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https://www.readbyqxmd.com/read/28543056/cloning-and-analysis-of-the-glwc-1-and-glwc-2-genes-encoding-putative-blue-light-photoreceptor-from-ganoderma-lucidum
#1
Xinran Xu, Xiangdong Chen, Wumengxiao Yu, Yu Liu, Weiwei Zhang, Jin Lan
Blue light plays an important role during the growth of Ganoderma lucidum, one of the best-known medicinal macrofungi in China. In the present study, we cloned Glwc-1 and Glwc-2, the homologue of the blue light photoreceptors Ncwc-1 and Ncwc-2 of Neurospora crassa, from G. lucidum. The deduced amino acid sequence of Glwc-1 contained the similar function domains as NcWC-1 including LOV, PAS B, PAS C, and PAC domains. The deduced amino acid sequence of Glwc-2 contained PAS domain and GATA-type zinc finger (Znf) domain as well as NcWC-2...
May 23, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28526138/gata-factors-master-regulators-of-gene-expression-in-trophoblast-progenitors
#2
Soumen Paul, Pratik Home, Bhaswati Bhattacharya, Soma Ray
Mammalian reproduction is critically dependent on trophoblast cells, which ensure embryo implantation and placentation. Development of trophoblast cell lineages is a multi-step process and relies upon proper spatial and temporal gene expression, which is regulated by multiple transcription factors. However, most of the transcription factors that are implicated in trophoblast development regulate gene expression at a specific developmental stage or in a specific trophoblast subtype. In contrast, recent studies from our group and other laboratories indicate that conserved GATA family of transcription factors, GATA2 and GATA3, are important to regulate gene expression at multiple stages of trophoblast development...
May 10, 2017: Placenta
https://www.readbyqxmd.com/read/28524840/a-novel-de-novo-gata-binding-protein-3-mutation-in-a-patient-with-hypoparathyroidism-sensorineural-deafness-and-renal-dysplasia-syndrome
#3
Xue-Ying Chu, Yue-Peng Li, Min Nie, Ou Wang, Yan Jiang, Mei Li, Wei-Bo Xia, Xiao-Ping Xing
No abstract text is available yet for this article.
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28524369/therapeutic-roles-of-telocytes-in-ova-induced-acute-asthma-in-mice
#4
Ling Ye, Dongli Song, Meiling Jin, Xiangdong Wang
Telocytes (TCs) newly discovered as the mesenchyme-derived interstitial cells were found to have supportive effects on mesenchymal stem cells (MSCs). The present study aimed at investigating effects of TCs or TCs gathered with MSCs on experimental airway inflammation and hyper-responsiveness. The TCs were isolated from the lung tissue of the female BALB/c mice. The ovalbumin (OVA)-induced asthma model was established. TCs (1 × 10(6) /2 × 10(6) ) and/or MSCs (1 × 10(6) ) were injected through mice tail vein for consecutive three days before OVA excited the mice...
May 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28521792/m2-macrophage-is-the-predominant-phenotype-in-airways-inflammatory-lesions-in-patients-with-granulomatosis-with-polyangiitis
#5
Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G M Kallenberg, Johanna Westra
BACKGROUND: Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repair and remodeling for M2 macrophages. The objective of this study was to evaluate the distribution of M1 and M2 macrophage phenotypes in biopsies from the airways of patients with active granulomatosis with polyangiitis (GPA) and to analyze their associations with T and B cells in those biopsies, and with nasal carriage of Staphylococcus aureus, disease parameters and therapy...
May 18, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28520732/differential-gene-expression-along-the-animal-vegetal-axis-in-the-ascidian-embryo-is-maintained-by-a-dual-functional-protein-foxd
#6
Shin-Ichi Tokuhiro, Miki Tokuoka, Kenji Kobayashi, Atsushi Kubo, Izumi Oda-Ishii, Yutaka Satou
In many animal embryos, a specific gene expression pattern is established along the animal-vegetal axis soon after zygotic transcription begins. In the embryo of the ascidian Ciona intestinalis, soon after the division that separates animal and vegetal hemispheres into distinct blastomeres, maternal Gata.a and β-catenin activate specific genes in the animal and vegetal blastomeres, respectively. On the basis of these initial distinct gene expression patterns, gene regulatory networks promote animal cells to become ectodermal tissues and vegetal cells to become endomesodermal tissues and a part of the nerve cord...
