Magdalena A Czubala, Robert H Jenkins, Mark Gurney, Leah Wallace, Benjamin Cossins, James Dennis, Marcela Rosas, Robert Andrews, Donald Fraser, Philip R Taylor
Recent interest in the biology and function of peritoneal tissue resident macrophages (pMΦ) has led to a better understanding of their cellular origin, programming and renewal. The programming of pMΦ is dependent on microenvironmental cues and tissue specific transcription factors, including GATA6. However, the contribution of microRNAs remains poorly defined. We conducted a detailed analysis of the impact of GATA6-deficiency on microRNA expression in mouse pMΦ. Our data suggest that for many of the pMΦ, microRNA composition may be established during tissue specialization, and that the effect of GATA6 knockout is largely unable to be rescued in the adult by exogenous GATA6...
March 29, 2024: Journal of Biological Chemistry