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limb transplant

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https://www.readbyqxmd.com/read/28910912/-percutaneous-catheterization-for-extracorporeal-membrane-oxygenation-a-retrospective-case-series
#1
X Y Li, H Y He, X Tang, R Wang, C Y Zhang, S Q Wang, B Sun, Z H Tong
Objective: To review the experience of percutaneous catheterization for extracorporeal membrane oxygenation (ECMO) by respiratory intensivists at a single institution. Methods: A retrospective review of 87 patients undergoing percutaneous catheterization for ECMO in Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital from November 2009 to January 2017. Subject demographics, type of support, cannulation configuration, types of cannulas, use of imaging modalities, and complications were recorded and summarized...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28904635/does-orthopaedic-surgery-improve-quality-of-life-and-function-in-patients-with-mucopolysaccharidoses
#2
N Williams, D Challoumas, D M Eastwood
PURPOSE: Mucopolysaccharidoses (MPS) are a group of rare lysosomal storage disorders associated with involvement of multiple organs along with a generalised skeletal dysplasia. Both haematopoetic stem cell transplant and enzyme replacement therapy have improved the outlook for patients while surgery remains high-risk and there is little information on clinical or functional outcome to justify many of the surgical procedures performed. This paper aims to summarise the orthopaedic surgical procedures in MPS patients for which quality of life (QoL) and functional data are available and to describe additional QoL and functional measurement tools of relevance to the assessment of orthopaedic outcomes in MPS...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28901186/recipient-adipose-derived-stem-cells-enhance-recipient-cell-engraftment-and-prolong-allotransplant-survival-in-a-miniature-swine-hind-limb-model
#3
Yur-Ren Kuo, Chien-Chang Chen, Yen-Chou Chen, Ching-Ming Chien
Donor mesenchymal stem cells (MSCs) could prolong vascularized composite allotransplantation (VCA) survival in our previous studies. However, recipient adipose tissue is easier to harvest than donor tissue for preconditioning modulation. Hence, this study investigated the efficacy of recipient autologous adipose-derived stem cells (rADSCs) for VCA survival. The heterotopic hind-limb transplantation from female donor to male recipient was performed in outbred miniature swine. Group I ( n = 6) was untreated controls...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28895682/composite-tissue-flap-transplantation-for-limb-salvage-surgery-in-cases-of-severe-lower-limb-burns
#4
Qinglin Li, Maoyang Gai, Gongming Wang, Fengli Ren, Chengdong Wang
No abstract text is available yet for this article.
September 12, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28885716/micrornas-are-potential-objective-and-early-biomarkers-for-acute-rejection-of-transplanted-limbs-in-a-rat-model
#5
Hiroki Oda, Ryosuke Ikeguchi, Tomoki Aoyama, Souichi Ohta, Takashi Noguchi, Yukitoshi Kaizawa, Hirofumi Yurie, Hisataka Takeuchi, Koji Yamamoto, Shuichi Matsuda
BACKGROUND: Limb transplantation is considered to be a treatment option for amputees. Visual skin inspection and histological assessment are used to assess rejection, but these techniques are largely subjective. Using a rat model, we examined the potential of several microRNAs (miRNAs) to be used as objective and minimally invasive biomarkers of acute rejection of transplanted limbs. METHODS: Three Brown Norway rats and 15 Lewis rats were assigned to 2 groups. In the allograft group, 3 Brown Norway rats were used as the donors and 6 Lewis rats as the recipients...
September 8, 2017: Microsurgery
https://www.readbyqxmd.com/read/28872119/intravital-microscopy-of-monocyte-homing-and-tumor-related-angiogenesis-in-a-murine-model-of-peripheral-arterial-disease
#6
Martin Wagner, Claudia Baer, Werner Zuschratter, Monika Riek-Burchardt, Christian Deffge, Soenke Weinert, Jerry C Lee, Ruediger C Braun-Dullaeus, Joerg Herold
The therapeutic goal for peripheral arterial disease and ischemic heart disease is to increase blood flow to ischemic areas caused by hemodynamic stenosis. Vascular surgery is a viable option in selected cases, but for patients without indications for surgery such as progression to rest pain, critical limb ischemia, or major disruptions to life or work, there are few possibilities for mitigating their disease. Cell therapy via monocyte-enhanced perfusion through the stimulation of collateral formation is one of a few non-invasive options...
