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https://www.readbyqxmd.com/read/28941386/trp64arg-polymorphism-of-the-adrb3-gene-associated-with-maximal-fat-oxidation-and-ldl-c-levels-in-non-obese-adolescents
#1
Íncare Correa de Jesus, Lupe Furtado Alle, Eva Cantalejo Munhoz, Larissa Rosa da Silva, Wendell Arthur Lopes, Luciane Viater Tureck, Katia Sheylla Malta Purim, Ana Claudia Kapp Titski, Neiva Leite
OBJECTIVE: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates (FATMAX) and the lipid profile levels in non-obese adolescents. METHODS: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric and body composition variables, in addition to total cholesterol (TC), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), triglycerides (TG), insulin (INS), and basal glycemia (GLIC), were evaluated...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28930919/2017-military-supplement-mini-review-perfluorocarbons-oxygen-transport-and-microcirculation-in-low-flow-states-in-vivo-and-in-vitro-studies
#2
Ivo P Torres Filho
The in vivo study of microvascular oxygen transport requires accurate and challenging measurements of several mass transfer parameters. Although recommended, blood flow and oxygenation are typically not measured in many studies where treatments for ischemia are tested. Therefore, the aim of this communication is to briefly review cardinal aspects of oxygen transport, and the effects of perfluorocarbon treatment on blood flow and oxygenation based mostly on studies performed in our laboratory. Since physiologically relevant events in oxygen transport take place at the microvascular level, we implemented the phosphorescence quenching technique coupled with non-invasive intravital videomicroscopy for quantitative evaluation of these events in vivo...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28930917/shock-2017-military-supplement-an-overview-of-two-human-trials-of-perfluorocarbon-emulsions-in-non-cardiac-surgery
#3
Donat R Spahn, Peter E Keipert
Perfluorochemicals (PFCs) constitute one class of artificial oxygen carriers that are being produced completely synthetically. One formulation that has been evaluated extensively in clinical trials is a 60% w/v perflubron-based emulsion. Efficacy and safety of this perflubron emulsion was evaluated in a Phase 2 and a large prospective randomized Phase 3 multicenter European study, which collectively included a total of 639 patients. Perflubron emulsion was highly successful in improving organ function, reversing physiologic transfusion triggers and in reducing the need for allogeneic blood transfusions...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28929735/heart-repair-using-nanogel-encapsulated-human-cardiac-stem-cells-in-mice-and-pigs-with-myocardial-infarction
#4
Junnan Tang, Xiaolin Cui, Thomas G Caranasos, M Taylor Hensley, Adam C Vandergriff, Yusak Hartanto, Deliang Shen, Hu Zhang, Jinying Zhang, Ke Cheng
Stem cell transplantation is currently implemented clinically but is limited by low retention and engraftment of transplanted cells and the adverse effects of inflammation and immunoreaction when allogeneic or xenogeneic cells are used. Here, we demonstrate the safety and efficacy of encapsulating human cardiac stem cells (hCSCs) in thermosensitive poly(N-isopropylacrylamine-co-acrylic acid) or P(NIPAM-AA) nanogel in mouse and pig models of myocardial infarction (MI). Unlike xenogeneic hCSCs injected in saline, injection of nanogel-encapsulated hCSCs does not elicit systemic inflammation or local T cell infiltrations in immunocompetent mice...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28926226/correlation-between-dissolved-protons-in-nickel-doped-bazr0-1ce0-7y0-1yb0-1o3-%C3%AE-and-its-electrical-conductive-properties
#5
Tomohiro Ishiyama, Haruo Kishimoto, Katherine Develos-Bagarinao, Katsuhiko Yamaji, Toshiaki Yamaguchi, Yoshinobu Fujishiro
The electrical conductivity of nickel (2 wt %)-doped BaZr0.1Ce0.7Y0.1Yb0.1O3-δ (BZCYYb) acceptor-doped perovskite oxide was evaluated under air and a 1% H2 atmosphere. The partial conductivity was calculated from the total conductivity and the transport number of each carrier (tH(+), tO(2-), and th(+)) obtained using the concentration cell method. Its correlation with the dissolution state of the protons in the oxide as studied by in situ diffuse reflection Fourier transform infrared spectroscopy is discussed...
