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https://www.readbyqxmd.com/read/29778960/rapid-colorimetric-detection-of-p53-protein-function-using-dna-gold-nanoconjugates-with-applications-for-drug-discovery-and-cancer-diagnostics
#1
Enock Assah, Walter Goh, Xin Ting Zheng, Ting Xiang Lim, Jun Li, David Lane, Farid Ghadessy, Yen Nee Tan
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. Due to its significance in cancer biology, relentless efforts have been directed toward understanding p53-DNA interactions for the development of cancer therapeutics and diagnostics. In this paper, we report a rapid, label-free and versatile colorimetric assay to detect wildtype p53 DNA-binding function in complex solutions. The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs)...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778887/biological-potential-of-oxo-vanadium-salicylediene-amino-acid-complexes-as-cytotoxic-antimicrobial-antioxidant-and-dna-interaction
#2
Mohamed Shaker S Adam, Hany Elsawy
New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV-Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs...
May 4, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29778831/black-plastics-linear-and-circular-economies-hazardous-additives-and-marine-pollution
#3
REVIEW
Andrew Turner
Black products constitute about 15% of the domestic plastic waste stream, of which the majority is single-use packaging and trays for food. This material is not, however, readily recycled owing to the low sensitivity of black pigments to near infrared radiation used in conventional plastic sorting facilities. Accordingly, there is mounting evidence that the demand for black plastics in consumer products is partly met by sourcing material from the plastic housings of end-of-life waste electronic and electrical equipment (WEEE)...
May 17, 2018: Environment International
https://www.readbyqxmd.com/read/29778610/a-decade-of-tevar-in-new-york-state-volumes-outcomes-and-implications-for-the-dissemination-of-endovascular-technology
#4
Jordan R Stern, Tianyi Sun, Jialin Mao, Art Sedrakyan, Andrew J Meltzer
INTRODUCTION: /Objectives: The purpose of this study was to characterize utilization and outcomes of TEVAR in New York State during the first decade of commercial availability, with respect to evolving indications, results, and costs. Of specific interest was evaluation of the volume-outcome relationship for this relatively uncommon procedure. METHODS: The New York Statewide Planning and Research Cooperative System (SPARCS) database was queried to identify patients undergoing TEVAR from 2005-2014 for aortic dissection (AD), non-ruptured aneurysm (NRA), and ruptured aneurysm (RA)...
May 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29778078/an-effective-and-low-cost-carbon-based-clean-up-method-for-pcdd-fs-and-pcbs-analysis-in-food
#5
Kleopatra Kedikoglou, Danae Costopoulou, Irene Vassiliadou, Evangelos Bakeas, Leondios Leondiadis
Sample preparation is of critical importance in dioxin analysis of food and feed samples. It is a complex procedure that includes lipid extraction followed by the application of chromatographic separation techniques, aiming in removing undesirable interferences from the matrix. The separation of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) from polychlorinated biphenyls (PCBs) is achieved by carbon-based materials which should have high fat capacity in order to be suitable for lipid-containing matrices...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778046/evaluation-of-the-microhaplotypes-panel-for-dna-mixture-analyses
#6
Peng Chen, Caiyong Yin, Zheng Li, Yan Pu, Youjia Yu, Peng Zhao, Dexin Chen, Weibo Liang, Lin Zhang, Feng Chen
The identification of a suspect in a DNA mixture typed with the standard short tandem repeat polymorphism (STR) kits has faced challenges. Several improved methods or technologies have been introduced to address this issue. However, some complex situations in the process remain elusive. In the present study, we presented a panel of 26 tiny microhaplotypes, each generating a relatively high (>3.0) effective number of alleles (Ae ) and possessing low (<50 bp) sequence lengths. The average Ae and heterozygosity values among the 9 populations of 26 microhaps were in ranges from 2...
May 12, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29777986/predicting-of-the-refractive-index-of-haemoglobin-using-the-hybrid-ga-svr-approach
#7
Tajudeen A Oyehan, Ibrahim O Alade, Aliyu Bagudu, Kazeem O Sulaiman, Sunday O Olatunji, Tawfik A Saleh
The optical properties of blood play crucial roles in medical diagnostics and treatment, and in the design of new medical devices. Haemoglobin is a vital constituent of the blood whose optical properties affect all of the optical properties of human blood. The refractive index of haemoglobin has been reported to strongly depend on its concentration which is a function of the physiology of biological cells. This makes the refractive index of haemoglobin an essential non-invasive bio-marker of diseases. Unfortunately, the complexity of blood tissue makes it challenging to experimentally measure the refractive index of haemoglobin...