August 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28860931/the-effect-of-pentoxifylline-on-l-1-sarcoma-tumor-growth-and-angiogenesis-in-balb-c-mice
#7
Barbara Joanna Bałan, Urszula Demkow, Piotr Skopiński, Małgorzata Bychawska, Ewa Skopińska-Różewska, Sławomir Lewicki, Robert Zdanowski
Methyloxantines are present in many herbs and vegetal foods, among them in tea, coffee and chocolate. Previous studies revealed that theophylline and theobromine have anti-angiogenic properties. Anti-tumor properties of theobromine were also described. Pentoxifylline (3,7-dimethyl-1-(5-oxohexyl)xanthine, PTX) is a synthetic xanthine derivative. It is a phosphodiesterase inhibitor and has various anti-inflammatory abilities. Pentoxifylline is widely used in therapy of inflammatory arterial diseases such as intermittent claudication of upper and lower limbs as well as in coronary heart disease...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28852709/ataxia-pancytopenia-syndrome-with-samd9l-mutations
#8
Sorina Gorcenco, Jonna Komulainen-Ebrahim, Karin Nordborg, Maria Suo-Palosaari, Sten Andréasson, Johanna Krüger, Christer Nilsson, Ulrika Kjellström, Elisa Rahikkala, Dominik Turkiewicz, Mikael Karlberg, Lars Nilsson, Jörg Cammenga, Ulf Tedgård, Josef Davidsson, Johanna Uusimaa, Andreas Puschmann
OBJECTIVE: We describe the neurologic, neuroradiologic, and ophthalmologic phenotype of 1 Swedish and 1 Finnish family with autosomal dominant ataxia-pancytopenia (ATXPC) syndrome and SAMD9L mutations. METHODS: Members of these families with germline SAMD9L c.2956C>T, p.Arg986Cys, or c.2672T>C, p.Ile891Thr mutations underwent structured interviews and neurologic and ophthalmologic examinations. Neuroimaging was performed, and medical records were reviewed...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28852436/feasibility-and-toxicity-of-hematopoietic-stem-cell-transplant-in-multiple-sclerosis
#9
REVIEW
Thomas Low Tat Kuan, Farahnaz Amini, Marjan Sadat Seghayat
Multiple sclerosis is a debilitating disease of the central nervous system. It affects people of all ages but is more prevalent among 20-40 year olds. Patients with MS can be presented with potentially any neurological symptom depending on the location of the lesion. A quarter of patients with MS suffer from bilateral lower limb spasticity among other symptoms. These devastating effects can be detrimental to the patient's quality of life. Hematopoietic stem cells (HSCs) have been used as a treatment for MS over the past 2 decades but their safety and efficacy has are undetermined...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28835071/-effects-of-axial-vascular-network-flap-of-scalp-or-anterolateral-thigh-perforator-flap-with-fascia-lata-on-repairing-defects-after-radical-resection-of-scalp-carcinoma-in-patients
#10
W F Zhang, X F Zhang, Q F Gao, X T Niu, Y J Ma, B E Wu, B Ma, F Liang, A W Wang
Objective: To observe the effects of axial vascular network flap of scalp or anterolateral thigh perforator flap with fascia lata on repairing defects after radical resection of scalp carcinoma in patients. Methods: From February 2006 to December 2015, twenty-one patients with scalp carcinoma were admitted to our hospital, and the carcinoma invaded external lamina or full-thickness of skull and dura mater. After perfect preoperative examination, carcinoma and scalp tissue in 3 to 5 cm from the edge of carcinoma, external lamina or full-thickness of skull and invaded dura mater were resected and sentinel lymph nodes around carcinoma were cleaned in 3 to 4 days after admission...
