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Red cell alloimmunization

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https://www.readbyqxmd.com/read/28983058/red-cell-alloimmunization-is-associated-with-development-of-autoantibodies-and-increased-red-cell-transfusion-requirements-in-myelodysplastic-syndrome
#1
Deepak Singhal, Monika M Kutyna, Rakchha Chhetri, Li Yan A Wee, Sophia Hague, Lakshmi Nath, Shriram V Nath, Romi Sinha, Nicholas Wickham, Ian D Lewis, David M Ross, Peter G Bardy, Luen Bik To, John Reynolds, Erica M Wood, David J Roxby, Devendra K Hiwase
Up to 90% of myelodysplastic syndrome patients require red blood cell transfusion, however comprehensive data addressing red cell alloimmunization are limited. This study evaluates the incidence and clinical impact of red cell alloimmunization in a large cohort of myelodysplastic syndrome patients registered in the statewide South Australian-MDS registry. Median age of the 817 patients was 73 years, and 66% were male. The cumulative incidence of alloimmunization was 11%. Disease-modifying therapy was associated with a lower risk of alloimmunization...
October 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28970677/red-cell-alloimmunization-in-repeatedly-transfused-patients
#2
Dimel K Bhuva, Jitendra H Vachhani
INTRODUCTION: Repeated blood transfusions can result in the production of alloantibodies against one or more red cell antigens, which complicates subsequent transfusions. Aims: The study was done to find incidence of various red cell alloantibodies; to determine the type of alloantibody; to identify the factors such as frequency of transfusion, splenectomy status, donor ethnicity and gender and their association with the development of antibody in repeatedly transfused patients. MATERIALS AND METHODS: This study was carried out in Dept...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28880379/red-blood-cell-alloimmunization-in-neonates-and-children-up-to-3-years-of-age
#3
Tugce Türkmen, Dan Qiu, Nina Cooper, Ulrich J Sachs, Wilhelm Wößmann, Dietmar Schranz, Klaus-Peter Zimmer, Harald Ehrhardt, Holger Hackstein, Gregor Bein
BACKGROUND: An alloimmune response to red blood cell (RBC) transfusion in neonates is a rare event. Several guidelines recommend limited pretransfusion testing in neonates. The evidence for these recommendations is based on small studies with sample sizes of between 30 and 90 infants. STUDY DESIGN AND METHODS: We conducted a retrospective cohort study among consecutive patients who received transfusions at a single university medical center. All non-alloimmunized patients who had received their first RBC transfusion between 1994 and 2013 and who underwent at least one antibody screening follow-up visit between 7 and 365 days after transfusion were included...
September 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28862180/red-cell-alloimmunization-role-of-advanced-immunohaematological-support-in-liver-transplantation
#4
Raj Nath Makroo, Soma Agrawal, Mohit Chowdhry, Aakanksha Bhatia, Uday Kumar Thakur
BACKGROUND & OBJECTIVES: Transfusion support forms an integral part of liver transplantation programme. Advanced immunohaematology services are required to deal with complex serological problems that can complicate transfusion therapy in these patients. Here, we report on red cell alloimmunization and presence of alloimmunization in donors and patients undergoing liver transplantation in a tertiary care hospital in north India. METHODS: Records of 1433 liver transplants performed from January 2009 to March 2015 were retrieved and reviewed...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28840609/red-blood-cell-alloimmunization-in-pregnancy-during-the-years-1996-2015-in-iceland-a-nation-wide-population-study
#5
Gunnar Bollason, Hulda Hjartardottir, Thorbjorn Jonsson, Sveinn Gudmundsson, Sveinn Kjartansson, Anna Margret Halldorsdottir
BACKGROUND: Red blood cell (RBC) alloimmunization during pregnancy is still a major problem. Historically, anti-D antibodies are most likely to cause severe hemolysis, but other antibodies are also important. In Iceland, postnatal RhIg prophylaxis was implemented in 1969, universal RBC antibody screening was implemented in 1978, but antenatal RhIg prophylaxis is not yet routine. STUDY DESIGN AND METHODS: This nation-wide population study gathered data on alloimmunized pregnancies in Iceland between 1996 and 2015...
August 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28840600/red-blood-cell-minor-antigen-mismatches-during-chronic-transfusion-therapy-for-sickle-cell-anemia
#6
Marianne E M Yee, Cassandra D Josephson, Anne M Winkler, Jennifer Webb, Naomi L C Luban, Traci Leong, Sean R Stowell, Ross M Fasano
BACKGROUND: Red blood cell (RBC) alloimmunization occurs at a high frequency in sickle cell anemia (SCA) despite serologic matching for Rh (C/c, E/e) and K antigens. RBC minor antigen genotyping allows for prediction of antigens and RH variants that may lead to alloimmunization. STUDY DESIGN AND METHODS: RBC antigen genotyping was performed on chronically transfused pediatric SCA patients, using PreciseType human erythrocyte antigen (HEA), RHCE, and RHD BeadChip arrays...
