keyword
https://read.qxmd.com/read/38467481/epigenetic-inheritance-of-phenotypes-associated-with-parental-exposure-to-cocaine
#1
JOURNAL ARTICLE
Matthew T Rich, Sarah E Swinford-Jackson, R Christopher Pierce
Parental exposure to drugs of abuse induces changes in the germline that can be transmitted across subsequent generations, resulting in enduring effects on gene expression and behavior. This transgenerational inheritance involves a dynamic interplay of environmental, genetic, and epigenetic factors that impact an individual's vulnerability to neuropsychiatric disorders. This chapter aims to summarize recent research into the mechanisms underlying the inheritance of gene expression and phenotypic patterns associated with exposure to drugs of abuse, with an emphasis on cocaine...
2024: Advances in Pharmacology
https://read.qxmd.com/read/38070842/epigenetic-mechanisms-of-nicotine-dependence
#2
REVIEW
Caspar Muenstermann, Kelly J Clemens
Smoking continues to be a leading cause of preventable disease and death worldwide. Nicotine dependence generates a lifelong propensity towards cravings and relapse, presenting an ongoing challenge for the development of treatments. Accumulating evidence supports a role for epigenetics in the development and maintenance of addiction to many drugs of abuse, however, the involvement of epigenetics in nicotine dependence is less clear. Here we review evidence that nicotine interacts with epigenetic mechanisms to enable the maintenance of nicotine-seeking across time...
December 7, 2023: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/37940687/astrocytic-transcriptional-and-epigenetic-mechanisms-of-drug-addiction
#3
REVIEW
Leanne M Holt, Eric J Nestler
Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action...
November 8, 2023: Journal of Neural Transmission
https://read.qxmd.com/read/37685899/long-lasting-epigenetic-changes-in-the-dopamine-transporter-in-adult-animals-exposed-to-amphetamine-during-embryogenesis-investigating-behavioral-effects
#4
JOURNAL ARTICLE
Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvelli
The dopamine transporter (DAT) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. DAT is also the major target of amphetamine (Amph). The effects of Amph on DAT have been intensively studied; however, the mechanisms underlying the long-term effects caused by embryonal exposure to addictive doses of Amph remain largely unexplored. As in mammals, in the nematode C. elegans Amph causes changes in locomotion which are largely mediated by the C...
August 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37643467/effects-of-smoking-on-genome-wide-dna-methylation-profiles-a-study-of-discordant-and-concordant-monozygotic-twin-pairs
#5
JOURNAL ARTICLE
Jenny van Dongen, Gonneke Willemsen, Eco J C de Geus, Dorret I Boomsma, Michael C Neale
BACKGROUND: Smoking-associated DNA methylation levels identified through epigenome-wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms, but the contribution of a shared genetic predisposition to smoking and DNA methylation levels is typically not accounted for. METHODS: We exploited a strong within-family design, that is, the discordant monozygotic twin design, to study reactiveness of DNA methylation in blood cells to smoking and reversibility of methylation patterns upon quitting smoking...
August 10, 2023: ELife
https://read.qxmd.com/read/37537419/neonatal-opioid-toxicity-opioid-withdrawal-abstinence-syndrome-with-emphasis-on-pharmacogenomics-and-respiratory-depression
#6
REVIEW
Brian A Baldo
The increasing use of opioids in pregnant women has led to an alarming rise in the number of cases of neonates with drug-induced withdrawal symptoms known as neonatal opioid withdrawal syndrome (NOWS). NOWS is a toxic heterogeneous condition with many neurologic, autonomic, and gastrointestinal symptoms including poor feeding, irritability, tachycardia, hypertension, respiratory defects, tremors, hyperthermia, and weight loss. Paradoxically, for the management of NOWS, low doses of morphine, methadone, or buprenorphine are administered...
October 2023: Archives of Toxicology
https://read.qxmd.com/read/37520658/endocannabinoid-signaling-and-epigenetics-modifications-in-the-neurobiology-of-stress-related-disorders
#7
REVIEW
Arthur A Coelho, Sávio Lima-Bastos, Pedro H Gobira, Sabrina F Lisboa
Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or reinstating substance use disorder. Stress causes several changes in the neuro-immune-endocrine axis, potentially resulting in prolonged dysfunction and diseases. Changes in several transmitters, including serotonin, dopamine, glutamate, gamma-aminobutyric acid (GABA), glucocorticoids, and cytokines, are associated with psychiatric disorders or behavioral alterations in preclinical studies...
