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https://www.readbyqxmd.com/read/28910373/lack-of-association-of-mri-determined-subclinical-cardiovascular-disease-with-dizziness-and-vertigo-in-a-cross-sectional-population-based-study
#1
Roberto Lorbeer, Holger Hetterich, Ralf Strobl, Anina Schafnitzel, Hannah Patscheider, Andreas Schindler, Katharina Müller-Peltzer, Wieland Sommer, Annette Peters, Christa Meisinger, Margit Heier, Wolfgang Rathmann, Fabian Bamberg, Eva Grill
OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness...
2017: PloS One
https://www.readbyqxmd.com/read/28906019/response-letter-to-optimising-physiology-for-adolescents-with-dysautonomia
#2
K Armstrong, A M De Souza, P Sneddon, J E Potts, V E Claydon, S Sanatani
We would like to thank Dr Thaxter Nesbeth (1) for her interest and insightful comments on our paper entitled, "Exercise and the multidisciplinary holistic approach to adolescent dysautonomia"(2). We agree that recurrent orthostatic intolerance is often best managed through lifestyle modification rather than pharmacologic intervention (at least as an initial step), and as such in the present study we evaluated the impact of our exercise programme incorporated in addition to our standard clinical multidisciplinary management approach...
September 14, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28904566/is-vitamin-d-deficiency-implicated-in-autonomic-dysfunction
#3
REVIEW
Rozina Wadhwania
Dysautonomia, dysfunction of the autonomic nervous system, presents with heterogeneous clinical features from an imbalanced regulation of the sympathetic and parasympathetic nervous systems. Low Vitamin D levels can explain the heterogeneous clinical features of migraine headaches, cardiac and gastrointestinal dysfunction, and oxidative stress evident in dysautonomia patients. The role of Vitamin D in modulating pain sensitivity has been recently established. However, there is a lack of research and understanding regarding the association between Vitamin D deficiency and autonomic dysfunction...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28904462/clinical-spectrum-therapeutic-outcomes-and-prognostic-predictors-in-sjogren-s-syndrome-associated-neuropathy
#4
Ajith Sivadasan, Karthik Muthusamy, Bimal Patel, Rohit Ninan Benjamin, A T Prabhakar, Vivek Mathew, Sanjith Aaron, Mathew Alexander
OBJECTIVES: There are limited data regarding long-term follow-up and therapeutic outcomes in Sjogren's syndrome (SS)-associated peripheral neuropathy. In this study, we aim to study the clinical, electrophysiological spectrum and therapeutic responses among the different subtypes of SS-associated neuropathy. The predictors of suboptimal treatment response will be identified. METHODS: The study included a retrospective cohort of patients with SS-associated neuropathy between January 2012 and November 2015...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28904457/delayed-orthostatic-hypotension-a-pilot-study-from-india
#5
Arun Grace Roy, Siby Gopinath, Suresh Kumar, Sudheeran Kannoth, Anand Kumar
INTRODUCTION: Orthostatic hypotension is defined as a sustained decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within three minutes of standing compared with blood pressure from the sitting or supine position or by head-up tilt-table testing (1). When sustained blood pressure (BP) drop is after three minutes of upright posture it is called delayed orthostatic hypotension (delayed OH) (2). AIM OF THE STUDY: To detect the incidence of delayed orthostatic hypotension in patients referred to our autonomic lab...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28902695/effectiveness-of-droxidopa-compared-to-midodrine-in-standing-blood-pressure-and-orthostatic-tolerance-in-adults-with-neurogenic-orthostatic-hypotension-a-systematic-review-protocol
#6
Kelli Patrick, Tina Martin
The question of this review is: what is the effectiveness of droxidopa compared to midodrine on standing blood pressure and orthostatic intolerance symptoms in adults with neurogenic orthostatic hypotension?
