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Lipid accumulation product

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https://www.readbyqxmd.com/read/29338075/lkb1-ampk-mediated-regulation-by-gentiopicroside-ameliorates-p2x7r-dependent-alcoholic-hepatosteatosis
#1
Xia Li, Yu Zhang, Quan Jin, Kai-Li Xia, Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Shun-Zong Song, Li-Hua Lian, Ji-Xing Nan
BACKGROUND AND PURPOSE: Regulating P2x7R-NLRP3 inflammasome activation might be a potential therapeutic strategy to treat alcoholic hepatosteatosis. We investigated whether this process would be modulated by gentiopicroside (GPS), which is the main active secoiridoid glycoside from Gentiana manshurica Kitagawa. EXPERIMENTAL APPROACH: In vivo models of acute and chronic alcoholic hepatosteatosis were established by intragastrically administrated ethanol or using chronic plus binge ethanol feeding of Lieber-DeCarli liquid diet to male C57BL/6 mice...
January 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29337346/effective-role-of-medium-supplementation-in-microalgal-lipid-accumulation
#2
Azadeh Fazeli Danesh, Peter Mooij, Sirous Ebrahimi, Robbert Kleerebezem, Mark van Loosdrecht
The present study investigated the interaction between starch and lipid accumulation was in a green microalgae enrichment culture. The objective was to optimize the lipid content by manipulation of the medium in regular batch culture. Two medium designs were evaluated: first a high ortho-P concentration with vitamin supplement (Pi-vitamins supplemented medium), second normal growth medium (control). Both media contained a low amount of nitrogen which was consumed during batch growth in three days. The batch experiments were prolonged continued for another four days with the absence of soluble nitrogen in the medium...
January 16, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29335836/adipogenesis-and-lipid-production-in-adipocytes-subjected-to-sustained-tensile-deformations-and-elevated-glucose-concentration-a-living-cell-scale-model-system-of-diabesity
#3
Maayan Lustig, Amit Gefen, Dafna Benayahu
Adipocyte fate commitment is characterized by morphological changes of fibroblastic pre-adipocyte cells, and specifically by accumulation of lipid droplets (LDs) as part of the adipogenesis metabolism. Formation of LDs indicates the production of triglycerides from glucose through an insulin-regulated glucose internalization process. In obesity, adipocytes typically become insulin resistant, and glucose transport into the cells is impaired, resulting in type 2 diabetes. In the present study, we monitored the adipogenesis in 3T3-L1 cultured cells exposed to high (450 mg/dL hyperglycemia) and low (100 mg/dL physiological) glucose concentrations, in a novel cell culture model system of diabesity...
January 15, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29333386/antioxidant-and-anti-adipogenic-activities-of-trapa-japonica-shell-extract-cultivated-in-korea
#4
DooJin Lee, Ok-Hwan Lee, Geunpyo Choi, Jong Dai Kim
Trapa japonica shell contains phenolic compounds such as tannins. Studies regarding the antioxidant and anti-adipogenic effects of Trapa japonica shell cultivated in Korea are still unclear. Antioxidant and anti-adipogenic activities were measured by in vitro assays such as 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity, 2,2'-azinobis( 3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activity, ferric reducing ability of plasma assay, reducing power, superoxide dismutase-like activity, and iron chelating ability in 3T3-L1 cells...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29332587/lysosomal-acid-lipase-deficiency-could-dyslipidemia-drive-the-diagnosis
#5
Ornella Guardamagna
LAL-deficiency (LAL-D) is a rare and systemic condition, secondary to LIPA gene mutations, responsible for lysosomal accumulation of cholesteryl esters and triglycerides, whose manifestations are very heterogeneous in terms of age of onset, severity and type of clinical and radiological manifestations. Dyslipidemia, hepatomegaly and hepatosteatosis with increased levels of transaminases are the most common features. The increased risk of premature atherosclerosis and cardiovascular disorders,, secondary to a generalized alteration of lipid profile and lipoprotein dysfunction associated with LAL-D, has been increasingly pointed out...
January 11, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29332147/phosphorus-allocation-and-phosphatase-activity-in-grasses-with-different-growth-rates
#6
Leandro Bittencourt de Oliveira, Anderson Cesar Ramos Marques, Fernando Luiz Ferreira de Quadros, Júlia Gomes Farias, Rogério Piccin, Gustavo Brunetto, Fernando Teixeira Nicoloso
Different growth rates of grasses from South American natural grasslands are adaptations to soils of low fertility. Grasses with fast growth rate are species with an accumulation of nutrients in soluble forms, with a high metabolic rate. This work aimed to study whether grasses with different growth rates have different phosphorus (P) uptake and efficiency of P use with high and low P availability in soil, as well as whether phosphatase activity is related to the species growth rate and variations in P biochemical forms in the tissues...
