keyword
MENU ▼
Read by QxMD icon Read
search

eGFR 59

keyword
https://www.readbyqxmd.com/read/29040276/the-impact-of-acute-kidney-injury-on-in-hospital-mortality-in-acute-ischemic-stroke-patients-undergoing-intravenous-thrombolysis
#1
Florica Gadalean, Mihaela Simu, Florina Parv, Ruxandra Vorovenci, Raluca Tudor, Adalbert Schiller, Romulus Timar, Ligia Petrica, Silvia Velciov, Cristina Gluhovschi, Flaviu Bob, Adelina Mihaescu, Bogdan Timar, Goce Spasovski, Viviana Ivan
INTRODUCTION: Acute kidney injury (AKI) increases the risk of death in acute ischemic stroke (AIS) patients. Intravenous thrombolytic therapy (iv. rt-PA) seems to be the most effective treatment for AIS patients. The effects of AKI on iv. rt-PA treated AIS cases is less studied. Our paper addresses this issue. METHODS: 45 consecutive stroke patients treated with iv. rt-PA (median age = 64 years; 29 male) and 59 age and sex matched controls not eligible for iv. rt-PA have been enrolled in our study...
2017: PloS One
https://www.readbyqxmd.com/read/29036269/longitudinal-blood-pressure-changes-and-kidney-function-decline-in-persons-without-chronic-kidney-disease-findings-from-the-mesa-study
#2
Gregory L Judson, Anna D Rubinsky, Michael G Shlipak, Ronit Katz, Holly Kramer, David R Jacobs, Michelle C Odden, Carmen A Peralta
Background: While changes in blood pressure (BP) are independently associated with cardiovascular events, less is known about the association between changes in BP and subsequent changes in renal function in adults with an estimated glomerular filtration rate (eGFR) of > 60 ml/min/1.73 m2. Methods: The present study included 3,920 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study who had ≥2 BP measurements during the first 5 years of MESA and had eGFR measurements at both year 5 and 10...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29029879/reduced-renal-function-in-patients-with-myotonic-dystrophy-type-1-and-the-association-to-ctg-expansion-and-other-potential-risk-factors-for-chronic-kidney-disease
#3
Annika Aldenbratt, Christopher Lindberg, Maria K Svensson
Myotonic dystrophy type 1 (DM1) affects several organs. Disease severity and age at onset are correlated to the CTG repeat expansion. The aim of this study was to assess renal function and the association to numbers of CTG repeat expansion in patients with DM1. Ninety-eight patients with DM1 were included. Glomerular filtration rate (measured GFR) was measured using iohexol clearance. Data on CTG repeats were available in 83/98 (85%) patients. The overall mGFR was 74 (16) ml/min/1.73 m(2) (range 38-134). Sixty-four patients (69%) had a mild and sixteen patients (17%) a moderate decrease in renal function (mGFR 60-89 and 30-59 ml/min/1...
August 15, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29029530/which-treatment-is-preferred-for-advanced-non-small-cell-lung-cancer-with-wild-type-epidermal-growth-factor-receptor-in-second-line-therapy-a-meta-analysis-comparing-immune-checkpoint-inhibitor-tyrosine-kinase-inhibitor-and-chemotherapy
#4
Di Wu, Chongyang Duan, Fenfang Wu, Liyong Chen, Size Chen
BACKGROUND: The recommendations regarding the optimum treatment for advanced non-small-cell lung cancer (NSCLC) patients with wild-type (WT) epidermal growth factor receptor (EGFR) tumors remain unclear. This meta-analysis was conducted to assess the efficacy among programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) antibody, EGFR-tyrosine kinase inhibitors (TKI) and chemotherapy in second-and third-line therapy. PATIENTS AND METHODS: Randomized trials investigating two of the three treatments were searched and included...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29025664/preparation-and-characterization-of-gellan-gum-glucosamine-clioquinol-film-as-oral-cancer-treatment-patch
#5
Wanchi Tsai, Huifang Tsai, Yinuan Wong, Juiyen Hong, Shwujen Chang, Mingwei Lee
To administer cancer drugs with improved convenience to patients and to enhance the bioavailability of cancer drugs for oral cancer therapy, this study prepared gellan gum/glucosamine/clioquinol (GG/GS/CQ) film as the oral cancer treatment patch. GG/GS/CQ film fabricated through the EDC-mediated coupling reactions (GG/GS/CQ/EDC film). The film of the physicochemical properties and drug release kinetics were studied. The effectiveness of GG/GS/CQ/EDC film as oral cancer treatment patch were evaluated with the animal model...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29016630/association-between-kidney-function-and-genetic-polymorphisms-in-atherosclerotic-and-chronic-kidney-diseases-a-cross-sectional-study-in-japanese-male-workers
