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Hepatocellular carcinoma with IVC thrombosis

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https://www.readbyqxmd.com/read/27586890/advanced-hepatocellular-carcinoma-with-hepatic-vein-tumor-thrombosis-and-renal-dysfunction-after-hepatic-arterial-infusion-chemotherapy-effectively-treated-by-liver-resection-with-active-veno-venous-bypass-report-of-a-case
#1
Atene Itoh, Hiroshi Sadamori, Kazuhisa Yabushita, Kazuteru Monden, Masashi Tatsukawa, Masayoshi Hioki, Tsuyoshi Hyodo, Kunihiro Omonishi, Toru Ueki, Satoshi Ohno, Kohsaku Sakaguchi, Norihisa Takakura
BACKGROUND: Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resection and active veno-venous bypass. CASE PRESENTATION: A 77-year-old man was diagnosed to have a large HCC with intrahepatic metastases and HVTT extending to the IVC...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27412755/tace-combined-with-implantation-of-irradiation-stent-versus-tace-combine-with-bare-stent-for-hcc-complicated-by-ivctt
#2
Qing-Hui Yang, Wen Zhang, Qing-Xin Liu, Ling-Xiao Liu, Lin-Lin Wu, Jian-Hua Wang, Zhi-Ping Yan, Jian-Jun Luo
PURPOSE: This study was designed to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with intra-IVC implantation of an irradiation stent for the treatment of hepatocellular carcinoma (HCC) complicated by inferior vena cava tumor thrombosis (IVCTT). METHODS: Sixty-one consecutive patients with HCC complicated by IVCTT treated by TACE combined with IVC stenting were retrospectively analysed. IVC stenting was performed using a stent loaded with (125)I seeds strands (the irradiation stent) in 33 patients (Group A) and 28 patients with a bare stent (Group B)...
September 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/26249525/complete-pathological-response-induced-by-sorafenib-for-advanced-hepatocellular-carcinoma-with-multiple-lung-metastases-and-venous-tumor-thrombosis-allowing-for-curative-resection
#3
Toshihiro Kitajima, Etsuro Hatano, Yusuke Mitsunori, Kojiro Taura, Yasuhiro Fujimoto, Masaki Mizumoto, Hideaki Okajima, Toshimi Kaido, Sachiko Minamiguchi, Shinji Uemoto
We report the first case of initially unresectable advanced hepatocellular carcinoma (HCC) with portal vein and hepatic venous tumor thrombosis and multiple lung metastases that allowed for curative hepatectomy after multidisciplinary treatment including sorafenib. A 54-year-old male presented with a large HCC in the right liver with tumor thrombosis of the left portal vein and middle hepatic vein (MHV) as well as multiple lung metastases. His serum alpha-fetoprotein level was elevated at 52,347 ng/mL and palliative treatment with sorafenib was initiated...
October 2015: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/26185885/effective-balloon-occluded-retrograde-transvenous-obliteration-of-the-superior-mesenteric-vein-inferior-vena-cava-shunt-in-a-patient-with-hepatic-encephalopathy-after-living-donor-liver-transplantation
#4
Zhassulan Baimakhanov, Akihiko Soyama, Mitsuhisa Takatsuki, Yusuke Inoue, Hajime Matsushima, Masaaki Hidaka, Amane Kitasato, Tomohiko Adachi, Tamotsu Kuroki, Ichiro Sakomoto, Susumu Eguchi
Balloon-occluded retrograde transvenous obliteration (BRTO) has become a common and effective procedure for treating hepatic encephalopathy due to a portosystemic shunt related to cirrhosis of the liver. However, this method of treatment has rarely been reported in patients after liver transplantation. Here, we report the case of a 52-year-old patient who underwent living donor liver transplantation (LDLT) due to hepatitis C virus-infected hepatocellular carcinoma that was complicated with portal vein thrombosis and a large portosystemic shunt between the superior mesenteric vein (SMV) and inferior vena cava (IVC)...
August 2014: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/26011214/recurrence-free-survival-of-a-hepatocellular-carcinoma-patient-with-tumor-thrombosis-of-the-inferior-vena-cava-after-treatment-with-sorafenib-and-hepatic-resection
#5
Kenichi Nakamura, Toru Beppu, Hiromitsu Hayashi, Hirohisa Okabe, Kastunori Imai, Hidetoshi Nitta, Akira Chikamoto, Takatoshi Ishiko, Masato Sasaki, Hideo Baba
Sorafenib (Nexabar, Bayer, Berlin, Germany), one of multikinase inhibitors, can infrequently downstage advanced hepatocellular carcinoma (HCC). There are some reports that sorafenib in combination with other modalities, such as transcatheter arterial chemoembolization (TACE) or radiation therapy, could represent a bridge to surgery. We have observed a progressive HCC case with hepatic vein tumor thrombosis proceeding to the inferior vena cava (IVC-HVTT) convert to a state of feasible curative resection after a multidisciplinary treatment which included sorafenib...