April 30, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29777932/application-of-a-surfactant-assisted-dispersive-liquid-liquid-microextraction-method-along-with-central-composite-design-for-micro-volume-based-spectrophotometric-determination-of-low-level-of-cr-vi-ions-in-aquatic-samples
#8
Hamid Reza Sobhi, Efat Azadikhah, Mohammad Behbahani, Ali Esrafili, Mahnaz Ghambarian
A fast, simple, low cost surfactant-assisted dispersive liquid-liquid microextraction method along with central composite design for the determination of low level of Cr(VI) ions in several aquatic samples has been developed. Initially, Cr(VI) ions present in the aqueous sample were readily reacted with 1,5‑diphenylcarbazide (DPC) in acidic medium through complexation. Sodium dodecyl sulfate (SDS), as an anionic surfactant, was then employed as an ion-pair agent to convert the cationic complex into the neutral one...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777828/mutual-connectivity-analysis-of-resting-state-functional-mri-data-with-local-models
#9
Adora M DSouza, Anas Z Abidin, Udaysankar Chockanathan, Giovanni Schifitto, Axel Wismüller
Functional connectivity analysis of functional MRI (fMRI) can represent brain networks and reveal insights into interactions amongst different brain regions. However, most connectivity analysis approaches adopted in practice are linear and non-directional. In this paper, we demonstrate the advantage of a data-driven, directed connectivity analysis approach called Mutual Connectivity Analysis using Local Models (MCA-LM) that approximates connectivity by modeling nonlinear dependencies of signal interaction, over more conventionally used approaches, such as Pearson's and partial correlation, Patel's conditional dependence measures, etcetera...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777686/molecular-interactions-between-geobacter-sulfurreducens-triheme-cytochromes-and-the-redox-active-analogue-for-humic-substances
#10
Joana M Dantas, Marisa R Ferreira, Teresa Catarino, Oleksandr Kokhan, P Raj Pokkuluri, Carlos A Salgueiro
The bacterium Geobacter sulfurreducens can transfer electrons to the quinone moieties of humic substances or to anthraquinone-2,6-disulfonate (AQDS), a model for the humic acids. The reduced form of AQDS (AH2 QDS) can also be used as energy source G. sulfurreducens. Such bi-directional utilization of humic substances confers competitive advantages to these bacteria in Fe(III) enriched environments. Previous studies have shown that the triheme cytochrome PpcA from G. sulfurreducens has a bi-functional behavior toward the humic substance analogue...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29777641/social-norms-and-adolescents-sexual-health-an-introduction-for-practitioners-working-in-low-and-mid-income-african-countries
#11
Beniamino Cislaghi, Holly Shakya
Donors, practitioners and scholars are increasingly interested in harnessing the potential of social norms theory to improve adolescents' sexual and reproductive health outcomes. However, social norms theory is multifaceted, and its application in field interventions is complex. An introduction to social norms that will be beneficial for those who intend to integrate a social norms perspective in their work to improve adolescents' sexual health in Africa is presented. First three main schools of thought on social norms, looking at the theoretical standpoint of each, are discussed...
March 2018: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29777372/cardiac-surgery-2017-reviewed
#12
REVIEW
Torsten Doenst, Hristo Kirov, Alexandros Moschovas, David Gonzalez-Lopez, Rauf Safarov, Mahmoud Diab, Steffen Bargenda, Gloria Faerber
For the year 2017, more than 21,000 published references can be found in PubMed when entering the search term "cardiac surgery". This review focusses on conventional cardiac surgery, considering the new interventional techniques only if they were directly compared to classic techniques but also entails aspects of perioperative intensive care management. The publications last year provided a plethora of new and interesting information that helped to quantify classic surgical treatment effects and provided new guidelines for the management of structural heart disease, which made comparisons to interventional techniques easier...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29777120/softness-induced-enhancement-in-net-throughput-of-non-linear-bio-fluids-in-nanofluidic-channel-under-edl-phenomenon
#13
Harshad Sanjay Gaikwad, Pranab Kumar Mondal, Somchai Wongwises
In this article, we describe the electro-hydrodynamics of non-Newtonian fluid in narrow fluidic channel with solvent permeable and ion-penetrable polyelectrolyte layer (PEL) grafted on channel surface with an interaction of non-overlapping electric double layer (EDL) phenomenon. In this analysis, we integrate power-law model in the momentum equation for describing the non-Newtonian rheology. The complex interplay between the non-Newtonian rheology and interfacial electrochemistry in presence of PEL on the walls leads to non-intuitive variations in the underlying flow dynamics in the channels...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776967/multicentre-study-of-maternal-and-neonatal-outcomes-in-individuals-with-prader-willi-syndrome
#14
Preeti Singh, Ranim Mahmoud, June-Anne Gold, Jennifer L Miller, Elizabeth Roof, Roy Tamura, Elisabeth Dykens, Merlin G Butler, Dan J Driscoll, Virginia Kimonis
INTRODUCTION: Prader-Willi syndrome (PWS) is a complex genetic disorder associated with three different genetic subtypes: deletion of the paternal copy of 15q11-q13, maternal UPD for chromosome 15 and imprinting defect. Patients are typically diagnosed because of neonatal hypotonia, dysmorphism and feeding difficulties; however, data on the prenatal features of PWS are limited. OBJECTIVE: The aim of the study was to identify and compare frequencies of prenatal and neonatal clinical features of PWS among the three genetic subtypes...