August 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28831719/petersen-s-hernia-after-living-donor-liver-transplantation
#11
Sodai Sakamoto, Ryoichi Goto, Norio Kawamura, Yasuyuki Koshizuka, Masaaki Watanabe, Minoru Ota, Tomomi Suzuki, Daisuke Abo, Kenichiro Yamashita, Toshiya Kamiyama, Akinobu Taketomi, Tsuyoshi Shimamura
BACKGROUND: Hepaticojejunostomy may be used for biliary reconstruction in certain cases of liver transplantation. In this occasion, Roux-en-Y biliary reconstruction is predominantly performed. Petersen's hernia is an internal hernia that can occur after Roux-en-Y reconstruction, and it may lead to extensive ischemic changes affecting incarcerated portions of the small bowel or Roux limb resulting in severe complications with a poor prognosis. CASE PRESENTATION: The present case was a 44-year-old male who underwent living donor liver transplantation (LDLT) for familial amyloid polyneuropathy and in whom biliary reconstruction was performed with Roux-en-Y hepaticojejunostomy...
August 23, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28828026/limb-ischemia-after-heart-transplantation-an-unusual-case-of-tissue-embolism
#12
Seyed Mohsen Mirhosseini, Ali Sanjari Moghaddam
Major complications of heart transplantation include graft rejection, infection, graft arteriosclerosis, malignancy, and drug toxicity. Among these complications, infections and thrombophilic disorders are of particular interest owing to their major contribution to morbidity and mortality among heart transplantation patients. Thrombophilic disorders are caused by imbalance between hypercoagulation and fibrinolytic states. In this report, we describe a 43-year-old man who had unusual complications of heart transplantation...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28827151/endothelial-and-cardiac-progenitor-cells-for-cardiovascular-repair-a-controversial-paradigm-in-cell-therapy
#13
REVIEW
Vanessa Bianconi, Amirhossein Sahebkar, Petri Kovanen, Francesco Bagaglia, Biagio Ricciuti, Paolo Calabrò, Giuseppe Patti, Matteo Pirro
Stem cells have the potential to differentiate into cardiovascular cell lineages and to stimulate tissue regeneration in a paracrine/autocrine manner; thus, they have been extensively studied as candidate cell sources for cardiovascular regeneration. Several preclinical and clinical studies addressing the therapeutic potential of endothelial progenitor cells (EPCs) and cardiac progenitor cells (CPCs) in cardiovascular diseases have been performed. For instance, autologous EPC transplantation and EPC mobilization through pharmacological agents contributed to vascular repair and neovascularization in different animal models of limb ischemia and myocardial infarction...
August 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28826883/comment-on-ex-vivo-flush-of-the-vascularised-limb-allograft-reduces-inflammatory-burden-prior-to-transplantation
#14
Daniel Wilks, Richard Baker, Simon Kay
No abstract text is available yet for this article.
June 21, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28823033/the-combination-of-mitomycin-induced-blood-cells-with-a-temporary-treatment-of-ciclosporin-a-prolongs-allograft-survival-in-vascularized-composite-allotransplantation
#15
Christian Andreas Radu, Sebastian Fischer, Yannick Diehm, Otto Hetzel, Florian Neubrech, Laura Dittmar, Christian Kleist, Martha Maria Gebhard, Peter Terness, Ulrich Kneser, Jurij Kiefer
BACKGROUND: Vascularized composite allotransplantation (VCA) is a rapidly expanding field of transplantation and provides a potential treatment for complex tissue defects. Peripheral blood mononuclear cells (PBMCs) shortly incubated with the antibiotic and chemotherapeutic agent mitomycin C (MMC) can suppress allogeneic T cell response and control allograft rejection in various organ transplantation models. MMC-incubated PBMCs (MICs) are currently being tested in a phase I clinical trial in kidney transplant patients...