July 2023: Neuronal Signaling
https://read.qxmd.com/read/37517704/manipulating-%C3%AE-fosb-in-d1-type-medium-spiny-neurons-of-the-nucleus-accumbens-reshapes-whole-brain-functional-connectivity
#8
JOURNAL ARTICLE
Marion Sourty, Md Taufiq Nasseef, Cédric Champagnol-Di Liberti, Mary Mondino, Vincent Noblet, Eric M Parise, Tamara Markovic, Caleb J Browne, Emmanuel Darcq, Eric J Nestler, Brigitte L Kieffer
BACKGROUND: The transcription factor, ΔFOSB, acting in the nucleus accumbens (NAc), has been shown to control transcriptional and behavioral responses to opioids and other drugs of abuse. However, circuit-level consequences of ΔFOSB induction on the rest of the brain-required for its regulation of complex behavior-remain unknown. METHODS: We used an epigenetic approach in mice to suppress or activate the endogenous Fosb gene, and therefore decrease or increase, respectively, levels of ΔFOSB selectively in D1-type medium spiny neurons of the NAc, and tested whether these modifications affect the organization of functional connectivity (FC) in the brain...
July 28, 2023: Biological Psychiatry
https://read.qxmd.com/read/37423274/addictive-drugs-modify-neurogenesis-synaptogenesis-and-synaptic-plasticity-to-impair-memory-formation-through-neurotransmitter-imbalances-and-signaling-dysfunction
#9
REVIEW
Ameneh Rezayof, Zahra Ghasemzadeh, Oveis Hosseinzadeh Sahafi
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels in the addicted brain. Well-supported scientific evidence suggests that drugs negatively affect memory formation, decision-making and inhibition, and emotional and cognitive behaviors. The mesocorticolimbic brain regions are involved in reward-related learning and habitual drug-seeking/taking behaviors to develop physiological and psychological dependence on the drugs. This review highlights the importance of specific drug-induced chemical imbalances resulting in memory impairment through various neurotransmitter receptor-mediated signaling pathways...
July 7, 2023: Neurochemistry International
https://read.qxmd.com/read/37415372/epigenetic-effects-of-psychoactive-drugs
#10
JOURNAL ARTICLE
Rania Ahmed, Kenneth Blum, Panayotis K Thanos
Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies heritable alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgenerationally...
2023: Current Pharmaceutical Design
https://read.qxmd.com/read/37315877/effect-of-germ-free-status-on-transcriptional-profiles-in-the-nucleus-accumbens-and-transcriptomic-response-to-chronic-morphine
#11
JOURNAL ARTICLE
Jonathon P Sens, Rebecca S Hofford, Drew D Kiraly
Opioid use disorder is a public health crisis that causes tremendous suffering for patients as well as substantial social and economic costs for society. There are currently available treatments for patients with opioid use disorder, but they remain intolerable or ineffective for many. Thus the need to develop new avenues for therapeutics development in this space is great. Substantial work in models of substance use disorders, including opioid use disorder, demonstrates that prolonged exposure to drugs of abuse leads to marked transcriptional and epigenetic dysregulation in limbic substructures...
June 12, 2023: Molecular and Cellular Neurosciences
https://read.qxmd.com/read/37265630/histone-modifications-in-cocaine-methamphetamine-and-opioids
#12
REVIEW
Junzhe Cheng, Ziping He, Qianqian Chen, Jiang Lin, Yilin Peng, Jinlong Zhang, Xisheng Yan, Jie Yan, Shuliang Niu
Cocaine, methamphetamine and opioids are leading causes of drug abuse-related deaths worldwide. In recent decades, several studies revealed the connection between and epigenetics. Neural cells acquire epigenetic alterations that drive the onset and progress of the SUD by modifying the histone residues in brain reward circuitry. Histone modifications, especially acetylation and methylation, participate in the regulation of gene expression. These alterations, as well as other host and microenvironment factors, are associated with a serious of negative neurocognitive disfunctions in various patient populations...
June 2023: Heliyon
https://read.qxmd.com/read/37207894/sex-differences-in-susceptibility-to-substance-use-disorder-role-for-x-chromosome-inactivation-and-escape
#13
JOURNAL ARTICLE
Kate Krueger, Felipe Lamenza, Howard Gu, Heithem El-Hodiri, Jason Wester, John Oberdick, Andy J Fischer, Steve Oghumu
There is a sex-based disparity associated with substance use disorders (SUDs) as demonstrated by clinical and preclinical studies. Females are known to escalate from initial drug use to compulsive drug-taking behavior (telescoping) more rapidly, and experience greater negative withdrawal effects than males. Although these biological differences have largely been attributed to sex hormones, there is evidence for non-hormonal factors, such as the influence of the sex chromosome, which underlie sex disparities in addiction behavior...
May 18, 2023: Molecular and Cellular Neurosciences
https://read.qxmd.com/read/36775113/biopharmaceuticals-against-substance-use-disorders-present-and-future
#14
REVIEW
Theofanis Vavilis, Eleni Stamoula, Athanasios Sachinidis, Malamatenia Lamprinou, Ioannis Dardalas, Georgios Papazisis
BACKGROUND AND OBJECTIVES: Pharmacological treatments available for substance use disorder (SUD) focus on pharmacodynamics, agonizing or antagonizing the drug of abuse (DOA) on receptor level. Drawbacks of this approach include the reliance on long-term patient compliance, on-target off-site effects, perpetuation of addiction and unavailability for many DOAs. Newer, pharmacokinetic approaches are needed that restrict DOA's access to the brain or disrupt DOA-instated brain changes maintaining addiction...