September 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28895755/hemodynamic-characterization-of-hypertensive-patients-with-an-exaggerated-orthostatic-blood-pressure-variation
#7
Jessica Barochiner, Lucas S Aparicio, José Alfie, Marcelo A Rada, Margarita S Morales, Carlos R Galarza, Paula E Cuffaro, Marcos J Marín, Rocío Martínez, Gabriel D Waisman
Exaggerated orthostatic blood pressure variation (EOV) is a poorly understood phenomenon related to high cardiovascular risk. We aimed to determine whether hypertensive patients with EOV have a distinct hemodynamic pattern, assessed through impedance cardiography. METHODS: In treated hypertensive patients, we measured the cardiac index (CI), systemic vascular resistance index (SVRI), blood pressure (BP), and heart rate (HR) in the supine and standing (after 3 minutes) positions, defining three groups according to BP variation: 1) Normal orthostatic BP variation (NOV): standing systolic BP (stSBP)-supine systolic BP (suSBP) between -20 and 20 mmHg and standing diastolic BP (stDBP)-supine diastolic BP (suDBP) between -10 and 10 mmHg; 2) orthostatic hypotension (OHypo): stSBP-suSBP≤-20 or stDBP-suDBP≤-10 mmHg; 3) orthostatic hypertension (OHyper): stSBP-suSBP≥20 or stDBP-suDBP≥10 mmHg...
September 12, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28889359/erratum-to-titrating-droxidopa-to-maximize-symptomatic-benefit-in-a-patient-with-parkinson-disease-and-neurogenic-orthostatic-hypotension
#8
Fiona Gupta, Beverly Karabin, Ali Mehdirad
No abstract text is available yet for this article.
September 9, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28889358/erratum-to-managing-neurogenic-orthostatic-hypotension-in-a-patient-presenting-with-pure-autonomic-failure-who-later-developed-parkinson-disease
#9
Fiona Gupta, Daniel Kremens, Steven Vernino, Beverly Karabin
No abstract text is available yet for this article.
September 9, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28887501/voluntary-liquorice-ingestion-increases-blood-pressure-via-increased-volume-load-elevated-peripheral-arterial-resistance-and-decreased-aortic-compliance
#10
Elina J Hautaniemi, Anna M Tahvanainen, Jenni K Koskela, Antti J Tikkakoski, Mika Kähönen, Marko Uitto, Kalle Sipilä, Onni Niemelä, Jukka Mustonen, Ilkka H Pörsti
We investigated the haemodynamic effects of two-week liquorice exposure (glycyrrhizin dose 290-370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885363/prevalence-risk-factors-and-prognosis-of-orthostatic-hypotension-in-diabetic-patients-a-systematic-review-and-meta-analysis
#11
REVIEW
Yu Zhou, Su-Jie Ke, Xiao-Ping Qiu, Li-Bin Liu
BACKGROUND: Orthostatic hypotension (OH) is a major clinical sign of cardiovascular autonomic dysfunction in diabetic patients. Our aim was to quantitatively evaluate the prevalence and risk factors of OH in patients with diabetes mellitus (DM) and assess its prognosis. METHODS: A comprehensive search of the PubMed, Embase, China National Knowledge Infrastructure, VIP Chinese Journal, Wanfang, and SINOMED databases was conducted for related published work up to September 25, 2016, and manually searched eligible studies from the references in accordance with the inclusion criteria...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883237/chronic-intestinal-pseudo-obstruction-and-orthostatic-hypotension-associated-with-small-cell-lung-cancer-that-improved-with-tumor-reduction-after-chemoradiotherapy
#12
Yusuke Izumi, Takeshi Masuda, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Chronic intestinal pseudo-obstruction (CIPO) is a rare disease with symptoms of ileus without obstruction. Most cases of CIPO are idiopathic, and CIPO as a paraneoplastic neurological syndrome (PNS) associated with small cell lung cancer (SCLC) is rare. A 63-year-old man was diagnosed with functional ileus and confined to bed due to orthostatic hypotension. Chest computed tomography revealed a right hilar mass suspected of being lung cancer. Based on detailed examinations, he was diagnosed with limited-stage SCLC...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28882124/phenotypic-expressions-of-hereditary-transthyretin-ala97ser-related-amyloidosis-attr-in-taiwanese
#13
Hui-Ching Hsu, Ming-Feng Liao, Jung-Lung Hsu, Ai-Lun Lo, Hung-Chou Kuo, Rong-Kuo Lyu, Victor Chien-Chia Wu, Chih-Wei Wang, Long-Sun Ro
BACKGROUND: The disease course and early signs specific to ATTR Ala97Ser, the most common endemic mutation in Taiwan, have not been well described. Since new medications can slow down the rate of disease progression, the early diagnosis of this heterogeneous and fatal disease becomes critical. METHODS: We retrospectively reviewed the characteristics of genetically confirmed ATTR Ala97Ser patients at a tertiary referral medical center. RESULTS: Eight patients from 7 different families were enrolled (61...
