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Red cell alloimmunization

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https://www.readbyqxmd.com/read/27913516/immunoregulatory-networks-in-sickle-cell-alloimmunization
#1
Karina Yazdanbakhsh
Red blood cell (RBC) transfusions are critical for treatment and prevention of complications of sickle cell disease (SCD), and most SCD patients will receive 1 or more transfusions by age 20. However, SCD alloimmunization remains a serious complication of transfusions that can lead to life-threatening acute and delayed transfusion reactions. Alloimmunization rates are higher in SCD patients most likely due to RBC antigenic differences between largely white donors vs mainly African-American recipients and frequency of transfusions...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913515/cellular-immune-responses-in-red-blood-cell-alloimmunization
#2
James C Zimring, Krystalyn E Hudson
In excess of 340 blood group antigens have now been described that vary between individuals. Thus, any unit of blood that is nonautologous represents a significant dose of alloantigen. Most blood group antigens are proteins, which differ by a single amino acid between donors and recipients. Approximately 1 out of every 70 individuals are transfused each year (in the United States alone), which leads to antibody responses to red blood cell (RBC) alloantigens in some transfusion recipients. When alloantibodies are formed, in many cases, RBCs expressing the antigen in question can no longer be safely transfused...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913514/understanding-red-blood-cell-alloimmunization-triggers
#3
Jeanne E Hendrickson, Christopher A Tormey
Blood group alloimmunization is "triggered" when a person lacking a particular antigen is exposed to this antigen during transfusion or pregnancy. Although exposure to an antigen is necessary for alloimmunization to occur, it is not alone sufficient. Blood group antigens are diverse in structure, function, and immunogenicity. In addition to red blood cells (RBCs), a recipient of an RBC transfusion is exposed to donor plasma, white blood cells, and platelets; the potential contribution of these elements to RBC alloimmunization remains unclear...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27873324/red-blood-cell-alloimmunization-in-patients-with-sickle-cell-disease-correlation-with-hla-and-cytokine-gene-polymorphisms
#4
Emilia Ângela Sippert, Jeane Eliete Laguila Visentainer, Hugo Vicentin Alves, Camila Rodrigues, Simone Cristina Olenscki Gilli, Marcelo Addas-Carvalho, Sara Teresinha Ollala Saad, Fernando Ferreira Costa, Lilian Castilho
BACKGROUND: The reason for the difference in susceptibility to red blood cell (RBC) alloimmunization among patients with sickle cell disease (SCD) is not clearly understood and is probably the result of multiple factors. Our hypothesis is that genetic polymorphisms are associated with RBC alloimmunization. STUDY DESIGN AND METHODS: We investigated the possible association of susceptibility to RBC alloimmunization with polymorphisms of HLA and cytokines genes in 161 SCD patients prior exposed to RBC transfusion...
November 21, 2016: Transfusion
https://www.readbyqxmd.com/read/27864153/immunogenicity-of-murine-mpeg-red-blood-cells-and-the-risk-of-anti-peg-antibodies-in-human-blood-donors
#5
Yevgeniya Le, Wendy M Toyofuku, Mark D Scott
The immunocamouflage of non-ABO blood group antigens by membrane grafted mPEG may attenuate the risk of RBC alloimmunization. However, concerns have been raised as to the immunogenic risk of PEG and PEG-RBC. To assess these risks, murine and human studies were done. Mice were exposed to soluble PEG prior to, or between, multiple transfusions (∼60 day intervals) of control or mPEG-RBC and cell survival was determined by flow cytometry. In some studies, the control and mPEG-RBC groups were reversed following one or more transfusions...
November 15, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27734515/bortezomib-decreases-the-magnitude-of-a-primary-humoral-immune-response-to-transfused-red-blood-cells-in-a-murine-model
#6
Prabitha Natarajan, Jingchun Liu, Manjula Santhanakrishnan, David R Gibb, Lewis M Slater, Jeanne E Hendrickson
BACKGROUND: Few therapeutic options currently exist to prevent or to mitigate transfusion-associated red blood cell (RBC) alloimmunization. We hypothesized that bortezomib, a proteasome inhibitor currently being utilized for HLA alloantibody and ADAMTS13 autoantibody reduction, may be beneficial in a transfusion setting. Herein, we utilized a reductionist murine model to test our hypothesis that bortezomib would decrease RBC alloimmune responses. STUDY DESIGN AND METHODS: Wild-type mice were treated with bortezomib or saline and transfused with murine RBCs expressing the human KEL glycoprotein...
