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Autoimmune thyroiditis

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https://www.readbyqxmd.com/read/28944137/pulmonary-hypertension-associated-with-antiphospholipid-antibody-call-for-a-screening-tool
#1
REVIEW
Rukma Parthvi, Rutuja R Sikachi, Abhinav Agrawal, Ajay Adial, Abhinav Vulisha, Sameer Khanijo, Arunabh Talwar
Antiphospholipid (aPL) antibodies are antibodies specific for anionic phospholipids. They are immunoglobulins that attack phospholipids, phospholipid-binding proteins, or phospholipid-protein complexes and are detected in anticardiolipin and lupus anticoagulant assays. aPL antibodies are often associated with antiphospholipid syndrome (APS) which can be idiopathic or from secondary causes such as systemic lupus erythematosus (SLE), infection or drugs. They have also been shown to be associated with Pulmonary Hypertension...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943512/prevalence-of-znt8-antibody-in-turkish-children-and-adolescents-with-new-onset-type-1-diabetes
#2
Selin Elmaoğulları, Seyit Ahmet Uçaktürk, Şehri Elbeg, Esra Döğer, Meltem Tayfun, Fatih Gürbüz, Aysun Bideci
OBJECTIVE: Zinc transporter 8 protein (ZnT8) is a transmembranic protein organizing the zinc transfer to insulin vesicles. Antibodies formed against ZnT8 (ZnT8A) are regarded as an independent autoimmunity demonstrator in type 1 diabetes (T1D) diagnosis Investigation of ZnT8ab prevalence in Turkish children with new onset T1D was planned in this study. METHODS: 84 patients between 1-18 years of age diagnosed with T1D between February 2015- March 2016 and the control group consisting of 50 healthy children without any autoimmune diseases were included in the study...
September 25, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28942902/monogenic-hashimoto-thyroiditis-associated-with-a-variant-in-the-thyroglobulin-tg-gene
#3
Mindy S Lo, Meghan Towne, Grace E VanNoy, Catherine A Brownstein, Andrew A Lane, Talal A Chatila, Pankaj B Agrawal
BACKGROUND: Risk of autoimmune thyroid disease (AITD) is strongly heritable. Multiple genes confer increased risk for AITD, but a monogenic origin has not yet been described. We studied a family with apparent autosomal dominant, early onset Hashimoto thyroiditis. METHODS: The family was enrolled in an IRB-approved protocol. Whole exome sequencing was used to study the proband and an affected sibling. The identified variant was studied in other family members by Sanger sequencing...
September 21, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28942732/is-graves-disease-a-primary-immunodeficiency-new-immunological-perspectives-on-an-endocrine-disease
#4
REVIEW
Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz
BACKGROUND: Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research. MAIN TEXT: Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016...
September 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28942661/-etanercept-induced-subacute-thyroiditis-case-report-and-literature-review
#5
Zoltán Hella, László Hodinka, Piroska Turbucz, Gábor László Kovács
65 years old male patient received 4 mg/day methylprednisolone baseline therapy and 50 mg/week etanercept treatment for 5 years due to rheumatoid arthritis. The patient experienced pain in neck, and developed weakness, fever and dysphagia. He had normal blood count but accelerated erythrocyte sedimentation rate (88 mm/hour), elevated CRP (49.3 mg/l) and hyperthyroidism (TSH 0.006 mIU/l, fT4 27.22 pmol/l, fT3 5.61 pmol/l). The autoimmune origin could be excluded because of normal values of antibodies against thyreoidea peroxidase and TSH receptor...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28942280/nitrate-induces-a-type-1-diabetic-profile-in-alligator-hatchlings
#6
Thea M Edwards, Heather J Hamlin, Haley Freymiller, Stephen Green, Jenna Thurman, Louis J Guillette
Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology...