May 2015: International Surgery
https://www.readbyqxmd.com/read/25937867/aetiological-factors-of-budd-chiari-syndrome-in-algeria
#6
Nawel Afredj, Nawal Guessab, Abdelbasset Nani, Sid Ahmed Faraoun, Ibtissem Ouled Cheikh, Rafik Kerbouche, Djouhar Hannoun, Zine Charef Amir, Hayet Ait Kaci, Kamel Bentabak, Aurélie Plessier, Dominique-Charles Valla, Valerie Cazals-Hatem, Marie-Hélène Denninger, Tadjeddine Boucekkine, Nabil Debzi
AIM: To study the clinical presentation of Budd-Chiari syndrome (BCS) and identify the aetiologies of this disease in Algeria. METHODS: Patients with BCS, hospitalised in our unit from January 2004 until June 2010 were included and the aetiological factors were assessed. Patients presenting a BCS in the setting of advanced-stage cirrhosis or a liver transplantation were excluded from the study. The diagnosis was established when an obstruction of hepatic venous outflow (thrombosis, stenosis or compression) was demonstrated...
April 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25194595/precaution-against-postoperative-venous-complications-after-major-hepatectomy-using-the-pedicled-omental-transposition-flap-report-of-two-cases
#7
Masato Narita, Ryo Matsusue, Hiroaki Hata, Takashi Yamaguchi, Tetsushi Otani, Iwao Ikai
INTRODUCTION: Vascular complications following hepato-pancreatic biliary surgery can be devastating, and therefore precaution of them must be critical. We report two cases in which the pedicled omental transposition flap might be effective to avoid postoperative venous complications following major hepatectomy. PRESENTATION OF CASE: Case 1 is a 80-year-old male who required to perform re-laparotomy at postoperative day 1 following major hepatectomy due to acute portal venous thrombosis (PVT)...
2014: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/24999677/tumor-thrombus-ancillary-findings-on-fdg-pet-ct-in-an-oncologic-population
#8
Mudalsha Ravina, Søren Hess, Mahesh Singh Chauhan, Mattakorottu Joseph Jacob, Abass Alavi
PURPOSE: Thrombosis in cancer may manifest itself as venous thromboembolic disease or tumor thrombosis (TT). We present our experience with incidentally detected TT on FDG PET/CT in 21 oncologic patients. PATIENTS AND METHODS: We retrospectively reviewed all FDG PET/CT examinations during a 5-year period at the Army Hospital Research and Referral in New Delhi, India, and included all oncology cases with FDG-avid thrombosis in the report. The diagnosis of TT was based on FDG-avid solid masses inside the vessels in patients with known malignancy...
September 2014: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/24971021/recall-radiation-dermatitis-by-sorafenib-following-stereotactic-body-radiation-therapy
#9
Chen-Hsi Hsieh, Shih-Chiang Lin, Pei-Wei Shueng, Deng-Yu Kuo
We report on a 63-year-old man with a history of hepatitis B virus-related hepatocellular carcinoma with a thrombus extending into the inferior vena cava, who received image-guided stereotactic body radiation therapy (SBRT) with helical tomotherapy, followed by sorafenib. A total tumor dose of 48 Gy was delivered by 6 fractions within 2 weeks. The tumor responded dramatically, and the patient tolerated the courses well. Ten days after SBRT, sorafenib (200 mg), at 1.5 tablets twice a day, was prescribed. One week later, grade 2 recall radiation dermatitis subsequently developed in the previous SBRT off-target area...
2014: OncoTargets and Therapy
https://www.readbyqxmd.com/read/24798618/surgical-treatment-of-hepatocellular-carcinoma-associated-with-hepatic-vein-tumor-thrombosis
#10
Takashi Kokudo, Kiyoshi Hasegawa, Satoshi Yamamoto, Junichi Shindoh, Nobuyuki Takemura, Taku Aoki, Yoshihiro Sakamoto, Masatoshi Makuuchi, Yasuhiko Sugawara, Norihiro Kokudo
BACKGROUND & AIMS: Presence of hepatic vein tumor thrombosis (HVTT) in patients with hepatocellular carcinoma (HCC) is regarded as signaling an extremely poor prognosis. However, little is known about the prognostic impact of surgical treatment for HVTT. METHODS: Our database of surgical resection for HCC between October 1994 and December 2011 in a tertiary care Japanese hospital was retrospectively analysed. We statistically compared the patient characteristics and surgical outcomes in HCC patients with tumor thrombosis in a peripheral hepatic vein, including microscopic invasion (pHVTT), tumor thrombosis in a major hepatic vein (mHVTT), and tumor thrombosis of the inferior vena cava (IVCTT)...
