keyword
MENU ▼
Read by QxMD icon Read
search

Low complexity domain

keyword
https://www.readbyqxmd.com/read/29141194/marginal-stability-drives-irreversible-unfolding-of-large-multi-domain-family-3-glycosylhydrolases-from-thermo-tolerant-yeast
#1
Mohammad Asif Shah, Saroj Mishra, Tapan Kumar Chaudhuri
Protein folding is an extremely complex and fast, yet perfectly defined process, involving interplay of many intra and inter-molecular forces. In vitro, these molecular interactions are reversible for many proteins e.g., smaller and monomeric, organized into single domains. However, refolding of larger multi-domain/multimeric proteins is much more complicated, proceeds in a hierarchal way and is often irreversible. In a comparative study on two large, multi-domain and multimeric isozymes, β -glucosidase I (BGLI) and β-glucosidase II (BGLII) from Pichia etchellsii, we studied spontaneous and assisted refolding under three denaturing conditions viz...
November 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29141085/the-contribution-of-foveal-and-peripheral-visual-information-to-ensemble-representation-of-face-race
#2
Wonmo Jung, Isabelle Bülthoff, Regine G M Armann
The brain can only attend to a fraction of all the information that is entering the visual system at any given moment. One way of overcoming the so-called bottleneck of selective attention (e.g., J. M. Wolfe, Võ, Evans, & Greene, 2011) is to make use of redundant visual information and extract summarized statistical information of the whole visual scene. Such ensemble representation occurs for low-level features of textures or simple objects, but it has also been reported for complex high-level properties...
November 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29139348/regulation-of-hepatitis-c-virus-replication-via-threonine-phosphorylation-of-the-ns5a-protein
#3
Niluka Goonawardane, Douglas Ross-Thriepland, Mark Harris
The hepatitis C virus non-structural 5A (NS5A) protein is highly phosphorylated and plays roles in both virus genome replication and assembly of infectious virus particles. NS5A comprises three domains separated by low complexity sequences (LCS). Mass spectrometry analysis of NS5A revealed the existence of a singly phosphorylated tryptic peptide corresponding to the end of LCS I and the beginning of domain II that contained a number of potential phosphorylatable residues (serines and threonines). Here we use a mutagenic approach to investigate the potential role of three of these threonine residues...
November 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29138440/structural-basis-for-dna-recognition-of-a-single-stranded-dna-binding-protein-from-enterobacter-phage-enc34
#4
Elina Cernooka, Janis Rumnieks, Kaspars Tars, Andris Kazaks
Modern DNA sequencing capabilities have led to the discovery of a large number of new bacteriophage genomes, which are a rich source of novel proteins with an unidentified biological role. The genome of Enterobacter cancerogenus bacteriophage Enc34 contains several proteins of unknown function that are nevertheless conserved among distantly related phages. Here, we report the crystal structure of a conserved Enc34 replication protein ORF6 which contains a domain of unknown function DUF2815. Despite the low (~15%) sequence identity, the Enc34 ORF6 structurally resembles the gene 2...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129631/binding-of-calcium-and-target-peptide-to-calmodulin-like-protein-cml19-the-centrin-2-of-arabidopsis-thaliana
#5
Valentina La Verde, Matteo Trande, Mariapina D'Onofrio, Paola Dominici, Alessandra Astegno
Calmodulin-like protein 19 (CML19) is an Arabidopsis centrin that modulates nucleotide excision repair (NER) by binding to RAD4 protein, the Arabidopsis homolog of human Xeroderma pigmentosum complementation group C protein. Although the necessity of CML19 as a part of the RAD4 plant recognition complex for functional NER is known at a cellular level, little is known at a molecular level. Herein, we used a combination of biophysical and biochemical approaches to investigate the structural and ion and target-peptide binding properties of CML19...
