keyword
https://read.qxmd.com/read/35553968/a-role-for-bd2-selective-bet-inhibitors-in-cocaine-seeking-behaviors
#21
JOURNAL ARTICLE
Christopher J Babigian, Mandakini Singh, Gregory Sartor
Epigenetic mechanisms play important roles in the maladaptive transcriptional and behavioral responses to drugs of abuse. Inhibition of bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation reader proteins, has been shown to reduce cocaine-seeking behaviors in animal models of addiction. To date, the role of BET protein in animal models of substance use disorder (SUD) has only been evaluated using pan-BET inhibitors, small molecules that bind to both bromodomains (BD1 and BD2) in all BET proteins...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35461814/prenatal-morphine-exposure-increases-gamma-oscillation-and-theta-coherence-in-the-rat-reward-system
#22
JOURNAL ARTICLE
Yanmei Chen, Xuebing Wang, Mei Xiao, Na Kang, Wanli Zeng, Jichuan Zhang
Previous studies have found that prenatal morphine (PNM) exposure leads to both increased and decreased risk of substance abuse in offspring. Understanding more about the neurobiological changes after the PNM exposure would help to understand more about this issue. Signalling from dopamine neurons of the ventral tegmental area (VTA) in the mesoaccumbal and mesocortical pathways plays a vital role in drug dependency. To provide further knowledge about the effects of PNM on drug seeking behavior and the dopamine system...
April 21, 2022: Neurotoxicology
https://read.qxmd.com/read/35416731/association-of-drinking-behaviors-with-txnip-dna-methylation-levels-in-leukocytes-among-the-general-japanese-population
#23
JOURNAL ARTICLE
Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Yuji Hattori, Yuya Ishihara, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
Background : Thioredoxin-interacting protein (TXNIP) controls the cellular redox balance by binding to and inhibiting the expression and function of thioredoxin. DNA methylation of the TXNIP gene is involved in the regulation of TXNIP mRNA expression. Changes in TXNIP DNA methylation levels are associated with the development of various diseases such as type 2 diabetes mellitus (T2DM). However, few studies have focused on the influence of lifestyle factors such as alcohol intake on TXNIP DNA methylation. Objectives : This research examines the association of drinking behaviors with TXNIP DNA methylation levels in the general Japanese population...
May 4, 2022: American Journal of Drug and Alcohol Abuse
https://read.qxmd.com/read/35314160/domain-selective-bet-inhibition-attenuates-transcriptional-and-behavioral-responses-to-cocaine
#24
JOURNAL ARTICLE
Mandakini B Singh, Christopher J Babigian, Gregory C Sartor
Epigenetic pharmacotherapies have emerged as a promising treatment option for substance use disorder (SUD) due to their ability to reverse maladaptive transcriptional and behavioral responses to drugs of abuse. In particular, inhibitors of bromodomain and extra terminal domain (BET) reader proteins have been shown to reduce cocaine- and opioid-seeking behaviors in rodents. However, only pan-BET inhibitors, small molecules that bind to both bromodomains (BD1 and BD2) with all BET proteins, have been investigated in animal models of SUD...
March 18, 2022: Neuropharmacology
https://read.qxmd.com/read/34949945/a-review-of-dna-risk-alleles-to-determine-epigenetic-repair-of-mrna-expression-to-prove-therapeutic-effectiveness-in-reward-deficiency-syndrome-rds-embracing-precision-behavioral-management
#25
REVIEW
Kenneth Blum, Bruce Steinberg, Marjorie C Gondre-Lewis, David Baron, Edward J Modestino, Rajendra D Badgaiyan, B William Downs, Debasis Bagchi, Raymond Brewer, Thomas McLaughlin, Abdalla Bowirrat, Mark Gold
This is a review of research on "Precision Behavioral Management" of substance use disorder (SUD). America is experiencing a high prevalence of substance use disorder, primarily involving legal and illegal opioid use. A 3000% increase in treatment for substance abuse has occurred between 2000 and 2016. Unfortunately, present day treatment of opioid abuse involves providing replacement therapy with powerful opioids to, at best, induce harm reduction, not prophylaxis. These interventions do not enhance gene expression and restore the balance of the brain reward system's neurotransmitters...