September 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28924345/delivery-of-paeonol-by-nanoparticles-enhances-its-in-vitro-and-in-vivo-antitumor-effects
#6
Cong Chen, Feng Jia, Zhibo Hou, Shu Ruan, Qibin Lu
Paeonol (Pae; 2'-hydroxy-4'-methoxyacetophenone) has attracted intense attention as a potential therapeutic agent against various cancers. However, the use of Pae is limited owing to its hydrophobicity. Recently, biodegradable polymeric nanoparticles with amphiphilic copolymers have been used as drug carriers; these have better bioavailability and are promising tumor-targeted drug delivery systems. In the current study, we prepared Pae-loaded nanoparticles (Pae-NPs) with amphiphilic block copolymers using nanoprecipitation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28920138/study-on-the-sediment-characteristics-of-the-snow-in-a-typical-residential-community-and-its-integrated-biological-treatment-pattern-in-harbin
#7
Bin-Xia Xue, Tong-Yu Li, Chun-Ying Li, Li Wei, Xiao-He Hou
Winter cities have severe shortages of water resources. The effective classification and recycling of urban water resources that are available here are therefore significant for the sustainable utilization of water in winter cities, and snow is a potential water resource. In this research, the water quality of the snow and the pollutant composition in the vehicle roads of a typical residential community of Harbin are analyzed. It is concluded that there is a large amount of suspended substances, including chemical oxygen demand (COD), salt, ammonia, and oil in this snow...
September 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28919576/simulation-of-the-effects-of-oxygen-carriers-and-scaffold-geometry-on-oxygen-distribution-and-cell-growth-in-a-channeled-scaffold-for-engineering-myocardium
#8
Alireza Zehi Mofrad, Shohreh Mashayekhan, Dariush Bastani
This study proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on oxygen distribution and cell growth in a 3D cardiac construct using computational fluid dynamics (CFD). Flow equations, oxygen balance equation and cell balance equation were solved using special initial and boundary conditions. The modeling results revealed that 55% increase in cardiac cell density occurred by using 6.4% perfluorocarbon oxygen carrier (PFC) compared to pure culture medium without PFC supplementation...
September 14, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28914306/enhanced-intermediate-temperature-co2-splitting-using-nonstoichiometric-ceria-and-ceria-zirconia
#9
Zhenlong Zhao, Mruthunjaya Uddi, Nikolai Tsvetkov, Bilge Yildiz, Ahmed F Ghoniem
CO2 splitting via thermo-chemical or reactive redox has emerged as a novel and promising carbon-neutral energy solution. Its performance depends critically on the properties of the oxygen carriers (OC). Ceria is recognized as one of the most promising OC candidates, because of its fast chemistry, high ionic diffusivity, and large oxygen storage capacity. The fundamental surface ion-incorporation pathways, along with the role of surface defects and the adsorbates remain largely unknown. This study presents a detailed kinetics study of CO2 splitting using CeO2 and Ce0...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28912566/enhancement-of-the-device-performance-and-the-stability-with-a-homojunction-structured-tungsten-indium-zinc-oxide-thin-film-transistor
#10
Hyun-Woo Park, Aeran Song, Dukhyun Choi, Hyung-Jun Kim, Jang-Yeon Kwon, Kwun-Bum Chung
Tungsten-indium-zinc-oxide thin-film transistors (WIZO-TFTs) were fabricated using a radio frequency (RF) co-sputtering system with two types of source/drain (S/D)-electrode material of conducting WIZO (homojunction structure) and the indium-tin oxide (ITO) (heterojunction structure) on the same WIZO active-channel layer. The electrical properties of the WIZO layers used in the S/D electrode and the active-channel layer were adjusted through oxygen partial pressure during the deposition process. To explain enhancements of the device performance and stability of the homojunction-structured WIZO-TFT, a systematic investigation of correlation between device performance and physical properties at the interface between the active layer and the S/D electrodes such as the contact resistance, surface/interfacial roughness, interfacial-trap density, and interfacial energy-level alignments was conducted...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911270/effective-partial-nitrification-of-ammonia-in-a-fluidized-bed-bioreactor
#11
Haolong Wang, Mingu Kim, Kai Li, Yuanyuan Shao, Jesse Zhu, George Nakhla
A lab-scale fluidized bed bioreactor with high-density polyethylene as biofilm carrier media was operated to study partial nitrification performance with high ammonia concentrations. The system was run at nitrogen loading rates (NLR) from 1.2 to 4.8 kg N/(m(3)·d) with empty bed contact time (EBCT) of 2.0 hrs and 2.7 hrs and four different influent ammonia concentrations of 100, 200, 300 and 400 mg/L. Dissolved oxygen concentration and temperature were maintained around 1.3 mg/L and 35˚C, respectively. Stable partial nitrification was successfully achieved during the whole period with low effluent NO3-N concentration at less than 15 mg/L, due to effective suppression of nitrite-oxidizing bacteria activity (NOB) at high concentrations of free ammonia (5...