September 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28940958/a-novel-neurog3-mutation-in-neonatal-diabetes-associated-with-a-neuro-intestinal-syndrome
#7
Suna Hancili, Amélie Bonnefond, Julien Philippe, Emmanuel Vaillant, Franck De Graeve, Olivier Sand, Kanetee Busiah, Jean-Jacques Robert, Michel Polak, Philippe Froguel, Ayla Güven, Martine Vaxillaire
Neonatal diabetes mellitus (NDM) is a rare form of non-autoimmune diabetes usually diagnosed in the first 6 months of life. Various genetic defects have been shown to cause NDM with diverse clinical presentations and variable severity. Among transcriptional factor genes associated with isolated or syndromic NDM, a few cases of homozygous mutations in the NEUROG3 gene have been reported, all mutated patients presenting with congenital malabsorptive diarrhea with or without diabetes at a variable age of onset from early life to childhood...
September 22, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28938453/variable-effects-of-dietary-selenium-in-mice-that-spontaneously-develop-a-spectrum-of-thyroid-autoantibodies
#8
Sandra M McLachlan, Holly Aliesky, Bianca Banuelos, Shane S Que Hee, Basil Rapoport
Selenium (Se) is a critical element in thyroid function and variable dietary Se intake influences immunity. Consequently, dietary Se could influence development of thyroid autoimmunity and provide an adjunct to treat autoimmune thyroid dysfunction. NOD.H2h4 mice spontaneously develop autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO). This mouse strain expressing a human TSHR A-subunit transgene in the thyroid also develops pathogenic TSHR autoantibodies. In this report, we investigated whether dietary Se influences these immune processes...
August 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28936757/vitamin-d-deficiency-affects-thyroid-autoimmunity-and-dysfunction-in-iodine-replete-area-korea-national-health-and-nutrition-examination-survey
#9
Mijin Kim, Eyun Song, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
PURPOSE: We evaluated the effects of vitamin D levels and iodine intake on thyroid autoimmunity and dysfunction in the Korean population. METHODS: In this nationwide population-based study, data were obtained from the Korea National Health and Nutrition Examination Survey VI-1 and 2 (2013 and 2014), which was the first nationwide survey that measured both serum 25-hydroxy vitamin D [25(OH)D] levels and urinary iodine concentrations (UICs) in Korea. A total of 4181 participants who underwent laboratory tests for thyroid function, serum 25(OH)D levels, and UICs were included...
September 21, 2017: Endocrine
https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#10
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28932121/treatment-of-pretibial-myxedema-with-intralesional-immunomodulating-therapy
#11
Ziwei Ren, Min He, Fang Deng, Yan Chen, Liyin Chai, Bing Chen, Wuquan Deng
OBJECTIVE: Local immune regulation therapy has been one of the therapeutic methods used for the treatment of autoimmune thyroid disease in patients with pretibial myxedema (PTM). However, the poor response rate and high recurrence rate are still major problems. Whether a premixed corticosteroid, compound betamethasone, could enhance remission rate and decrease recurrence rate in patients with PTM was investigated in the present study. SUBJECTS AND METHODS: We have performed a clinical utility observation of compound betamethasone with intralesional injections based on basic thyroid disease treatment in 32 PTM patients between January 2008 and August 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28929982/comorbidity-of-autoimmune-thyroid-disorders-and-psychiatric-disorders-during-the-postpartum-period-a-danish-nationwide-register-based-cohort-study
#12
V Bergink, V J M Pop, P R Nielsen, E Agerbo, T Munk-Olsen, X Liu
BACKGROUND: The postpartum period is well-known risk period for the first onset of autoimmune thyroid disorders (AITDs) as well as first onset of psychiatric disorders. These two disorders are some of the most prevalent medical conditions postpartum, often misdiagnosed and disabling if left untreated. Our study was designed to explore the possible bidirectional association between AITDs and psychiatric disorders during the postpartum period. METHODS: A population-based cohort study through linkage of Danish national registers, which comprised 312 779 women who gave birth to their first child during 1997-2010...
September 20, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28929353/anti-parietal-cell-antibodies-in-patients-with-autoimmune-thyroid-diseases
#13
S R R Utiyama, R S De Bem, T L Skare, G A De Carvalho, L M Teixeira, M Bertolazo, S O Ioshii, R Nisihara
BACKGROUND: Autoimmune thyroid disease (ATD) patients may have a higher prevalence of anti-parietal cell antibodies (APCA) than normal population. OBJECTIVE: To study the prevalence of APCA in a cohort of ATD patients to know its association with patient's clinical profile and gastrointestinal complaints. METHODS: APCA was sought for by indirect immunofluorescence test in 243 ATD patients: 136 (55.9%) with Graves' disease and 107 (44.0%) with Hashimoto's thyroiditis...