September 2014: Journal of Hepatology
https://www.readbyqxmd.com/read/24791850/budd-chiari-syndrome-as-an-initial-presentation-of-hepatocellular-carcinoma-a-case-report
#11
Lavinia Alice Bălăceanu, Camelia Cristina Diaconu, Gheorghiţa Aron
We report the case of a 84-year-old admitted with symptoms of congestive heart failure. Ultrasonography revealed a hyperechoic nodule in the left lobe of the liver, with a peripheral hypoechoic rim, multiple irregular hypoechoic nodules in both hepatic lobes, portal vein, inferior vena cava, and right atrium thrombosis. On ultrasonographic and alpha-fetoprotein criteria the case was interpreted as hepatocellular carcinoma with Budd-Chiari syndrome. The particularity of the case is the initial presentation of the hepatocellular carcinoma as Budd-Chiari syndrome...
June 2014: Medical Ultrasonography
https://www.readbyqxmd.com/read/24490520/-surgery-for-patients-with-hepatocellular-carcinoma-and-inferior-vena-cava-tumor-thrombus
#12
Tao Zhang, Ji-Wei Huang, Yong Zeng
OBJECTIVE: To investigate the surgical procedure, safety and efficacy of liver resection with inferior vena cava (IVC) thrombectomy in the treatment of the patients with hepatocellular carcinoma (HCC) and IVC tumor thrombus. METHODS: A retrospective study was conducted to analyze the data of 10 patients with HCC and IVC tumor thrombus undergoing liver resection and thrombectomy was analyzed. The surgical procedure included two parts, firstly the involving liver lobes were transected using the anterior approach without pedicle clamping, then the tumor thrombus were removed from the IVC under total hepatic vascular exclusion (THVE)...
November 2013: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/24379750/three-dimensional-conformal-radiotherapy-for-hepatocellular-carcinoma-in-patients-unfit-for-resection-ablation-or-chemotherapy-a-retrospective-study
#13
Vassilis Kouloulias, Eftychia Mosa, John Georgakopoulos, Kalliopi Platoni, Ilias Brountzos, Anna Zygogianni, Christos Antypas, Paraskevas Kosmidis, Kyriaki Mystakidou, Maria Tolia, Ivelina Beli, Athanasios Gouliamos, John Kouvaris, Nikoalos Kelekis
PURPOSE: The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT). METHODS: Between 2007 and 2012, in a retrospective way, 9 patients (median age 69 years) with advanced HCC and IVCTT unfit for surgery, radiofrequency ablation, embolization, or chemotherapy were treated with three-dimensional conformal radiotherapy (3DCRT)...
2013: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24325788/long-term-survival-of-patients-with-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus-treated-with-sorafenib-combined-with-transarterial-chemoembolization-report-of-two-cases-and-literature-review
#14
Heng-Jun Gao, Li Xu, Yao-Jun Zhang, Min-Shan Chen
The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus formation in the main vasculature is extremely poor. Sorafenib combined with transarterial chemoembolization is a novel treatment approach for advanced HCC. In this study, we report two HCC patients with inferior vena cava tumor thrombus who underwent the combination treatment. The overall survival times for these two patients were 44 months and 35 months, respectively. Our report suggests that sorafenib combined with transarterial chemoembolization may be a viable choice for patients with advanced HCC even with inferior vena cava tumor thrombus...
May 2014: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/24157050/no-touch-en-bloc-right-lobe-living-donor-liver-transplantation-with-inferior-vena-cava-replacement-for-hepatocellular-carcinoma-close-to-retrohepatic-inferior-vena-cava-case-report
#15
D-B Moon, S-G Lee, S Hwang, K-H Kim, C-S Ahn, T-Y Ha, G-W Song, D-H Jung, G-C Park, J-M Namkoong, H-W Park, Y-H Park, C-S Park
Current studies have shown that living-donor liver transplantation (LDLT) for hepatocelluar carcinoma (HCC) satisfying the Milan criteria does not compromise patient survival or increase HCC recurrence compared with deceased-donor liver transplantation (DDLT). For patients with HCC beyond the Milan criteria, however, worse outcomes are expected after LDLT than after DDLT, despite insufficient data to reach a conclusion. Regarding operative technique, LDLT might be a less optimal cancer operation for HCC located at the hepatic vein confluence and/or paracaval portion...
