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Neural plasticity

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https://www.readbyqxmd.com/read/28932187/linking-network-activity-to-synaptic-plasticity-during-sleep-hypotheses-and-recent-data
#1
REVIEW
Carlos Puentes-Mestril, Sara J Aton
Research findings over the past two decades have supported a link between sleep states and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain this relationship. For example, multiple studies have shown structural alterations to synapses (including changes in synaptic volume, spine density, and receptor composition) indicative of synaptic weakening after a period of sleep. Direct measures of neuronal activity and synaptic strength support the idea that a period of sleep can reduce synaptic strength...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28931463/severe-streptomycin-ototoxicity-in-the-mouse-utricle-leads-to-a-flat-epithelium-but-the-peripheral-neural-degeneration-is-delayed
#2
Guo-Peng Wang, Ishani Basu, Lisa A Beyer, Hiu Tung Wong, Donald L Swiderski, Shu-Sheng Gong, Yehoash Raphael
The damaged vestibular sensory epithelium of mammals has a limited capacity for spontaneous hair cell regeneration, which largely depends on the transdifferentiation of surviving supporting cells. Little is known about the response of vestibular supporting cells to a severe insult. In the present study, we evaluated the impact of a severe ototoxic insult on the histology of utricular supporting cells and the changes in innervation that ensued. We infused a high dose of streptomycin into the mouse posterior semicircular canal to induce a severe lesion in the utricle...
September 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/28928640/hdac3-inhibitor-rgfp966-modulates-neuronal-memory-for-vocal-communication-signals-in-a-songbird-model
#3
Mimi L Phan, Mark M Gergues, Shafali Mahidadia, Jorge Jimenez-Castillo, David S Vicario, Kasia M Bieszczad
Epigenetic mechanisms that modify chromatin conformation have recently been under investigation for their contributions to learning and the formation of memory. For example, the role of enzymes involved in histone acetylation are studied in the formation of long-lasting memories because memory consolidation requires gene expression events that are facilitated by an open state of chromatin. We recently proposed that epigenetic events may control the entry of specific sensory features into long-term memory by enabling transcription-mediated neuronal plasticity in sensory brain areas...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28926184/experience-dependent-neural-plasticity-learning-and-memory-in-the-era-of%C3%A2-epitranscriptomics
#4
REVIEW
Laura J Leighton, Ke Ke, Esmi L Zajaczkowski, Jordan Edmunds, Robert C Spitale, Timothy W Bredy
In this short review, we highlight recent findings in the emerging field of epitranscriptomic mechanisms and discuss their potential role in neural plasticity, learning and memory. These include the influence of RNA modifications on activity-induced RNA structure states, RNA editing and RNA localization, and how qualitative state changes in RNA increase the functional diversity and information-carrying capacity of RNA molecules. We predict that RNA modifications may be just as important for synaptic plasticity and memory as quantitative changes in transcript and protein abundance, but with the added advantage of not being required to signal back to the nucleus, and therefore better suited to be coordinated with the temporal dynamics of learning...
September 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28925069/myelin-plasticity-neural-activity-and-traumatic-neural-injury
#5
REVIEW
Bethany R Kondiles, Philip J Horner
The possibility that adult organisms exhibit myelin plasticity has recently become a topic of great interest. Many researchers are exploring the role of myelin growth and adaptation in daily functions such as memory and motor learning. Here we consider evidence for three different potential categories of myelin plasticity: the myelination of previously bare axons, remodeling of existing sheaths, and the removal of a sheath with replacement by a new internode. We also review evidence that points to the importance of neural activity as a mechanism by which oligodendrocyte precursor cells (OPCs) are cued to differentiate into myelinating oligodendrocytes, which may potentially be an important component of myelin plasticity...