#6
Yoko Kubo, Takahiro Imaizumi, Masahiko Ando, Masahiro Nakatochi, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Kyoko Kikuchi, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui, Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida, Shoichi Maruyama
BACKGROUND: Several single nucleotide polymorphisms (SNPs) have been implicated in the predisposition to chronic kidney disease (CKD). Atherosclerotic disease is deeply involved in the incidence of CKD; however, whether SNPs related to arteriosclerosis are involved in CKD remains unclear. This study aimed to identify SNPs associated with CKD and to examine whether risk allele accumulation is associated with CKD. METHODS: We conducted a cross-sectional study using data of 4814 male workers to examine the association between estimated glomerular filtration rate (eGFR) and 59 candidate polymorphisms (17 CKD, 42 atherosclerotic diseases)...
2017: PloS One
https://www.readbyqxmd.com/read/29016597/the-clinical-utility-and-cost-impact-of-cystatin-c-measurement-in-the-diagnosis-and-management-of-chronic-kidney-disease-a-primary-care-cohort-study
#7
Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal
BACKGROUND: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-based estimates of GFR be used to confirm or exclude the diagnosis in people with GFR 45-59 ml/min/1.73 m2 and no albuminuria (CKD G3aA1). Whilst there is good evidence for cystatin C being a marker of GFR and risk in people with CKD, its use to define CKD in this manner has not been evaluated in primary care, the setting in which most people with GFR in this range are managed...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28994180/a-conjugate-of-an-anti-egfr-vhh-and-a-cell-penetrating-peptide-drives-receptor-internalization-and-blocks-egfr-activation
#8
Sanne van Lith, Dirk van den Brand, Rike Wallbrecher, Sander van Duijnhoven, Roland Brock, William Leenders
Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell penetrating peptide, corresponding to amino acids 38-59 of human lactoferrin, and the recombinant llama single-domain antibody (VHH) 7D12 that binds the human epidermal growth factor receptor (EGFR), was generated via sortase A-mediated transpeptidation. The conjugate blocks EGF-mediated EGFR activation with higher efficacy than both modalities alone, a phenomenon that is caused by both effective receptor blockade and internalization...
October 10, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28992939/kidney-function-bone-mineral-metabolism-markers-and-future-risk-of-peripheral-artery-disease
#9
Chao Yang, Lucia Kwak, Shoshana H Ballew, Pranav S Garimella, Bernard G Jaar, Aaron R Folsom, Gerardo Heiss, Elizabeth Selvin, Pamela L Lutsey, Josef Coresh, Kunihiro Matsushita
BACKGROUND AND AIMS: Reduced kidney function is a risk factor for lower-extremity peripheral artery disease (PAD). However, the associations of novel filtration markers with PAD are yet to be quantified. Moreover, little is known on whether bone-mineral metabolism (BMM) markers are related to incident PAD beyond kidney function. METHODS: Using data from 12,472 participants at baseline (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) study, we comprehensively quantified the associations of kidney related markers with incident PAD (defined as hospitalizations with diagnosis of lower-extremity atherosclerosis, revascularization, or amputation)...
September 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28992348/location-of-glomerular-immune-deposits-not-codeposition-of-immunoglobulin-g-influences-definitive-renal-outcomes-in-immunoglobulin-a-nephropathy
#10
Anthony S Alvarado, Nicole K Andeen, Sergey Brodsky, Alice Hinton, Tibor Nadasdy, Charles E Alpers, Christopher Blosser, Behzad Najafian, Brad H Rovin
Background: It has been suggested that the prognosis of immunoglobulin (IgA) nephropathy (IgAN) is adversely affected if there is codeposition of IgG in the glomeruli or if immune deposits are present in the glomerular capillary walls. We sought to understand how these variables affect clinical outcome. Methods: A total of 80 IgAN biopsies were retrospectively divided into groups: (i) IgA without IgG deposition versus IgA + IgG and (ii) immune deposits restricted to the mesangium versus mesangium and peripheral capillary walls (PCWs)...