November 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29125470/magnetic-behavior-of-metastable-fe-films-grown-on-ir-111
#6
Alberto Calloni, Matteo Cozzi, Madan Sangarashettyhalli Jagadeesh, Gianlorenzo Bussetti, Franco Ciccacci, Lamberto Duo
We investigated the growth of ultra-thin Fe films on Ir(111) by means of <i>in-situ</i> low energy electron diffraction and spin-resolved photoemission techniques. We observe a (1x1) diffraction pattern, characteristic of the <i>fcc</i> substrate, below 4 monolayers (ML). Then, a complex superstructure starts to develop, compatible with the formation of <i>bcc</i>-like Fe domains aligned with the substrate according to the Kourdjumov-Sachs orientation relationships. The analysis of the diffraction patterns reveals a progressive evolution towards a fully relaxed <i>bcc</i> lattice, characteristic of bulk Fe...
November 10, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29122978/the-structural-basis-of-ryanodine-receptor-ion-channel-function
#7
REVIEW
Gerhard Meissner
Large-conductance Ca(2+) release channels known as ryanodine receptors (RyRs) mediate the release of Ca(2+) from an intracellular membrane compartment, the endo/sarcoplasmic reticulum. There are three mammalian RyR isoforms: RyR1 is present in skeletal muscle; RyR2 is in heart muscle; and RyR3 is expressed at low levels in many tissues including brain, smooth muscle, and slow-twitch skeletal muscle. RyRs form large protein complexes comprising four 560-kD RyR subunits, four ∼12-kD FK506-binding proteins, and various accessory proteins including calmodulin, protein kinases, and protein phosphatases...
November 9, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29121516/comparing-motor-performance-praxis-coordination-and-interpersonal-synchrony-between-children-with-and-without-autism-spectrum-disorder-asd
#8
Maninderjit Kaur, Sudha M Srinivasan, Anjana N Bhat
Children with Autism Spectrum Disorder (ASD) have basic motor impairments in balance, gait, and coordination as well as autism-specific impairments in praxis/motor planning and interpersonal synchrony. Majority of the current literature focuses on isolated motor behaviors or domains. Additionally, the relationship between cognition, symptom severity, and motor performance in ASD is unclear. We used a comprehensive set of measures to compare gross and fine motor, praxis/imitation, motor coordination, and interpersonal synchrony skills across three groups of children between 5 and 12 years of age: children with ASD with high IQ (HASD), children with ASD with low IQ (LASD), and typically developing (TD) children...
November 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29118990/expanding-hiv-aids-care-service-sites-a-cross-sectional-survey-of-community-pharmacists-views-in-south-east-nigeria
#9
Nnenna Ajagu, Maureen Ugonwa Anetoh, Sunday Odunke Nduka
Background: Community pharmacists are very accessible to most patients yet; they have been underutilized in the aspect of providing HIV care and services. The World Health Organisation recently recommended expanding community pharmacists' roles to address the increasing complexity of antiretroviral agents and co-infection drug regimen. This study therefore was designed to assess the readiness and willingness of community pharmacists in Nigeria to participate in the care of people living with HIV/AIDS and the possible inclusion of their pharmacy premises as sites for HIV care services...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29116821/memory-and-linguistic-executive-functions-of-children-with-borderline-intellectual-functioning
#10
Andrea B Água Dias, Cristina P Albuquerque, Mário R Simões
Children with Borderline Intellectual Functioning (BIF) have received a minimal amount of research attention and have been studied in conjunction with Intellectual and Developmental Disabilities. The present study intends to broaden the knowledge of BIF, by analyzing domains such as verbal memory and visual memory, as well as tasks that rely simultaneously on memory, executive functions, and language. A cross-sectional, comparison study was carried out between a group of 40 children with BIF (mean age = 10...
