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https://www.readbyqxmd.com/read/28324160/regulation-of-blood-oxygen-transport-in-hibernating-mammals
#1
Inge G Revsbech, Angela Fago
Along with the periodic reductions in O2 requirements of mammalian hibernators during winter, the O2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood-O2 affinity, which causes a decreased O2 unloading to tissues, while having similar or lower tissue O2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O2 affinity of the hemoglobin, the O2 carrier protein of the blood...
March 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28323418/bio-inspired-polydopamine-coated-hemoglobin-as-potential-oxygen-carriers-with-antioxidant-properties
#2
Quan Wang, Ruirui Zhang, Mingzi Lu, Guoxing You, Ying Wang, Gan Chen, Caiyan Zhao, Zhen Wang, Xiang Song, Yan Wu, Lian Zhao, Hong Zhou
Oxidative side reaction is one of major factors hindering the development of hemoglobin-based oxygen carriers (HBOCs). To avoid the oxidative toxicity, we designed and synthesized polydopamine coated hemoglobin (Hb-PDA) nanoparticles via simple one-step assemblage without any toxic reagent. Hb-PDA nanoparticles showed oxidative protection of Hb by inhibiting the generation of methemoglobin (MetHb) and ferryl (Fe IV) Hb, as well as excellent antioxidant properties by scavenging free radicals and reactive oxygen species (ROS)...
March 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28319219/interface-defect-tuneable-macro-and-micro-photoluminescence-behaviours-of-trivalent-europium-ions-in-electrospun-zro2-zno-porous-nanobelts
#3
Yanzhe Mao, Jinglong Bai, Mingxiang Zhang, Hao Zhao, Gengzhi Sun, Xiaojun Pan, Zhenxing Zhang, Jinyuan Zhou, Erqing Xie
It was demonstrated that suitable interfaces between two materials can enhance the separation of photogenerated carriers. In this study, ZrO2/ZnO interfaces with type I structure were designed and prepared by the electrospinning technique. The obtained ZrO2/ZnO:Eu(3+) (ZZOE) composites are highly porous in the form of nanobelts with width of 600-700 nm, comprising ZnO and ZrO2 nanocrystals, and the Eu doping can hinder the t-m phase transition of ZrO2. By tuning the annealing temperature, the inner stress and defects can be well controlled to improve the photoluminescence (PL) of the ZZOE porous nanobelts...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28317341/metal-doping-for-enhancing-the-photoelectrochemical-behavior-of-lafeo3-photocathodes
#4
María Isabel Díez-García, Roberto Gómez
The development of tandem devices for water photosplitting requires finding photocathodic materials based on earth-abundant elements and showing long-term stability in aqueous electrolytes. Ternary metal oxides seem to be a viable option, among which perovskites stand out. In this context, transparent and compact LaFeO3 thin film electrodes have been prepared by sol-gel, both undoped and doped with metals (M) such as magnesium or zinc. Pristine electrodes support the development of cathodic photocurrents in 0...
