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Lipid accumulation product

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https://www.readbyqxmd.com/read/28526981/rubisco-mutants-of-chlamydomonas-reinhardtii-display-divergent-photosynthetic-parameters-and-lipid-allocation
#1
M G Esquível, A R Matos, J Marques Silva
Photosynthesis and lipid allocation were investigated in Rubisco small subunit mutants of the microalga Chlamydomonas reinhardtii. Comparative analyses were undertaken with cells grown photoheterotrophically under sulphur-replete or sulphur-depleted conditions. The Y67A Rubisco mutant, which has previously demonstrated a pronounced reduction in Rubisco levels and higher hydrogen production rates than the wild type, also shows the following divergences in photosynthetic phenotype and lipid allocation: (i) low Fv/Fm (maximum photochemical efficiency), (ii) low effective quantum yield of photosystem II (ΦPSII), (iii) low effectiveness at protection against high light intensities, (iv) a higher level of total lipids per pigment and (v) changes in the relative proportions of different fatty acids, with a marked decrease in unsaturated fatty acids (FAs)...
May 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28522438/anti-inflammatory-effects-of-oxpapc-involve-endothelial-cell-mediated-generation-of-lxa4
#2
Yunbo Ke, Noureddine Zebda, Olga Oskokova, Taras Afonyushkin, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov
Rationale: Oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine generates a group of bioactive oxidized phospholipid products (OxPAPC) with a broad range of biological activities. Barrier-enhancing and anti-inflammatory effects of OxPAPC on pulmonary endothelial cells (EC) are critical for prevention of acute lung injury caused by bacterial pathogens or excessive mechanical ventilation. Anti-inflammatory properties of OxPAPC are associated with its antagonistic effects on toll-like receptors and suppression of RhoA GTPase signaling...
May 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28521611/sgpl1-sphingosine-phosphate-lyase-1-modulates-neuronal-autophagy-via-phosphatidylethanolamine-production
#3
Daniel N Mitroi, Indulekha Karunakaran, Markus Gräler, Julie D Saba, Dan Ehninger, María Dolores Ledesma, Gerhild van Echten-Deckert
Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy are increasingly recognized. Here we provide in vitro and in vivo evidence for a previously unidentified route through which SGPL1 modulates autophagy in neurons. SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II...
May 4, 2017: Autophagy
https://www.readbyqxmd.com/read/28518475/lipid-bodies-accumulation-in-leishmania-infantum-infected-c57bl-6-macrophages
#4
Nilda E Rodríguez, Ryan D Lockard, Elizabeth A Turcotte, Théo Araujo-Santos, Patrícia T Bozza, Valéria M Borges, Mary E Wilson
Lipid bodies (LBs) are intracellular accumulations of neutral lipids surrounded by a single membrane. These organelles are involved in the production of eicosanoids, which modulate immunity by either promoting or dampening inflammatory responses. Leishmania infantum, the etiological agent of visceral leishmaniasis in Brazil, is an intracellular parasite that causes disease by suppressing macrophage microbicidal responses. C57BL/6 mouse bone marrow-derived macrophages infected with L. infantum strain LcJ had higher numbers of LB+ cells (P<0...