August 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28820837/non-contrast-mr-lymphography-for-evaluation-of-lymph-node-transfer-for-secondary-upper-limb-lymphedema
#16
Lionel Arrivé, Sarah Derhy, Chrif Dlimi, Sanaa El Mouhadi, Laurence Monnier-Cholley, Corinne Becker
BACKGROUND: Our purpose was to evaluate the results of axillary lymph node transplantation (LNT) with non-contrast magnetic resonance (MR) lymphography in 15 patients with secondary upper limb lymphedema. METHODS: Fifteen female patients with lymphedema following breast cancer treatment underwent LNT. Non-contrast MR lymphography was obtained with a free-breathing 3D fast spin-echo sequence. Images analysis criteria included: (A) before surgery: a) severity of lymphedema graded as absent, mild, moderate, and severe; b) involvement of the muscular compartment; c) distal dilated lymphatic vessels; (B) after surgery: a) visualization of site of transplantation; b) visualization of transplanted lymph nodes; c) severity of lymphedema with regard to pretransplantation severity (i...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28815344/long-term-survival-after-hematopoietic-stem-cell-transplantation-for-complete-stat1-deficiency
#17
Samuele Naviglio, Elena Soncini, Donatella Vairo, Arnalda Lanfranchi, Raffaele Badolato, Fulvio Porta
PURPOSE: Complete signal transducer and activator of transcription 1 (STAT1) deficiency is a rare autosomal recessive condition characterized by impairment of intracellular signaling from both type I and type II interferons (IFN). Affected patients are prone to early severe mycobacterial and viral infections, which usually result in death before 18 months of age. We previously reported a patient affected by complete STAT1 deficiency who underwent hematopoietic stem cell transplantation (HSCT)...
August 16, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28793833/synergistic-therapeutic-effect-of-three-dimensional-stem-cell-clusters-and-angiopoietin-1-on-promoting-vascular-regeneration-in-ischemic-region
#18
Jungmi Kang, Jeong-Kee Yoon, Seung Ja Oh, Byung-Soo Kim, Sang-Heon Kim
Peripheral artery disease (PAD) is an ischemic disease characterized by reduced blood flow to the legs, feet, and hands. Human mesenchymal stem cells (MSCs) are an attractive cell source to treat PAD in regenerative medicine. However, in clinical applications, the use of adult stem cells has several limitations, such as low cell viability and low therapeutic efficiency. In the present study, we described an innovative method of culturing three-dimensional stem cell clusters (AngioclusterTM, AC), demonstrated the potential for ACs to differentiate into vascular cells, and assessed the synergistic effects of ACs and angiopoietin-1 (Ang-1) on angiogenesis in ischemic animal models...
August 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28793038/transplantation-of-human-immature-dental-pulp-stem-cell-in-dogs-with-chronic-spinal-cord-injury
#19
Matheus Levi Tajra Feitosa, Carlos Alberto Palmeira Sarmento, Renato Zonzini Bocabello, Patrícia Cristina Baleeiro Beltrão-Braga, Graciela Conceição Pignatari, Robson Fortes Giglio, Maria Angelica Miglino, Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio
Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation...
July 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28767168/the-possibility-of-free-tissue-transfer-as-a-nutrient-flap-for-critical-ischemic-foot-a-case-report
#20
Kentaro Tanaka, Kimihiro Igari, Mitsuhiro Kishino, Satoshi Usami, Tsutomu Homma, Takahiro Toyofuku, Yoshinori Inoue, Mutsumi Okazaki
Microsurgical procedure of free tissue transfer in critical limb ischemia patients with large ulceration has already been established. The nutrient flap concept was that transferred tissue functioned not only to cover the skin defect but also as a supplementary blood supply to the ischemic lower leg. This report showed the justification for this concept, which was rarely discussed. A 58-year-old male patient with progressive forefoot gangrene caused by arteriosclerosis obliterans was presented. The distal bypass procedure was performed as revascularization surgery, and a latissimus dorsi (LD) myocutaneous flap was transplanted to cover ulceration...
August 2, 2017: Microsurgery
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