September 19, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28924215/bilingual-cortical-control-of-between-and-within-language-competition
#6
Viorica Marian, James Bartolotti, Sirada Rochanavibhata, Kailyn Bradley, Arturo E Hernandez
The human capacity to master multiple languages is remarkable and leads to structural and functional changes in the brain. Understanding how the brain accommodates multiple languages simultaneously is crucial to developing a complete picture of our species' linguistic capabilities. To examine the neural mechanisms involved in processing two languages, we looked at cortical activation in Spanish-English bilinguals in response to phonological competition either between two languages or within a language. Participants recognized spoken words in a visual world task while their brains were scanned using functional magnetic resonance imaging (fMRI)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924007/multiple-signaling-pathways-coordinately-regulate-forgetting-of-olfactory-adaptation-through-control-of-sensory-responses-in-c-elegans
#7
Tomohiro Kitazono, Sayuri Hara-Kuge, Osamu Matsuda, Akitoshi Inoue, Manabi Fujiwara, Takeshi Ishihara
Forgetting memories is important for animals to properly respond to continuously changing environments. To elucidate the mechanisms of forgetting, we used one of the behavioral plasticities of C. elegans hermaphrodite, olfactory adaptation to an attractive odorant, diacetyl, as a simple model of learning. In C. elegans, the TIR-1/JNK-1 pathway accelerates forgetting of olfactory adaptation by facilitating neural secretion from AWC sensory neurons. In this study, to identify the downstream effectors of the TIR-1/JNK-1 pathway, we conducted a genetic screen for suppressors of the gain-of-function mutant of tir-1 (ok1052), which shows excessive forgetting...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28922973/a-new-wnt1-cre-tomatorosa-es-cell-line-a-tool-for-studying-neural-crest-cell-integration-capacity
#8
Soledad Acuna Mendoza, Sabrina Martin, Sabine Kuchler-Bopp, Sandy Ribes, Jeremy H Thalgott, Catherine Chaussain, Sophie Creuzet, Hervé Lesot, Franck Lebrin, Anne Poliard
Neural crest (NC) cells are a migratory, multipotent population giving rise to numerous lineages in the embryo. Their plasticity renders attractive their use in tissue engineering-based therapies but further knowledge on their in vivo behaviour is required before clinical transfer may be envisioned. We here describe isolation and characterization of a new mouse ES line derived from Wnt1-CRE-R26 RosaTomatoTdv blastocyst and show that it displays the characteristics of typical ES cells. Furthermore, these cells can be efficiently directed towards a NC stem cell-like phenotype as attested by concomitant expression of NC marker genes and Tomato fluorescence...
September 19, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28921686/the-effects-of-dynamical-synapses-on-firing-rate-activity-a-spiking-neural-network-model
#9
Radwa Khalil, Marie Z Moftah, Ahmed A Moustafa
Accumulating evidence relates the fine-tuning of synaptic maturation and regulation of neural network activity to several key factors, including GABAA signaling and a lateral spread length between neighboring neurons (i.e. local connectivity). Furthermore, a number of studies consider Short-Term synaptic Plasticity (STP) as an essential element in the instant modification of synaptic efficacy in the neuronal network and in modulating responses to sustained ranges of external Poisson Input Frequency (IF). Nevertheless, evaluating the firing activity in response to the dynamical interaction between STP (triggered by ranges of IF), and these key parameters in vitro remains elusive...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28919555/disturbances-of-systemic-and-hippocampal-insulin-sensitivity-in-macrophage-migration-inhibitory-factor-mif-knockout-male-mice-lead-to-behavioral-changes-associated-with-decreased-psa-ncam-levels
#10
Ana Djordjevic, Biljana Bursać, Nataša Veličković, Ljupka Gligorovska, Djurdjica Ignjatović, Mirko Tomić, Gordana Matić
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine well known for its role in inflammation enhancement. However, a growing body of evidence is emerging on its role in energy metabolism in insulin sensitive tissues such as hippocampus, a brain region implicated in cognition, learning and memory. We hypothesized that genetic deletion of MIF may result in the specific behavioral changes, which may be linked tо impairments in brain or systemic insulin sensitivity by possible changes of the hippocampal synaptic plasticity...
September 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28919535/altered-gray-matter-volume-cerebral-blood-flow-and-functional-connectivity-in-chronic-stroke-patients
#11
Peifang Miao, Caihong Wang, Peng Li, Sen Wei, Chunshan Deng, Dandan Zheng, Jingliang Cheng
It is entangled connections and intensive functional interactions between cortex and subcortical structures that enable our brain to perform delicate movement, and poses plasticity to recover from stroke. However, it is still unclear how cortical structures and functions change in well-recovered patients from subcortical infarctions in motor pathway. In order to reveal neuroplasticity underlying well-recovered stroke patients, both structural (gray matter volume, GMV) and functional reorganizations (cerebral blood flow, CBF and resting-state functional connectivity, rsFC) were investigated by using multi-modal MRI...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28919088/resilience-in-mathematics-after-early-brain-injury-the-roles-of-parental-input-and-early-plasticity
#12
Dana E Glenn, Özlem Ece Demir-Lira, Dominic J Gibson, Eliza L Congdon, Susan C Levine
Children with early focal unilateral brain injury show remarkable plasticity in language development. However, little is known about how early brain injury influences mathematical learning. Here, we examine early number understanding, comparing cardinal number knowledge of typically developing children (TD) and children with pre- and perinatal lesions (BI) between 42 and 50 months of age. We also examine how this knowledge relates to the number words children hear from their primary caregivers early in life...
