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eGFR 59

Perdana Samekto Tyasnugroho Suyoto
Meta-analysis was conducted to clarify the effect of low carbohydrate diet (LCD) on renal function in patients with type 2 diabetes mellitus (T2DM). An extensive literature search was conducted on scientific databases including PubMed, Scopus, and Cochrane Library until September 2017. Only controlled trials on human subjects written in English were included in this meta-analysis. Several markers of renal function were compared between subjects who adopted a LCD or control diet, including estimated glomerular filtration rate (eGFR), creatinine clearance, urinary albumin, serum creatinine, and serum uric acid...
June 14, 2018: Diabetes/metabolism Research and Reviews
Aparna Harbhajanka, Satyapal Chahar, Kristy Miskimen, Paula Silverman, Lyndsay Harris, Nicole Williams, Vinay Varadan, Hannah Gilmore
The transcription factor SOX10 mediates the differentiation of neural crest-derived cells, and SOX10 by immunohistochemistry(IHC) is used primarily for the diagnosis of melanoma. SOX10 expression has been previously documented in benign breast myoepithelial cells. However there is limited literature on its expression in triple negative breast carcinoma(TNBC). The aim was to study the clinical, pathologic and molecular profiles of SOX10+ tumors in TNBC. Tissue microarrays of TNBC were evaluated for SOX10 expression in 48cases...
June 9, 2018: Human Pathology
Paola Fioretto, Stefano Del Prato, John B Buse, Ronald Goldenberg, Francesco Giorgino, Daniel Reyner, Anna Maria Langkilde, C David Sjӧstrӧm, Peter Sartipy
AIMS: Dapagliflozin is a selective inhibitor of sodium glucose co-transporter 2 (SGLT2). This study assessed the efficacy and safety of dapagliflozin 10 mg versus placebo in patients with type 2 diabetes (T2D) and moderate renal impairment (estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73m2 ; chronic kidney disease [CKD] stage 3A). MATERIALS AND METHODS: In this double-blind, parallel group, Phase 3 study (NCT02413398, patients with inadequately controlled T2D (HbA1c 7...
June 11, 2018: Diabetes, Obesity & Metabolism
Kyung Soo Kim, Seok Won Park, Yong Wook Cho, Soo Kyung Kim
BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² and/or the presence of albuminuria. RESULTS: The mean age was 70...
May 31, 2018: Diabetes & Metabolism Journal
Ming Yu, Sean K Maden, Matthew Stachler, Andrew M Kaz, Jessica Ayers, Yuna Guo, Kelly T Carter, Amber Willbanks, Tai J Heinzerling, Rachele M O'Leary, Xinsen Xu, Adam Bass, Apoorva K Chandar, Amitabh Chak, Robin Elliott, Joseph E Willis, Sanford D Markowitz, William M Grady
OBJECTIVE: To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). DESIGN: We performed genome-wide DNA methylation profiling on samples of non-dysplastic BE from cancer-free patients (n=59), EAC (n=23), normal squamous oesophagus (n=33) and normal fundus (n=9), and identified methylation subtypes using a recursively partitioned mixture model. We assessed genomic alterations for 9 BE and 22 EAC samples with massively parallel sequencing of 243 EAC-associated genes, and we conducted integrative analyses with transcriptome data to identify epigenetically repressed genes...
June 8, 2018: Gut
Andrew Willis, Winston Crasto, Laura Gray, Helen Dallosso, Ghazala Waheed, Geri Gray, Melanie J Davies, Kamlesh Khunti
BACKGROUND: Adherence to evidence-based cardiovascular risk factor targets in patients with type 2 diabetes and microalbuminuria has shown long-term reduction in mortality and morbidity. Strategies to achieve such adherence have been delivered at individual patient level and are not cost-effective. Health care professional-level intervention has the potential to promote better adherence at lower cost. OBJECTIVE: The aim of this study was to assess the effectiveness of a multifactorial technology-driven intervention comprising health care professional training, a software prompt installed on practice systems, clinician email support, and enhanced performance and feedback reporting...
June 8, 2018: JMIR Research Protocols
Sung Jin Kim, Jaeyoon Jung, Chanwoo Lee, Sejun Park, Sang Hoon Song, Hye-Sung Won, Kun Suk Kim
We investigated long-term functional changes in the kidney and bladder of patients with posterior urethral valve (PUV) who underwent fetal intervention or postnatal surgery.We retrospectively reviewed the medical records of 28 consecutive patients treated for PUV at our institution. Detailed data on medical and surgical histories, particularly on pre- and postnatal treatment modality, including fetal vesicoamniotic shunt, endoscopic valve ablation, and vesicostomy, were collected and analyzed. Long-term renal function was evaluated based on serum levels of creatinine (sCr), estimated glomerular filtration rate (eGFR), and renal scans...
