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https://www.readbyqxmd.com/read/29331483/gata4-is-a-transcriptional-regulator-of-r-spondin1-in-japanese-flounder-paralichthys-olivaceus
#1
Xiumei Liu, Zan Li, Bo Wang, He Zhu, Yuezhong Liu, Jie Qi, Quanqi Zhang
GATA4 is a well-known transcription factor of the GATA family implicated in regulation of sex determination and gonadal development in mammals. In this study, we cloned the full-length cDNA of Paralichthys olivaceus gata4 (Po-gata4). Phylogenetic, gene structure, and synteny analysis showed that Po-GATA4 is homologous to GATA4 of teleost and tetrapod. Po-gata4 transcripts were detected in Sertoli cells, spermatogonia, oogonia and oocytes, with higher transcript levels overall in the testis than the ovary. The promoter region of P...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29330410/the-impact-of-comt-and-childhood-maltreatment-on-suicidal-behaviour-in-affective-disorders
#2
Alexandra Bernegger, Klemens Kienesberger, Laura Carlberg, Patrick Swoboda, Birgit Ludwig, Romina Koller, Michelle Inaner, Melanie Zotter, Nestor Kapusta, Martin Aigner, Helmuth Haslacher, Siegfried Kasper, Alexandra Schosser
The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample of 258 affective disorder patients a detailed clinical assessment (e...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325712/a-novel-gata-like-zinc-finger-transcription-factor-involving-in-hematopoiesis-of-eriocheir-sinensis
#3
Yannan Li, Zhihao Jia, Qilin Yi, Xiaorui Song, Yu Liu, Yunke Jia, Lingling Wang, Linsheng Song
GATA transcription factor is a family of DNA-binding proteins that can recognize and bind to sequence of (A/T) GATA (A/G). In the present study, a GATA-like protein (named as EsGLP) was characterized from Eriocheir sinensis, including an 834 bp full length open reading frame of EsGLP, encoding a polypeptide of 277 amino acids. The deduced amino acid sequence of EsGLP contained one conserved GATA-type zinc finger of the form Cys-X2-Cys-X17-Cys-X2-Cys, with four cysteine sites. The EsGLP mRNA transcripts were mainly detected in the hematopoietic tissue, hepatopancreas and gonad...
January 8, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29317235/differentiating-breast-carcinoma-with-signet-ring-features-from-gastrointestinal-signet-ring-carcinoma-assessment-of-immunohistochemical-markers
#4
Yiang Hui, Yihong Wang, Gahie Nam, Jacqueline Fanion, Ashlee Sturtevant, Kara A Lombardo, Murray B Resnick
Signet-ring morphology is recognized throughout the gastrointestinal tract. However, this pattern may be observed in other primary sites giving rise to diagnostic challenges in the work-up of metastases. Relatively newer immunohistochemical markers have not been evaluated in this context. We assessed expression patterns of several common immunohistochemical markers in tumors with signet-ring morphology to delineate a pragmatic approach to this differential diagnosis. Primary breast and gastrointestinal carcinomas showing signet-ring features were reviewed...