March 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28315643/benefits-of-21-oxygen-compared-with-100-oxygen-for-delivery-of-isoflurane-to-mice-mus-musculus-and-rats-rattus-norvegicus
#5
Laura A Wilding, Joe A Hampel, Basma M Khoury, Stacey Kang, David Machado-Aranda, Krishnan Raghavendran, Jean A Nemzek
At research institutions, isoflurane delivered by precision vaporizer to a face mask is the standard for rodent surgery and for procedures with durations that exceed a few minutes. Pure oxygen is often used as the carrier gas for isoflurane anesthesia, despite documented complications from long-term 100% oxygen use in humans and known occupational safety risks. We therefore examined the effect of anesthetic delivery gas on physiologic variables in mice and rats. Rodents were anesthetized for 60 min with isoflurane delivered in either 21% or 100% oxygen by means of a nose cone...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28314096/enhanced-performance-in-azo-based-transparent-flexible-tfts-due-to-oxygen-vacancy-in-zno-film-with-zn-al-o-interface-fabricated-by-atomic-layer-deposition
#6
Yang Li, Rui Yao, Huanhuan Wang, Xiaoming Wu, Jinzhu Wu, Xiaohong Wu, Wei Qin
Highly conductive and optical transparent Al doped ZnO (AZO) thin film composing of ZnO with Zn-Al-O interface was fabricated by thermal atomic layer deposition (ALD) method. The as-prepared AZO thin film exhibits excellent electrical and optical properties, with high stability and compatibility with temperature-sensitive flexible photoelectronic devices: film resistivity is as low as 5.7×10-4 Ω·cm; the carrier concentration is high up to 2.2×1021 cm-3; optical transparency is greater than 80 % in a visible range; the growth temperature is below 150 °C on the PEN substrate...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28301760/metal-free-motifs-for-solar-fuel-applications
#7
Stefan Ilic, Marija R Zoric, Usha Pandey Kadel, Yunjing Huang, Ksenija D Glusac
Metal-free motifs, such as graphitic carbon nitride, conjugated polymers, and doped nanostructures, are emerging as a new class of Earth-abundant materials for solar fuel devices. Although these metal-free structures show great potential, detailed mechanistic understanding of their performance remains limited. Here, we review important experimental and theoretical findings relevant to the role of metal-free motifs as either photoelectrodes or electrocatalysts. First, the light-harvesting characteristics of metal-free photoelectrodes (band energetics, exciton binding energies, charge carrier mobilities and lifetimes) are discussed and contrasted with those in traditional inorganic semiconductors (such as Si)...
March 15, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28299924/improvement-of-electrical-characteristics-and-stability-of-amorphous-indium-gallium-zinc-oxide-thin-film-transistors-using-nitrocellulose-passivation-layer
#8
Kwan Yup Shin, Young Jun Tak, Won-Gi Kim, Seonghwan Hong, Hyun Jae Kim
In this research, nitrocellulose is proposed as a new material for the passivation layers of amorphous indium gallium zinc oxide thin film transistors (a-IGZO TFTs). The a-IGZO TFTs with nitrocellulose passivation layers (NC-PVLs) demonstrate improved electrical characteristics and stability. The a-IGZO TFTs with NC-PVLs exhibit improvements in field-effect mobility (μFE) from 11.72 ± 1.14 to 20.68 ± 1.94 cm2/Vs, threshold voltage (Vth) from 1.85 ± 1.19 to 0.56 ± 0.35 V, and on/off current ratio (Ion/off) from (5...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28294960/overview-of-potential-clinical-applications-of-hemoglobin-vesicles-hbv-as-artificial-red-cells-evidenced-by-preclinical-studies-of-the-academic-research-consortium
#9
REVIEW
Hiromi Sakai
Hemoglobin (Hb) is the most abundant protein in whole blood. This fact implies that the oxygen binding and releasing function of Hb is the most vital for sustaining life. All Hb is compartmentalized in red blood cells (RBCs) with corpuscular Hb concentration of about 35 g/dL, covered with a thin biomembrane. In spite of its abundance, Hb sometimes shows toxicity once it is leaked from RBCs. The shielding effect of the RBC membrane is physiologically important. Based on this structural importance, we have studied artificial red cells (Hb vesicles, HbV) as artificial oxygen carriers, which encapsulate a purified and concentrated Hb solution in phospholipid vesicles, mimicking the cellular structure of RBCs...
March 15, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28291267/a-win-win-nanoplatform-tio2-yb-ho-f-for-nir-light-induced-synergistic-therapy-and-imaging
#10
Jie Zhou, Pei Luo, Chong Sun, Lingchang Meng, Weiran Ye, Shanshan Chen, Bin Du
To avoid the defect of low energy transfer efficiency in core-shell UCNP-TiO2 NPs, doping rare earth into TiO2 and improving the photocatalytic activity of TiO2 itself under Vis-NIR light might be a more direct and efficient strategy for high (1)O2 production. Here, we designed a TiO2:Yb,Ho,F-β-CD@DTX/HA nanoplatform using TiO2:Yb,Ho,F as the core, β-CD as the drug carrier, hyaluronic acid (HA) as the capping agent and target, and then applied it for 808 nm induced photodynamic-chemotherapy and 980 nm upconversion fluorescence/MR imaging...