September 15, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28904409/biomedical-applications-of-polyhydroxyalkanoates
#12
REVIEW
Subhasree Ray, Vipin Chandra Kalia
Polyhydroxyalkanoates (PHA) are produced by a large number of microbes under stress conditions such as high carbon (C) availability and limitations of nutrients such as nitrogen, potassium, phosphorus, magnesium, and oxygen. Here, microbes store C as granules of PHAs-energy reservoir. PHAs have properties, which are quite similar to those of synthetic plastics. The unique properties, which make them desirable materials for biomedical applications is their biodegradability, biocompatibility, and non-toxicity...
September 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28899945/bindings-of-no-co-and-o2-to-multi-functional-globin-type-dehaloperoxidase-follow-the-sliding-scale-rule
#13
Gang Wu, Jing Zhao, Stefan Franzen, Ah-Lim Tsai
Dehaloperoxidase-hemoglobin (DHP), a multifunctional globin protein, functions not only as an oxygen carrier as typical globins such as myoglobin, but also as a peroxidase, a mono- and di-oxygenase, peroxygenase, and an oxidase. Kinetics of DHP binding to NO, CO, and O2 were characterized for wild type DHP A and B and the H55D and H55V DHP A mutants. All three gaseous ligands bind to DHP significantly more weakly than sperm whale myoglobin (SWMb). Both CO and NO bind to DHP in a one-step process to form a stable six-coordinate complex...
September 12, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28898731/ferroelectric-spontaneous-polarization-steering-charge-carriers-migration-for-promoting-photocatalysis-and-molecular-oxygen-activation
#14
Hongwei Huang, Shuchen Tu, Xin Du, Yihe Zhang
Introducing a polarization electric field in photocatalyst system is regarded asa new concept for photocatalytic activity enhancement. In this work, we first unearth that the spontaneous polarization of ferroelectric BaTiO3 promotes the photocatalytic and molecular oxygen activation performance of the narrow-band-gap semiconductor BiOI. Ferroelectric tetragonal-phase BaTiO3 (T-BaTiO3) were prepared via calcination of nonferroelectric cubic-phase BaTiO3 (C-BaTiO3), and their polarization ability was verified via ultrasonication-assisted piezoelectric catalytic degradation...
September 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28898468/nanodroplet-containing-polymers-for-efficient-low-power-light-upconversion
#15
Roberto Vadrucci, Angelo Monguzzi, Felipe Saenz, Bodo D Wilts, Yoan C Simon, Christoph Weder
Sensitized triplet-triplet-annihilation-based photon upconversion (TTA-UC) permits the conversion of light into radiation of higher energy and involves a sequence of photophysical processes between two dyes. In contrast to other upconversion schemes, TTA-UC allows the frequency shifting of low-intensity light, which makes it particularly suitable for solar-energy harvesting technologies. High upconversion yields can be observed for low viscosity solutions of dyes; but, in solid materials, which are better suited for integration in devices, the process is usually less efficient...