June 2018: Medicine (Baltimore)
Benjamin Lazarus, Aozhou Wu, Jung-Im Shin, Yingying Sang, G Caleb Alexander, Alex Secora, Lesley A Inker, Josef Coresh, Alex R Chang, Morgan E Grams
Importance: Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in patients with chronic kidney disease. Objective: To quantify the association between metformin use and hospitalization with acidosis across the range of estimated glomerular filtration rate (eGFR), accounting for change in eGFR stage over time...
June 4, 2018: JAMA Internal Medicine
Masao Iwagami, Laurie A Tomlinson, Kathryn E Mansfield, Ian J Douglas, Liam Smeeth, Dorothea Nitsch
AIM: To estimate the risk of gastrointestinal (GI) bleeding associated with serotonin reuptake inhibitors (SSRIs) by level of kidney function. METHODS: We conducted a cohort study using the Clinical Practice Research Datalink linked to Hospital Episode Statistics. We identified patients with chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73m2 for ≥3 months), and a comparison group of patients without it. Patients with CKD were further classified as stage 3a (eGFR 45-59 mL/min/1...
June 4, 2018: British Journal of Clinical Pharmacology
Chun-Chieh Wang, Huey-Shyan Lin, Yi-Luan Huang, Fu-Zong Wu, Chiung-Chen Chuo, Yu-Jeng Ju, Carol C Wu, Ming-Ting Wu
BACKGROUND: To evaluate the frequency of renal artery dissection (RAD) and renal hypoperfusion in aortic dissection (AD) and its effect on subsequent renal atrophy in patients who did not undergo therapeutic intervention. METHODS: Initial CT data of 155 patients with acute AD (Stanford type A = 88, B = 67) were retrospectively analyzed. The false lumen statuses were patent (n = 94), partially thrombosed (n = 25), and completely thrombosed (n = 36) (also called as intramural hematoma (IMH))...
May 26, 2018: Journal of Cardiovascular Computed Tomography
Athanasios Kitsos, Evangelia Dounousi, Rigas Kalaitzidis, Anna Challa, Kostas C Siamopoulos, Stelios Tigas
OBJECTIVE: Obesity and renal disease are both associated with low serum 25(OH)D. The aims of the present study were to (a) assess vitamin D status and compare serum vitamin D levels in overweight/obese versus normal-weight individuals according to eGFR and (b) assess the role of 25(OH)D in the development of secondary hyperparathyroidism (SHPT). DESIGN: Serum 25(OH)D, 1,25(OH)2 D, parathyroid hormone (PTH), calcium, and phosphate were measured in 104 subjects with BMI > 25 kg/m2 ...
April 17, 2018: Hormones: International Journal of Endocrinology and Metabolism
Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Chunxue Wang, Yuesong Pan, Xia Meng, Yilong Wang, Yongjun Wang
OBJECTIVES: Statin use during hospitalization improves prognosis in patients with ischaemic stroke. However, it remains uncertain whether acute ischaemic stroke patients with chronic kidney disease (CKD) benefit from statin therapy. We investigated the effect of statin use during hospitalization in reducing short-term mortality of patients with ischaemic stroke and CKD. METHODS: Data of first-ever ischaemic stroke patients without a history of pre-stroke statin treatment was derived from the China National Stroke Registry...
May 31, 2018: European Neurology
Lewei Zhu, Long Jiang, Jie Yang, Weiquan Gu, Jianxing He
Background: Adenosquamous carcinoma (ASC) is a mixed glandular and squamous cell carcinoma (SCC) with more aggressive behavior than the other histologic subtypes of lung cancer. We aim to evaluate the prognosis of patients with ASC after surgical resection. Methods: We reviewed records of patients who underwent surgical resection for lung cancer in two institutes between January 2010 and December 2015. Survival data were collected with a median follow-up of 59 (range from 10 to 85) months...
April 2018: Journal of Thoracic Disease
Hengrui Liang, Zhenkui Pan, Wei Wang, Chengye Guo, Difei Chen, Jianrong Zhang, Yiyin Zhang, Shiyan Tang, Jianxing He, Wenhua Liang
Background: Treatment-naive epidermal growth factor receptor (EGFR) T790M mutation is more inclined to coexist with L858R than with 19 del in non-small cell lung cancer (NSCLC) patients. However, EGFR-tyrosine kinase inhibitors (EGFR-TKIs) might alter this status. We sought to compare the prevalence of T790M upon acquired resistance to EGFR-TKIs between 19 del and L858R by assembling all existing data. Methods: Electronic databases were comprehensively searched for eligible studies...