May 18, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28510254/effects-of-mutant-tdp-43-on-the-nrf2-are-pathway-and-protein-expression-of-mafk-and-jdp2-in-nsc-34-cells
#5
Y P Tian, F Y Che, Q P Su, Y C Lu, C P You, L M Huang, S G Wang, L Wang, J X Yu
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons and lacks an effective treatment. The disease pathogenesis has not been clarified at present. Pathological transactive response DNA-binding protein 43 (TDP-43) plays an important role in the pathogenesis of ALS. Nuclear translocation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is found in a mutant TDP-43 transgenic cell model, but its downstream antioxidant enzyme expression is decreased. To elucidate the specific mechanism of Nrf2/ARE (antioxidant responsive element) signaling dysfunction, we constructed an ALS cell model with human mutant TDP-43 using the NSC-34 cell line to evaluate the impact of the TDP-43 mutation on the Nrf2/ARE pathway...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28507542/reactive-oxygen-species-mediated-cellular-stress-response-and-lipid-accumulation-in-oleaginous-microorganisms-the-state-of-the-art-and-future-perspectives
#6
REVIEW
Kun Shi, Zhen Gao, Tian-Qiong Shi, Ping Song, Lu-Jing Ren, He Huang, Xiao-Jun Ji
Microbial oils, which are mainly extracted from yeasts, molds, and algae, have been of considerable interest as food additives and biofuel resources due to their high lipid content. While these oleaginous microorganisms generally produce only small amounts of lipids under optimal growth conditions, their lipid accumulation machinery can be induced by environmental stresses, such as nutrient limitation and an inhospitable physical environmental. As common second messengers of many stress factors, reactive oxygen species (ROS) may act as a regulator of cellular responses to extracellular environmental signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28507131/involvement-of-a-gut-retina-axis-in-protection-against-dietary-glycemia-induced-age-related-macular-degeneration
#7
Sheldon Rowan, Shuhong Jiang, Tal Korem, Jedrzej Szymanski, Min-Lee Chang, Jason Szelog, Christa Cassalman, Kalavathi Dasuri, Christina McGuire, Ryoji Nagai, Xue-Liang Du, Michael Brownlee, Naila Rabbani, Paul J Thornalley, James D Baleja, Amy A Deik, Kerry A Pierce, Justin M Scott, Clary B Clish, Donald E Smith, Adina Weinberger, Tali Avnit-Sagi, Maya Lotan-Pompan, Eran Segal, Allen Taylor
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss of photoreceptor cells. Epidemiologic studies indicate important contributions of dietary patterns to the risk for AMD, but the mechanisms relating diet to disease remain unclear. Here we investigate the effect on AMD of isocaloric diets that differ only in the type of dietary carbohydrate in a wild-type aged-mouse model. The consumption of a high-glycemia (HG) diet resulted in many AMD features (AMDf), including RPE hypopigmentation and atrophy, lipofuscin accumulation, and photoreceptor degeneration, whereas consumption of the lower-glycemia (LG) diet did not...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28504059/coupled-microalgal-cultivation-with-treatment-of-domestic-sewage-and-high-level-co2
#8
Liqun Jiang, Juan Cheng, Haiyan Pei, Shuo Zhang, Zhigang Yang, Changliang Nie, Lijie Zhang
The ability of Scenedesmus quadricauda SDEC-13 to accumulate biomass and remove nutrients in domestic sewage from campus when incorporated with 15% CO2 was explored. The maximum specific growth rate, biomass productivity, biomass concentration and CO2 fixation rate were 0.14 d(-1), 0.08 g/L/d, 0.69 g/L and 0.076 g-CO2/L/d respectively. The lipid content of SDEC-13 at different culture phases was also evaluated and it increased following nutrient limitation. The removal efficiencies of TN, TP, nitrate and ammonium were all above 90%...
May 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28502908/chronic-administration-of-antioxidant-resin-from-virola-oleifera-attenuates-atherogenesis-in-ldlr-mice
#9
Paola Nogueira Coutinho, Beatriz Peters Pereira, Ana Claudia Hertel Pereira, Marcella Leite Porto, Arícia Leone Evangelista Monteiro de Assis, Afrânio Côgo Destefani, Silvana Santos Meyrelles, Elisardo Corral Vasquez, Breno Valentim Nogueira, Tadeu Uggere de Andrade, Denise Coutinho Endringer, Marcio Fronza, Thiago Melo Costa Pereira
ETHNOPHARMACOLOGICAL RELEVANCE: Virola oleifera (Schott) A. C. Smith, Myristicaceae has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and our previous data indicated the antioxidant properties in other oxidative stress-related models. However, its effects on atherosclerosis (AT) are not yet investigated. AIMS OF THE STUDY: To evaluate the influence of resin from Virola oleifera (RV) on progression of AT in LDLr(-/-) mice...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28501921/cranberry-vaccinium-macrocarpon-extract-treatment-improves-triglyceridemia-liver-cholesterol-liver-steatosis-oxidative-damage-and-corticosteronemia-in-rats-rendered-obese-by-high-fat-diet
#10
Thamara C Peixoto, Egberto G Moura, Elaine de Oliveira, Patrícia N Soares, Deysla S Guarda, Dayse N Bernardino, Xu Xue Ai, Vanessa da S T Rodrigues, Gabriela Rodrigues de Souza, Antonio Jorge Ribeiro da Silva, Mariana S Figueiredo, Alex C Manhães, Patrícia C Lisboa
PURPOSE: Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract (CE) can improve this dysfunction in HFD-induced obesity in rats since it has an important antioxidant activity. Here, we evaluated the effects of CE in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors, hepatic morphology and oxidative balance in a HFD model. METHODS: At postnatal day 120 (PN120), male Wistar rats were assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44...
