Li-Na Mu, Wei Cao, Zuo-Feng Zhang, Lin Cai, Qing-Wu Jiang, Nai-Chieh You, Binh Yang Goldstein, Guo-Rong Wei, Chuan-Wei Chen, Qing-Yi Lu, Xue-Fu Zhou, Bao-Guo Ding, Jun Chang, Shun-Zhang Yu
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
August 2007: Cancer Causes & Control: CCC