
Åsa Lindgren, Nahid Karami, Roger Karlsson, Christina Åhrén, Martin Welker, Edward R B Moore, Liselott Svensson Stadler
In this study we present a method using whole cell MALDI-TOF MS and VITEK MS RUO/SARAMIS as a rapid epidemiological screening tool. MRSA was used as a model organism for setting up the screening strategy. A collection of well-characterised MRSA strains representing the 19 most common Pulsed-Field Gel Electrophoresis (PFGE)-types in the region of South-West Sweden for the past 20 years was analysed with MALDI-TOF MS. A total of 111 MRSA strains were used for creating 19 PFGE-specific Superspectra using VITEK MS RUO/SARAMIS...
September 18, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28924568/convolutional-neural-network-for-high-accuracy-functional-near-infrared-spectroscopy-in-a-brain-computer-interface-three-class-classification-of-rest-right-and-left-hand-motor-execution
#12
Thanawin Trakoolwilaiwan, Bahareh Behboodi, Jaeseok Lee, Kyungsoo Kim, Ji-Woong Choi
The aim of this work is to develop an effective brain-computer interface (BCI) method based on functional near-infrared spectroscopy (fNIRS). In order to improve the performance of the BCI system in terms of accuracy, the ability to discriminate features from input signals and proper classification are desired. Previous studies have mainly extracted features from the signal manually, but proper features need to be selected carefully. To avoid performance degradation caused by manual feature selection, we applied convolutional neural networks (CNNs) as the automatic feature extractor and classifier for fNIRS-based BCI...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28924476/clinical-validation-of-real-time-tissue-change-monitoring-during-prostate-tissue-ablation-with-high-intensity-focused-ultrasound
#13
Narendra T Sanghvi, Wo-Hsing Chen, Roy Carlson, Clint Weis, Ralf Seip, Toyoaki Uchida, Michael Marberger
BACKGROUND: The purpose of these clinical studies was to validate a Tissue Change Monitoring (TCM) algorithm in vivo. TCM is a quantitative tool for the real-time assessment of HIFU dose. TCM provides quantitative analysis of the backscatter pulse echo signals (pre and immediately post HIFU) for each individual ablative site, using ultrasonic tissue characterization as a surrogate for monitoring tissue temperature. Real-time analysis generates an energy difference parameter (ΔE in dB) that is proportional to tissue temperature...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28924329/a-computational-tool-for-accelerated-analysis-of-oligomeric-proanthocyanidins-in-plants
#14
Mengliang Zhang, Jianghao Sun, Pei Chen
A computational tool was developed to facilitate proanthocyanidin analysis using data collected by ultra-high-performance liquid chromatography-diode array detection-high resolution accurate mass-mass spectrometry (UHPLC-DAD-HRAM-MS). Both identification and semi-quantitation of proanthocyanidins can be achieved by the developed computational tool. It can extract proanthocyanidin chromatographic peaks, deconvolute the isotopic patterns of A-type, B-type, and multi-charged proanthocyanidins ions, and predict proanthocyanidin structures...
March 2017: Journal of Food Composition and Analysis
https://www.readbyqxmd.com/read/28924314/comparison-between-standing-broad-jump-test-and-wingate-test-for-assessing-lower-limb-anaerobic-power-in-elite-sportsmen
#15
Anup Krishnan, Deep Sharma, Madhu Bhatt, Apoorv Dixit, P Pradeep
BACKGROUND: Lower limb explosive power is an important motor quality for sporting performance and indicates use of anaerobic energy systems like stored ATP and Creatine phosphate system. Weightlifting, Fencing and Wrestling use it for monitoring and identification of potential sportsmen. The Wingate test and Standing Broad Jump (SBJ) test are reliable and accurate tests for its assessment. This study conducted on elite Indian sportsmen tries to analyse feasibility of use of the SBJ test in sports and military medicine when Wingate test is impractical...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28923709/the-impact-of-heat-waves-and-cold-spells-on-respiratory-emergency-department-visits-in-beijing-china
#16
Xuping Song, Shigong Wang, Tanshi Li, Jinhui Tian, Guowu Ding, Jiaxin Wang, Jiexin Wang, Kezheng Shang
The objectives of this article were (i) to find the association between extreme temperatures and respiratory emergency department (ED) visits and (ii) to explore the added effects of heat waves and cold spells on respiratory ED visits in Beijing from 2009 to 2012. A quasi-Poisson generalised linear model combined with a distributed lag non-linear model was performed to quantify this association. The results indicated that (i) ambient temperature related to respiratory ED visits exhibited a U-shaped association...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28923651/high-resolution-magic-angle-spinning-nuclear-magnetic-resonance-spectroscopy-for-the-metabolic-assessment-of-acute-rejection-after-cardiac-transplantation-in-rats
#17
C W Lee, J S Lee, C W Woo, S Kim
PURPOSE: To evaluate the potential of high-resolution magic angle spinning (HR-MAS) (1)H nuclear magnetic resonance (NMR) spectroscopy for metabolite characterization and the differentiation of acute rejection after heart transplantation in rat models. METHODS: We transplanted syngeneic heart grafts from Lewis rats (n = 4) and allogeneic heart grafts from F344 rats (n = 4) heterotopically into Lewis recipients. On day 7 postoperatively, the transplanted hearts were harvested for ex vivo (1)H NMR spectroscopy and HR-MAS (1)H NMR spectroscopy...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923587/visual-performance-of-a-quadrifocal-trifocal-intraocular-lens-following-removal-of-the-crystalline-lens
#18
Thomas Kohnen, Michael Herzog, Eva Hemkeppler, Sabrina Schönbrunn, Nina De Lorenzo, Kerstin Petermann, Myriam Böhm
PURPOSE: To evaluate visual performance after implantation of a quadrifocal intraocular lens (IOL). DESIGN: Prospective, non-comparative case series METHODS: Setting: Department of Ophthalmology, Goethe University, Frankfurt, Germany. Patient or Study Population: Twenty-seven patients (54 eyes) received bilateral implantation of the PanOptix IOL (AcrySof® IQ PanOptixTM, Alcon Research, Fort Worth, TX, USA) pre-enrollment. Exclusion criteria were previous ocular surgeries, corneal astigmatism of >1...
September 15, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28923457/blood-flow-regulation-and-oxidative-stress-during-submaximal-cycling-exercise-in-patients-with-cystic-fibrosis
#19
Matthew A Tucker, Breana Berry, Nichole Seigler, Gareth W Davison, John C Quindry, Dabney Eidson, Kathleen T McKie, Ryan A Harris
BACKGROUND: The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated. METHODS: A maximal graded exercise test was conducted to determine exercise capacity (VO2 peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV1 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound...
September 8, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28923418/active-modulation-in-neat-carbon-dioxide-packed-column-comprehensive-two-dimensional-supercritical-fluid-chromatography
#20
Orjen Petkovic, Pierre Guibal, Patrick Sassiat, Jérôme Vial, Didier Thiébaut
After demonstrating in a first paper the feasibility of SFCxSFC without decompression of the mobile phase, a modified interface has been developed in order to perform active modulation between the two SFC dimensions. In this paper, it is shown that the new interface enabled independent control of modulation parameters in SFCxSFC and performed a band compression effect of solutes between the two SFC dimensions. The effectiveness of this new modulation process was studied using a Design of Experiments. The SFCxSFC prototype was applied to the analysis of a real oil sample to demonstrate the benefits of the active modulator; in comparison to our previous results obtained without active modulation, better separation was obtained with the new interface owing to the peak compression occurring in the modulator...
August 26, 2017: Journal of Chromatography. A
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