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Mthfr c677t hcc

Paolo Ventura, Giorgia Venturelli, Matteo Marcacci, Massimo Fiorini, Stefano Marchini, Chiara Cuoghi, Antonello Pietrangelo
BACKGROUND: Portal vein thrombosis (PVT) is serious complication of liver cirrhosis (LC), especially in the presence of hepatocellular carcinoma (HCC). The liver plays a key role in homocysteine (Hcy) metabolism: mild hyperhomocysteinemia (HHcy) has been described in LC. HHcy is a risk factor for deep vein thrombosis. Methylen-tetrahydrofolate-reductase (MTHFR) C677T polymorphism is the commonest determinant of mild HHcy and has been involved also in cancer development. AIM: To investigate a possible relation between HHcy, MTHFR status, HCC and PVT in patients affected by LC...
May 2016: Thrombosis Research
Xiaosheng Qi, Xing Sun, Junming Xu, Zhaowen Wang, Jinyan Zhang, Zhihai Peng
Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are considered to have some influence on both folate metabolism and cancer risk. Previous studies on the associations of MTHFR genetic polymorphisms with hepatocellular carcinoma (HCC) risk in Chinese population reported inconsistent results. We performed this meta-analysis to comprehensively assess the associations. Finally, 12 individual case-control studies were included into the meta-analysis. There were seven studies (6,384 subjects) on the MTHFR C677T polymorphism and five studies (4,502 subjects) on the MTHFR A1298C polymorphism...
March 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yu-Hong Qi, Li-Ping Yao, Guang-Bin Cui, Jun Liang, Qiu-Ju Shao, Ling-Feng Yan, Pang Du
OBJECTIVE: Several studies have indicated an association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and the risk of hepatocellular carcinoma (HCC). However, the conclusions are inconsistent. Therefore, a meta-analysis was performed. METHODS: Databases like Pubmed, EMBASE, and EBSCO (up to September 2012) were searched to retrieve case-control trials about MTHFR (C677T or A1298C) polymorphisms and HCC. Literatures were independently screened by two researchers according to the inclusion and exclusion criteria...
April 2014: Clinics and Research in Hepatology and Gastroenterology
Hongli Sun, Bing Han, Hongpeng Zhai, Xinhua Cheng, Kai Ma
Previous studies investigated the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and hepatocellular carcinoma risk, but the impact of MTHFR C677T polymorphism on hepatocellular carcinoma was still unclear, owing to the obvious inconsistence from those studies. This study aimed to quantify the strength of the association between MTHFR C677T polymorphism and hepatocellular carcinoma risk by performing a meta-analysis. We searched the PubMed and Wanfang databases for studies on the association between MTHFR C677T polymorphism and hepatocellular carcinoma risk...
January 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chang-Sheng Kuo, Chi-Yun Huang, Hsing-Tao Kuo, Chin-Pao Cheng, Chien-Hung Chen, Chin-Li Lu, Feili-Lo Yang, Rwei-Fen Syu Huang
SCOPE: Metabolic genotypes of 5,10-methylenetetrahydrofolate reductase (MTHFR) and folate status on oxidative DNA lesions in hepatocellular carcinoma (HCC) has not been elucidated. The aims of the study were to investigate the folate-polymorphic interactions on genetic oxidative damage in association with advanced HCC malignancy and prognosis. METHODS AND RESULTS: The study included 232 HCC patients with folate nutrition, MTHFR C677T polymorphic, p53 genetic and tumour pathological data collected and analyzed for their survivals after a 7...
February 2014: Molecular Nutrition & Food Research
Xue Qin, Qiliu Peng, Zhiping Chen, Yan Deng, Shan Huang, Juanjuan Xu, Haiwei Li, Shan Li, Jinmin Zhao
BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) risk was inconsistent and underpowered. To clarify the effects of MTHFR gene polymorphisms on the risk of HCC, a meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of HCC was conducted. METHODS: The authors searched PubMed, EMBASE, Cochrane Library, Web of Science, and Chinese Biomedical Literature database (CBM) for the period up to July 2012...
2013: PloS One
Fei Jin, Li-Shuai Qu, Xi-Zhong Shen
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. The non-synonymous single nucleotide polymorphism (nsSNP), C677T (Ala>Val, rs1801133), has been verified to impair enzyme activity. The association with cancer susceptibility, including hepatocellular carcinoma (HCC), has also been widely studied. The results, however, were inconsistent. To shed light on the influence of MTHFR C677T polymorphism on HCC, a meta-analysis was conducted...
2009: Diagnostic Pathology
Carlo Fabris, Pierluigi Toniutto, Edmondo Falleti, Elisabetta Fontanini, Annarosa Cussigh, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Claudio Avellini, Rosalba Minisini, Mario Pirisi
BACKGROUND: A single nucleotide polymorphism (SNP) C677T in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified. The TT or CT genotypes show a marked reduction of the enzyme activity; this causes higher homocysteine levels and alterations of folate metabolism. Folate metabolism is essential for DNA synthesis and methylation, crucial steps in carcinogenesis. In this paper, we investigated whether the MTHFR C677T SNP could influence the occurrence of hepatocellular carcinoma (HCC) in a cohort of patients transplanted for end stage liver disease of different etiologies...
January 2009: Alcoholism, Clinical and Experimental Research
Li-Na Mu, Wei Cao, Zuo-Feng Zhang, Lin Cai, Qing-Wu Jiang, Nai-Chieh You, Binh Yang Goldstein, Guo-Rong Wei, Chuan-Wei Chen, Qing-Yi Lu, Xue-Fu Zhou, Bao-Guo Ding, Jun Chang, Shun-Zhang Yu
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
August 2007: Cancer Causes & Control: CCC
Zhong-zheng Zhu, Wen-ming Cong, Shu-fang Liu, Zhi-hong Xian, Wei-qing Wu
OBJECTIVE: To evaluate the possible association of the MTHFR C677T polymorphism with genetic susceptibility to hepatocellular carcinoma (HCC) in a Chinese population. METHODS: Five hundred and eight HCC cases and 543 controls were studied. The MTHFR genotypes were determined using a PCR-based restriction fragment length polymorphism (RFLP) method. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs) from unconditional logistic regression models were used to evaluate relative risks...
March 2006: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Raphaƫl Saffroy, Patrick Pham, Franck Chiappini, Marine Gross-Goupil, Laurent Castera, Daniel Azoulay, Alain Barrier, Didier Samuel, Brigitte Debuire, Antoinette Lemoine
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Different polymorphisms have been described for this enzyme, the most studied being the C677T, which has been shown to be associated with predisposition to colorectal cancer in patients who consume a high alcohol diet. The aim of this study was to determine whether the MTHFR polymorphism is related to hepatocellular carcinoma (HCC) in patients with alcoholic cirrhosis...
August 2004: Carcinogenesis
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