January 6, 2018: Human Pathology
https://www.readbyqxmd.com/read/29305990/effect-of-yeast-xanthophyllomyces-dendrorhous-and-plant-saint-john-s-wort-lemon-balm-and-rosemary-extract-based-functional-diets-on-antioxidant-and-immune-status-of-atlantic-salmon-salmo-salar-subjected-to-crowding-stress
#5
Sebastián Reyes-Cerpa, Eva Vallejos-Vidal, María José Gonzalez-Bown, Jonathan Morales-Reyes, Diego Pérez-Stuardo, Deborah Vargas, Mónica Imarai, Víctor Cifuentes, Eugenio Spencer, Ana María Sandino, Felipe E Reyes-López
Salmon farming may face stress due to the intensive culture conditions with negative impacts on overall performance. In this aspect, functional feed improves not only the basic nutritional requirements but also the health status and fish growth. However, to date no studies have been carried out to evaluate the effect of functional diets in salmon subjected to crowding stress. Thus, the aim of this study was to evaluate the effect of yeast (Xanthophyllomyces dendrorhous; diet A) and the combination of plant extracts (common Saint John's wort, lemon balm, and rosemary; diet B) on the antioxidant and immune status of Atlantic salmon grown under normal cultured conditions and then subjected to crowding stress...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29299171/melatonin-up-regulates-the-expression-of-the-gata-4-transcription-factor-and-increases-testosterone-secretion-from-leydig-cells-through-ror%C3%AE-signaling-in-an-in-vitro-goat-spermatogonial-stem-cell-differentiation-culture-system
#6
Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C Yan Cheng, Zheng-Xing Lian, Yi-Xun Liu
Because androgen function is regulated by its receptors, androgen-androgen receptor signaling is crucial for regulating spermatogenesis. Androgen is mainly testosterone secreted by testis. Based on the results of early studies in goats, the administration of melatonin over an extended period of time increases steroid production, but the underlying mechanism remains unclear. Here, we report the expression of the melatonin membrane receptors MT1 and MT2 and the retinoic acid receptor-related orphan receptor-alpha (RORα) in the goat testis...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299165/gata3-induced-vwf-upregulation-in-the-lung-adenocarcinoma-vasculature
#7
Yinghua Xu, Silin Pan, Jing Liu, Fengyun Dong, Zuowang Cheng, Jinjin Zhang, Ruixia Qi, Qi Zang, Caiqing Zhang, Xia Wang, Jiandong Zhang, Fufang Wang, Thaddeus D Allen, Ju Liu
Lung adenocarcinoma (LAC) is the leading cause of cancer-related death worldwide. Aberrant expression of genes expressed preferentially in the lung tumor vasculature may yield clues for prognosis and treatment. Von Willebrand factor (vWF) is a large multifunctional glycoprotein with a well-known function in hemostasis. However, vWF has been reported to exert an anti-tumor effect, independent of its role in hemostasis. We investigated the expression of vWF in LAC through immunohistochemical staining of tumor tissue microarrays (TMAs)...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283388/evolutionary-dynamics-of-the-w-chromosome-in-caenophidian-snakes
#8
Barbora Augstenová, Sofia Mazzoleni, Lukáš Kratochvíl, Michail Rovatsos
The caenophidian (assigned also as "advanced") snakes are traditionally viewed as a group of reptiles with a limited karyotypic variation and stable ZZ/ZW sex chromosomes. The W chromosomes of the caenophidian snakes are heterochromatic, and pioneering studies demonstrated that they are rich in repetitive elements. However, a comparative study of the evolutionary dynamics of the repetitive content of the W chromosome across the whole lineage is missing. Using molecular-cytogenetic techniques, we explored the distribution of four repetitive motifs (microsatellites GATA, GACA, AG and telomeric-like sequences), which are frequently accumulated in differentiated sex chromosomes in vertebrates, in the genomes of 13 species of the caenophidian snakes covering a wide phylogenetic spectrum of the lineage...
December 28, 2017: Genes
https://www.readbyqxmd.com/read/29275211/up-regulation-of-pomc-and-cart-mrnas-by-intermittent-hypoxia-via-gata-transcription-factors-in-human-neuronal-cells
#9
Ryogo Shobatake, Ken Takasawa, Hiroyo Ota, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Tomoko Uchiyama, Mai Makino, Kazuma Sugie, Shin Takasawa, Satoshi Ueno
Sleep apnea syndrome (SAS) is characterized by intermittent hypoxia (IH) during sleep. SAS and obesity are strongly related to each other. Here, we investigated the effect of IH on the expression of major appetite regulatory genes in human neuronal cells. We exposed NB-1, SH-SY5Y, and SK-N-SH human neuronal cells to IH (64 cycles of 5 min hypoxia and 10 min normoxia), normoxia, or sustained hypoxia for 24 h and measured the mRNA levels of proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), galanin, galanin-like peptide, ghrelin, pyroglutamylated RFamide peptide, agouti-related peptide, neuropeptide Y, and melanocortin 4 receptor by real-time RT-PCR...