September 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28879902/review-of-tremor-in-parkinson-s-disease-and-atypical-parkinsonian-disorders
#14
Pooja Mailankody, M Netravathi, Pramod Kumar Pal
Rest tremor (RT), a cardinal feature of Parkinson's disease (PD) is often accompanied by other types of tremor such as action tremor, which includes postural tremor, kinetic tremor, re-emergent tremor (ReT), and orthostatic tremor (OT). Literature on other tremors of PD, especially ReT and OT, is scarce. Tremor can be present in any of the atypical parkinsonian disorders such as progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, and dementia with Lewy bodies. RT can even be the presenting symptom of these disorders...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28873293/the-role-of-midodrine-for-hypotension-outside-of-the-intensive-care-unit
#15
Lawrence B Gutman, Ben J Wilson
Midodrine is an oral, peripherally acting alpha-adrenergic agonist. After gaining Food and Drug Administration (FDA) approval in 1996 for orthostatic hypotension, its use has evolved to target vasoplegic conditions such as intradialytic hypotension in the end-stage renal disease population, refractory ascites in cirrhotic patients to support diuresis, and in hepatorenal syndrome. Upon oral ingestion, the drug undergoes enzymatic hydrolysis to an active metabolite, desglymidodrine. Its use has been well tolerated at 2...
August 23, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28866058/surgical-fat-patch-improves-secondary-intracranial-hypotension-orthostatic-headache-associated-with-lumbosacral-dural-ectasia-case-report
#16
Beretta Elena, Franzini Andrea, Cordella Roberto, Nazzi Vittoria, Valentini Laura Grazia, Franzini Angelo
BACKGROUND: Secondary intracranial hypotension is a clinical syndrome associated with the reduction of the cerebrospinal fluid volume and dural continuity violation. The main symptoms are orthostatic headache associated with nausea, vomiting, diplopia, dizziness and tinnitus. The treatment is usually non-specific. CASE DESCRIPTION: The authors describe the case of a 37-years-old woman who developed secondary intracranial hypotension caused by lumbosacral iatrogenic dural ectasia following de-tethering surgery...
August 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28863200/autonomic-dysfunction-a-guide-for-fps
#17
Kristen Thornton, Marlon O Mitchell
Impotence, bladder dysfunction, GI symptoms, and orthostatic hypotension can signal autonomic dysfunction. Here's what you'll see and how to respond.
September 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28862943/inter-relations-of-orthostatic-blood-pressure-change-aortic-stiffness-and-brain-structure-and-function-in-young-adults
#18
Leroy L Cooper, Jayandra J Himali, Alyssa Torjesen, Connie W Tsao, Alexa Beiser, Naomi M Hamburg, Charles DeCarli, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase, Gary F Mitchell
BACKGROUND: Relations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment. METHODS AND RESULTS: In a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age±SD, 47±8 years), we assessed orthostatic change in mean arterial pressure (MAP), aortic stiffness (carotid-femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging...
August 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28862519/novel-insights-into-symptomatology-of-moyamoya-disease-in-pediatric-patients-survey-of-symptoms-suggestive-of-orthostatic-intolerance
#19
Haruto Uchino, Ken Kazumata, Masaki Ito, Naoki Nakayama, Kiyohiro Houkin
OBJECTIVE A specific population of young patients with moyamoya disease (MMD) persistently experience physical symptoms not attributable to focal ischemia. These symptoms, highly suggestive of orthostatic intolerance (also termed "orthostatic dysregulation"), were investigated and reported as potential determinants of quality of life in young MMD patients. METHODS Forty-six patients (6-30 years of age) were selected from a group of 122 patients who were diagnosed with MMD before 18 years of age. The authors administered a structured questionnaire consisting of 11 items based on screening checklists published in the Japanese clinical guidelines for juvenile orthostatic dysregulation in young patients...
September 1, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28862474/tympanic-membrane-temperature-decreases-during-head-up-tilt-relation-to-frontal-lobe-oxygenation-and-middle-cerebral-artery-mean-blood-flow-velocity
#20
David Lorr, Anton Lund, Mats Fredrikson, Niels H Secher
INTRODUCTION: Changes in blood flow influence temperature of surrounding tissues. Since the internal carotid artery (ICA) and internal jugular vein (IJV) neighbor the tympanic membrane, changes in their blood flow most likely determine changes in tympanic membrane temperature (TMT). We sought to evaluate the relationship between changes during a head-up tilt (HUT) induced reduction in cerebral blood flow (CBF) and TMT. METHODS: Ten male subjects (age 19-28 years) underwent 50° HUT until presyncope...
September 1, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
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