January 13, 2018: Oecologia
https://www.readbyqxmd.com/read/29332119/autofluorescence-of-skin-advanced-glycation-end-products-as-a-risk-factor-for-open-angle-glaucoma-the-alienor-study
#7
Cedric Schweitzer, Audrey Cougnard-Gregoire, Vincent Rigalleau, Jean-Francois Dartigues, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Catherine Helmer, Jean-Francois Korobelnik, Cecile Delcourt
Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331649/friend-or-foe-reactive-oxygen-species-production-scavenging-and-signaling-in-plant-response-to-environmental-stresses
#8
Weronika Czarnocka, Stanisław Karpiński
In the natural environment, plants are exposed to a variety of biotic and abiotic stress conditions that trigger rapid changes in the production and scavenging of reactive oxygen species (ROS). The production and scavenging of ROS is compartmentalized, which means that, depending on stimuli type, they can be generated and eliminated in different cellular compartments such as the apoplast, plasma membrane, chloroplasts, mitochondria, peroxisomes, and endoplasmic reticulum. Although the accumulation of ROS is generally harmful to cells, ROS play an important role in signaling pathways that regulate acclimatory and defense responses in plants, such as systemic acquired acclimation (SAA) and systemic acquired resistance (SAR)...
January 10, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29331517/tofu-whey-wastewater-is-a-promising-basal-medium-for-microalgae-culture
#9
Shi-Kai Wang, Xu Wang, Jing Miao, Yong-Ting Tian
Tofu whey wastewater (TWW) is an abundant, nutrient riched and safety wastewater and is regarded as an excellent alternative medium in fermentation. In this study, the feasibility of algal cultivation using TWW as the basal medium was investigated. Results indicated that through simple pH adjustment, TWW presented a better culture performance at autotrophic, heterotrophic, and mixotrophic modes compared with that of regular green algae medium, BG-11. The biomass productivities of Chlorella pyrenoidosa at each trophic mode were 4...
January 4, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29330693/the-enhanced-biomass-and-lipid-accumulation-in-coccomyxa-subellipsoidea-with-an-integrated-treatment-strategy-initiated-by-brewery-effluent-and-phytohormones
#10
Tingting Liu, Fei Luo, Zhenyao Wang, Yuqin Li
Brewery effluent (BE) as an appreciable and sustainable resource presented new possibilities in low-cost algal biomass production, whereas the relatively low essential macronutrients hindered extensive applications as growth medium for microalgae cultivation. The objective of this study was to investigate the feasibility of an integrated treatment strategy initiated by BE coupling phytohormones in augmenting biomass and lipid accumulation in Coccomyxa subellipsoidea. Results revealed that BE coupling synthetic 1-naphthaleneacetic acid (NAA) accomplished the favorable lipid productivity of 481...
January 12, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29329098/effect-of-organic-amendments-on-cadmium-stress-to-pea-a-multivariate-comparison-of-germinating-vs-young-seedlings-and-younger-vs-older-leaves
#11
Saliha Shamshad, Muhammad Shahid, Marina Rafiq, Sana Khalid, Camille Dumat, Muhammad Sabir, Behzad Murtaza, Abu Bakr Umer Farooq, Noor S Shah
Despite significant recent advancement in research, biogeochemical behavior of heavy metals with respect to their applied form is still topical. Moreover, metal toxicity to plants may vary with their stage of development/maturity. Therefore, this study for the first time evaluated the influence of ethylenediaminetetraacetic acid (EDTA) and citric acid (CA) on cadmium (Cd) accumulation and toxicity to germinating and young pea seedlings as well as in younger and older leaves. The experimental setup of current study consisted of two separate studies...
January 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29328933/economic-assessment-of-biodiesel-production-from-wastewater-sludge
#12
Jiaxin Chen, Rajeshwar Dayal Tyagi, Ji Li, Xiaolei Zhang, Patrick Drogui, Feiyun Sun
Currently, there are mainly two pathways of the biodiesel production from wastewater sludge including 1) directly extracting the lipid in sludge and then converting the lipid to biodiesel through trans-esterification, and 2) employing sludge as medium to cultivate oleaginous microorganism to accumulate lipid and then transferring the lipid to biodiesel. So far, the study was still in research stage and its cost feasibility was not yet investigated. In this study, biodiesel production from wastewater sludge was designed and the cost was estimated with SuperPro Designer...
January 4, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29328807/conversion-of-agricultural-streams-and-food-processing-by-products-to-value-added-compounds-using-filamentous-fungi
#13
Lauryn G Chan, Joshua L Cohen, Juliana Maria Leite Nobrega de Moura Bell
The design of new food products and increased agricultural activities have produced a diversity of waste streams or by-products that contain a high load of organic matter. The underutilization of these streams presents a serious threat to the environment and to the financial viability of the agricultural sector and the food industry. Oleaginous microorganisms, such as yeast and microalgae, have been used to convert the organic matter present in many agricultural waste streams into an oil-rich biomass. Filamentous fungi are promising oleaginous microorganisms because of their high lipid accumulation potential and simple biomass recovery, the latter being related to their pellet-like growth morphology in submerged cultivation...
