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https://www.readbyqxmd.com/read/28222386/heterogeneous-fractionation-profiles-of-meta-analytic-coactivation-networks
#1
Angela R Laird, Michael C Riedel, Mershack Okoe, Radu Jianu, Kimberly L Ray, Simon B Eickhoff, Stephen M Smith, Peter T Fox, Matthew T Sutherland
Computational cognitive neuroimaging approaches can be leveraged to characterize the hierarchical organization of distributed, functionally specialized networks in the human brain. To this end, we performed large-scale mining across the BrainMap database of coordinate-based activation locations from over 10,000 task-based experiments. Meta-analytic coactivation networks were identified by jointly applying independent component analysis (ICA) and meta-analytic connectivity modeling (MACM) across a wide range of model orders (i...
February 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28222299/adaptive-low-rank-subspace-learning-with-online-optimization-for-robust-visual-tracking
#2
Risheng Liu, Di Wang, Yuzhuo Han, Xin Fan, Zhongxuan Luo
In recent years, sparse and low-rank models have been widely used to formulate appearance subspace for visual tracking. However, most existing methods only consider the sparsity or low-rankness of the coefficients, which is not sufficient enough for appearance subspace learning on complex video sequences. Moreover, as both the low-rank and the column sparse measures are tightly related to all the samples in the sequences, it is challenging to incrementally solve optimization problems with both nuclear norm and column sparse norm on sequentially obtained video data...
February 10, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28222262/a-nature-inspired-strategy-toward-superhydrophobic-fabrics-for-versatile-oil-water-separation
#3
Cailong Zhou, Zhaodan Chen, Hao Yang, Kun Hou, Xinjuan Zeng, Yanfen Zheng, Jiang Cheng
Phytic acid, a naturally occurring component, widely found in many plants, can strongly bond toxic mineral elements in human body due to its six phosphate groups. Some of the metal ions present the property of bonding with phytic acid to form insoluble coordination complexes aggregations even in room temperature. Herein, a superhydrophobic cotton fabric was prepared by a novel and facile nature-inspired strategy which introduced phytic acid metal complexes aggregations to generate rough hierarchical structures on fabric surface followed with PDMS modification...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222250/long-term-treatment-of-cancer-associated-thrombosis-the-choice-of-the-optimal-anticoagulant
#4
REVIEW
I Elalamy, I Mahé, W Ageno, G Meyer
Patients with cancer associated thrombosis (CAT) carry a higher risk of recurrence, bleeding and mortality as compared to non-cancer patients. The specific profile of cancer patients combining frequent co-morbidities, the use of anti-tumoral therapies and the cancer progression itself represent a major therapeutic challenge for choosing a long-term anticoagulant treatment. This review discusses the practical basis of that choice among available drugs for the long-term antithrombotic strategy linked to their pharmacology, mechanism of action, evidence of clinical benefits, advantages and limitations in such a complex clinical context...
February 21, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28222235/visual-appearance-of-a-virtual-upper-limb-modulates-the-temperature-of-the-real-hand-a-thermal-imaging-study-in-immersive-virtual-reality
#5
G Tieri, A Gioia, M Scandola, E F Pavone, S M Aglioti
To explore the link between Sense of Embodiment (SoE) over a virtual hand and physiological regulation of skin temperature, twenty-four healthy participants were immersed in virtual reality through a Head Mounted Display and had their real limb temperature recorded by means of a high-sensitivity infrared camera. Participants observed a virtual right upper limb (appearing either normally, or with the hand detached from the forearm) or limb-shaped non-corporeal control objects (continuous or discontinuous wooden blocks) from a first-person perspective...
February 21, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28222198/algorithmic-design-of-a-noise-resistant-and-efficient-closed-loop-deep-brain-stimulation-system-a-computational-approach
#6
Sofia D Karamintziou, Ana Luísa Custódio, Brigitte Piallat, Mircea Polosan, Stéphan Chabardès, Pantelis G Stathis, George A Tagaris, Damianos E Sakas, Georgia E Polychronaki, George L Tsirogiannis, Olivier David, Konstantina S Nikita
Advances in the field of closed-loop neuromodulation call for analysis and modeling approaches capable of confronting challenges related to the complex neuronal response to stimulation and the presence of strong internal and measurement noise in neural recordings. Here we elaborate on the algorithmic aspects of a noise-resistant closed-loop subthalamic nucleus deep brain stimulation system for advanced Parkinson's disease and treatment-refractory obsessive-compulsive disorder, ensuring remarkable performance in terms of both efficiency and selectivity of stimulation, as well as in terms of computational speed...