November 8, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29116267/permeation-pathways-through-lateral-domains-in-model-membranes-of-skin-lipids
#11
Annalaura Del Regno, Rebecca Notman
An understanding of how molecules permeate the complex lipid matrix of the stratum corneum (SC) skin barrier is important for transdermal drug delivery, preventing the adsorption of toxic chemicals and tackling skin diseases. In this paper we present atomistic molecular dynamics simulations of skin-lipid bilayers composed of ceramides, cholesterol (CHOL) and free fatty acids at different lipid compositions and levels of hydration and investigate both perpendicular and lateral permeation pathways through the systems...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29109416/mixed-quantum-dot-solar-cells
#12
Zhenyu Yang, James Z Fan, Andrew H Proppe, F Pelayo García de Arquer, David Rossouw, Oleksandr Voznyy, Xinzheng Lan, Min Liu, Grant Walters, Rafael Quintero-Bermudez, Bin Sun, Sjoerd Hoogland, Gianluigi A Botton, Shana O Kelley, Edward H Sargent
Colloidal quantum dots are emerging solution-processed materials for large-scale and low-cost photovoltaics. The recent advent of quantum dot inks has overcome the prior need for solid-state exchanges that previously added cost, complexity, and morphological disruption to the quantum dot solid. Unfortunately, these inks remain limited by the photocarrier diffusion length. Here we devise a strategy based on n- and p-type ligands that judiciously shifts the quantum dot band alignment. It leads to ink-based materials that retain the independent surface functionalization of quantum dots, and it creates distinguishable donor and acceptor domains for bulk heterojunctions...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098725/the-structure-of-the-large-regulatory-%C3%AE-subunit-of-phosphorylase-kinase-examined-by-modeling-and-hydrogen-deuterium-exchange
#13
Mary Ashley Rimmer, Owen W Nadeau, Jianyi Yang, Antonio Artigues, Yang Zhang, Gerald M Carlson
Phosphorylase kinase (PhK), a 1.3 MDa regulatory enzyme complex in the glycogenolysis cascade, has four copies each of four subunits, (αβγδ)4 , and 325 kDa of unique sequence (the mass of an αβγδ protomer). The α, β and δ subunits are regulatory, and contain allosteric activation sites that stimulate the activity of the catalytic γ subunit in response to diverse signaling molecules. Due to its size and complexity, no high resolution structures have been solved for the intact complex or its regulatory α and β subunits...
November 3, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29094320/rare-diseases-drug-discovery-and-informatics-resource
#14
REVIEW
Mingzhu Zhao, Dong-Qing Wei
A rare disease refers to any disease with very low prevalence individually. Although the impacted population is small for a single disease, more than 6000 rare diseases affect millions of people across the world. Due to the small market size, high cost and possibly low return on investment, only in recent years, the research and development of rare disease drugs have gradually risen globally, in several domains including gene therapy, enzyme replacement therapy, and drug repositioning. Due to the complex etiology and heterogeneous symptoms, there is a large gap between basic research and patient unmet needs for rare disease drug discovery...
November 1, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29092411/chaotic-one-dimensional-domains-induced-by-periodic-potentials-in-normal-dispersion-fiber-lasers
#15
Deterlino Urzagasti, Bryan A Vargas, Luzmila A Quispe-Flores
We investigate numerically the effects of external time-periodic potentials on time-localized perturbations to the amplitude of electromagnetic waves propagating in normal-dispersion fiber lasers which are described by the complex Ginzburg-Landau equation. Two main effects were found: The formation of domains enclosed by two maxima of the external periodic field and the generation of a chaotic behavior of these domains in the region of relatively high amplitudes and low frequencies of the external fields. Maps and bifurcation diagrams of the largest Lyapunov exponent and moments, such as energy and momentum, are also provided for different values of the amplitude and frequency of such external potentials...