2021: Psychology Research and Behavior Management
https://read.qxmd.com/read/34895699/prenatal-%C3%AE-9-tetrahydrocannabinol-exposure-in-males-leads-to-motivational-disturbances-related-to-striatal-epigenetic-dysregulation
#26
JOURNAL ARTICLE
Randall J Ellis, Anissa Bara, Claudia A Vargas, Amy L Frick, Eddie Loh, Joseph Landry, Teddy O Uzamere, James E Callens, Qammarah Martin, Prashanth Rajarajan, Kristen Brennand, Aarthi Ramakrishnan, Li Shen, Henrietta Szutorisz, Yasmin L Hurd
BACKGROUND: Cannabis remains one of the most widely abused drugs during pregnancy. In utero exposure to its principal psychoactive component, Δ9 -tetrahydrocannabinol (THC), can result in long-term neuropsychiatric risk for the progeny. This study investigated epigenetic signatures underlying these enduring consequences. METHODS: Rat dams were exposed daily to THC (0.15 mg/kg) during pregnancy, and adult male offspring were examined for reward and depressive-like behavioral endophenotypes...
September 27, 2021: Biological Psychiatry
https://read.qxmd.com/read/34884841/developmental-stressors-induce-innate-immune-memory-in-microglia-and-contribute-to-disease-risk
#27
REVIEW
Elisa Carloni, Adriana Ramos, Lindsay N Hayes
Many types of stressors have an impact on brain development, function, and disease susceptibility including immune stressors, psychosocial stressors, and exposure to drugs of abuse. We propose that these diverse developmental stressors may utilize a common mechanism that underlies impaired cognitive function and neurodevelopmental disorders such as schizophrenia, autism, and mood disorders that can develop in later life as a result of developmental stressors. While these stressors are directed at critical developmental windows, their impacts are long-lasting...
December 2, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34757001/jq1-attenuates-psychostimulant-but-not-opioid-induced-conditioned-place-preference
#28
JOURNAL ARTICLE
C J Babigian, H J Wiedner, C Wahlestedt, G C Sartor
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned behaviors, but their role in the behavioral response to other drugs of abuse remains unclear. To address this knowledge gap, we examined the effects of the BET inhibitor, JQ1, on nicotine, amphetamine, morphine, and oxycodone conditioned place preference (CPP). Similar to previous cocaine studies, systemic administration of JQ1 caused a dose-dependent reduction in the acquisition of amphetamine and nicotine CPP in male mice...
February 10, 2022: Behavioural Brain Research
https://read.qxmd.com/read/34716387/influence-of-psychostimulants-and-opioids-on-epigenetic-modification-of-class-iii-histone-deacetylase-hdac-sirtuins-in-glial-cells
#29
JOURNAL ARTICLE
Kalaiselvi Sivalingam, Mayur Doke, Mansoor A Khan, Thangavel Samikkannu
Substance abuse affects the central nervous system (CNS) and remains a global health problem. Psychostimulants, such as cocaine and methamphetamine (METH), and opioids affect neuronal function and lead to behavioral impairments via epigenetic modification. Epigenetic changes occur via classical pathways, especially the class III histone deacetylase (HDAC)-sirtuin (SIRT) family, that act as cellular sensors to regulate energy homeostasis and coordinate cellular responses to maintain genome integrity. However, SIRT family (1-7)-associated neurodegeneration has not been elucidated in the context of energy metabolism...
October 29, 2021: Scientific Reports
https://read.qxmd.com/read/34627873/epigenetics-in-aud-and-acm
#30
REVIEW
Lin Wu, Yingmei Zhang, Jun Ren
Alcohol consumption prompts detrimental psychological, pathophysiological and health issues, representing one of the major causes of death worldwide. Alcohol use disorder (AUD), which is characterized by compulsive alcohol intake and loss of control over alcohol usage, arises from a complex interplay between genetic and environmental factors. More importantly, long-term abuse of alcohol is often tied with unfavorable cardiac remodeling and contractile alterations, a cadre of cardiac responses collectively known as alcoholic cardiomyopathy (ACM)...