October 13, 2016: Transfusion
https://www.readbyqxmd.com/read/27706858/complications-of-intrauterine-intravascular-blood-transfusions-lessons-learned-after-1678-procedures
#7
Carolien Zwiers, Irene T M Lindenburg, Frans J C M Klumper, Masja de Haas, Dick Oepkes, Inge L van Kamp
BACKGROUND: maternal alloimmunization to fetal red blood cell antigens is a major cause of fetal anemia, which in untreated cases can lead to hydrops and perinatal death. The cornerstone of the management during pregnancy is intrauterine intravascular blood transfusion. Although this procedure is considered to be relatively safe, (procedure-related) complications continue to occur. OBJECTIVES: to evaluate procedure-related complications and perinatal loss rates of intrauterine transfusion and changes over time, aiming to identify factors leading to improved outcome...
October 5, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27662015/interleukin-6-receptor-alpha-signaling-drives-anti-rbc-alloantibody-production-and-t-follicular-helper-cell-differentiation-in-a-murine-model-of-red-blood-cell-alloimmunization
#8
LETTER
Abhinav Arneja, Juan E Salazar, Wenyu Jiang, Jeanne E Hendrickson, James C Zimring, Chance John Luckey
No abstract text is available yet for this article.
November 2016: Haematologica
https://www.readbyqxmd.com/read/27634204/treatments-for-hematological-malignancies-in-contrast-to-those-for-solid-cancers-are-associated-with-reduced-red-cell-alloimmunization
#9
Dorothea Evers, Jaap Jan Zwaginga, Janneke Tijmensen, Rutger A Middelburg, Masja de Haas, Karen M K de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C V Péquériaux, Francisca Hudig, Johanna G van der Bom
Red cell alloimmunization may induce severe hemolytic side effects. Identification of risk modifying conditions will help tailor preventative strategies. This study aims to quantify the associations of hematological malignancies and solid cancers with red cell alloimmunization in patients receiving red cell transfusions. We performed a nested multicenter case-control study in a source population of 24,063 patients receiving their first and subsequent red cell transfusions during an eight year follow-up period...
September 15, 2016: Haematologica
https://www.readbyqxmd.com/read/27605858/direct-antiglobulin-test-positivity-in-multi-transfused-thalassemics
#10
Ashish Jain, Ajju Agnihotri, Neelam Marwaha, Ratti Ram Sharma
INTRODUCTION: Red cell allo- and auto-immunization is a well recognized problem in multi-transfused thalassemic patients. We conducted this study on 301 multi-transfused thalassemic patients under the Thalassemia Transfusion Programme of Advanced Pediatric Centre of PGIMER. AIMS AND OBJECTIVES: The study was designed to determine the frequency of alloimmunization and autoimmunization in multi-transfused thalassemic patients and to establish the specificity of alloantibody to red cell antigens, if alloimmunization is detected...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27605852/impact-of-antigenic-exposures-and-role-of-molecular-blood-grouping-in-enhancing-transfusion-safety-in-chronically-transfused-thalassemics
#11
Raj Nath Makroo, Soma Agrawal, Aakanksha Bhatia, Mohit Chowdhry, Uday Kumar Thakur
BACKGROUND: Red cell alloimmunization is an acknowledged complication of blood transfusion. Current transfusion practices for thalassemia do not cater to this risk. Serological phenotyping is usually not reliable in these cases unless performed before the first transfusion. Under such circumstances, molecular blood grouping is an effective alternative. AIM: To perform molecular blood group genotyping in chronically transfused thalassemia patients and assess the risk of antigenic exposure and incidence of alloimmunization with current transfusion protocols...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27605851/alloimmunization-in-multitransfused-liver-disease-patients-impact-of-underlying-disease
#12
Meenu Bajpai, Shruti Gupta, Priyanka Jain
INTRODUCTION: Transfusion support is vital to the management of patients with liver diseases. Repeated transfusions are associated with many risks such as transfusion-transmitted infection, transfusion immunomodulation, and alloimmunization. MATERIALS AND METHODS: A retrospective data analysis of antibody screening and identification was done from February 2012 to February 2014 to determine the frequency and specificity of irregular red-cell antibodies in multitransfused liver disease patients...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27518929/new-apheresis-indications-in-hematological-disorders
#13
Huy P Pham, Joseph Schwartz
PURPOSE OF REVIEW: Therapeutic apheresis can be used to treat many diseases. The American Society for Apheresis (ASFA) publishes Guidelines on the use of therapeutic apheresis every 3 years with the goal of providing the best available evidence for apheresis practice as well as clinical expertise. The 2016 (7th ed.) ASFA Guidelines contain 87 diseases (up from 78 in the 6th ed.) and 179 indications. This review outlines three new therapeutic apheresis indications for hematological disorders...