October 2013: Transplantation Proceedings
https://www.readbyqxmd.com/read/24093164/surgical-management-of-hepatocellular-carcinoma-with-tumor-thrombi-in-the-inferior-vena-cava-or-right-atrium
#16
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Hirofumi Kamachi, Yosuke Tsuruga, Kazuaki Nakanishi, Tsuyoshi Shimamura, Satoru Todo, Akinobu Taketomi
BACKGROUND: The prognosis for advanced hepatocellular carcinoma (HCC) with tumor thrombi in the inferior vena cava (IVC) or right atrium (RA) is poor, and there is no established effective treatment for this condition. Thus study aimed to evaluate the efficacy of surgical resection and prognosis after surgery for such cases. METHODS: Between January 1990 and December 2012, 891 patients underwent hepatectomy for HCC at our institution. Of these, 13 patients (1.5%) diagnosed with advanced HCC with tumor thrombi in the IVC or RA underwent hepatectomy and thrombectomy...
2013: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/23915104/inferior-vena-cava-tumor-thrombus-that-directly-infiltrated-from-paracaval-lymph-node-metastases-in-a-patient-with-recurrent-hepatocellular-carcinoma
#17
Shinya Imada, Kohei Ishiyama, Kentaro Ide, Tsuyoshi Kobayashi, Hironobu Amano, Hirotaka Tashiro, Koji Arihiro, Hiroshi Aikata, Kazuaki Chayama, Hideki Ohdan
Herein, we present the case of a patient with recurrent hepatocellular carcinoma (HCC) who had paracaval lymph node (LN) metastases with an inferior vena cava (IVC) tumor thrombus after a hepatectomy. A 65-year-old man with chronic hepatitis B virus infection received an extended anterior segmentectomy because of two hepatic tumors, located in segments 7 and 8. Histological examination of both resected specimens showed mostly moderately differentiated HCC with some poorly differentiated areas, and liver cirrhosis (A2/F4)...
2013: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/23737955/effectiveness-of-stereotactic-body-radiotherapy-for-hepatocellular-carcinoma-with-portal-vein-and-or-inferior-vena-cava-tumor-thrombosis
#18
Mian Xi, Li Zhang, Lei Zhao, Qiao-Qiao Li, Su-Ping Guo, Zi-Zhen Feng, Xiao-Wu Deng, Xiao-Yan Huang, Meng-Zhong Liu
BACKGROUND: To report the feasibility, efficacy, and toxicity of stereotactic body radiotherapy (SBRT) for the treatment of portal vein tumor thrombosis (PVTT) and/or inferior vena cava tumor thrombosis (IVCTT) in patients with advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Forty-one patients treated with SBRT using volumetric modulated arc therapy (VMAT) for HCC with PVTT/IVCTT between July 2010 and May 2012 were analyzed. Of these, 33 had PVTT and 8 had IVCTT...
2013: PloS One
https://www.readbyqxmd.com/read/23701153/balloon-venoplasty-for-liver-failure-due-to-stenosis-of-the-left-hepatic-vein-after-right-tri-segmentectomy
#19
Daisuke Imai, Kenei Furukawa, Hiroaki Shiba, Shigeki Wakiyama, Takeshi Gocho, Katsuhiko Yanaga
A 41-year-old male patient with hepatitis B underwent right tri-segmentectomy and total caudate lobectomy for a huge hepatocellular carcinoma associated with complete occlusion of the inferior vena cava with thrombosis of the infrahepatic inferior vena cava due to tumor compression. Five months later, he was readmitted for ascites and hyperbilirubinemia. Venography revealed stenosis and tortuosity of the left hepatic vein and the inferior vena cava, for which balloon angioplasty of the left hepatic vein and the inferior vena cava was performed using an 8-mm and 10-mm balloon, respectively...
April 2013: International Surgery
https://www.readbyqxmd.com/read/23267897/-a-case-of-advanced-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus-and-multiple-intrahepatic-metastases-treated-successfully-by-transcatheter-arterial-chemoembolization-and-radical-hepatectomy
#20
Chihiro Yamanaka, Hiroshi Wada, Naoki Hama, Shogo Kobayashi, Hirofumi Akita, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori, Hiroaki Nagano
A 76-year-old man, who had been treated with interferon-α(IFN-α) for hepatitis C, was diagnosed with multiple hepatocellular carcinomas (HCC; S7/8, S8, S5, S2) with right hepatic vein tumor thrombus (Vv2). He initially underwent transcatheter arterial chemoembolization(TACE). One month after TACE, the hepatic vein tumor thrombi extended into the inferior vena cava(Vv3). No distant metastasis was observed, and his liver function was well-preserved. Therefore, we performed a posterior segmentectomy, partial hepatectomy(S8, S5, S2), inferior vena cava tumor thrombus excision, and cholecystectomy...
November 2012: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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