February 10, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/36358910/molecular-insights-into-epigenetics-and-cannabinoid-receptors
#15
REVIEW
Balapal S Basavarajappa, Shivakumar Subbanna
The actions of cannabis are mediated by G protein-coupled receptors that are part of an endogenous cannabinoid system (ECS). ECS consists of the naturally occurring ligands N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the CB1 and CB2 cannabinoid receptors. Epigenetics are heritable changes that affect gene expression without changing the DNA sequence, transducing external stimuli in stable alterations of the DNA or chromatin structure...
October 26, 2022: Biomolecules
https://read.qxmd.com/read/36233105/epigenetic-modulation-of-opioid-receptors-by-drugs-of-abuse
#16
REVIEW
Ke Zhang Reid, Brendan Matthew Lemezis, Tien-Chi Hou, Rong Chen
Chronic exposure to drugs of abuse produces profound changes in gene expression and neural activity associated with drug-seeking and taking behavior. Dysregulation of opioid receptor gene expression is commonly observed across a variety of abused substances including opioids, cocaine, and alcohol. Early studies in cultured cells showed that the spatial and temporal gene expression of opioid receptors are regulated by epigenetic mechanisms including DNA and histone modifications and non-coding RNAs. Accumulating evidence indicate that drugs of abuse can modulate opioid receptor gene expression by targeting various epigenetic regulatory networks...
October 5, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35936504/microrna-regulation-of-the-environmental-impact-on-adolescent-neurobehavioral-development-a-systematic-review
#17
Ana Vázquez-Ágredos, Fernando Gámiz, Milagros Gallo
Adolescence is a late developmental period marked by pronounced reorganization of brain networks in which epigenetic mechanisms play a fundamental role. This brain remodeling is associated with a peculiar behavior characterized by novelty seeking and risky activities such as alcohol and drug abuse, which is associated with increased susceptibility to stress. Hence, adolescence is a vulnerable postnatal period since short- and long-term deleterious effects of alcohol drinking and drug abuse are a serious worldwide public health concern...
2022: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/35928279/maternal-methamphetamine-exposure-influences-behavioral-sensitization-and-nucleus-accumbens-dna-methylation-in-subsequent-generation
#18
JOURNAL ARTICLE
Nan Dong, Jie Zhu, Rui Wang, Shuai Wang, Yanjiong Chen, Changhe Wang, Eyleen L K Goh, Teng Chen
The deleterious effects of methamphetamine (METH) exposure extend beyond abusers, and may potentially impact the vulnerability of their offspring in developing addictive behaviors. Epigenetic signatures have been implicated in addiction, yet the characteristics to identify prenatal METH abuse to offspring addiction risk remains elusive. Here, we used escalating doses of METH-exposed mouse model in F0 female mice before and during pregnancy to simulate the human pattern of drug abuse and generated METH-induced behavioral sensitization to investigate the addictive behavior in offspring mice...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35892093/hiv-1-tat-and-cocaine-impact-astrocytic-energy-reservoirs-and-epigenetic-regulation-by-influencing-the-linc01133-hsa-mir-4726-5p-ndufa9-axis
#19
JOURNAL ARTICLE
Mayur Doke, Jay P McLaughlin, James J Cai, Gurudutt Pendyala, Fatah Kashanchi, Mansoor A Khan, Thangavel Samikkannu
Clinical research has proven that HIV-positive (HIV+ ) individuals with cocaine abuse show behavioral and neurocognitive disorders. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), are known to regulate gene expression in the contexts of HIV infection and drug abuse. However, there are no specific lncRNA or miRNA biomarkers associated with HIV-1 Transactivator of transcription protein (Tat) and cocaine coexposure. In the central nervous system (CNS), astrocytes are the primary regulators of energy metabolism, and impairment of the astrocytic energy supply can trigger neurodegeneration...
September 13, 2022: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/35627277/sex-differences-in-psychostimulant-abuse-implications-for-estrogen-receptors-and-histone-deacetylases
#20
REVIEW
Oscar V Torres
Substance abuse is a chronic pathological disorder that negatively affects many health and neurological processes. A growing body of literature has revealed gender differences in substance use. Compared to men, women display distinct drug-use phenotypes accompanied by recovery and rehabilitation disparities. These observations have led to the notion that sex-dependent susceptibilities exist along the progression to addiction. Within this scope, neuroadaptations following psychostimulant exposure are thought to be distinct for each sex...
May 17, 2022: Genes
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