October 2017: Chaos
https://www.readbyqxmd.com/read/29092222/streaking-of-43-attosecond-soft-x-ray-pulses-generated-by-a-passively-cep-stable-mid-infrared-driver
#16
Thomas Gaumnitz, Arohi Jain, Yoann Pertot, Martin Huppert, Inga Jordan, Fernando Ardana-Lamas, Hans Jakob Wörner
Attosecond metrology has so far largely remained limited to titanium:sapphire lasers combined with an active stabilization of the carrier-envelope phase (CEP). These sources limit the achievable photon energy to ∼100 eV which is too low to access X-ray absorption edges of most second- and third-row elements which are central to chemistry, biology and material science. Therefore, intense efforts are underway to extend attosecond metrology to the soft-X-ray (SXR) domain using mid-infrared (mid-IR) drivers. Here, we introduce and experimentally demonstrate a method that solves the long-standing problem of the complete temporal characterization of ultra-broadband (≫10 eV) attosecond pulses...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29081348/health-professionals-views-on-health-literacy-issues-for-culturally-and-linguistically-diverse-women-in-maternity-care-barriers-enablers-and-the-need-for-an-integrated-approach
#17
Jo-Anne Hughson, Fiona Marshall, Justin Oliver Daly, Robyn Woodward-Kron, John Hajek, David Story
Objective To identify health literacy issues when providing maternity care to culturally and linguistically diverse (CALD) women, and the strategies needed for health professionals to collaboratively address these issues.Methods A qualitative case study design was undertaken at one large metropolitan Australian hospital serving a highly CALD population. Semistructured interviews were conducted with a range of maternity healthcare staff. The data were analysed thematically. The study is informed by a framework of cultural competence education interventions for health professionals and a health literacy framework...
October 30, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29079435/molecular-dynamics-and-binding-selectivity-of-nucleotides-and-polynucleotide-substrates-with-eif2c2-ago2-paz-domain
#18
Mahmoud Kandeel, Yukio Kitade
RNA interference (RNAi) constitutes a major target in drug discovery. Recently, we reported that the Argonaute protein 2 (Ago2) PAZ domain selectively binds with all ribonucleotides except adenine and poorly recognizes deoxyribonucleotides. The binding properties of the PAZ domain with polynucleotides and the molecular mechanisms of substrates' selectivity remains unclear. In this study, the binding potencies of polynucleotides and the associated conformational and dynamic changes in PAZ domain are investigated...
October 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29079199/chd8short-a-naturally-occurring-truncated-form-of-a-chromatin-remodeler-lacking-the-helicase-domain-is-a-potent-transcriptional-coregulator
#19
Gary R Kunkel, Jessica A Tracy, Frank L Jalufka, Arne C Lekven
Chromodomain-Helicase-DNA binding protein 8 (CHD8) is a member of a large family of eukaryotic ATP-dependent chromatin remodeling complexes. Loss of function alleles of human chd8 are correlated with autism spectrum disorder. The CHD subfamily members contain a tandem pair of chromodomains that are adjacent to a centrally located Snf2-like helicase domain. An alternatively spliced variant mRNA of CHD8 was identified years ago in mammals that encode a truncated form of the protein, called Duplin, that lacks the helicase domain and everything else in the carboxyl direction...
October 24, 2017: Gene
https://www.readbyqxmd.com/read/29073019/structure-and-dynamics-of-the-rnapii-ctdsome-with-rtt103
#20
Olga Jasnovidova, Tomas Klumpler, Karel Kubicek, Sergei Kalynych, Pavel Plevka, Richard Stefl
RNA polymerase II contains a long C-terminal domain (CTD) that regulates interactions at the site of transcription. The CTD architecture remains poorly understood due to its low sequence complexity, dynamic phosphorylation patterns, and structural variability. We used integrative structural biology to visualize the architecture of the CTD in complex with Rtt103, a 3'-end RNA-processing and transcription termination factor. Rtt103 forms homodimers via its long coiled-coil domain and associates densely on the repetitive sequence of the phosphorylated CTD via its N-terminal CTD-interacting domain...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
71593
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"