August 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28838449/successful-blood-transfusion-management-of-a-living-donor-liver-transplant-recipient-in-the-presence-of-anti-jr-a-a-case-report
#7
N Kurata, Y Onishi, H Kamei, T Hori, M Komagome, C Kato, T Matsushita, Y Ogura
A 48-year-old Japanese woman was diagnosed with Budd-Chiari syndrome and transferred for possible living donor liver transplantation (LDLT). Examinations before LDLT revealed that the recipient had anti-Jr(a) and preformed donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA). Rituximab was administrated at 16 days prior to the patient's scheduled LDLT for the prophylaxis of antibody-mediated rejection by DSA. The clinical significance of anti-Jr(a) has not been clearly established because of the rarity of this antibody, so we discussed blood transfusion strategy with the Department of Blood Transfusion Service and prepared for Jr(a)-negative packed red blood cells (RBCs)...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28836263/b-cells-require-type-1-interferon-to-produce-alloantibodies-to-transfused-kel-expressing-red-blood-cells-in-mice
#8
David R Gibb, Jingchun Liu, Manjula Santhanakrishnan, Prabitha Natarajan, David J Madrid, Seema Patel, Stephanie C Eisenbarth, Christopher A Tormey, Sean R Stowell, Akiko Iwasaki, Jeanne E Hendrickson
BACKGROUND: Alloantibodies to red blood cell (RBC) antigens can cause significant hemolytic events. Prior studies have demonstrated that inflammatory stimuli in animal models and inflammatory states in humans, including autoimmunity and viremia, promote alloimmunization. However, molecular mechanisms underlying these findings are poorly understood. Given that Type 1 interferons (IFN-α/β) regulate antiviral immunity and autoimmune pathology, the hypothesis that IFN-α/β regulates RBC alloimmunization was tested in a murine model...
August 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28827079/application-of-genomics-for-transfusion-therapy-in-sickle-cell-anemia
#9
Stella T Chou, Connie M Westhoff
The application of genomic approaches is impacting all areas of laboratory testing including transfusion medicine. Use of DNA-based test methods is particularly applicable for red cell and platelet antigen typing as the majority of genes encoding the carrier proteins and carbohydrates are now known and were cloned in the 1990's. Many of the antigenic polymorphisms are due to single nucleotide changes (SNP's) in the respective genes and DNA-arrays that target these changes have been validated by comparison with conventional serologic typing...
August 8, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28815969/-318c-t-polymorphism-of-the-ctla-4-gene-is-an-independent-risk-factor-for-rbc-alloimmunization-among-sickle-cell-disease-patients
#10
V B Oliveira, M R Dezan, F C A Gomes, S F Menosi Gualandro, J E Krieger, A C Pereira, J D Marsiglia, J E Levi, V Rocha, A Mendrone-Junior, E C Sabino, C L Dinardo
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) molecule is expressed on T-lymphocyte membrane and negatively influences the antigen-presenting process. Reduced expression of CTLA-4 due to gene polymorphisms is associated with increased risk of autoimmune disorders, whose physiopathology is similar to that of post-transfusion red blood cell (RBC) alloimmunization. Our goal was to evaluate if polymorphisms of CTLA-4 gene that affect protein expression are associated with RBC alloimmunization. This was a case-control study in which 134 sickle cell disease (SCD) patients and 253 non-SCD patients were included...
October 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28815406/successful-management-of-a-hydropic-fetus-with-severe-anemia-and-thrombocytopenia-caused-by-anti-cd36-antibody
#11
Xiuzhang Xu, Lin Li, Wenjie Xia, Haoqiang Ding, Dawei Chen, Jing Liu, Jing Deng, Yangkai Chen, Zhiming He, Jiali Wang, Yuan Shao, Sentot Santoso, Xin Ye, Qun Fang
Cases of CD36 deficiency are not rare in Asian populations, foetal and neonatal alloimmune thrombocytopenia (FNAIT) caused by anti-CD36 isoantibodies appears more frequent than other HPA alloantibodies. However, little is known about the treatment of anti-CD36 mediated FNAIT in this region. A Chinese male foetus, whose mother had a history of multiple intrauterine foetal demise and/or hydrops, was diagnosed with severe FNAIT at 27 weeks of gestational age. Immunological analysis revealed total absence of CD36 on platelets and monocytes from mother, caused by a 329-330delAC mutation of the CD36 gene...