November 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27499223/immunological-complications-of-blood-transfusions
#14
Anneke Brand
Most adverse blood transfusion (BT) events are immune-mediated and in the majority of severe reactions antibodies can be identified as causal factors. Alloimmunization not only causes symptomatic reactions, transfused cells can also be (silently) destroyed. Immunization by BT can contribute to hemolytic disease of the newborn as well as to allograft rejection after transplantation. Reversely, pregnancy and transplantation may evoke immunity hampering transfusion therapy. Besides causing mortality and morbidity, alloimmunization has a huge economic impact...
July 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27494244/flow-cytometry-in-detection-of-fetal-red-blood-cells-and-maternal-f-cells-to-identify-fetomaternal-hemorrhage
#15
Mariela Granero Farias, Suzane Dal Bó, Simone Martins de Castro, Aline Reis da Silva, Joyce Bonazzoni, Luciana Scotti, Sergio H Almeida Martins Costa
Accurate detection and quantitation of fetomaternal hemorrhage (FMH) is critical to the obstetric management of rhesus D alloimmunization in Rh-negative pregnant women. The flow cytometry is based on the detection of fetal red blood cells using a monoclonal anti-HbF antibody, and is the method most indicated for this estimation. The objective of this study was to quantify fetal red blood cell levels of pregnant women using flow cytometry. We analyzed 101 peripheral blood samples from Rh-negative and Rh-positive women, whose mean age was 24 years (20-32 years), after vaginal delivery or cesarean section...
2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27488141/gaps-in-research-on-adverse-events-to-transfusion-in-pediatrics
#16
REVIEW
Ronald Jackups, William Savage
Adverse consequences of blood transfusion in children are not completely understood. Much remains to be learned about defining their mechanisms, learning how they can be avoided, and improving our understanding how to minimize the morbidity of their consequences. All types of transfusion reactions can occur in children. This article focuses on four adverse consequences that have particular relevance for pediatric populations: cytomegalovirus transmission, red blood cell alloimmunization, immune altering consequences of transfusion, and necrotizing enterocolitis...
October 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27455830/comparison-of-double-rbc-collection-by-blood-cell-separators
#17
Pimpun Kitpoka, Sarawan Chanthet, Viroje Chongkolwatana, Ampaiwan Chuansumrit, Mongkol Kunakorn
BACKGROUND: The problem of red blood cell (RBC) shortage occurs because of the expanding demand for blood utilization and the dfficulties in donor recruitment and retention. Resources can be maximized by using current technology to collect two units of RBC from the same donor during a single collection session. OBJECTIVE: To evaluate the performance, collection efficiency (CE), production cost, and donor satisfactions of two commercially available blood cell separators (BCS) for double dose red cell (DDRC) collection...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27454234/red-blood-cell-alloimmunization-new-findings-at-the-bench-and-new-recommendations-for-the-bedside
#18
Jeanne E Hendrickson, Stephanie C Eisenbarth, Christopher A Tormey
PURPOSE OF REVIEW: To summarize recent discoveries from clinical studies and animal models that contribute to understanding the alloimmune response to non-ABO blood group antigens. RECENT FINDINGS: Several studies have confirmed high rates of alloimmunization among patients requiring chronic red blood cell (RBC) transfusion. Moreover, 'triggers' for alloantibody development in the transfusion setting have been identified, with a number of investigations linking recipient inflammation to a higher likelihood of alloimmunization...
November 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27444377/-single-donor-protocol-transfusion-practices-and-multiple-transfusion-risk-factors-in-neonatal-intensive-care-unit
#19
C Dollat, C Pierron, A Keslick, E Billoir, A François, P-H Jarreau
In France since 2002, the single-donor transfusion protocol, using four pediatric units from the same adult donor's packed red blood cells (PRBCs) in multiply transfused newborns, is recommended in preterm neonates to reduce the risks of infection and alloimmunization. This protocol is controversial, however, because it causes the transfusion of stored blood, which could have adverse consequences. Before the new recommendations of the French Haute Autorité de santé (National authority for health) in 2015, we conducted a national practice survey in 63 neonatal intensive care units (NICU) and a retrospective study of the characteristics of 103 children transfused within our unit, to better target beneficiaries...
September 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27442304/the-experience-of-extended-blood-group-genotyping-by-next-generation-sequencing-ngs-investigation-of-patients-with-sickle-cell-disease
#20
Y Fichou, M Mariez, C Le Maréchal, C Férec
BACKGROUND: Patients suffering from haemoglobinopathies may be treated by red blood cell (RBC) transfusion on a regular basis and then exposed to multiple antigens with a recurrent, potential risk of alloimmunization routinely prevented by extended RBC antigen cross-matching. While time-consuming and labour-intensive serological analyses are the gold standard for RBC typing, genotyping by current high-throughput molecular tools, including next-generation sequencing (NGS), appears to offer a potent alternative...
July 21, 2016: Vox Sanguinis
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