October 7, 2021: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/34453125/molecular-genetics-of-cocaine-use-disorders-in-humans
#31
REVIEW
Noèlia Fernàndez-Castillo, Judit Cabana-Domínguez, Roser Corominas, Bru Cormand
Drug addiction, one of the major health problems worldwide, is characterized by the loss of control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse produce serious consequences on health and have a negative impact on the family environment and on interpersonal and work relationships. At a wider scale, they have significant socio-economic and public health consequences and they cause delinquency and citizen insecurity. Cocaine, a psychostimulant substance, is one of the most used illicit drugs, especially in America, Western Europe, and Australia...
January 2022: Molecular Psychiatry
https://read.qxmd.com/read/34312305/maternal-oxycodone-treatment-results-in-neurobehavioral-disruptions-in-mice-offspring
#32
JOURNAL ARTICLE
Rachel E Martin, Madison T Green, Jessica A Kinkade, Robert R Schmidt, Tess E Willemse, A Katrin Schenk, Jiude Mao, Cheryl S Rosenfeld
Opioid drugs are increasingly being prescribed to pregnant women. Such compounds can also bind and activate opioid receptors in the fetal brain, which could lead to long-term brain and behavioral disruptions. We hypothesized that maternal treatment with oxycodone (OXY), the primary opioid at the center of the current crisis, leads to later neurobehavioral disorders and gene expression changes in the hypothalamus and hippocampus of resulting offspring. Female mice were treated daily with 5 mg OXY/kg or saline solution (control; CTL) for two weeks before breeding and then throughout gestation...
July 2021: ENeuro
https://read.qxmd.com/read/33925016/histone-methylation-regulation-in-neurodegenerative-disorders
#33
REVIEW
Balapal S Basavarajappa, Shivakumar Subbanna
Advances achieved with molecular biology and genomics technologies have permitted investigators to discover epigenetic mechanisms, such as DNA methylation and histone posttranslational modifications, which are critical for gene expression in almost all tissues and in brain health and disease. These advances have influenced much interest in understanding the dysregulation of epigenetic mechanisms in neurodegenerative disorders. Although these disorders diverge in their fundamental causes and pathophysiology, several involve the dysregulation of histone methylation-mediated gene expression...
April 28, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33893716/integration-of-evidence-across-human-and-model-organism-studies-a-meeting-report
#34
REVIEW
Rohan H C Palmer, Emma C Johnson, Hyejung Won, Renato Polimanti, Manav Kapoor, Apurva Chitre, Molly A Bogue, Chelsie E Benca-Bachman, Clarissa C Parker, Oana Ursu, Anurag Verma, Timothy Reynolds, Jason Ernst, Michael Bray, Soo Bin Kwon, Dongbing Lai, Bryan C Quach, Nathan C Gaddis, Laura Saba, Hao Chen, Michael Hawrylycz, Shan Zhang, Yuan Zhou, Spencer Mahaffey, Christian Fischer, Sandra Sanchez-Roige, Anita Bandrowski, Lu Qing, Li Shen, Vivek Philip, Joel Gelernter, Laura J Bierut, Dana B Hancock, Howard J Edenberg, Eric O Johnson, Eric J Nestler, Peter B Barr, Pjotr Prins, Desmond J Smith, Schahram Akbarian, Thorgeir Thorgeirsson, Dave Walton, Erich Baker, Daniel Jacobson, Abraham A Palmer, Michael Miles, Elissa J Chesler, Jake Emerson, Arpana Agrawal, Maryann Martone, Robert W Williams
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs...
April 23, 2021: Genes, Brain, and Behavior
https://read.qxmd.com/read/33789338/comparison-of-the-sensitizing-effects-of-cocaine-and-ethanol-on-histone-deacetylase-isoforms-in-the-rat-brain
#35
JOURNAL ARTICLE
Shijie Xu, Ja Wook Koo, Ung Gu Kang
Behavioral sensitization, an animal model of drug addiction, persists for a prolonged period after repeated exposure to drugs of abuse. The persistence of an addiction behavioral phenotype suggests long-lasting changes in gene regulation at the epigenetic level. We measured the expression of histone deacetylases (HDACs) isoforms in the prefrontal cortex and dorsal striatum following the development of sensitization to cocaine (15 mg/kg, administered five times) and ethanol (0.5 g/kg, administered 15 times) to investigate the epigenetic changes that mediate sensitization...