2017: PloS One
https://www.readbyqxmd.com/read/28222159/the-role-of-spatial-mobility-in-malaria-transmission-in-the-brazilian-amazon-the-case-of-porto-velho-municipality-rond%C3%A3-nia-brazil-2010-2012
#7
Jussara Rafael Angelo, Tony Hiroshi Katsuragawa, Paulo Chagastelles Sabroza, Lino Augusto Sander de Carvalho, Luiz Hildebrando Pereira da Silva, Carlos Afonso Nobre
BACKGROUND: This study aims to describe the role of mobility in malaria transmission by discussing recent changes in population movements in the Brazilian Amazon and developing a flow map of disease transmission in this region. METHODOLOGY/PRINCIPAL FINDINGS: This study presents a descriptive analysis using an ecological approach on regional and local scales. The study location was the municipality of Porto Velho, which is the capital of Rondônia state, Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28222022/central-and-peripheral-control-of-food-intake
#8
M M I Abdalla
The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake...
January 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28222005/a-modular-low-complexity-ecg-delineation-algorithm-for-real-time-embedded-systems
#9
Jose Manuel Bote, Joaquin Recas, Francisco Rincon, David Atienza, Roman Hermida
This work presents a new modular and lowcomplexity algorithm for the delineation of the different ECG waves (QRS, P and T peaks, onsets and end). Involving a reduced number of operations per second and having a small memory footprint, this algorithm is intended to perform realtime delineation on resource-constrained embedded systems. The modular design allows the algorithm to automatically adjust the delineation quality in run time to a wide range of modes and sampling rates, from a Ultra-low power mode when no arrhythmia is detected, in which the ECG is sampled at low frequency, to a complete High-accuracy delineation mode in which the ECG is sampled at high frequency and all the ECG fiducial points are detected, in case of arrhythmia...
February 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28221991/detecting-clinically-meaningful-shape-clusters-in-medical-image-data-metrics-analysis-for-hierarchical-clustering-applied-to-healthy-and-pathological-aortic-arches
#10
Jan L Bruse, Maria A Zuluaga, Abbas Khushnood, Kristin McLeod, Hopewell N Ntsinjana, Tain-Yen Hsia, Maxime Sermesant, Xavier Pennec, Andrew M Taylor, Silvia Schievano
OBJECTIVE: Today's growing medical image databases call for novel processing tools to structure the bulk of data and extract clinically relevant information. Unsupervised hierarchical clustering may reveal clusters within anatomical shape data of patient populations as required for modern Precision Medicine strategies. Few studies have applied hierarchical clustering techniques to three-dimensional patient shape data and results depend heavily on the chosen clustering distance metrics and linkage functions...
February 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28221988/prevalence-and-phylogenetic-characterization-of-escherichia-coli-and-hygiene-indicator-bacteria-isolated-from-leafy-green-produce-beef-and-pork-obtained-from-farmers-markets-in-pennsylvania
#11
Joshua A Scheinberg, Edward G Dudley, Jonathan Campbell, Beth Roberts, Michael DiMarzio, Chitrita DebRoy, Catherine N Cutter
The popularity of farmers' markets in the United States has led to over 8,400 farmers' markets being in operation in 2015. As farmers' markets have increased in size and complexity in the kinds of foods sold at these venues, so have the potential food safety risks. Since 2008, seven major foodborne illness outbreaks and two recalls associated with food products from farmers' markets have occurred, causing 80 known reported illnesses and one death. Various researchers also have observed vendors performing high-risk food safety retail behaviors, and others have identified microbiological hazards in foods sold at farmers' markets...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221801/balancing-segregation-and-complexation-in-amphiphilic-copolymers-by-architecture-and-confinement
#12
Pascal Hebbeker, Alexander A Steinschulte, Stefanie Schneider, Felix A Plamper
Segregation is a well-known principle for micellization, as solvophobic components try to minimize interactions with other entities (such as solvent) by self-assembly. An opposite principle is based on complexation (or coacervation), leading to the coassembly/association of different components. Most cases in the literature rely on only one of these modes, though the classical micellization scheme (such as spherical micelles, wormlike micelles, and vesicles) can be enriched by a subtle balance of segregation and complexation...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221774/surface-electronic-state-modulated-single-crystalline-001-tio2-nanosheets-for-sensitive-electrochemical-sensing-of-heavy-metal-ions
#13
Wen-Yi Zhou, Jinyun Liu, Jieyao Song, Jinjin Li, Jinhuai Liu, Xing-Jiu Huang
Intrinsically low conductivity and poor reactivity restrict many semiconductors from electrochemical detection. Usually, metal- and carbon-based modifications of semiconductors are necessary, making them complex, expensive, and unstable. Here, for the first time, we present a surface-electronic-state-modulation-based concept applied to semiconductors. This concept enables pure semiconductors to be directly available for ultrasensitive electrochemical detection of heavy-metal ions without any modifications. As an example, a defective single-crystalline (001) TiO2 nanosheet exhibits high electrochemical performance toward Hg(II), including a sensitivity of 270...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28221766/proteoform-profile-mapping-of-the-human-serum-complement-component-c9-reveals-unexpected-new-features-of-n-o-and-c-glycosylation
#14
Vojtech Franc, Yang Yang, Albert J R Heck
The human complement C9 protein (~65 kDa) is a member of the complement pathway. It plays an essential role in the membrane attack complex (MAC), which forms a lethal pore on the cellular surface of pathogenic bacteria. Here, we charted in detail the structural micro-heterogeneity of C9 purified from human blood serum, using an integrative workflow combining high-resolution native mass spectrometry and (glyco)peptide-centric proteomics. The proteoform profile of C9 was acquired by high-resolution native mass spectrometry, which revealed the co-occurrence of ~50 distinct MS signals...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28221701/accelerated-combinatorial-high-throughput-star-polymer-synthesis-via-a-rapid-one-pot-sequential-aqueous-raft-rosa-raft-polymerization-scheme
#15
Steffen Cosson, Maarten Danial, Julien Rosselgong Saint-Amans, Justin J Cooper-White
Advanced polymerization methodologies, such as reversible addition-fragmentation transfer (RAFT), allow unprecedented control over star polymer composition, topology, and functionality. However, using RAFT to produce high throughput (HTP) combinatorial star polymer libraries remains, to date, impracticable due to several technical limitations. Herein, the methodology "rapid one-pot sequential aqueous RAFT" or "rosa-RAFT," in which well-defined homo-, copolymer, and mikto-arm star polymers can be prepared in very low to medium reaction volumes (50 µL to 2 mL) via an "arm-first" approach in air within minutes, is reported...