April 2018: Journal of Thoracic Disease
Herbert H Loong, Victoria M Raymond, Yukimasa Shiotsu, Daniel T T Chua, Peter M L Teo, Tony Yung, Stan Skrzypczak, Richard B Lanman, Tony S K Mok
BACKGROUND: Genomic profiling of cell-free circulating tumor DNA (ctDNA) is a potential alternative to repeat invasive biopsy in patients with advanced cancer. We report the first real-world cohort of comprehensive genomic assessments of patients with non-small-cell lung cancer (NSCLC) in a Chinese population. PATIENTS AND METHODS: We performed a retrospective analysis of patients with advanced or metastatic NSCLC whose physician requested ctDNA-based genomic profiling using the Guardant360 platform from January 2016 to June 2017...
May 7, 2018: Clinical Lung Cancer
Jiyun Lee, Joon Ho Shim, Woong-Yang Park, Hee Kyung Kim, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Epidermal growth factor receptor (EGFR)‒tyrosine kinase inhibitors (TKIs) are effective clinical therapeutics for EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib, a third-generation EGFR TKI, has proven effective against T790M mutations. However, the vast majority of patients acquire resistance following successful treatment. A 59-year-old female metastatic NSCLC patient developed resistance after 43 weeks of osimertinib. CancerSCAN of the metastatic liver lesion revealed a EGFR C797G mutation at an allele frequency of 72%, a pre-existing T790M mutation (73%) in cis and an exon 19 deletion (87%)...
May 23, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
C Rory Goodwin, Prakash Rath, Olutobi Oyinlade, Hernando Lopez, Salman Mughal, Shuli Xia, Yunqing Li, Harsharan Kaur, Xin Zhou, A Karim Ahmed, Sandra Ho, Alessandro Olivi, Bachchu Lal
OBJECTIVES: Receptor tyrosine kinases (RTK), such as c-Met and epidermal growth factor receptor (EGFR), are implicated in the malignant progression of glioblastoma. Studies show that RTK systems can co-modulate distinct and overlapping oncogenic downstream signaling pathways. EGFRvIII, a constitutively activated EGFR deletion mutant variant, leads to increased tumor growth and diminishes the tumor growth response to HGF: c-Met pathway inhibitor therapy. Conversely, activation of the c-Met pathway diminishes the tumor growth response to EGFR pathway inhibitors...
March 9, 2018: Clinical Neurology and Neurosurgery
Claire Gerber, Xuan Cai, Jungwha Lee, Timothy Craven, Julia Scialla, Nao Souma, Anand Srivastava, Rupal Mehta, Amanda Paluch, Alexander Hodakowski, Rebecca Frazier, Mercedes R Carnethon, Myles Selig Wolf, Tamara Isakova
BACKGROUND AND OBJECTIVES: Type 2 diabetes and associated CKD disproportionately affect blacks. It is uncertain if racial disparities in type 2 diabetes-associated CKD are driven by biologic factors that influence propensity to CKD or by differences in type 2 diabetes care. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a post hoc analysis of 1937 black and 6372 white participants of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial to examine associations of black race with change in eGFR and risks of developing microalbuminuria, macroalbuminuria, incident CKD (eGFR<60 ml/min per 1...
May 24, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Vassilios Raptis, Constantinos Bakogiannis, Charalampos Loutradis, Afroditi K Boutou, Athanasios Sioulis, Elias Balaskas, Pantelis Zebekakis, Pantelis A Sarafidis
BACKGROUND/AIMS: The pathophysiology of renal disease progression in autosomal dominant polycystic disease (ADPKD) is largely unknown. Recent evidence suggests microvascular dysfunction leading to renal ischemia, as an additional pathway for renal function decline. This study examined the levels of serum Fas ligand (FasL), serum myostatin and urine transforming growth factor-beta 1 (TGF-β1) and their association with markers of endothelial dysfunction, in ADPKD patients with preserved or impaired renal function...
May 22, 2018: Kidney & Blood Pressure Research
Houry Puzantian, Scott R Akers, Garrett Oldland, Khuzaima Javaid, Rachana Miller, Yueya Ge, Bilal Ansari, Jonathan Lee, Arpita Suri, Zeba Hasmath, Raymond Townsend, Julio A Chirinos
Background: Large artery stiffening is increased in advanced CKD, but likely develops progressively in earlier stages of CKD. Active matrix Gla-Protein (MGP) is a potent vitamin-K dependent inhibitor of vascular calcification. A recent animal model demonstrated intrinsic abnormalities in vitamin K metabolism even in early CKD, but whether early human CKD is associated with vascular vitamin K deficiency is unknown. Methods: We enrolled 137 adults without HF with varying degrees of renal function: normal eGFR (>90 mL/min; n=59), mildly reduced eGFR (stage 2 CKD: eGFR = 60-89 mL/min; n=53) or at least moderately reduced eGFR (stage 3-5 CKD; eGFR<60 ml/min; n=25)...
May 17, 2018: American Journal of Hypertension
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