March 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28288573/hemoglobin-vesicles-prolong-the-time-to-circulatory-collapse-in-rats-during-apnea
#11
Yusuke Naito, Hiromi Sakai, Satoki Inoue, Masahiko Kawaguchi
BACKGROUND: Hemoglobin vesicles (HbV) are hemoglobin-based oxygen carriers manufactured by liposome encapsulation of hemoglobin molecules. We hypothesised that the infusion of oxygenated HbV could prolong the time to circulatory collapse during apnea in rats. METHODS: Twenty-four Sprague-Dawley rats were randomly divided into four groups (Air, Oxy, NS and HbV). The rats were anaesthetized with isoflurane and the trachea was intubated using 14-gauge intravenous catheters...
March 14, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28286504/molluskan-hemocyanins-activate-the-classical-pathway-of-the-human-complement-system-through-natural-antibodies
#12
Javier Pizarro-Bauerle, Ismael Maldonado, Eduardo Sosoniuk-Roche, Gerardo Vallejos, Mercedes N López, Flavio Salazar-Onfray, Lorena Aguilar-Guzmán, Carolina Valck, Arturo Ferreira, María Inés Becker
Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable immunostimulatory properties when inoculated in mammals, such as the generation of high levels of antibodies, a strong cellular reaction, and generation of non-specific antitumor immune responses in some types of cancer, particularly for superficial bladder cancer. These proteins have the ability to bias the immune response toward a Th1 phenotype. However, despite all their current uses with beneficial clinical outcomes, a clear mechanism explaining these properties is not available...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28285577/the-in-vitro-influence-of-a-genetic-superoxide-hydrogen-peroxide-imbalance-on-immunosenescence
#13
Fernanda Barbisan, Verônica Farina Azzolin, Euler Esteves Ribeiro, Marta Maria Medeiros Frescura Duarte, Ivana Cruz
As superoxide is a key molecule of inflammatory activation, superoxide- hydrogen peroxide (S-HP) imbalance genetically caused could to alter immunosenescence patterns. To test this hypothesis, we collect and cultured peripheral blood mononuclear cells carrier´s different genotypes of a genetic polymorphism located in the superoxide dismutase manganese dependent gene (Val16Ala-SOD2). We used an in vitro genetic model based in prior studies, which suggested association between homozygous genotypes (AA and VV) and alterations in oxidative-inflammatory mediators...
March 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28282052/a-synthetic-redox-biofilm-made-from-metalloprotein-prion-domain-chimera-nanowires
#14
Lucie Altamura, Christophe Horvath, Saravanan Rengaraj, Anaëlle Rongier, Kamal Elouarzaki, Chantal Gondran, Anthony L B Maçon, Charlotte Vendrely, Vincent Bouchiat, Marc Fontecave, Denis Mariolle, Patrice Rannou, Alan Le Goff, Nicolas Duraffourg, Michael Holzinger, Vincent Forge
Engineering bioelectronic components and set-ups that mimic natural systems is extremely challenging. Here we report the design of a protein-only redox film inspired by the architecture of bacterial electroactive biofilms. The nanowire scaffold is formed using a chimeric protein that results from the attachment of a prion domain to a rubredoxin (Rd) that acts as an electron carrier. The prion domain self-assembles into stable fibres and provides a suitable arrangement of redox metal centres in Rd to permit electron transport...