February 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28221392/a-4-5-quinolimide-based-fluorescent-sensor-for-the-turn-on-detection-of-cd-2-with-live-cell-imaging
#16
Yu Zhang, Xiangfeng Guo, Mengmeng Zheng, Rui Yang, Hongming Yang, Lihua Jia, Mengmeng Yang
A 4,5-quinolimide derivative, BNA, bearing the amide-DPA receptor, was synthesized as a turn-on fluorescent sensor for Cd(2+). Under physiological conditions, BNA could distinguish Cd(2+) from Zn(2+), showing turn-on fluorescence behaviour and an increased fluorescence lifetime. BNA and Cd(2+) formed a 1 : 1 stoichiometric complex, and the detection limit was measured to be as low as 11 nM. Furthermore, BNA was utilized for fluorescence imaging of Cd(2+) in live cells. To the best of our knowledge, it is the first 4,5-quinolimide-based sensor for the detection of metal ions...
February 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28221129/new-mycobacterium-tuberculosis-complex-sublineage-brazzaville-congo
#17
Sven Malm, Laure S Ghoma Linguissi, Emmanuel M Tekwu, Jeannhey C Vouvoungui, Thomas A Kohl, Patrick Beckert, Anissa Sidibe, Sabine Rüsch-Gerdes, Igor K Madzou-Laboum, Sylvie Kwedi, Véronique Penlap Beng, Matthias Frank, Francine Ntoumi, Stefan Niemann
Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26)...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28220885/cancer-cell-mitochondria-targeting-by-pancratistatin-analogs-is-dependent-on-functional-complex-ii-and-iii
#18
Dennis Ma, Christopher Pignanelli, Daniel Tarade, Tyler Gilbert, Megan Noel, Fadi Mansour, Scott Adams, Alexander Dowhayko, Kyle Stokes, Sergey Vshyvenko, Tomas Hudlicky, James McNulty, Siyaram Pandey
Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been shown to selectively induce apoptosis in cancer cells. However, its low availability in nature has hindered its clinical advancement. We synthesized PST analogs and a medium-throughput screen was completed. Analogs SVTH-7, -6, and -5 demonstrated potent anti-cancer activity greater than PST and several standard chemotherapeutics...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220638/a-novel-clinical-framework-the-use-of-dispositions-in-clinical-practice-a-person-centred-approach
#19
Matthew Low
This paper explores a novel clinical framework that is underpinned by a specific philosophical perspective of causation and its utility in clinical practice. A dispositional theory of causation may overcome challenges that clinicians face in complex clinical presentations including those that are medically unexplained. Dispositionalism identifies causes not as regular events necessitating an effect but rather phenomena, which are highly complex, context-sensitive, and which tend toward an effect. Diagnostic uncertainty and causal explanation are significant challenges in terms of clinical reasoning, communication, and the overall therapeutic outcome...
February 21, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28220558/supporting-patients-with-type-1-diabetes-using-continuous-subcutaneous-insulin-infusion-therapy-difficulties-disconnections-and-disarray
#20
Lin Perry, Steven James, Robyn Gallagher, Janet Dunbabin, Katharine Steinbeck, Julia Lowe
RATIONALE, AIMS, AND OBJECTIVES: Use of continuous subcutaneous insulin infusion therapy in type 1 diabetes management is high. However, the incorporation of this technology into self-care is not without challenges, and the support of an appropriately skilled health care team is recommended. This study aimed to examine the support context for patients using continuous subcutaneous insulin infusion therapy from the health care professional perspective, as well as contextual influences for health care professionals and their patients...
February 21, 2017: Journal of Evaluation in Clinical Practice
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