August 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28992097/association-of-serum-albumin-levels-with-kidney-function-decline-and-incident-chronic-kidney-disease-in-elders
#11
Joshua Lang, Ronit Katz, Joachim H Ix, Orlando M Gutierrez, Carmen A Peralta, Chirag R Parikh, Suzanne Satterfield, Snezana Petrovic, Prasad Devarajan, Michael Bennett, Linda F Fried, Steven R Cummings, Mark J Sarnak, Michael G Shlipak
Background: Previous studies in HIV-infected individuals have demonstrated serum albumin to be strongly associated with kidney function decline, independent of urine albumin and inflammatory markers. Lower serum albumin concentrations may be an under-appreciated risk factor for kidney function decline in elders. Methods: We performed a cohort analysis in the Health Aging and Body Composition Study, a cohort of well-functioning, bi-racial, community-dwelling elders between the age of 70 and 79 years...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28991887/changes-in-kidney-function-associated-with-daily-tenofovir-disoproxil-fumarate-emtricitabine-for-hiv-preexposure-prophylaxis-use-in-the-united-states-demonstration-project
#12
Eric C Tang, Eric Vittinghoff, Peter L Anderson, Stephanie E Cohen, Susanne Doblecki-Lewis, Oliver Bacon, Megan E Coleman, Wairimu Chege, Susan P Buchbinder, Michael A Kolber, Richard Elion, Michael Shlipak, Albert Y Liu
BACKGROUND: HIV preexposure prophylaxis (PrEP) using daily oral tenofovir-disoproxil-fumarate/emtricitabine (TDF/FTC) is effective for preventing HIV acquisition, but concerns remain about its potential kidney toxicity. This study examined kidney function in individuals using PrEP in real-world clinical settings. SETTING: Demonstration project in two sexually transmitted infection clinics and a community health center. METHODS: We evaluated kidney function among men who have sex with men and transgender women taking TDF/FTC PrEP for up to 48 weeks...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28988295/associations-between-clinical-data-and-computed-tomography-features-in-patients-with-epidermal-growth-factor-receptor-mutations-in-lung-adenocarcinoma
#13
Yiyuan Cao, Haibo Xu, Meiyan Liao, Yanjuan Qu, Liying Xu, Dongyong Zhu, Bicheng Wang, Sufang Tian
BACKGROUND: To analyse the differences in computed tomography (CT) features between patients with lung adenocarcinoma who have epidermal growth factor receptor (EGFR) mutations and those who have wild-type EGFR. METHODS: Patients with lung adenocarcinoma (n = 156) were enrolled from October 2013 to March 2016, including 56 patients with wild-type EGFR and 100 patients with EGFR mutations. Two independent radiologists evaluated patient characteristics and imaging features...
October 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28975101/clustering-of-chronic-kidney-disease-and-cardiovascular-risk-factors-in-south-west-nigeria
#14
Rotimi Oluyombo, Michael Adeyemi Olamoyegun, Olugbenga Edward Ayodele, Patience Olayinka Akinwusi, Adewale Akinsola
BACKGROUND: There exists a synergy between chronic kidney disease (CKD) and cardiovascular risk factors (CVRFs) with increased morbidity and poor outcomes. OBJECTIVES: Data relating to this clustering in black homogenous populations is scanty. We aim to investigate this relationship in Nigerian communities. PATIENTS AND METHODS: It was a cross-sectional observation study from semi-urban communities in South-West Nigeria. We used modified World Health Organization (WHO) questionnaire on chronic diseases (WHO STEPS) to gather information on socio-demographic data, biophysical and clinical characteristics...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28974261/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-57-66-edited-by-chinese-journal-of-cancer
#15
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 57. What are the major stresses that drive the formation, progression, and metastasis of a cancer? Question 58. What is the mechanism responsible for altering an acidic intracellular pH and a basic extracellular pH in normal tissue cells to a basic intracellular pH and an acidic extracellular pH in cancer cells, a fundamental and yet largely ignored phenomenon? Question 59...