September 19, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28928829/braf-v600e-mutation-contributes-papillary-thyroid-carcinoma-and-hashimoto-thyroiditis-with-resistance-to-thyroid-hormone-a-case-report-and-literature-review
#14
Wanjia Xing, Xiaohong Liu, Qingqing He, Zongjing Zhang, Zhaoshun Jiang
Resistance to thyroid hormone (RTH) is a rare autosomal hereditary disorder characterized by increased serum thyroid hormone (TH) levels with unsuppressed or increased thyrotropin concentration. It remains unknown whether the coexistence of RTH with papillary thyroid carcinoma (PTC) and Hashimoto thyroiditis (HT) is incidental or whether it possesses a genetic or pathophysiological association. In the present study, a case of RTH with PTC and HT in an 11-year-old Chinese patient was examined and the clinical presentation of RTH with PTC was discussed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926868/polycystic-ovary-syndrome-pcos-in-juvenile-and-adult-type-1-diabetes-in-a-german-austrian-cohort
#15
Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard W Holl
Context While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Design and Setting Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28925103/autoimmune-diseases-involving-skin-and-intestinal-mucosa-are-more-frequent-in-adolescents-and-young-adults-suffering-from-atopic-dermatitis
#16
REVIEW
Francesca Cipriani, Alice Marzatico, Giampaolo Ricci
Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Our systematic review included 22 articles from PubMed describing the reciprocal association between AD and autoimmune diseases. Although not all the studies achieved statistically significant results, patients suffering from autoimmune diseases involving skin and intestinal mucosa, such as vitiligo, alopecia areata, celiac disease and inflammatory bowel diseases, showed a higher risk to have AD as comorbidity...
September 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28922436/genetic-risk-factors-for-autoimmune-thyroid-disease-might-affect-the-susceptibility-to-and-modulate-the-progression-of-primary-biliary-cholangitis
#17
Aleksander Kuś, Magdalena Arłukowicz-Grabowska, Konrad Szymański, Ewa Wunsch, Małgorzata Milkiewicz, Rafał Płoski, Zakera Shums, Gary L Norman, Piotr Milkiewicz, Tomasz Bednarczuk, Marcin Krawczyk
BACKGROUND AND AIMS: Patients with primary biliary cholangitis (PBC) frequently suffer from extrahepatic autoimmune conditions, of which autoimmune thyroid disease (AITD) is one of the most common. Previous studies identified several genetic variants increasing the odds of developing AITD. Here we investigate whether AITD-associated polymorphisms might also play a role in the development and clinical course of PBC and PBC associated with AITD (PBC-AITD). METHODS: To this end, we prospectively recruited 230 patients with PBC and 421 healthy controls...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28919585/association-of-human-leukocyte-antigens-class-i-and-ii-with-graves-disease-in-iranian-population
#18
Zahra Mehraji, Ali Farazmand, Alireza Esteghamati, Sina Noshad, Maryam Sadr, Somayeh Amirzargar, Mir Saeed Yekaninejad, Aliakbar Amirzargar
BACKGROUND: Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. OBJECTIVE: To identify HLA polymorphisms that might confer susceptibility or protect against GD...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#19
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28916403/a-case-of-severe-acquired-hypertriglyceridemia-in-a-7-year-old-girl
#20
Jessica S Lilley, MacRae F Linton, Jennifer C Kelley, T Brent Graham, Sergio Fazio, Hagai Tavori
We report a case of severe type I hyperlipoproteinemia caused by autoimmunity against lipoprotein lipase (LPL) in the context of presymptomatic Sjögren's syndrome. A 7-year-old mixed race (Caucasian/African American) girl was admitted to the intensive care unit at Vanderbilt Children's Hospital with acute pancreatitis and shock. She was previously healthy aside from asthma and history of Hashimoto's thyroiditis. Admission triglycerides (TGs) were 2191 mg/dL but returned to normal during the hospital stay and in the absence of food intake...
August 12, 2017: Journal of Clinical Lipidology
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