December 21, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29262331/the-lxcxe-retinoblastoma-protein-binding-motif-of-fog-2-regulates-adipogenesis
#10
Olivier Goupille, Tipparat Penglong, Zahra Kadri, Marine Granger-Locatelli, Raphaël Denis, Serge Luquet, Cécile Badoual, Suthat Fucharoen, Leila Maouche-Chrétien, Philippe Leboulch, Stany Chrétien
GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown fat conversion...
December 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/29249045/longitudinal-patterning-in-roots-a-gata2-auxin-interaction-underlies-and-maintains-the-root-transition-domain
#11
Keni Jiang, Vincent Yung, Taisei Chiba, Lewis J Feldman
In Arabidopsis thaliana root meristems the GATA2 transcription factor is a marker for the root transition domain, is auxin regulated, and functions to restrict cell division activity. The growing part of roots is comprised of three discrete regions; the proliferative domain (PD), an elongation zone, and interposed between these two, the transition domain (TD), which is the focus of this investigation. Within the TD, it is hypothesized that cells are reprogrammed, losing the capacity to divide and begin to differentiate...
December 16, 2017: Planta
https://www.readbyqxmd.com/read/29235613/can-gata3-immunocytochemistry-be-utilized-as-a-reliable-diagnostic-marker-for-metastatic-breast-carcinoma-in-cytological-materials-a-comparative-study-with-mammaglobin-and-gcdfp-15-expression
#12
Nesreen H Hafez, HebatAllah M Shaaban
OBJECTIVE: Cytomorphologic differentiation of metastatic breast carcinoma from non breast metastases in cytological materials can be difficult. Current breast immunocytochemical markers have low sensitivities. Transcription factor GATA 3 is a promising marker for detecting breast differentiation in cytological materials. The aim of the study was to assess the diagnostic value of GATA 3 as a breast differentiation marker in metastatic cytological materials and to compare it with expression of mammaglobin and gross cystic disease fluid protein-15 (GCDFP-15)...
December 13, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29229250/genome-wide-transcriptomics-analysis-identifies-sox7-and-sox18-as-specifically-regulated-by-gata4-in-cardiomyogenesis
#13
Boni A Afouda, Adam T Lynch, Eduardo de Paiva Alves, Stefan Hoppler
The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA factors in a genome-wide transcriptomics analysis. The genes regulated by gata4 are particularly interesting because GATA4 is able to induce differentiation of beating cardiomyocytes in Xenopus and in mammalian systems. Among the specifically gata4-regulated transcripts we identified two SoxF family members, sox7 and sox18...
December 8, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29227022/the-gata-type-ivb-zinc-finger-transcription-factor-ssnsd1-regulates-asexual-sexual-development-and-appressoria-formation-in-sclerotinia-sclerotiorum
#14
Jingtao Li, Wenhui Mu, Selvakumar Veluchamy, Yanzhi Liu, Yanhua Zhang, Hongyu Pan, Jeffrey A Rollins
The sclerotium, a multicellular structure made from the compact aggregation of vegetative hyphae, is critical for the long-term survival and sexual reproduction of the plant pathogenic fungus Sclerotinia sclerotiorum. The development and carpogenic germination of sclerotia are regulated by integrating signals from both environmental and endogenous processes. Here we report on the regulatory functions of the S. sclerotiorum GATA-type IVb zinc-finger transcription factor SsNsd1 in these processes. SsNsd1 is orthologous to the Aspergillus nidulans NsdD (never in sexual development) and the Neurospora crassa SUB-1 (submerged protoperithecia-1) proteins...