May 18, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29776897/reach-and-acceptability-of-a-mobile-reminder-strategy-and-facebook-group-intervention-for-weight-management-in-less-advantaged-adolescents-insights-from-the-pralimap-in%C3%A3-s-trial
#15
Laura Saez, Johanne Langlois, Karine Legrand, Marie-Hélène Quinet, Edith Lecomte, Abdou Y Omorou, Serge Briançon
BACKGROUND: Although information and communication technology interventions appear to be a promising means of reducing the health inequality gap in overweight and obesity prevention, research on information and communication technology interventions is lacking outside the Anglo-Saxon world. OBJECTIVE: The aim of this study was to assess the reach and acceptability of 2 information and communication technology interventions delivered as part of a French nutritional program: an SMS text messaging (short message service, SMS) attendance-reminder for collective sessions strategy and a Facebook challenge group...
May 18, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29776661/the-role-of-intra-napl-diffusion-on-mass-transfer-from-mgp-residuals
#16
Saeid Shafieiyoun, Neil R Thomson
An experimental and computational study was performed to investigate the role of multi-component intra-NAPL diffusion on NAPL-water mass transfer. Molecular weight and the NAPL component concentrations were determined to be the most important parameters affecting intra-NAPL diffusion coefficients. Four NAPLs with different viscosities but the same quantified mass were simulated. For a spherical NAPL body, a combination of NAPL properties and interphase mass transfer rate can result in internal diffusion limitations...
April 24, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29776546/recent-advances-in-analytical-methods-for-the-determination-of-4-alkylphenols-and-bisphenol-a-in-solid-environmental-matrices-a-critical-review
#17
REVIEW
N Salgueiro-González, S Castiglioni, E Zuccato, I Turnes-Carou, P López-Mahía, S Muniategui-Lorenzo
The problem of endocrine disrupting compounds (EDCs) in the environment has become a worldwide concern in recent decades. Besides their toxicological effects at low concentrations and their widespread use in industrial and household applications, these pollutants pose a risk for non-target organisms and also for public safety. Analytical methods to determine these compounds at trace levels in different matrices are urgently needed. This review critically discusses trends in analytical methods for well-known EDCs like alkylphenols and bisphenol A in solid environmental matrices, including sediment and aquatic biological samples (from 2006 to 2018)...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29776482/does-pain-intensity-matter-the-relation-between-coping-and-quality-of-life-in-pediatric-patients-with-chronic-pain
#18
Alexis K Yetwin, Nicole E Mahrer, Cindy John, Jeffrey I Gold
PURPOSE: Chronic pain is a complex and debilitating chronic health condition that negatively impacts a child's daily function. Previous investigations of coping behaviors in youth with chronic illness have suggested that secondary control/accommodative coping may be more adaptive than primary control/active coping or disengagement/passive coping. However, studies have not considered how pain intensity may change the effect of various coping strategies on functioning in this pediatric population...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29776020/paramagnetic-colloids-chaotic-routes-to-clusters-and-molecules
#19
Hamed Abdi, Rasam Soheilian, Randall M Erb, Craig E Maloney
We present computer simulations and experiments on dilute suspensions of superparamagnetic particles subject to rotating magnetic fields. We focus on chains of four particles and their decay routes to stable structures. At low rates, the chains track the external field. At intermediate rates, the chains break up but perform a periodic (albeit complex) motion. At sufficiently high rates, the chains generally undergo chaotic motion at short times and decay to either closely packed clusters or more dispersed, colloidal molecules at long times...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775859/facilitating-complex-dna-mixture-interpretation-by-sequencing-highly-polymorphic-haplotypes
#20
Lev Voskoboinik, Uzi Motro, Ariel Darvasi
Interpretation of complex DNA mixtures is an ongoing challenge in the field of forensic genetics. Commonly used STR markers are quite polymorphic, enabling very high statistical association between a single source DNA profile from a crime scene and a matching suspect. STR typing of low order mixtures with two and three contributors also commonly produces high statistical association for a contributor, using current interpretation software. However higher order mixtures, with four contributors or more, are more challenging...
May 2, 2018: Forensic Science International. Genetics
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