January 12, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29327194/agro-industrial-waste-recycling-by-trichosporon-fermentans-conversion-of-waste-sweetpotato-vines-alone-into-lipid
#14
Qi Shen, Yue Chen, Hui Lin, Qun Wang, Yuhua Zhao
Agro-industrial waste can be used to replace traditional carbohydrates, such as sucrose, starch, and glucose in many industrial fermentation processes. This study investigated the conversion of pre-treated waste sweetpotato vines (SV) into lipid by Trichosporon fermentans under the separate hydrolysis and fermentation (SHF) and the simultaneous saccharification and fermentation (SSF) processes. The results showed that SV autoclaving significantly increased the lipid accumulation of T. fermentans compared with acid or alkaline hydrolysis...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29326167/the-protein-kinase-ck2-substrate-jabba-modulates-lipid-metabolism-during-drosophila-oogenesis
#15
Emily A McMillan, Sheila M Longo, Michael D Smith, Sarah Broskin, Baicheng Lin, Nisha K Singh, Todd I Strochlic
Lipid metabolism plays a critical role in female reproduction. During oogenesis, maturing oocytes accumulate high levels of neutral lipids that are essential for both energy production and for the synthesis of other lipid molecules. Metabolic pathways within the ovary are partially regulated by protein kinases that link metabolic status to oocyte development. While the functions of several kinases in this process are well established, the roles that many other kinases play in coordinating metabolic state with female germ cell development are unknown...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29323721/brain-derived-neurotrophic-factor-modulates-cholesterol-homeostasis-and-apolipoprotein-e-synthesis-in-human-cell-models-of-astrocytes-and-neurons
#16
Maria Stefania Spagnuolo, Aldo Donizetti, Lucia Iannotta, Vincenza Aliperti, Chiara Cupidi, Amalia Cecilia Bruni, Luisa Cigliano
In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism has been associated with different diseases. Brain-derived neurotrophic factor (BDNF) was previously reported to elicit cholesterol biosynthesis and promote the accumulation of presynaptic proteins in cholesterol-rich lipid rafts, but no data are available on its ability to modulate physiological mechanisms involved in cholesterol homeostasis...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322661/utility-of-three-novel-insulin-resistance-related-lipid-indexes-for-predicting-type-2-diabetes-mellitus-among-people-with-normal-fasting-glucose-in-rural-china
#17
Bingyuan Wang, Ming Zhang, Yu Liu, Xizhuo Sun, Lu Zhang, Chongjian Wang, Li Linlin, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu
BACKGROUND: Inexpensive and easily measurable indexes are needed to predict type 2 diabetes mellitus (T2DM) early in rural areas of China. We aimed to compare triglyceride glucose (TyG), visceral adiposity (VAI), and lipid accumulation product (LAP) along with traditional individual measures and their ratios for predicting T2DM. METHODS: Data for 11,113 people with baseline normal fasting glucose in a rural Chinese cohort were followed for a median of 6.0 years...
January 11, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29322013/dillenia-indica-l-attenuates-diabetic-nephropathy-via-inhibition-of-advanced-glycation-end-products-accumulation-in-stz-nicotinamide-induced-diabetic-rats
#18
Navpreet Kaur, Lalit Kishore, Randhir Singh
The present study was aimed to evaluate advanced glycation end products (AGEs) inhibitory activity of alcohol and hydro-alcohol extract (DAE and DHE) of Dillenia indica L. (Family: Dilleniaceae) and its potential in treatment of diabetic nephropathy by targeting markers of oxidative stress. D. indica was evaluated for its in vitro inhibitory activity against formation of AGEs by using bovine serum albumin. Diabetes was induced in male Wistar rats by streptozotocin (65 mg/kg i.p.) 15 min after nicotinamide (230 mg/kg, i...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29320955/therapeutic-roles-of-statins-in-gynecology-and-obstetrics-the-current-evidence
#19
Burak Zeybek, Maged Costantine, Gokhan S Kilic, Mostafa A Borahay
INTRODUCTION: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320169/short-medium-and-long-chain-chlorinated-paraffins-in-wildlife-from-paddy-fields-in-the-yangtze-river-delta
#20
Xinyu Du, Bo Yuan, Yihui Zhou, Jonathan P Benskin, Yanling Qiu, Ge Yin, Jianfu Zhao
Short-chain chlorinated paraffins (SCCPs) were added to Annex A of the Stockholm Convention on Persistent Organic Pollutants in April, 2017. As a consequence of this regulation, increasing production and usage of alternatives, such as medium- and long-chain chlorinated paraffins (MCCPs and LCCPs, respectively), is expected. Little is known about the environmental fate and behavior of MCCPs and LCCPs. In the present study, SCCPs, MCCPs, and LCCPs were analyzed in nine wildlife species from paddy fields in the Yangtze River Delta, China, using atmospheric pressure chemical ionization-quadrupole time-of-flight mass spectrometry...
January 10, 2018: Environmental Science & Technology
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