May 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28512288/lactic-acid-bacteria-specific-induction-of-cd4-foxp3-t-cells-ameliorates-shrimp-tropomyosin-induced-allergic-response-in-mice-via-suppression-of-mtor-signaling
#7
Linglin Fu, Jixiang Peng, Shushu Zhao, Yan Zhang, Xiurong Su, Yanbo Wang
The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28502089/association-between-cytokine-profile-and-transcription-factors-produced-by-t-cells-subsets-in-early-and-late-onset-preeclampsia
#8
Vanessa R Ribeiro, Mariana Romao-Veiga, Graziela G Romagnoli, Mariana L Matias, Priscila R Nunes, Vera Therezinha M Borges, Jose C Peracoli, Maria Terezinha S Peracoli
Preeclampsia (PE) is an obstetric pathology characterized by abnormal activation of the innate and adaptive immune system dependent on the imbalance of T helper subsets. The present study aimed to evaluate the gene and protein expression of Th1/Th2/Th17/Treg T-cell transcription factors in peripheral blood lymphocytes from pregnant women with PE employing RT-qPCR and flow cytometry techniques, as well as the cytokine profile produced by these CD4(+) T cell subsets in the plasma of pregnant women with PE, classified in early-onset PE (n=20), late-onset PE (n=20) and normotensive pregnant women (n=20)...
May 14, 2017: Immunology
https://www.readbyqxmd.com/read/28499720/t-follicular-helper-and-th2-cells-in-allergic-responses
#9
REVIEW
Masato Kubo
IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by TH2 and TFH cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer...
May 9, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28490464/perioperative-cox-2-and-beta-adrenergic-blockade-improves-metastatic-biomarkers-in-breast-cancer-patients-in-a-phase-ii-randomized-trial
#10
Lee Shaashua, Maytal Shabat-Simon, Rita Haldar, Pini Matzner, Oded Zmora, Moshe Shabtai, Eran Sharon, Tanir Allweis, Iris Barshack, Lucile Hayman, Jesusa M G Arevalo, Jeffrey Ma, Maya Horowitz, Steve W Cole, Shamgar Ben-Eliyahu
<br /> <p>Translational studies suggest that excess perioperative release of catecholamines and prostaglandins may facilitate metastasis and reduce disease-free survival. This trial tested the combined perioperative blockade of these pathways in breast cancer patients.</p> <br />Experimental Design: <br /> <p>In a randomized placebo-controlled biomarker trial, 38 early-stage breast cancer patients received 11 days of perioperative treatment with a beta-adrenergic antagonist (propranolol) and a cyclooxygenase-2 (COX-2) inhibitor (etodolac), beginning five days before surgery...
May 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28490401/immunopathologic-characteristics-of-nasal-polyps-in-adult-koreans-a-single-center-study
#11
Seung-Heon Shin, Yee-Hyuk Kim, Mi-Kyung Ye, Sung-Yong Choi
BACKGROUND: Chronic rhinosinusitis with nasal polyps (NP) (CRSwNP) is classified into eosinophilic and noneosinophilic types based on the level of tissue eosinophilia. The immunopathologic features of Western and Asian CRSwNP differ. OBJECTIVES: The aim of this study was to investigate the immunopathologic characteristics of Korean patients with eosinophilic NP versus noneosinophilic NP and those with atopic NP versus nonatopic NP. METHODS: Tissue samples were collected from 81 patients with NP and 24 controls...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28487987/g-protein-phosphorylated-gata4-and-vegf-expression-in-the-hearts-of-transgenic-mice-overexpressing-%C3%AE-1-and-%C3%AE-2-adrenergic-receptors
#12
Hyun-Jin Tae, Natalia Petrashevskaya, In Hye Kim, Joon Ha Park, Jae-Chul Lee, Moo-Ho Won, Yang Hee Kim, Ji Hyeon Ahn, Jinseu Park, Soo Young Choi, Yong Hwan Jeon
β1- and β2-adrenergic receptors (ARs) regulate cardiac contractility, calcium handling and protein phosphorylation. The present study aimed to examine the expression levels of vascular endothelial growth factor A (VEGF‑A) and several G proteins, and the phosphorylation of transcription factor GATA binding protein 4 (GATA4), by western blot analysis, using isolated hearts from 6 month‑old transgenic (TG) mice that overexpress β1AR or β2AR. Cardiac contractility/relaxation and heart rate was increased in both β1AR TG and β2AR TG mouse hearts compared with wild type; however, no significant differences were observed between the β1‑ and β2AR TG mouse hearts...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28484662/utility-of-immunohistochemistry-and-etv6-12p13-gene-rearrangement-in-identifying-secretory-carcinoma-of-salivary-gland-among-previously-diagnosed-cases-of-acinic-cell-carcinoma
#13
Rana Naous, Shengle Zhang, Alfredo Valente, Melissa Stemmer, Kamal K Khurana
Objective. Secretory carcinoma is a recently described entity with characteristic immunoprofile and ETV6 (12p13) rearrangement. Before its initial description, it was generally diagnosed as acinic cell carcinoma (ACCi). We evaluated immunoprofile and ETV6 rearrangement in cytological and surgical cases of previously diagnosed ACCi, in an attempt to identify any misclassified SC. Methods. Fifteen cytology and surgical cases of ACCi diagnosed over a 13-year period were retrieved and subjected to immunohistochemistry for S-100, mammaglobin, GATA-3 and DOG-1 as well as FISH for ETV6 (12p13)...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28484278/role-of-gata-binding-protein-4-gata4-in-the-regulation-of-tooth-development-via-gnai3