December 11, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29216945/-expression-and-meaning-of-t-bet-and-gata3-mrna-in-t-lymphocyte-of-patients-during-the-operation-with-cardiopulmonary-bypass
#15
Haifeng Ni, Yingbin Xiao
OBJECTIVE: To investigate the effects of cardiopulmonary bypass (CPB) on the differentiation of T lymphocyte subsets and the expression of specific transcription regulator T-bet/GATA binding protein 3 (GATA3). METHODS: A prospective double-blind study was conducted. Patients with CPB pulmonary repair of ventricular septal defect (observation group) or off-pump ligation of ductus arteriosus (control group) with 20 cases each in the 150th Military Hospital from February 2015 to February 2016 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216911/dynamic-expression-of-cytokine-and-transcription-factor-genes-during-experimental-fasciola-gigantica-infection-in-buffaloes
#16
Wei Shi, Zhi-Yong Wei, Hany M Elsheikha, Fu-Kai Zhang, Zhao-An Sheng, Ke-Jing Lu, Dong-Ying Wang, Wei-Yi Huang, Xing-Quan Zhu
BACKGROUND: Determining the mechanisms involved in the immune-pathogenesis of the tropical liver fluke, Fasciola gigantica, is crucial to the development of any effective therapeutic intervention. Here, we examined the differential gene expression of cytokines and transcription factors in the liver of F. gigantica-infected buffaloes, over the course of infection. METHODS: Water buffaloes (swamp type) were infected orally with 500 F. gigantica encysted metacercariae...
December 8, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29212709/a-eukaryotic-nicotinate-inducible-gene-cluster-convergent-evolution-in-fungi-and-bacteria
#17
Judit Ámon, Rafael Fernández-Martín, Eszter Bokor, Antonietta Cultrone, Joan M Kelly, Michel Flipphi, Claudio Scazzocchio, Zsuzsanna Hamari
Nicotinate degradation has hitherto been elucidated only in bacteria. In the ascomycete Aspergillus nidulans, six loci, hxnS/AN9178 encoding the molybdenum cofactor-containing nicotinate hydroxylase, AN11197 encoding a Cys2/His2 zinc finger regulator HxnR, together with AN11196/hxnZ, AN11188/hxnY, AN11189/hxnP and AN9177/hxnT, are clustered and stringently co-induced by a nicotinate derivative and subject to nitrogen metabolite repression mediated by the GATA factor AreA. These genes are strictly co-regulated by HxnR...
December 2017: Open Biology
https://www.readbyqxmd.com/read/29208183/promoter-motifs-required-for-c-mpl-gene-expression-induced-by-thrombopoietin-in-cmk-cells
#18
Masataka Sunohara, Iwao Sato, Shigeru Morikawa
Thrombopoietin (TPO) and its receptor, c-Mpl, are the central regulators of megakaryocyte development and platelet production and are also crucial to regulate megakaryocytopoiesis. TPO remarkably elevated c-mpl promoter activity, while the protein kinase C (PKC) inhibitors, GF109203, H7 and Calphostin C, clearly reduced the steady level of its promoter activity.  In the present study, motifs crucial for c-mpl promoter activity induced by TPO treatment has been analyzed using a human megakaryoblastic cell line, CMK...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29207126/melatonin-enhances-the-apoptotic-effects-and-modulates-the-changes-in-gene-expression-induced-by-docetaxel-in-mcf%C3%A2-7-human-breast-cancer-cells
#19
Carolina Alonso-González, Javier Menéndez-Menéndez, Alicia González-González, Alicia González, Samuel Cos, Carlos Martínez-Campa
Results from clinical trials and multiple in vivo and in vitro studies point to melatonin as a promising adjuvant molecule with many beneficial effects when concomitantly administered with chemotherapy. Melatonin palliates side‑effects and enhances the efficacy of chemotherapeutic agents. However, the mechanisms through which melatonin regulates molecular changes induced by chemotherapeutic agents remain largely unknown. In this study, we demonstrated that melatonin enhanced the anti-proliferative and apoptotic responses to low doses of docetaxel in breast cancer cells...
November 28, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29207039/effective-component-of-salvia%C3%A2-miltiorrhiza-in-promoting-cardiomyogenic-differentiation-of-human-placenta%C3%A2-derived-mesenchymal-stem-cells
#20
Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Our previous study indicated that Salvia miltiorrhiza (SM) induced human placenta‑derived mesenchymal stem cells (hPDMSCs) to differentiate into cardiomyocytes, however, the effective component of SM in promoting cardiomyogenic differentiation remained to be elucidated. In the present study, the most commonly examined components of SM, including danshensu, salvianolic acid B, protocatechuic aldehyde, tanshinone I (TS I), TS IIA and cryptotanshinone, were used to determine the effective components of SM in promoting cardiomyogenic differentiation...
November 28, 2017: International Journal of Molecular Medicine
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