February 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28281469/cyclodextrin-gated-mesoporous-silica-nanoparticles-as-drug-carriers-for-red-light-induced-drug-release
#15
Shiqiang Chai, Yu Guo, Zhenyu Zhang, Zhen Chai, Yurong Ma, Limin Qi
Long wavelength light-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have attracted much attention in the last few years. In this paper, a red light (660 nm)-responsive drug delivery system based on low-cost cyclodextrin (CD)-gated MSNs containing a photodynamic therapy (PDT) photosensitizer (Chlorin e6, Ce6) was developed for the first time. The drug release experiment in water demonstrated that with the irradiation of red light, Ce6 can be excited to generate singlet oxygen, which can further cleave the singlet oxygen sensitive linker to trigger the departure of CD and the release of cargo...
April 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28278587/functionality-of-albumin-derived-perfluorocarbon-based-artificial-oxygen-carriers-in-the-langendorff-heart-%C3%A2
#16
Anna Wrobeln, Klaus D Schlüter, Jürgen Linders, Manfred Zähres, Christian Mayer, Michael Kirsch, Katja B Ferenz
The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen...
February 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28276516/electrochemical-tuning-of-the-optical-properties-of-nanoporous-gold
#17
D Jalas, L-H Shao, R Canchi, T Okuma, S Lang, A Petrov, J Weissmüller, M Eich
Using optical in-situ measurements in an electrochemical environment, we study the electrochemical tuning of the transmission spectrum of films from the nanoporous gold (NPG) based optical metamaterial, including the effect of the ligament size. The long wavelength part of the transmission spectrum around 800 nm can be reversibly tuned via the applied electrode potential. The NPG behaves as diluted metal with its transition from dielectric to metallic response shifted to longer wavelengths. We find that the applied potential alters the charge carrier density to a comparable extent as in experiments on gold nanoparticles...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274767/copper-sulfide-nanoparticle-based-localized-drug-delivery-system-as-an-effective-cancer-synergistic-treatment-and-theranostic-platform
#18
Lin Hou, Xiaoning Shan, Lisha Hao, Qianhua Feng, Zhenzhong Zhang
Localized cancer treatment with combination therapy has attracted increasing attention for effective inhibition of tumor growth. In this work, we introduced diffusion molecular retention (DMR) tumor targeting effect, a new strategy that employed transferrin (Tf) modified hollow mesoporous CuS nanoparticles (HMCuS NPs) to undergo extensive diffuse through the interstitium and tumor retention after a peritumoral (PT) injection. Herein, HMCuS NPs with strong near-infrared (NIR) absorption and photothermal conversion efficiency could serve as not only a drug carrier but also a powerful contrast agent for photoacoustic imaging to guide chemo-phototherapy...
March 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28273808/role-of-ul3-in-multidrug-resistance-in-p53-mutated-lung-cancer-cells
#19
Annapina Russo, Assunta Saide, Silvia Smaldone, Raffaella Faraonio, Giulia Russo
Cancer is one of the most common causes of death among adults. Chemotherapy is crucial in determining patient survival and quality of life. However, the development of multidrug resistance (MDR) continues to pose a significant challenge in the management of cancer. In this study, we analyzed the role of human ribosomal protein uL3 (formerly rpL3) in multidrug resistance. Our studies revealed that uL3 is a key determinant of multidrug resistance in p53-mutated lung cancer cells by controlling the cell redox status...
March 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28270086/therapeutic-implications-of-superoxide-dismutase-and-its-importance-inkinase-drug-discovery
#20
Monalisa Mukherjee, Satyendra K Rajput, Deepa Suhag, Apoorv Gupta, Aarti Singh, Vipin Kumar, Adeeba Shakeel, Arun Kumar Sharma, Nameet Kaur
In recent years, several scientific investigations have reported the therapeutic implications of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical trials. Indeed, various kinase, molecular signaling and physiological process has altered by reactive oxygen species. In spite of the abundant available literature reports, patents, clinical trials and commercialized products, the therapeutic application of SOD as a potential drug still remains unclear. Owing to the technical challenges associated with the utilization of SOD as a drug, we revisited the structural arrangement and cellular signaling, significant association with kinase which exploring the new target sites and introduction of new formulation strategies such as gene modulation, nano-formulations and click chemistry is a prerequisite...
March 7, 2017: Current Topics in Medicinal Chemistry
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