Marion Sourty, Md Taufiq Nasseef, Cédric Champagnol-Di Liberti, Mary Mondino, Vincent Noblet, Eric M Parise, Tamara Markovic, Caleb J Browne, Emmanuel Darcq, Eric J Nestler, Brigitte L Kieffer
BACKGROUND: The transcription factor, ΔFOSB, acting in the nucleus accumbens (NAc), has been shown to control transcriptional and behavioral responses to opioids and other drugs of abuse. However, circuit-level consequences of ΔFOSB induction on the rest of the brain-required for its regulation of complex behavior-remain unknown. METHODS: We used an epigenetic approach in mice to suppress or activate the endogenous Fosb gene, and therefore decrease or increase, respectively, levels of ΔFOSB selectively in D1-type medium spiny neurons of the NAc, and tested whether these modifications affect the organization of functional connectivity (FC) in the brain...
July 28, 2023: Biological Psychiatry