May 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28501381/salinity-induced-oxidative-stress-alters-the-physiological-responses-and-improves-the-biofuel-potential-of-green-microalgae-acutodesmus-dimorphus
#11
Kaumeel Chokshi, Imran Pancha, Arup Ghosh, Sandhya Mishra
The main aim of the present study was to analyze salinity stress induced physiological and biochemical changes in a freshwater microalgae Acutodesmus dimorphus. During single-stage cultivation, the accumulations of lipids and carbohydrates increased with an increase in an initial salinity of the culture medium. The carbohydrate and lipid accumulations of 53.30±2.76% and 33.40±2.29%, respectively, were observed in 200mM NaCl added culture. During two-stage cultivation, salinity stress of 200mM was favorable for the growth up to 2days, as suggested by higher biomass, lower levels of oxidative stress biomarkers and no significant changes in the biochemical composition of the cells...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28501380/crispri-mediated-phosphoenolpyruvate-carboxylase-regulation-to-enhance-the-production-of-lipid-in-chlamydomonas-reinhardtii
#12
Pei-Hsun Kao, I-Son Ng
In this study, CRISPRi (clustered regularly interspaced short palindromic repeats interference) was used for the first time to regulate expression of exogenously supplied rfp gene as a proof-of-concept, and endogenous PEPC1 gene as a proof-of-function in Chlamydomonas reinhardtii. The efficiency of 94% and stability of 7 generations via CRISPRi mediated gene regulation in C. reinhardtii have been demonstrated by RFP. Gene PEPC1 encoding proteins are essential for controlling the carbon flux that enters the TCA cycle and plays a crucial role in carbon partitioning of substrates in competition with lipid synthesis...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28499251/sequestration-of-polyunsaturated-fatty-acids-in-membrane-phospholipids-of-caenorhabditis-elegans-dauer-larva-attenuates-eicosanoid-biosynthesis-for-prolonged-survival
#13
Sin Man Lam, Zehua Wang, Jie Li, Xun Huang, Guanghou Shui
Mechanistic basis governing the extreme longevity and developmental quiescence of dauer juvenile, a "non-ageing" developmental variant of Caenorhabditis elegans, has remained largely obscure. Using a lipidomic approach comprising multiple reaction monitoring transitions specific to distinct fatty acyl moieties, we demonstrated that in comparison to other developmental stages, the membrane phospholipids of dauer larva contain a unique enrichment of polyunsaturated fatty acids (PUFAs). Esterified PUFAs in phospholipids exhibited temporal accumulation throughout the course of dauer endurance, followed by sharp reductions prior to termination of diapause...
May 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28497289/systematic-analysis-of-the-lysine-acetylome-reveals-diverse-functions-of-lysine-acetylation-in-the-oleaginous-yeast-yarrowia-lipolytica
#14
Guangyuan Wang, Lizhong Guo, Wenxing Liang, Zhenming Chi, Lin Liu
Lysine acetylation of proteins, a major post-translational modification, plays a critical regulatory role in almost every aspects in both eukaryotes and prokaryotes. Yarrowia lipolytica, an oleaginous yeast, is considered as a model for bio-oil production due to its ability to accumulate a large amount of lipids. However, the function of lysine acetylation in this organism is elusive. Here, we performed a global acetylproteome analysis of Y. lipolytica ACA-DC 50109. In total, 3163 lysine acetylation sites were identified in 1428 proteins, which account for 22...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28494415/studies-on-curative-efficacy-of-monoterpene-eugenol-on-anti-leukemic-drug-arsenic-trioxide-induced-cardiotoxicity
#15
Prakash Binu, Nellikunnath Priya, Surendran Abhilash, Radhakrishnan Chandraprabha Vineetha, Raveendran Harikumaran Nair
BACKGROUND: Arsenic trioxide (As2O3) is emerging as a frontline agent for the treatment of acute promyelocytic leukemia (APL) but the therapeutic application is limited by its toxicity. QT prolongation, torsades de pointes and sudden cardiac death have been implicated in the As2O3 therapy. So eugenol is a monoterpene compound is well known for its antioxidant properties and protective effect on the cardiovascular system. OBJECTIVE: In this study, the cardioprotective effect of eugenol on cardiac electrical conductivity, tissue electrolytes, myocardial markers, antioxidant system, lipid peroxidation and nitric oxide production was investigated in male Wistar rats treated with arsenic trioxide...