August 16, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28804957/pre-and-post-transfusion-alloimmunization-in-dogs-characterized-by-2-antiglobulin-enhanced-cross-match-tests
#12
I Goy-Thollot, U Giger, C Boisvineau, R Perrin, M Guidetti, B Chaprier, A Barthélemy, C Pouzot-Nevoret, B Canard
BACKGROUND: When dogs are transfused, blood compatibility testing varies widely but may include dog erythrocyte antigen (DEA) 1 typing and rarely cross-matching. OBJECTIVES: Prospective study to examine naturally occurring alloantibodies against red blood cells (RBCs) and alloimmunization by transfusion using 2 antiglobulin-enhanced cross-match tests. ANIMALS: Eighty client-owned anemic, 72 donor, and 7 control dogs. METHODS: All dogs were typed for DEA 1 and some also for DEA 4 and DEA 7...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28742673/practice-bulletin-no-181-prevention-of-rh-d-alloimmunization
#13
(no author information available yet)
Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1)...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742667/practice-bulletin-no-181-summary-prevention-of-rh-d-alloimmunization
#14
(no author information available yet)
Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1)...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28719385/prevention-of-hemolytic-disease-of-the-fetus-and-newborn-what-have-we-learned-from-animal-models
#15
Yoelys Cruz-Leal, Danielle Marjoram, Alan H Lazarus
PURPOSE OF REVIEW: This review aims to highlight recent advances in our understanding of how anti-red blood cell (RBC) antibodies prevent erythrocyte immunization with an emphasis on new murine models. RECENT FINDINGS: New murine models with clinically relevant human erythrocyte antigens have been used to understand the alloimmunization process and its inhibition. The search to elucidate the mechanism of action of IgG-mediated inhibition of erythrocyte alloimmunization has provided new evidence in support of a potential role for epitope masking, immune deviation and/or antigen modulation in this process...
July 20, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28717357/high-levels-of-cxcl8-and-low-levels-of-cxcl9-and-cxcl10-in-women-with-maternal-rhd-alloimmunization
#16
Juliana Araújo de Carvalho Schettini, Thomás Virgílio Gomes, Alexandra Karla Santos Barreto, Claudeir Dias da Silva Júnior, Marina da Matta, Isabela Cristina Neiva Coutinho, Maria do Carmo Valgueiro Costa de Oliveira, Leuridan Cavalcante Torres
Maternal RhD alloimmunization is an inflammatory response against protein antigens in fetal red blood cells (RBC). However, not all women become alloimmunized when exposed to RhD(+) fetal RBC. Thus, this study aimed to evaluate levels of inflammatory chemokines in RhD(-) pregnant women with erythrocyte alloimmunization. CXCL8, CXCL9, CCL5, and CXCL10 levels were determined from cell culture supernatants by flow cytometry in 46 (30 non-alloimmunized RhD(-) and 16 previously alloimmunized RhD(-)) pregnant women...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28664822/passenger-lymphocyte-syndrome-in-the-abo-incompatible-kidney-transplant-recipient-receiving-rituximab
#17
Shunji Nishide, Junji Uchida, Kazuya Kabei, Tomoaki Iwai, Nobuyuki Kuwabara, Toshihide Naganuma, Norihiko Kumada, Yoshiaki Takemoto, Tatsuya Nakatani
Passenger lymphocyte syndrome is a rare but important disease in which the donor lymphocytes produce antibodies to the red blood cell antigens of the recipient, causing alloimmune hemolysis. It occurs in ABO blood group-mismatched solid-organ and/or bone marrow transplant. We report a case of passenger lymphocyte syndrome occurring after ABO-incompatible kidney transplant. The recipient received rituximab as a desensitization protocol. On posttransplant day 18, the recipient showed a fall in her hemoglobin levels without identifiable bleeding source and an elevation of total bilirubin...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28657764/two-cases-of-the-variant-rhd-dau5-allele-associated-with-maternal-alloanti-d
#18
Jennifer A Duncan, Susan Nahirniak, Rodrigo Onell, Gwen Clarke
Rh is a complex blood group system with diverse genotypes that may encode weak and partial D variants. Standard serologic analysis may identify clinically significant D variants as D+; nevertheless, individuals with these D variants should be managed as D- patients to prevent antibody formation to absent D epitopes. Variant identification is necessary during pregnancy to allow for timely and appropriate Rh immune globulin (RhIG) prophylaxis for hemolytic disease of the fetus and newborn (HDFN) as D alloimmunization can occur with some D variants...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28651884/-transfusions-in-myelodysplastic-syndromes
#19
C Rose
PRBC transfusion remains the mainstay of treatment of anemia in MDS after failure of erythropoiesis stimulating agents. The most common transfusion trigger in transfusion-dependent MDS patients is 80g/L. This level is based only on expert consensus; a randomized controlled trial comparing restrictive against liberal policy is required to evaluate potential impact of transfusion policy on with QoL and survival. Prophylactic antigen matching for RhCE and K must be used in order to reduce the risk of red blood cell (RBC) alloimmunization...
September 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28643386/risks-and-trends-of-red-blood-cell-transfusion-in-obstetric-patients-a-retrospective-study-of-45-213-deliveries-using-administrative-data
#20
Nadine Shehata, Michaël Chassé, Jo Ann Colas, Malia Murphy, Alan J Forster, Ann K Malinowski, Robin Ducharme, Dean A Fergusson, Alan Tinmouth, Kumanan Wilson
BACKGROUND: Transfusion data for obstetric patients are scarce. Identifying characteristics associated with red blood cell transfusion (RBCT) is of importance to better identify patients who would benefit from blood conservation strategies as the risk of alloimmunization from RBCT has the potential to affect the fetus and newborn. STUDY DESIGN AND METHODS: We conducted a retrospective cohort study using hospital administrative data to identify trends and risk factors of RBCT in obstetric patients...
September 2017: Transfusion
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