September 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28895735/reduction-sensitive-paclitaxel-prodrug-self-assembled-nanoparticles-with-tetrandrine-effectively-promote-synergistic-therapy-against-drug-sensitive-and-multidrug-resistant-breast-cancer
#16
Mengjuan Jiang, Ruoshi Zhang, Yingli Wang, Wenna Jing, Ying Liu, Yan Ma, Bingjun Sun, Menglin Wang, Peizhuo Chen, Hongzhuo Liu, Zhonggui He
Co-delivery of multiple drugs with complementary anticancer mechanisms by nano-carriers offers an effective strategy to treat cancers. Herein, conjugation (PTX-SS-VE) of paclitaxel (PTX) to vitamin E succinate (VE) self-assembled nanoparticles were used to load tetrandrine (TET) for combinational treatment against breast carcinoma. The ratio of PTX-SS-VE and TET was optimized. Compared with PTX, the TET/PTX-SS-VE co-loaded nanoparticles (TPNPs) demonstrated superior cytotoxicity against both MCF-7 cells and MCF-7/Adr cells...
September 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28884612/conjugation-with-20%C3%A2-kda-dextran-decreases-the-autoxidation-rate-of-bovine-hemoglobin
#17
Jun Zhang, Ying Wang, Guo-Xing You, Quan Wang, Shan Zhang, Wei-Li Yu, Tao Hu, Lian Zhao, Hong Zhou
Haemoglobin-based oxygen carrier (HBOC) is highly susceptible to autoxidation that renders a series of tissue and cellular toxicities. HBOC is prepared by chemical modification of haemoglobin (Hb), which typically increases the autoxidation rate of Hb. Thus, it is necessary to decrease the autoxidation of HBOC. In the present study, two dextran-bHb conjugates (dex20-bHb and dex40-bHb) were prepared by conjugation with 20 kDa or 40 kDa dextrans, where the thiol group of Cys-93(β) was reversibly protected...
September 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28875840/stimuli-responsive-carriers-for-controlled-intracellular-drug-release
#18
Yan Sheng, Jiaming Hu, Junfeng Shi, Ly James Lee
Stimuli-responsive carriers are a class of drug delivery systems which can change their physicochemical properties and/or structural conformations in response to specific stimuli. Although passive and active drug targeting has proved to reduce the side effects to normal cells, controlled intracellular drug release should be included in drug carriers to enhance the bioavailability of drugs at the disease site. This review focuses on several recent advances in the development of stimuli-responsive carriers for spatially and temporally controlled release of therapeutic agents in response to intracellular stimuli, such as pH, redox potential, reactive oxygen species, enzyme and temperature...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28869330/butyrate-loaded-chitosan-hyaluronan-nanoparticles-a-suitable-tool-for-sustained-inhibition-of-ros-release-by-activated-neutrophils
#19
Pasquale Sacco, Eva Decleva, Fabio Tentor, Renzo Menegazzi, Massimiliano Borgogna, Sergio Paoletti, Kåre Andre Kristiansen, Kjell Morten Vårum, Eleonora Marsich
Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA...
September 4, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28868064/hydrogen-peroxide-is-involved-in-%C3%AE-cyclodextrin-hemin-complex-induced-lateral-root-formation-in-tomato-seedlings
#20
Weiti Cui, Dan Zhu, Wenbiao Shen, Yudong Mei, Dekun Hu, Yujian Shi, Yong Ren, Wei Shen, Quan Gu, Daokun Xu, Liqin Huang
Although previous results showed that β-cyclodextrin-hemin complex (β-CDH) could induce tomato lateral root (LR) formation, the corresponding downstream messengers are still not fully understood. In this report, similar to the inducing effects of exogenously applied hydrogen peroxide (H2O2), we discovered that β-CDH elicited RBOH1 transcript upregulation, endogenous H2O2 accumulation, and thereafter tomato LR development. Above responses were sensitive to dimethylthiourea (DMTU) and ascorbic acid (AsA), two membrane-permeable scavengers of H2O2, showing that accumulation of H2O2 and LR formation were significantly blocked...
2017: Frontiers in Plant Science
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