May 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28491041/describing-the-diapause-preparatory-proteome-of-the-beetle-colaphellus-bowringi-and-identifying-candidates-affecting-lipid-accumulation-using-isobaric-tags-for-mass-spectrometry-based-proteome-quantification-itraq
#16
Qian-Qian Tan, Wen Liu, Fen Zhu, Chao-Liang Lei, Daniel A Hahn, Xiao-Ping Wang
Prior to entering diapause, insects must prepare themselves physiologically to withstand the stresses of arresting their development for a lengthy period. While studies describing the biochemical and cellular milieu of the maintenance phase of diapause are accumulating, few studies have taken an "omics" approach to describing molecular events during the diapause preparatory phase. We used isobaric tags and mass spectrometry (iTRAQ) to quantitatively compare the expression profiles of proteins identified during the onset of diapause preparation phase in the heads of adult female cabbage beetles, Colaphellus bowringi...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28489128/obesity-bariatric-surgery-and-oxidative-stress
#17
Roberta Cattaneo Horn, Gabriela Tassotti Gelatti, Natacha Cossettin Mori, Ana Caroline Tissiani, Mariana Spanamberg Mayer, Elvio Almeida Pereira, Marcelo Ross, Paulo Ricardo Moreira, Josiane Woutheres Bortolotto, Tamiris Felippin
Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method: We have assessed 16 morbidly obese women five days before and 180 days after the surgery...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28489094/theoretical-insights-into-the-mechanism-of-ferroptosis-suppression-via-inactivation-of-a-lipid-peroxide-radical-by-liproxstatin-1
#18
Xiehuang Sheng, Chao Shan, Jianbiao Liu, Jintong Yang, Bin Sun, Dezhan Chen
Ferroptosis is a recently discovered iron-dependent form of non-apoptotic cell death caused by the accumulation of membrane lipid peroxidation products, which is involved in various pathological conditions of the brain, kidney, liver and heart. A potent spiroquinoxalinamine derivative named liproxstatin-1 is discovered by high-throughput screening, which is able to suppress ferroptosis via lipid peroxide scavenging in vivo. Thus, molecular simulations, density functional theory (DFT) and variational transition-state theory with a small-curvature tunneling (SCT) coefficient are utilized to elucidate the detailed mechanisms of inactivation of a lipid peroxide radical by liproxstatin-1...
May 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28488470/antioxidant-enzymes-responses-in-shoots-of-arsenic-hyperaccumulator-isatis-cappadocica-desv-under-interaction-of-arsenate-and-phosphate
#19
Zahra Souri, Naser Karimi, Letúzia M de Oliveira
Isatis cappadocica is known to be a potential accumulator of arsenic (As), but all mechanisms of As detoxification have not been investigated yet. Current study investigated the effects of arsenate and phosphate interaction on growth, lipid peroxidation, As accumulation, phosphorus (P) accumulation, and the activities of some antioxidant enzymes in I. cappadocica. Plants were exposed to 50, 200, 800 & 1200 μmol L(-1) arsenate and 5, 50, 200, 800 & 1600 μmol L(-1) phosphate for 28 days in hydroponic system...
May 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28488119/co2-removal-from-biogas-by-cyanobacterium-leptolyngbya-sp-cchf1-isolated-from-the-lake-chapala-mexico-optimization-of-the-temperature-and-light-intensity
#20
Francisco J Choix, Raúl Snell-Castro, Jorge Arreola-Vargas, Alberto Carbajal-López, Hugo O Méndez-Acosta
In the present study, the capacity of the cyanobacterium Leptolyngbya sp. CChF1 to remove CO2 from real and synthetic biogas was evaluated. The identification of the cyanobacterium, isolated from the lake Chapala, was carried out by means of morphological and molecular analyses, while its potential for CO2 removal from biogas streams was evaluated by kinetic experiments and optimized by a central composite design coupled to a response surface methodology. Results demonstrated that Leptolyngbya sp. CChF1 is able to remove CO2 and grow indistinctly in real or synthetic biogas streams, showing tolerance to high concentrations of CO2 and CH4, 25 and 75%, respectively...
May 10, 2017: Applied Biochemistry and Biotechnology
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