#14
Shuyu Guo, Yuxin Zhang, Tingting Zhou, Dongyue Wang, Yajuan Weng, Lin Wang, Junqing Ma
Transcription factor GATA4 regulates cardiac and osteoblast differentiation. However, its role in tooth development is not clear. Therefore, we generated Wnt1-Cre;GATA4 (fl/fl) mice, with conditional inactivation of the GATA4 gene in the dental papilla mesenchymal cells. Phenotypic analysis showed short root deformity along with reduced expressions of odonto/osteogenic markers. Proliferation (but not apoptosis) of cells around the apical area of the root was attenuated. In vitro, we knocked down GATA4 expression in stem cells of dental apical papilla (SCAPs)...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28480320/data-of-10-ssr-markers-for-genomes-of-homo-sapiens-and-monkeys
#15
K K V V V S Reddy, S Viswanadha Raju, Chinta Someswara Rao
In this data, we present 10 Simple Sequence Repeat(SSR) markers TAGA, TCAT, GAAT, AGAT, AGAA, GATA, TATC, CTTT, TCTG and TCTA which are extracted from the genomes of homo sapiens and monkeys using string matching mechanism [1]. All loci showed 4 Base Pair(bp) in allele size, indicating that there are some polymorphisms between individuals correlating to the number of SSR repeats that maybe useful for the detection of similarity among the genotypes. Collectively, these data show that the SSR extraction is a valuable method to illustrate genetic variation of genomes...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28476053/transmission-of-donor-derived-breast-carcinoma-as-a-recurrent-mass-in-a-keratolimbal-allograft
#16
Audra K Miller, Jonathan W Young, David J Wilson, Jennifer Dunlap, Winston Chamberlain
PURPOSE: To report a case of local transmission of invasive lobular carcinoma from a donor to a recipient in a keratolimbal allograft after cessation of systemic immunosuppressive therapy. METHODS: This is a case report including the clinicopathologic findings. Sections of the donor breast tumor and recipient conjunctival lesions were stained with hematoxylin and eosin. Immunohistochemical studies were performed using pancytokeratin, CK7, CK20, CAM 5.2, CD138, TTF1, estrogen receptor, progesterone receptor, GATA-3, GCDFP-15, and mammaglobin...
June 2017: Cornea
https://www.readbyqxmd.com/read/28475878/gotta-have-gata-for-human-pancreas-development
#17
David S Lorberbaum, Lori Sussel
Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports utilize hPSCs to characterize GATA6 function during human pancreas development. One functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation, but it is inadequate for functional β cell differentiation.
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28470571/immunohistochemical-analysis-of-the-expression-of-breast-markers-in-basal-like-breast-carcinomas-defined-as-triple-negative-cancers-expressing-keratin-5
#18
Tamás Zombori, Gábor Cserni
Estrogen and progesterone receptors are possible markers for suggesting a mammary origin of metastatic carcinoma, but are useless in cases of triple negative breast cancers (TNBC). Five other potential markers of breast origin were investigated on tissue microarrays in a series of TNBCs showing keratin 5 expression, consistent with a basal-like phenotype. GATA-3 staining was observed in 82 of 115 triple negative cases (71.3%) including 23 cases with >5% staining. Mammaglobin staining was detected in 30 cases (26...
May 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28468609/a-novel-trps1-mutation-in-a-moroccan-family-with-tricho-rhino-phalangeal-syndrome-type-iii-case-report
#19
W Smaili, S Chafai Elalaoui, S Meier, M Zerkaoui, A Sefiani, K Heinimann
BACKGROUND: Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant disorder characterized by craniofacial and skeletal malformations including short stature, thin scalp hair, sparse lateral eyebrows, pear-shaped nose and cone shaped epiphyses. This condition is caused by haploinsufficiency of the TRPS1 gene. Previous genotype-phenotype studies have correlated exon 6 missense mutations with TRPS type III, a severe form of type I with pronounced, facial characteristics, short stature and brachydactyly and differing from type II by the absence of exostoses and mental retardation...
May 3, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28464076/impact-of-a-timed-release-follicle-stimulating-hormone-treatment-from-one-to-three-months-of-age-on-endocrine-and-testicular-development-of-prepubertal-bulls
#20
B R Harstine, L H Cruppe, F M Abreu, M D Utt, R S Cipriano, A Lemes, C Premanandan, J M DeJarnette, M L Day
In prepubertal bulls, FSH facilitates testis maturation and a transient proliferation of Sertoli cells. Two experiments examined the effects of exogenous FSH on hormone secretion and testis development in Angus bulls. Exogenous FSH treatment consisted of an intramuscular injection (i.m.) of 30 mg FSH (Folltropin-V) in a 2% hyaluronic acid solution (FSH-HA). In Exp. 1, bulls (50 ± 6.5 d of age) received either FSH-HA ( = 5) or saline (control; = 5) on d 50 and 53.5. Blood samples were collected via jugular venipuncture to assess FSH concentrations every 6 h for 24 h after treatment and every 12 h until 84 h...
April 2017: Journal of Animal Science
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