October 3, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28965904/nephrogenic-systemic-fibrosis-a-survey-of-the-use-of-gadolinium-based-contrast-agents-in-ghana
#16
A D Piersson, P N Gorleku
INTRODUCTION: The aim of this study is to identify current practice of administration of gadolinium-based contrast agents (GBCAs) in Ghana. METHOD: A total of 13 MRI (magnetic resonance imaging) facilities were sent a survey questionnaire to request information on their current practice with the use of GBCAs. RESULTS: Gadodiamide, a high risk GBCA accounted for 67% of first line agents. 5 (42%) had a departmental protocol on the administration of GBCAs with regards to its association with nephrogenic systemic fibrosis (NSF)...
November 2017: Radiography
https://www.readbyqxmd.com/read/28964618/long-term-fate-of-renal-function-after-open-surgery-for-juxtarenal-and-pararenal-aortic-aneurysm
#17
Masayuki Sugimoto, Noriko Takahashi, Kiyoaki Niimi, Akio Kodama, Hiroshi Banno, Kimihiro Komori
BACKGROUND: Although the indications for endovascular aneurysm repair for abdominal aortic aneurysm have been expanding, our primary strategy for pararenal and juxtarenal abdominal aortic aneurysm (P/JRAA) is open surgery (OS). One consequence of OS for P/JRAA is transient renal ischemia owing to renal artery clamping, which can be followed by acute kidney injury (AKI). Prior studies referred to the impact of renal ischemia on AKI, but they have rarely evaluated longer-term renal function...
September 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28964554/impact-of-cardio-renal-syndrome-on-adverse-outcomes-in-patients-with-fabry-disease-in-a-long-term-follow-up
#18
M Siegenthaler, U Huynh-Do, P Krayenbuehl, E Pollock, U Widmer, H Debaix, E Olinger, M Frank, M Namdar, F Ruschitzka, A Nowak
AIMS: Fabry disease (FD) is a rare X-linked lysosomal storage disease with a deficiency of α-galactosidase A leading to progressive sphingolipid accumulation in different organs, among them heart and kidney. We evaluated the impact of cardio-renal syndrome (CRS) on the incidence of major cardiovascular complications and death in a prospective FD cohort. METHODS AND RESULTS: A total of 104 genetically proven FD patients were annually followed at the University Hospitals Zurich and Bern...
September 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28958502/dacomitinib-versus-gefitinib-as-first-line-treatment-for-patients-with-egfr-mutation-positive-non-small-cell-lung-cancer-archer-1050-a-randomised-open-label-phase-3-trial
#19
Yi-Long Wu, Ying Cheng, Xiangdong Zhou, Ki Hyeong Lee, Kazuhiko Nakagawa, Seiji Niho, Fumito Tsuji, Rolf Linke, Rafael Rosell, Jesus Corral, Maria Rita Migliorino, Adam Pluzanski, Eric I Sbar, Tao Wang, Jane Liang White, Sashi Nadanaciva, Rickard Sandin, Tony S Mok
BACKGROUND: Dacomitinib is a second-generation, irreversible EGFR tyrosine kinase inhibitor. We compared its efficacy and safety with that of the reversible EGFR tyrosine kinase inhibitor gefitinib in the first-line treatment of patients with advanced EGFR-mutation-positive non-small-cell lung cancer (NSCLC). METHODS: In this international, multicentre, randomised, open-label, phase 3 study (ARCHER 1050), we enrolled adults (aged ≥18 years or ≥20 years in Japan and South Korea) with newly diagnosed advanced NSCLC and one EGFR mutation (exon 19 deletion or Leu858Arg) at 71 academic medical centres and university hospitals in seven countries or special administrative regions...
September 25, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28948753/impact-of-chronic-kidney-disease-on-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-a-long-term-single-centre-mortality-study
#20
Mattia Peyracchia, Paolo Scacciatella, Federico Conrotto, Ilaria Meynet, Lorenza M Biava, Carlo Budano, Mauro Pennone, Maurizio D'Amico, Fiorenzo Gaita
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). METHODS: The study cohort consists of 501 patients (pts), enrolled from October 2005 to December 2012. The median follow-up was 46...
September 25, 2017: Minerva Cardioangiologica
keyword
keyword
71588
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"