March 30, 2021: Neuroreport
https://read.qxmd.com/read/33788811/comparison-of-the-sensitizing-effects-of-cocaine-and-ethanol-on-histone-deacetylase-isoforms-in-the-rat-brain
#36
COMPARATIVE STUDY
Shijie Xu, Ja Wook Koo, Ung Gu Kang
Behavioral sensitization, an animal model of drug addiction, persists for a prolonged period after repeated exposure to drugs of abuse. The persistence of an addiction behavioral phenotype suggests long-lasting changes in gene regulation at the epigenetic level. We measured the expression of histone deacetylases (HDACs) isoforms in the prefrontal cortex and dorsal striatum following the development of sensitization to cocaine (15 mg/kg, administered five times) and ethanol (0.5 g/kg, administered 15 times) to investigate the epigenetic changes that mediate sensitization...
April 7, 2021: Neuroreport
https://read.qxmd.com/read/33655865/adolescent-substance-abuse-transgenerational-consequences-and-epigenetics
#37
JOURNAL ARTICLE
Hamed Salmanzadeh, Mohammad Ahmadi-Soleimani, Maryam Azadi, Robert F Halliwell, Hossein Azizi
Adolescence is the transitional period between childhood and adulthood and a critical period in brain development. Adolescence in humans is also associated with increased expression of risk-taking behaviors. Epidemiological and clinical studies, for example, show a surge of drug abuse and raise the hypothesis that the adolescent brain undergoes critical changes resulting in diminished control. Determining how substance abuse during this critical period might cause long-term neurobiological changes in cognition and behavior is therefore critically important...
March 3, 2021: Current Neuropharmacology
https://read.qxmd.com/read/33602824/hdac3-activity-within-the-nucleus-accumbens-regulates-cocaine-induced-plasticity-and-behavior-in-a-cell-type-specific-manner
#38
JOURNAL ARTICLE
R R Campbell, E A Kramár, L Pham, J H Beardwood, A S Augustynski, A J López, O S Chitnis, G Delima, J Banihani, D P Matheos, M A Wood
Epigenetic mechanisms regulate processes of neuroplasticity critical to cocaine-induced behaviors. This includes the class I histone deacetylase (HDAC) HDAC3, known to act as a negative regulator of cocaine-associated memory formation within the nucleus accumbens (NAc). Despite this, it remains unknown how cocaine alters HDAC3-dependent mechanisms. Here, we profiled HDAC3 expression and activity in total NAc mouse tissue following cocaine exposure. Although chronic cocaine did not affect expression of Hdac3 within the NAc, chronic cocaine did affect promoter-specific changes in HDAC3 and H4K8Ac occupancy...
February 10, 2021: Journal of Neuroscience
https://read.qxmd.com/read/33597276/evidence-for-modulation-of-substance-use-disorders-by-the-gut-microbiome-hidden-in-plain-sight
#39
JOURNAL ARTICLE
Mariana Angoa-Pérez, Donald M Kuhn
The gut microbiome modulates neurochemical function and behavior and has been implicated in numerous central nervous system (CNS) diseases, including developmental, neurodegenerative, and psychiatric disorders. Substance use disorders (SUDs) remain a serious threat to the public well-being, yet gut microbiome involvement in drug abuse has received very little attention. Studies of the mechanisms underlying SUDs have naturally focused on CNS reward circuits. However, a significant body of research has accumulated over the past decade that has unwittingly provided strong support for gut microbiome participation in drug reward...
April 2021: Pharmacological Reviews
https://read.qxmd.com/read/33461664/exposure-to-drugs-of-abuse-induce-effects-that-persist-across-generations
#40
JOURNAL ARTICLE
Annalisa M Baratta, Richa S Rathod, Sonja L Plasil, Amit Seth, Gregg E Homanics
Substance use disorders are highly prevalent and continue to be one of the leading causes of disability in the world. Notably, not all people who use addictive drugs develop a substance use disorder. Although substance use disorders are highly heritable, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Vulnerability to developing drug addiction depends on the interplay between genetics and environment. Additionally, evidence from the past decade has pointed to the role of epigenetic inheritance in drug addiction...
2021: International Review of Neurobiology
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