July 24, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28918313/learning-with-three-factors-modulating-hebbian-plasticity-with-errors
#13
REVIEW
Łukasz Kuśmierz, Takuya Isomura, Taro Toyoizumi
Synaptic plasticity is a central theme in neuroscience. A framework of three-factor learning rules provides a powerful abstraction, helping to navigate through the abundance of models of synaptic plasticity. It is well-known that the dopamine modulation of learning is related to reward, but theoretical models predict other functional roles of the modulatory third factor; it may encode errors for supervised learning, summary statistics of the population activity for unsupervised learning or attentional feedback...
September 14, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#14
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28917001/a-neural-network-model-for-familiarity-and-context-learning-during-honeybee-foraging-flights
#15
Jurek Müller, Martin Nawrot, Randolf Menzel, Tim Landgraf
How complex is the memory structure that honeybees use to navigate? Recently, an insect-inspired parsimonious spiking neural network model was proposed that enabled simulated ground-moving agents to follow learned routes. We adapted this model to flying insects and evaluate the route following performance in three different worlds with gradually decreasing object density. In addition, we propose an extension to the model to enable the model to associate sensory input with a behavioral context, such as foraging or homing...
September 15, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28916843/the-implicit-learning-of-metrical-and-non-metrical-rhythms-in-blind-and-sighted-adults
#16
Claudia Carrara-Augustenborg, Benjamin G Schultz
Forming temporal expectancies plays a crucial role in our survival as it allows us to identify the occurrence of temporal deviants that might signal potential dangers. The dynamic attending theory suggests that temporal expectancies are formed more readily for rhythms that imply a beat (i.e., metrical rhythms) compared to those that do not (i.e., nonmetrical rhythms). Moreover, metrical frameworks can be used to detect temporal deviants. Although several studies have demonstrated that congenital or early blindness correlates with modality-specific neural changes that reflect compensatory mechanisms, few have examined whether blind individuals show a learning advantage for auditory rhythms and whether learning can occur unintentionally and without awareness, that is, implicitly...
September 15, 2017: Psychological Research
https://www.readbyqxmd.com/read/28915964/decreased-use-of-spatial-pattern-separation-in-contemporary-lifestyles-may-contribute-to-hippocampal-atrophy-and-diminish-mental-health
#17
Lindy Birkel
The spatial pattern separation process has not yet been proposed as a pivotal neural activity affecting hippocampal volume, a metric of mental health. The dentate gyrus/CA3 region is increasingly implicated in hippocampal atrophy, its putative role in spatial pattern separation appears to be impaired in mental health disorders, and performance on a task indicative of pattern separation correlates with dentate gyrus/CA3 volume. Spatial pattern separation is thought to utilize the heightened neural plasticity of newborn neurons in the dentate gyrus to distinguish highly similar aspects of scene so that these remain distinct in memory rather than lost...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28914603/synaptic-up-scaling-preserves-motor-circuit-output-after-chronic-natural-inactivity
#18
Joseph M Santin, Mauricio Vallejo, Lynn K Hartzler
Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity.  Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations.  Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive.  To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter...
September 15, 2017: ELife
https://www.readbyqxmd.com/read/28913349/brain-computer-interface-for-clinical-purposes-cognitive-assessment-and-rehabilitation
#19
REVIEW
Laura Carelli, Federica Solca, Andrea Faini, Paolo Meriggi, Davide Sangalli, Pietro Cipresso, Giuseppe Riva, Nicola Ticozzi, Andrea Ciammola, Vincenzo Silani, Barbara Poletti
Alongside the best-known applications of brain-computer interface (BCI) technology for restoring communication abilities and controlling external devices, we present the state of the art of BCI use for cognitive assessment and training purposes. We first describe some preliminary attempts to develop verbal-motor free BCI-based tests for evaluating specific or multiple cognitive domains in patients with Amyotrophic Lateral Sclerosis, disorders of consciousness, and other neurological diseases. Then we present the more heterogeneous and advanced field of BCI-based cognitive training, which has its roots in the context of neurofeedback therapy and addresses patients with neurological developmental disorders (autism spectrum disorder and attention-deficit/hyperactivity disorder), stroke patients, and elderly subjects...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912706/dynamic-neural-fields-with-intrinsic-plasticity
#20
Claudius Strub, Gregor Schöner, Florentin Wörgötter, Yulia Sandamirskaya
Dynamic neural fields (DNFs) are dynamical systems models that approximate the activity of large, homogeneous, and recurrently connected neural networks based on a mean field approach. Within dynamic field theory, the DNFs have been used as building blocks in architectures to model sensorimotor embedding of cognitive processes. Typically, the parameters of a DNF in an architecture are manually tuned in order to achieve a specific dynamic behavior (e.g., decision making, selection, or working memory) for a given input pattern...
2017: Frontiers in Computational Neuroscience
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